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The map label for this gene is fdhA [H]

Identifier: 78355520

GI number: 78355520

Start: 482681

End: 484426

Strand: Direct

Name: fdhA [H]

Synonym: Dde_0473

Alternate gene names: 78355520

Gene position: 482681-484426 (Clockwise)

Preceding gene: 78355519

Following gene: 78355521

Centisome position: 12.94

GC content: 62.94

Gene sequence:

>1746_bases
GTGGCCGGTCTGGCCGCAGCATTCGGAAGCGGAGCCATGACGAATTCCATTGATGAACTGGAGAGCATGGGGGCCGGCGA
TGTGATTTTTGCCGTGGGTACAAACACCACGGAATGCCATCCGGTCATAGGGGCCAATATGCTTCAGGCCGTGCGTCAGG
GGGCCCGTCTGGTGGTGGCCGACCCGCGCGCCGTTACGCTTGCGGCGCACGCCGCGGTGTGGCTGCGTCTGCGTCCCGGC
ACTGATGTGGCGCTGCTGAACGGCATTGCTCATGTGATTATTTCCGAAGGTCTTGCCGACGAGGCATTCATCGCGCAGCG
CACCGAAGGATATGCGGCGTTCCGCGAAACCGTGCTGCGCTGCACGCCGCAAAAGGCATCGGCAATCACAGGCGTACCGG
CGGACGACATCCGCTCCGCGGCACGCATTCTGGGCTGCGCCGCCAACGTCTCCACCTATTACACCATGGGCATCACGCAA
CACACCTCCGGCGTGGACAATGTGCGCGCCGTGGCCAACATCGCGCTGCTTACCGGTAATGCGGGGCGGCCGGGTACAGG
GGTCAATCCGTTGCGCGGACAGAACAATGTGCAGGGCGCATGCGATATGGGTGCCCTGCCCGATGTTTTGCCCGCGTACC
AGCGCGTGACCGACCCTGCCGTGCGTGAGCGCTTTGCGGCCGCGTGGGGCAGAGAAGTTCCCGGAAAGCCGGGGTTGCGC
ATACCTGACGTGCTGCACGGGCTGGAACACGGCACTGTGCGGGCTTTGTATGTTTTTGGTGAAAATCCCATGCGCAGCGA
TCCTGATGTGGGCCATGTGGAACACTGTCTGGACGCTGCGGAGTTTCTGGTGGTGCAGGATATTTTTCTTACCGAGACAG
CCGCAAAGGCGCATGTGGTGCTGCCGGGAGCGTCCTTTGCCGAAAAGGACGGCACGTTTTCCAGTACCGAACGCAGGGTG
CAGCGCATCCGCAGGGCGGTGCCCCCCGCAGGCGGCAGCCGCCCGGACTGGCAGATACTCAGCGAGCTTCTGACCCGTAT
GGGGGCAGGGCCGGAGTATGGTTCGCCGGAGGAAATATTTGACGAAATGCGGGCGCTGACCCCCAGTTACGCAGGCATAA
CCTATGCCCGTCTGGAAAAGGGCGGCCTGCAGTGGCCTTGCCCGGATGTTGATCATCCGGGCACGCCGGTGCTGCACCGG
AACGCATTTATGCGCGGCCGGGGGGCTTTTCTTGCCGTGGAGCACCGTGAACCGGCGGAACTGCCGGATGACGCGTATCC
GCTGATGCTTACCACCGGAAGGGTTGTTGCCCATTATCATACCGGCACCATGACCCGCCGCTGCTGGGGGCTGAACGGCG
TGGCCCCTGAAGAGCAGGTGGAGCTGCATCCTGACGATGCGGCGCCTCTGGGGATAGCCGACGGCGATATGGTGCGGCTC
ACTTCGCGCCGGGGCAGTATGACCGCGCGGGTGCATGTGACCGAAAAAACCATGCGCGGTCTGGTCTTTGTCACATTCCA
CTACAGCGAAAGCTGCGGCAACGTGCTGACCAACAGCGCGGCAGACCCTGAAACAGGCACCGCGGAACTGAAAATATGTT
CGGTGCGCGTGGAAAAAGCAGACCGGCAGGGCCCCTGTCCGGCGGATACCGCCGGACGGCGGCCGGAGGCGGCTGCTCAG
AAACACTATTCCGAACCGGCGGTGCATCCTGCCGGAACACCGGAGAAAATATGCAATCCCAGTTGA

Upstream 100 bases:

>100_bases
TTGTACCAACGAAGAAAATTATCTGATGCAGAAGTTCATGCGTGCGGCCGTCGGCACCAATAATGTCGACCACTGCGCCC
GTCTCTGACACGCTCCCACC

Downstream 100 bases:

>100_bases
GTGATTTTGTGGTGGCAGATGCTTCGCGCTGCATAGGCTGCCGTGTGTGCGAGGTGGCCTGCGCCGTGGCGCACACCGCT
ACAGGCAAGGAACACCCCGT

Product: formate dehydrogenase, chain A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 581; Mature: 580

Protein sequence:

>581_residues
MAGLAAAFGSGAMTNSIDELESMGAGDVIFAVGTNTTECHPVIGANMLQAVRQGARLVVADPRAVTLAAHAAVWLRLRPG
TDVALLNGIAHVIISEGLADEAFIAQRTEGYAAFRETVLRCTPQKASAITGVPADDIRSAARILGCAANVSTYYTMGITQ
HTSGVDNVRAVANIALLTGNAGRPGTGVNPLRGQNNVQGACDMGALPDVLPAYQRVTDPAVRERFAAAWGREVPGKPGLR
IPDVLHGLEHGTVRALYVFGENPMRSDPDVGHVEHCLDAAEFLVVQDIFLTETAAKAHVVLPGASFAEKDGTFSSTERRV
QRIRRAVPPAGGSRPDWQILSELLTRMGAGPEYGSPEEIFDEMRALTPSYAGITYARLEKGGLQWPCPDVDHPGTPVLHR
NAFMRGRGAFLAVEHREPAELPDDAYPLMLTTGRVVAHYHTGTMTRRCWGLNGVAPEEQVELHPDDAAPLGIADGDMVRL
TSRRGSMTARVHVTEKTMRGLVFVTFHYSESCGNVLTNSAADPETGTAELKICSVRVEKADRQGPCPADTAGRRPEAAAQ
KHYSEPAVHPAGTPEKICNPS

Sequences:

>Translated_581_residues
MAGLAAAFGSGAMTNSIDELESMGAGDVIFAVGTNTTECHPVIGANMLQAVRQGARLVVADPRAVTLAAHAAVWLRLRPG
TDVALLNGIAHVIISEGLADEAFIAQRTEGYAAFRETVLRCTPQKASAITGVPADDIRSAARILGCAANVSTYYTMGITQ
HTSGVDNVRAVANIALLTGNAGRPGTGVNPLRGQNNVQGACDMGALPDVLPAYQRVTDPAVRERFAAAWGREVPGKPGLR
IPDVLHGLEHGTVRALYVFGENPMRSDPDVGHVEHCLDAAEFLVVQDIFLTETAAKAHVVLPGASFAEKDGTFSSTERRV
QRIRRAVPPAGGSRPDWQILSELLTRMGAGPEYGSPEEIFDEMRALTPSYAGITYARLEKGGLQWPCPDVDHPGTPVLHR
NAFMRGRGAFLAVEHREPAELPDDAYPLMLTTGRVVAHYHTGTMTRRCWGLNGVAPEEQVELHPDDAAPLGIADGDMVRL
TSRRGSMTARVHVTEKTMRGLVFVTFHYSESCGNVLTNSAADPETGTAELKICSVRVEKADRQGPCPADTAGRRPEAAAQ
KHYSEPAVHPAGTPEKICNPS
>Mature_580_residues
AGLAAAFGSGAMTNSIDELESMGAGDVIFAVGTNTTECHPVIGANMLQAVRQGARLVVADPRAVTLAAHAAVWLRLRPGT
DVALLNGIAHVIISEGLADEAFIAQRTEGYAAFRETVLRCTPQKASAITGVPADDIRSAARILGCAANVSTYYTMGITQH
TSGVDNVRAVANIALLTGNAGRPGTGVNPLRGQNNVQGACDMGALPDVLPAYQRVTDPAVRERFAAAWGREVPGKPGLRI
PDVLHGLEHGTVRALYVFGENPMRSDPDVGHVEHCLDAAEFLVVQDIFLTETAAKAHVVLPGASFAEKDGTFSSTERRVQ
RIRRAVPPAGGSRPDWQILSELLTRMGAGPEYGSPEEIFDEMRALTPSYAGITYARLEKGGLQWPCPDVDHPGTPVLHRN
AFMRGRGAFLAVEHREPAELPDDAYPLMLTTGRVVAHYHTGTMTRRCWGLNGVAPEEQVELHPDDAAPLGIADGDMVRLT
SRRGSMTARVHVTEKTMRGLVFVTFHYSESCGNVLTNSAADPETGTAELKICSVRVEKADRQGPCPADTAGRRPEAAAQK
HYSEPAVHPAGTPEKICNPS

Specific function: Catalyzes the oxidation of formate [H]

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI3868721, Length=545, Percent_Identity=41.651376146789, Blast_Score=450, Evalue=1e-127,
Organism=Escherichia coli, GI1788534, Length=653, Percent_Identity=26.0336906584992, Blast_Score=185, Evalue=5e-48,
Organism=Escherichia coli, GI3868719, Length=597, Percent_Identity=23.9530988274707, Blast_Score=132, Evalue=6e-32,
Organism=Escherichia coli, GI3868720, Length=463, Percent_Identity=26.3498920086393, Blast_Score=126, Evalue=4e-30,
Organism=Escherichia coli, GI1787778, Length=298, Percent_Identity=27.8523489932886, Blast_Score=102, Evalue=9e-23,
Organism=Escherichia coli, GI145693196, Length=530, Percent_Identity=25.0943396226415, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI87081797, Length=408, Percent_Identity=25.4901960784314, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI171474008, Length=541, Percent_Identity=25.1386321626617, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1787870, Length=370, Percent_Identity=25.6756756756757, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI87081994, Length=351, Percent_Identity=25.0712250712251, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565758, Length=221, Percent_Identity=29.4117647058824, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006478
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006963
- InterPro:   IPR006655 [H]

Pfam domain/function: PF04879 Molybdop_Fe4S4; PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.2.1.2 [H]

Molecular weight: Translated: 61984; Mature: 61853

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAGLAAAFGSGAMTNSIDELESMGAGDVIFAVGTNTTECHPVIGANMLQAVRQGARLVVA
CCCCHHHHCCCCHHCCHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEE
DPRAVTLAAHAAVWLRLRPGTDVALLNGIAHVIISEGLADEAFIAQRTEGYAAFRETVLR
CCCEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHH
CTPQKASAITGVPADDIRSAARILGCAANVSTYYTMGITQHTSGVDNVRAVANIALLTGN
CCCCHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHEEEEEECC
AGRPGTGVNPLRGQNNVQGACDMGALPDVLPAYQRVTDPAVRERFAAAWGREVPGKPGLR
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCC
IPDVLHGLEHGTVRALYVFGENPMRSDPDVGHVEHCLDAAEFLVVQDIFLTETAAKAHVV
HHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
LPGASFAEKDGTFSSTERRVQRIRRAVPPAGGSRPDWQILSELLTRMGAGPEYGSPEEIF
ECCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
DEMRALTPSYAGITYARLEKGGLQWPCPDVDHPGTPVLHRNAFMRGRGAFLAVEHREPAE
HHHHHCCCCCCCEEEEEHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCC
LPDDAYPLMLTTGRVVAHYHTGTMTRRCWGLNGVAPEEQVELHPDDAAPLGIADGDMVRL
CCCCCCCEEEECCEEEEEEECCCHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEE
TSRRGSMTARVHVTEKTMRGLVFVTFHYSESCGNVLTNSAADPETGTAELKICSVRVEKA
ECCCCCEEEEEEEEHHHHCCEEEEEEECCCHHHHHHHCCCCCCCCCCEEEEEEEEEEECC
DRQGPCPADTAGRRPEAAAQKHYSEPAVHPAGTPEKICNPS
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHCCCCC
>Mature Secondary Structure 
AGLAAAFGSGAMTNSIDELESMGAGDVIFAVGTNTTECHPVIGANMLQAVRQGARLVVA
CCCHHHHCCCCHHCCHHHHHHCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCEEEEE
DPRAVTLAAHAAVWLRLRPGTDVALLNGIAHVIISEGLADEAFIAQRTEGYAAFRETVLR
CCCEEEEEEEEEEEEEECCCCCHHHHHHHHHHHHHCCCCCHHHHHHHCCHHHHHHHHHHH
CTPQKASAITGVPADDIRSAARILGCAANVSTYYTMGITQHTSGVDNVRAVANIALLTGN
CCCCHHCCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHEEEEEECC
AGRPGTGVNPLRGQNNVQGACDMGALPDVLPAYQRVTDPAVRERFAAAWGREVPGKPGLR
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCC
IPDVLHGLEHGTVRALYVFGENPMRSDPDVGHVEHCLDAAEFLVVQDIFLTETAAKAHVV
HHHHHHCCCCCCEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
LPGASFAEKDGTFSSTERRVQRIRRAVPPAGGSRPDWQILSELLTRMGAGPEYGSPEEIF
ECCCCHHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHH
DEMRALTPSYAGITYARLEKGGLQWPCPDVDHPGTPVLHRNAFMRGRGAFLAVEHREPAE
HHHHHCCCCCCCEEEEEHHCCCCCCCCCCCCCCCCCEEECCCCCCCCCCEEEEECCCCCC
LPDDAYPLMLTTGRVVAHYHTGTMTRRCWGLNGVAPEEQVELHPDDAAPLGIADGDMVRL
CCCCCCCEEEECCEEEEEEECCCHHHHHCCCCCCCCCCCEEECCCCCCCCCCCCCCEEEE
TSRRGSMTARVHVTEKTMRGLVFVTFHYSESCGNVLTNSAADPETGTAELKICSVRVEKA
ECCCCCEEEEEEEEHHHHCCEEEEEEECCCHHHHHHHCCCCCCCCCCEEEEEEEEEEECC
DRQGPCPADTAGRRPEAAAQKHYSEPAVHPAGTPEKICNPS
CCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]