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The map label for this gene is mutM [H]

Identifier: 78355589

GI number: 78355589

Start: 554443

End: 555330

Strand: Direct

Name: mutM [H]

Synonym: Dde_0542

Alternate gene names: 78355589

Gene position: 554443-555330 (Clockwise)

Preceding gene: 78355588

Following gene: 78355590

Centisome position: 14.86

GC content: 60.81

Gene sequence:

>888_bases
ATGCCTGAACTGCCAGAAGTGGAAACCATCGCCCGCGGGCTTGCCCCCGAACTTACCGGGCGCAGAATAACGGAAGTTGA
AGTGTTCAATGCCGGAAGCGTGCAGGGAGACAGAGAAGTCTTTGACGCCTGCACGCCCGGACGCGTCATTGCCGGTGTGG
GCCGCAGAGGCAAACTGCTGCTGGTGCATCTGGAAAAAGAGCGGCGGCAGGGTGCCGCCTGCAGAGCGGTGCTGGACCAC
AGACCCGCCGGTGATACGCCGGATATGCTGGCGTTTCATCTGCGCATGAGCGGCAGACTTTTCATCTACGGACCGGAGCA
GCTTCCCGGTCCGCATACACGCATAATCATCACGCTTGATTCGGGACGCAGGCTGTTTTTTGACGATGCGCGCAAGTTCG
GTTCGTGCCGTGCGCTTTCGCCCTTCAGCAGGCCGCTGTGGCGGTTCTGGGCCACACTGGGGCCGGAACCGCTGGACGTG
GACCGTGAGACATTCATTGAGCAGTTCGCAGAACGGCGCAAAGCCGTGAAAGCCCTGTTGCTGGATCAGACAGTGATAGC
AGGGGTGGGCAACATCTATGCGGACGAGTCGCTTTTCAGGGCCGGAATCAGACCGGATGCCCGGCCGGGCGACTGGACGC
GCGACGAAGCTGAACGCCGTCTGGGCAGGCTGTATGATGAACTGCGCGAAGTGCTGCGCGAGGCCATCAGCGAATGCGGT
TCGTCCATACGCGATTACCGTGATGCCAGAGGCGATGCCGGAGCTTTTCAGAACTGTTTCAGGGTTTACGGGCGCAGCGG
AATGCAGTGCGTCAGCTGCAGAGATGCACTGACCACGGCCAGAGTGGCCGGGCGCACCACGGTGTACTGCAGCAACTGCC
AGAAATAA

Upstream 100 bases:

>100_bases
CTTTTTTGTGCGCTGCCGCCGGTGTTCCGCGCGGGCAGCATGGTCTGCCGGTGCACTATCATACCACTGCGCACCGTACG
GGTGCGGCGGAGGATGTCAT

Downstream 100 bases:

>100_bases
GGTGCAACCGTATCATGAACGGTGAAGTTCCGGAACAGGGCAGCCCATCGCTGACGACTTCTGGCGCTCAGGGCGGGCAC
GAGCAGTGTGCTGTGGCGCG

Product: DNA-(apurinic or apyrimidinic site) lyase / formamidopyrimidine-DNA glycosylase

Products: NA

Alternate protein names: Fapy-DNA glycosylase; DNA-(apurinic or apyrimidinic site) lyase mutM; AP lyase mutM [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MPELPEVETIARGLAPELTGRRITEVEVFNAGSVQGDREVFDACTPGRVIAGVGRRGKLLLVHLEKERRQGAACRAVLDH
RPAGDTPDMLAFHLRMSGRLFIYGPEQLPGPHTRIIITLDSGRRLFFDDARKFGSCRALSPFSRPLWRFWATLGPEPLDV
DRETFIEQFAERRKAVKALLLDQTVIAGVGNIYADESLFRAGIRPDARPGDWTRDEAERRLGRLYDELREVLREAISECG
SSIRDYRDARGDAGAFQNCFRVYGRSGMQCVSCRDALTTARVAGRTTVYCSNCQK

Sequences:

>Translated_295_residues
MPELPEVETIARGLAPELTGRRITEVEVFNAGSVQGDREVFDACTPGRVIAGVGRRGKLLLVHLEKERRQGAACRAVLDH
RPAGDTPDMLAFHLRMSGRLFIYGPEQLPGPHTRIIITLDSGRRLFFDDARKFGSCRALSPFSRPLWRFWATLGPEPLDV
DRETFIEQFAERRKAVKALLLDQTVIAGVGNIYADESLFRAGIRPDARPGDWTRDEAERRLGRLYDELREVLREAISECG
SSIRDYRDARGDAGAFQNCFRVYGRSGMQCVSCRDALTTARVAGRTTVYCSNCQK
>Mature_294_residues
PELPEVETIARGLAPELTGRRITEVEVFNAGSVQGDREVFDACTPGRVIAGVGRRGKLLLVHLEKERRQGAACRAVLDHR
PAGDTPDMLAFHLRMSGRLFIYGPEQLPGPHTRIIITLDSGRRLFFDDARKFGSCRALSPFSRPLWRFWATLGPEPLDVD
RETFIEQFAERRKAVKALLLDQTVIAGVGNIYADESLFRAGIRPDARPGDWTRDEAERRLGRLYDELREVLREAISECGS
SIRDYRDARGDAGAFQNCFRVYGRSGMQCVSCRDALTTARVAGRTTVYCSNCQK

Specific function: Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyr

COG id: COG0266

COG function: function code L; Formamidopyrimidine-DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FPG-type zinc finger [H]

Homologues:

Organism=Escherichia coli, GI1790066, Length=304, Percent_Identity=33.5526315789474, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015886
- InterPro:   IPR015887
- InterPro:   IPR000191
- InterPro:   IPR012319
- InterPro:   IPR020629
- InterPro:   IPR010979
- InterPro:   IPR000214
- InterPro:   IPR010663 [H]

Pfam domain/function: PF01149 Fapy_DNA_glyco; PF06831 H2TH; PF06827 zf-FPG_IleRS [H]

EC number: =3.2.2.23; =4.2.99.18 [H]

Molecular weight: Translated: 33076; Mature: 32945

Theoretical pI: Translated: 8.49; Mature: 8.49

Prosite motif: PS51066 ZF_FPG_2 ; PS51068 FPG_CAT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPELPEVETIARGLAPELTGRRITEVEVFNAGSVQGDREVFDACTPGRVIAGVGRRGKLL
CCCCCCHHHHHHHCCCHHCCCEEEEEEEECCCCCCCHHHHHHCCCCCCEEECCCCCCCEE
LVHLEKERRQGAACRAVLDHRPAGDTPDMLAFHLRMSGRLFIYGPEQLPGPHTRIIITLD
EEEECHHHCCCHHHHHHHHCCCCCCCHHHHHHEEEECCEEEEECCCCCCCCCEEEEEEEC
SGRRLFFDDARKFGSCRALSPFSRPLWRFWATLGPEPLDVDRETFIEQFAERRKAVKALL
CCCEEEHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDQTVIAGVGNIYADESLFRAGIRPDARPGDWTRDEAERRLGRLYDELREVLREAISECG
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSIRDYRDARGDAGAFQNCFRVYGRSGMQCVSCRDALTTARVAGRTTVYCSNCQK
HHHHHHHHCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCEEEECCCCC
>Mature Secondary Structure 
PELPEVETIARGLAPELTGRRITEVEVFNAGSVQGDREVFDACTPGRVIAGVGRRGKLL
CCCCCHHHHHHHCCCHHCCCEEEEEEEECCCCCCCHHHHHHCCCCCCEEECCCCCCCEE
LVHLEKERRQGAACRAVLDHRPAGDTPDMLAFHLRMSGRLFIYGPEQLPGPHTRIIITLD
EEEECHHHCCCHHHHHHHHCCCCCCCHHHHHHEEEECCEEEEECCCCCCCCCEEEEEEEC
SGRRLFFDDARKFGSCRALSPFSRPLWRFWATLGPEPLDVDRETFIEQFAERRKAVKALL
CCCEEEHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHH
LDQTVIAGVGNIYADESLFRAGIRPDARPGDWTRDEAERRLGRLYDELREVLREAISECG
HHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
SSIRDYRDARGDAGAFQNCFRVYGRSGMQCVSCRDALTTARVAGRTTVYCSNCQK
HHHHHHHHCCCCHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA