Click here to switch to the map view.

The map label for this gene is cobB [H]

Identifier: 78355576

GI number: 78355576

Start: 534937

End: 536364

Strand: Direct

Name: cobB [H]

Synonym: Dde_0529

Alternate gene names: 78355576

Gene position: 534937-536364 (Clockwise)

Preceding gene: 304570580

Following gene: 78355578

Centisome position: 14.34

GC content: 60.08

Gene sequence:

>1428_bases
ATGTCAGCCATACGGCAGGAGGGTCAGGTGAGCATTCCCAGAGTCATCATAGCGGGTCTGAACGGCGGTTCGGGAAAAAC
CATTGTCAGTCTGGGGCTTTGCCGTGCATGGACACGCGCCGGCCGCAACGTGAAGCCGTTCAAAAAAGGGCCGGACTACA
TTGATGCCCGCTGGCTTGCGCTGGCAACGGGTAACCCGGCCACGAATCTGGATCCGTATCTGGTTTCCGCGCAGGTCATG
CGTTCACTGTTTGTCACGGCGGGCAAAGGCTACGACGGAGCCGTGATTGAAGGCAACAGGGGGCTGTATGACGGCAAGGA
TGTCACAGGCAGCTGTTCCACGGCCGAAGTGGCGCGGCAGCTGGACACCCCGGTGGTGCTGGTGATGAACTGCACCAAAA
TGACCCGCACTGCCGCCGCACTGGTGGGCGGCATGGCGGCTTTTGAGCCTGATCTCAATCTGGCCGGAGTGGTGTTGAAC
CAGACAGCCAACGAACGGCATCGCGGCGTACTGCGCGCCGCCATCGAACAGTATACCGATGTGCCCGTGCTCGGGGCGCT
GCCGCGTATGCGCAGCAACCCCATACCGGAGCGGCACATGGGGCTGTGGTCAGATACCGAAATGCACGACAGCCGGTCGC
CTTTAGATGCCGTGGCAGATTTTTTATGTGACAACGCCGATGTGGAGCGCATCTGGCAGATAGCGCGTCAGGTCCCTGCT
GCTGATTCAGCTCTCATCCCCGACCTGTGGGATATGCTGCCCGCGGATGCCGCTGTGGGACCGGTGCGCATCGGCTATGT
GCGCGATGCGGCGCTGTGGTTTTATTATGAAGAAAATCTGGAAGCCCTGCGCCGTGCCGGTGCCGAGCTGGTGGAACTGA
CCCTGCTGGATGATGCGCCGTGGCCGGAACTCCATGGCCTGTATCTGGGGGGTGGTTTTCCCGAGACTCTGGCGGAGCGT
CTTTCCGCCAATATTGCGGCGCGGGCGCGTGTAAAGTCGCTTTCAGAAGCGGGTATGCCCGTGTATGCCGAGTGCGGCGG
TTTTATGTATCTGGGACGCACCCTGCGGTATGGCGGAGTTGAATACCCCATGGCGGATGTTTTTCCGGTATGCACAACCG
TGCATGAACGGCCGCAGGGGCTGGGCTATGTGGAAGCCCTTGTGGTGGAGGACAACCCTTTTCACGCCACAGGTACCCGT
GTGCGCGGCCACGAATTTCATTATTCGCGTGCGGTGGCGTATGAGGGCGAATCTGTGCGCCATGCGTTCAGAATGGAGCG
GGGCGAAGGTATGGGTGAAGATGCAGACGGCATGATAGTACGCAATACCTTTGCAGGGTATACCCACCTTTTTGCTCCGG
GCGAACCGCACTGGGCAGTGAATTTTGTGCGGGCTGCGGCCCGTTATCGTGACGCAGAAGCTGATTGA

Upstream 100 bases:

>100_bases
GCAAGCAGGCCAGCGCTGAAGGCGAATAAGTTTTTCTGCCAGGAAGGTTCGCCTTCTTGACGGGACAGCGTATGAACTGC
AAAGTTCATACGCTTTTTTT

Downstream 100 bases:

>100_bases
AGCCTGTCTGCGGGGCTGTAAGCGCTCAGTGTCTGTTGGTCAGCCACACGCCGCAGCCTACCAGCACTGCGCCGCCCAGC
AGCGAAAGGGCCACGGGTTC

Product: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) / cobyrinate a,c-diamide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 475; Mature: 474

Protein sequence:

>475_residues
MSAIRQEGQVSIPRVIIAGLNGGSGKTIVSLGLCRAWTRAGRNVKPFKKGPDYIDARWLALATGNPATNLDPYLVSAQVM
RSLFVTAGKGYDGAVIEGNRGLYDGKDVTGSCSTAEVARQLDTPVVLVMNCTKMTRTAAALVGGMAAFEPDLNLAGVVLN
QTANERHRGVLRAAIEQYTDVPVLGALPRMRSNPIPERHMGLWSDTEMHDSRSPLDAVADFLCDNADVERIWQIARQVPA
ADSALIPDLWDMLPADAAVGPVRIGYVRDAALWFYYEENLEALRRAGAELVELTLLDDAPWPELHGLYLGGGFPETLAER
LSANIAARARVKSLSEAGMPVYAECGGFMYLGRTLRYGGVEYPMADVFPVCTTVHERPQGLGYVEALVVEDNPFHATGTR
VRGHEFHYSRAVAYEGESVRHAFRMERGEGMGEDADGMIVRNTFAGYTHLFAPGEPHWAVNFVRAAARYRDAEAD

Sequences:

