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The map label for this gene is adrA [H]

Identifier: 78357561

GI number: 78357561

Start: 2538309

End: 2540564

Strand: Direct

Name: adrA [H]

Synonym: Dde_2518

Alternate gene names: 78357561

Gene position: 2538309-2540564 (Clockwise)

Preceding gene: 78357560

Following gene: 78357562

Centisome position: 68.05

GC content: 57.8

Gene sequence:

>2256_bases
ATGACAGCACTGCTTCCATTCCAGATGCGGCTATTTTTTATGAAAAAACACTTTTTTCCGGTAATCATGGGGCTGGTCAG
CCTCATCGCCTTTGTGGCAGCCATGGCGGGGTTCGATTTCACCACCGCCTCGGAATACGCTGCGCAGTTCAGCCGGCAGC
AGGCTCTGCAGGTGCGCGTGGCAACCAACGCCATAGAAGACCAGCTGGACATGATTTCCGCATCCGGCGCATCACTTGCT
GGGCATGCCCGCTTTGCCATCGACTACGGTGCCACATACCAGGCAAAGCTGCTCAGCGCGCACATCACAAGACAGCCGAA
CATCCTTGCTTATGTTCTTATGGATACCCCGCACAGCCTTAAAAGCGTGGAGCTGGCTTCCGTCCCGCTTTCCATGGAAG
CCGCGGCATACGCGCAGGAATGGATAACGCAAAACTGGAGCAACGCCCCAGAACAACTGGCCGGCAACCTGCTCAAAGCT
CCCCTGCACATCACCCCCGAACACCAGCTTGCAGGACTGCTTTATCCTTTTTCGGACGGCAAAAAGCTGCTGGGCATGTC
TGCCACGGTTGTCAGCCTCACACGGATAATCAAGCGGTATGTGGCCGACCTGCATGTGGACAACATAGGGCAAGGCTACC
TGCTGGCGGATGACGGCACACTGCTTTTCGACCCTGACAGCAACAACATCGGTAAAAACATATTTACCCATATCTATGAA
AACGCACCGGAACGGATGCATGTTTTCCGGGAAGTGCTGGCAGCCAGATCCGGCAGCGGCATCTTTGACTTTCCCGACAC
GGAAAACAGCAAAGCCCAGCAGATGCTGCTGGCGTGGGACACGGTCGATTTCGCAGGACGCAGGCTCAAGGTCTGTCTGG
CCGTATCGGGCGATACCGTCAACGAGGTAATGCAGCGTCAGGCCCGCTGGCGCATCGCCGCGGGGGTACTGTTTCTGGTG
GGGCTGGTGCTGGCAAGCACACTCATCATCTACCGGTCGGGGCTTGCCAAAGTGCGGGAAAATGAAGAGCGCCTGCAGAT
GGCTCTTACCGGCAATCAGGACGGGCTGTGGGACTGGAACATACCGGACGGCAGAGTTTACTATTCTCCCCGCTGGAAAG
AAATAATGGGACTTGAAACCGACCAGCAGCTGTCATCGCCCGAAGAATGGTCATCGCGCATTCACCGCGCCGACAAAGAA
GAGGTGACAGCCCACCTGCAGGAGCATCTGCGGGGCGGTGTCCCTTACTTTCAGACAGAGCACCGTGCGGTGCGCGCCGA
CGGGGCTGTCATCTGGGTGCTGGAACGCGGAGCCGTCATAAGCCACGACCGCGAAGGGAAACCCGCCCGTCTGGTAGGCA
CCACCACCGATGTAACAGCGCGGCGGCAGGCCATGATGGAACGCGACATGCTGTTCCGCAACTCCATAGACCTGCTGGCC
ATCACGGATGTTGAAGGCAACATACTTGAAGCCAATCCGGCATGGGAAAACATGCTGGGCTGGACCGCTGAAGAGCTGCG
CCTGCCGCCCTGTTTCGATTATGTGCACCCCGATGATGTACCCAAGGCTGCGGAAAATTTTGCTTTGCTGATGAAAGGCA
TTCCCGTACGGGCGCATGAAGGCCGTTTTTTAAAAAAAGAAGGCAGCTGGATTTGGCTTTCGTGGAACGTGCTGCCCGAC
ATGCAGCACCGGCGCATCTATGTAACCGCACGTGACATCAGCAGGCAGAAGGCACACGAGCGCAGGCTGCATGAACAGGC
ATCCACGGACGAGTTGACAGGCATATTCAACCGACGCCGCGTACTGGACATCGGCAAAGCCGAAATGGCCCGTTCACGGC
GCTTCGGACGCCCGCTGGCATGCCTCATGATAGACATAGACCACTTTAAACAGATCAATGACACATACGGACACGTGGCG
GGTGATGCCGTGCTGCGGGGGGTCACGGCCACGCTTTCGGCCGGCCTGCGCCAGAGCGATACGCTGGGCCGGCTGGGGGG
CGAAGAGTTCATTGTCTTCATGCCCGAAACAGATGCCGAGGGGGCAATGCATACAGCGGAAAGGCTGCGGCAGGCCGTGG
AACAGAGTTCGGTGCTGATGGACGGCGAAGGAGCCAGTCCCGGCATTACCGTCAGTCTGGGCGTAACCGTGCTGGCGCCG
GAAACGGCATCGCTGGATGCATTCATTGCTGCCGCCGATGCAGCCCTGTACCGTGCCAAGGAAAACGGAAGAAACAGAGT
CGAATTTCAGAAATGA

Upstream 100 bases:

>100_bases
TTTCACACATTCAAGCCCTGTTATAGTTCACAAACGAAAAACAGCGCTTACTTGTGCCGGAAACTAATCATTTTCCGGAA
GCCGGCACACGGCTAGTATC

Downstream 100 bases:

>100_bases
ACGCAGCCCGCACTGCACTTTTATCTTGACGTTGGCGCTGTAATATGATGCTAGGCTTTTTTTAAATTGATATCCCCCCG
GATATGCCAAGGAGAACCAC

Product: diguanylate cyclase with PAS/PAC sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 751; Mature: 750

Protein sequence:

>751_residues
MTALLPFQMRLFFMKKHFFPVIMGLVSLIAFVAAMAGFDFTTASEYAAQFSRQQALQVRVATNAIEDQLDMISASGASLA
GHARFAIDYGATYQAKLLSAHITRQPNILAYVLMDTPHSLKSVELASVPLSMEAAAYAQEWITQNWSNAPEQLAGNLLKA
PLHITPEHQLAGLLYPFSDGKKLLGMSATVVSLTRIIKRYVADLHVDNIGQGYLLADDGTLLFDPDSNNIGKNIFTHIYE
NAPERMHVFREVLAARSGSGIFDFPDTENSKAQQMLLAWDTVDFAGRRLKVCLAVSGDTVNEVMQRQARWRIAAGVLFLV
GLVLASTLIIYRSGLAKVRENEERLQMALTGNQDGLWDWNIPDGRVYYSPRWKEIMGLETDQQLSSPEEWSSRIHRADKE
EVTAHLQEHLRGGVPYFQTEHRAVRADGAVIWVLERGAVISHDREGKPARLVGTTTDVTARRQAMMERDMLFRNSIDLLA
ITDVEGNILEANPAWENMLGWTAEELRLPPCFDYVHPDDVPKAAENFALLMKGIPVRAHEGRFLKKEGSWIWLSWNVLPD
MQHRRIYVTARDISRQKAHERRLHEQASTDELTGIFNRRRVLDIGKAEMARSRRFGRPLACLMIDIDHFKQINDTYGHVA
GDAVLRGVTATLSAGLRQSDTLGRLGGEEFIVFMPETDAEGAMHTAERLRQAVEQSSVLMDGEGASPGITVSLGVTVLAP
ETASLDAFIAAADAALYRAKENGRNRVEFQK

Sequences:

>Translated_751_residues
MTALLPFQMRLFFMKKHFFPVIMGLVSLIAFVAAMAGFDFTTASEYAAQFSRQQALQVRVATNAIEDQLDMISASGASLA
GHARFAIDYGATYQAKLLSAHITRQPNILAYVLMDTPHSLKSVELASVPLSMEAAAYAQEWITQNWSNAPEQLAGNLLKA
PLHITPEHQLAGLLYPFSDGKKLLGMSATVVSLTRIIKRYVADLHVDNIGQGYLLADDGTLLFDPDSNNIGKNIFTHIYE
NAPERMHVFREVLAARSGSGIFDFPDTENSKAQQMLLAWDTVDFAGRRLKVCLAVSGDTVNEVMQRQARWRIAAGVLFLV
GLVLASTLIIYRSGLAKVRENEERLQMALTGNQDGLWDWNIPDGRVYYSPRWKEIMGLETDQQLSSPEEWSSRIHRADKE
EVTAHLQEHLRGGVPYFQTEHRAVRADGAVIWVLERGAVISHDREGKPARLVGTTTDVTARRQAMMERDMLFRNSIDLLA
ITDVEGNILEANPAWENMLGWTAEELRLPPCFDYVHPDDVPKAAENFALLMKGIPVRAHEGRFLKKEGSWIWLSWNVLPD
MQHRRIYVTARDISRQKAHERRLHEQASTDELTGIFNRRRVLDIGKAEMARSRRFGRPLACLMIDIDHFKQINDTYGHVA
GDAVLRGVTATLSAGLRQSDTLGRLGGEEFIVFMPETDAEGAMHTAERLRQAVEQSSVLMDGEGASPGITVSLGVTVLAP
ETASLDAFIAAADAALYRAKENGRNRVEFQK
>Mature_750_residues
TALLPFQMRLFFMKKHFFPVIMGLVSLIAFVAAMAGFDFTTASEYAAQFSRQQALQVRVATNAIEDQLDMISASGASLAG
HARFAIDYGATYQAKLLSAHITRQPNILAYVLMDTPHSLKSVELASVPLSMEAAAYAQEWITQNWSNAPEQLAGNLLKAP
LHITPEHQLAGLLYPFSDGKKLLGMSATVVSLTRIIKRYVADLHVDNIGQGYLLADDGTLLFDPDSNNIGKNIFTHIYEN
APERMHVFREVLAARSGSGIFDFPDTENSKAQQMLLAWDTVDFAGRRLKVCLAVSGDTVNEVMQRQARWRIAAGVLFLVG
LVLASTLIIYRSGLAKVRENEERLQMALTGNQDGLWDWNIPDGRVYYSPRWKEIMGLETDQQLSSPEEWSSRIHRADKEE
VTAHLQEHLRGGVPYFQTEHRAVRADGAVIWVLERGAVISHDREGKPARLVGTTTDVTARRQAMMERDMLFRNSIDLLAI
TDVEGNILEANPAWENMLGWTAEELRLPPCFDYVHPDDVPKAAENFALLMKGIPVRAHEGRFLKKEGSWIWLSWNVLPDM
QHRRIYVTARDISRQKAHERRLHEQASTDELTGIFNRRRVLDIGKAEMARSRRFGRPLACLMIDIDHFKQINDTYGHVAG
DAVLRGVTATLSAGLRQSDTLGRLGGEEFIVFMPETDAEGAMHTAERLRQAVEQSSVLMDGEGASPGITVSLGVTVLAPE
TASLDAFIAAADAALYRAKENGRNRVEFQK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI1786584, Length=184, Percent_Identity=37.5, Blast_Score=127, Evalue=3e-30,
Organism=Escherichia coli, GI145693134, Length=178, Percent_Identity=41.0112359550562, Blast_Score=124, Evalue=3e-29,
Organism=Escherichia coli, GI1788381, Length=418, Percent_Identity=26.3157894736842, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI87081881, Length=176, Percent_Identity=38.6363636363636, Blast_Score=117, Evalue=3e-27,
Organism=Escherichia coli, GI1787262, Length=165, Percent_Identity=38.7878787878788, Blast_Score=112, Evalue=1e-25,
Organism=Escherichia coli, GI87082007, Length=197, Percent_Identity=35.0253807106599, Blast_Score=109, Evalue=6e-25,
Organism=Escherichia coli, GI1787816, Length=166, Percent_Identity=39.1566265060241, Blast_Score=99, Evalue=1e-21,
Organism=Escherichia coli, GI87081977, Length=159, Percent_Identity=33.3333333333333, Blast_Score=91, Evalue=3e-19,
Organism=Escherichia coli, GI1788085, Length=161, Percent_Identity=32.2981366459627, Blast_Score=88, Evalue=3e-18,
Organism=Escherichia coli, GI1787541, Length=180, Percent_Identity=31.1111111111111, Blast_Score=82, Evalue=2e-16,
Organism=Escherichia coli, GI1787802, Length=170, Percent_Identity=30.5882352941176, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI87081974, Length=169, Percent_Identity=27.2189349112426, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR007894 [H]

Pfam domain/function: PF00990 GGDEF; PF05230 MASE2 [H]

EC number: NA

Molecular weight: Translated: 83811; Mature: 83680

Theoretical pI: Translated: 6.44; Mature: 6.44

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS00438 CATALASE_2 ; PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALLPFQMRLFFMKKHFFPVIMGLVSLIAFVAAMAGFDFTTASEYAAQFSRQQALQVRV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEH
ATNAIEDQLDMISASGASLAGHARFAIDYGATYQAKLLSAHITRQPNILAYVLMDTPHSL
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCC
KSVELASVPLSMEAAAYAQEWITQNWSNAPEQLAGNLLKAPLHITPEHQLAGLLYPFSDG
CCEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEECCCHHHCEEEEECCCC
KKLLGMSATVVSLTRIIKRYVADLHVDNIGQGYLLADDGTLLFDPDSNNIGKNIFTHIYE
CCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHH
NAPERMHVFREVLAARSGSGIFDFPDTENSKAQQMLLAWDTVDFAGRRLKVCLAVSGDTV
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEHEECCHHHCCCEEEEEEEECCCHH
NEVMQRQARWRIAAGVLFLVGLVLASTLIIYRSGLAKVRENEERLQMALTGNQDGLWDWN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCEECC
IPDGRVYYSPRWKEIMGLETDQQLSSPEEWSSRIHRADKEEVTAHLQEHLRGGVPYFQTE
CCCCEEEECCCHHHHHCCCCCHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEECC
HRAVRADGAVIWVLERGAVISHDREGKPARLVGTTTDVTARRQAMMERDMLFRNSIDLLA
CCEEECCCEEEEEEECCCEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEE
ITDVEGNILEANPAWENMLGWTAEELRLPPCFDYVHPDDVPKAAENFALLMKGIPVRAHE
EECCCCCEEECCCCHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEECC
GRFLKKEGSWIWLSWNVLPDMQHRRIYVTARDISRQKAHERRLHEQASTDELTGIFNRRR
CCEEEECCCEEEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
VLDIGKAEMARSRRFGRPLACLMIDIDHFKQINDTYGHVAGDAVLRGVTATLSAGLRQSD
EEECCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLGRLGGEEFIVFMPETDAEGAMHTAERLRQAVEQSSVLMDGEGASPGITVSLGVTVLAP
CHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEEEEEECC
ETASLDAFIAAADAALYRAKENGRNRVEFQK
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
TALLPFQMRLFFMKKHFFPVIMGLVSLIAFVAAMAGFDFTTASEYAAQFSRQQALQVRV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHEEEH
ATNAIEDQLDMISASGASLAGHARFAIDYGATYQAKLLSAHITRQPNILAYVLMDTPHSL
HHHHHHHHHHHHHCCCCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCC
KSVELASVPLSMEAAAYAQEWITQNWSNAPEQLAGNLLKAPLHITPEHQLAGLLYPFSDG
CCEEEECCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCEECCCHHHCEEEEECCCC
KKLLGMSATVVSLTRIIKRYVADLHVDNIGQGYLLADDGTLLFDPDSNNIGKNIFTHIYE
CCHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCEEEECCCCCCCHHHHHHHHHH
NAPERMHVFREVLAARSGSGIFDFPDTENSKAQQMLLAWDTVDFAGRRLKVCLAVSGDTV
CCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHEEEHEECCHHHCCCEEEEEEEECCCHH
NEVMQRQARWRIAAGVLFLVGLVLASTLIIYRSGLAKVRENEERLQMALTGNQDGLWDWN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHEEEEEECCCCCCEECC
IPDGRVYYSPRWKEIMGLETDQQLSSPEEWSSRIHRADKEEVTAHLQEHLRGGVPYFQTE
CCCCEEEECCCHHHHHCCCCCHHCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEECC
HRAVRADGAVIWVLERGAVISHDREGKPARLVGTTTDVTARRQAMMERDMLFRNSIDLLA
CCEEECCCEEEEEEECCCEEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEE
ITDVEGNILEANPAWENMLGWTAEELRLPPCFDYVHPDDVPKAAENFALLMKGIPVRAHE
EECCCCCEEECCCCHHHHHCCCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEECC
GRFLKKEGSWIWLSWNVLPDMQHRRIYVTARDISRQKAHERRLHEQASTDELTGIFNRRR
CCEEEECCCEEEEEECCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHCCHHHHHHHHHCCC
VLDIGKAEMARSRRFGRPLACLMIDIDHFKQINDTYGHVAGDAVLRGVTATLSAGLRQSD
EEECCHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
TLGRLGGEEFIVFMPETDAEGAMHTAERLRQAVEQSSVLMDGEGASPGITVSLGVTVLAP
CHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEEEEEEECC
ETASLDAFIAAADAALYRAKENGRNRVEFQK
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]