>Translated_475_residues
MSAIRQEGQVSIPRVIIAGLNGGSGKTIVSLGLCRAWTRAGRNVKPFKKGPDYIDARWLALATGNPATNLDPYLVSAQVM
RSLFVTAGKGYDGAVIEGNRGLYDGKDVTGSCSTAEVARQLDTPVVLVMNCTKMTRTAAALVGGMAAFEPDLNLAGVVLN
QTANERHRGVLRAAIEQYTDVPVLGALPRMRSNPIPERHMGLWSDTEMHDSRSPLDAVADFLCDNADVERIWQIARQVPA
ADSALIPDLWDMLPADAAVGPVRIGYVRDAALWFYYEENLEALRRAGAELVELTLLDDAPWPELHGLYLGGGFPETLAER
LSANIAARARVKSLSEAGMPVYAECGGFMYLGRTLRYGGVEYPMADVFPVCTTVHERPQGLGYVEALVVEDNPFHATGTR
VRGHEFHYSRAVAYEGESVRHAFRMERGEGMGEDADGMIVRNTFAGYTHLFAPGEPHWAVNFVRAAARYRDAEAD
>Mature_474_residues
SAIRQEGQVSIPRVIIAGLNGGSGKTIVSLGLCRAWTRAGRNVKPFKKGPDYIDARWLALATGNPATNLDPYLVSAQVMR
SLFVTAGKGYDGAVIEGNRGLYDGKDVTGSCSTAEVARQLDTPVVLVMNCTKMTRTAAALVGGMAAFEPDLNLAGVVLNQ
TANERHRGVLRAAIEQYTDVPVLGALPRMRSNPIPERHMGLWSDTEMHDSRSPLDAVADFLCDNADVERIWQIARQVPAA
DSALIPDLWDMLPADAAVGPVRIGYVRDAALWFYYEENLEALRRAGAELVELTLLDDAPWPELHGLYLGGGFPETLAERL
SANIAARARVKSLSEAGMPVYAECGGFMYLGRTLRYGGVEYPMADVFPVCTTVHERPQGLGYVEALVVEDNPFHATGTRV
RGHEFHYSRAVAYEGESVRHAFRMERGEGMGEDADGMIVRNTFAGYTHLFAPGEPHWAVNFVRAAARYRDAEAD

Specific function: Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1797

COG function: function code H; Cobyrinic acid a,c-diamide synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR004484
- InterPro:   IPR017929
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: NA

Molecular weight: Translated: 51814; Mature: 51683

Theoretical pI: Translated: 5.48; Mature: 5.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAIRQEGQVSIPRVIIAGLNGGSGKTIVSLGLCRAWTRAGRNVKPFKKGPDYIDARWLA
CCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
LATGNPATNLDPYLVSAQVMRSLFVTAGKGYDGAVIEGNRGLYDGKDVTGSCSTAEVARQ
EECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHH
LDTPVVLVMNCTKMTRTAAALVGGMAAFEPDLNLAGVVLNQTANERHRGVLRAAIEQYTD
CCCCEEEEEECHHHHHHHHHHHHCHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCC
VPVLGALPRMRSNPIPERHMGLWSDTEMHDSRSPLDAVADFLCDNADVERIWQIARQVPA
CCHHHCCCHHCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCC
ADSALIPDLWDMLPADAAVGPVRIGYVRDAALWFYYEENLEALRRAGAELVELTLLDDAP
CCCCCCCHHHHHCCCCCCCCCEEEEEEEEEEEEEEEHHHHHHHHHCCCCEEEEEEECCCC
WPELHGLYLGGGFPETLAERLSANIAARARVKSLSEAGMPVYAECGGFMYLGRTLRYGGV
CCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCEEECCCHHHCCCC
EYPMADVFPVCTTVHERPQGLGYVEALVVEDNPFHATGTRVRGHEFHYSRAVAYEGESVR
CCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCEEEEECCHHHH
HAFRMERGEGMGEDADGMIVRNTFAGYTHLFAPGEPHWAVNFVRAAARYRDAEAD
HHHHHHHCCCCCCCCCCEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SAIRQEGQVSIPRVIIAGLNGGSGKTIVSLGLCRAWTRAGRNVKPFKKGPDYIDARWLA
CCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEE
LATGNPATNLDPYLVSAQVMRSLFVTAGKGYDGAVIEGNRGLYDGKDVTGSCSTAEVARQ
EECCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHH
LDTPVVLVMNCTKMTRTAAALVGGMAAFEPDLNLAGVVLNQTANERHRGVLRAAIEQYTD
CCCCEEEEEECHHHHHHHHHHHHCHHHCCCCCCEEEEEEECCCCHHHHHHHHHHHHHHCC
VPVLGALPRMRSNPIPERHMGLWSDTEMHDSRSPLDAVADFLCDNADVERIWQIARQVPA
CCHHHCCCHHCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHCCC
ADSALIPDLWDMLPADAAVGPVRIGYVRDAALWFYYEENLEALRRAGAELVELTLLDDAP
CCCCCCCHHHHHCCCCCCCCCEEEEEEEEEEEEEEEHHHHHHHHHCCCCEEEEEEECCCC
WPELHGLYLGGGFPETLAERLSANIAARARVKSLSEAGMPVYAECGGFMYLGRTLRYGGV
CCCCCEEEECCCCHHHHHHHHHCCHHHHHHHHHHHHCCCCEEECCCCEEECCCHHHCCCC
EYPMADVFPVCTTVHERPQGLGYVEALVVEDNPFHATGTRVRGHEFHYSRAVAYEGESVR
CCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCCCCCCEEECCEEEEECCHHHH
HAFRMERGEGMGEDADGMIVRNTFAGYTHLFAPGEPHWAVNFVRAAARYRDAEAD
HHHHHHHCCCCCCCCCCEEEEEECCCCEEEECCCCCCHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA