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The map label for this gene is sdcS [H]

Identifier: 78355373

GI number: 78355373

Start: 313943

End: 315418

Strand: Direct

Name: sdcS [H]

Synonym: Dde_0326

Alternate gene names: 78355373

Gene position: 313943-315418 (Clockwise)

Preceding gene: 78355372

Following gene: 78355374

Centisome position: 8.42

GC content: 55.76

Gene sequence:

>1476_bases
ATGTCTACCAAAGCTCAATCGACATCGTTTGACTGGAAGAGACTGTGCTTCATGTTGCTGGGGGTGACTGCTTTTCTGGT
GATCTACTATTCTCCGGCGTGGCCGGATGCGGTGGATCCGCTGGGTGAACGGTTCCCGCTTTCGAAAGAGGCCAAGGGTG
CTCTTGCCGTATTTATGTTTGCCGGTCTGTGGTGGGTGTTCGAGGTGGTGCCCATCGGCATCACCAGTCTGGGTATCGGC
GTGCTGCAGGTTCTTTTCTTTGTCCGTCCGCCCGAAAAAGCGTTCAAGGACTTCATGGACCCGTCGGTGCTCTTTATTTT
TGCTTCCATCATGATCGGTCTGGTGTTTACCAAAACCGGGCTGACAAAGCGACTTGCCTATAAAATGCTGATGGTCGTGG
GTGAAAAAACAAGCCGCATCTATCTGGGCGTGTTTGTGGTCACCGCGCTGCTGACGCATATTATGGCACATACTGCGGTG
GCGGCCACCGTGTATCCGCTGCTGCTGGCCATTTATGCTCTGTACGACGACACCGGCAGCAAGACCCGTTTTGGTAAGGG
GCTGTTCATCGGCATGGCCTATGTGGCCGGCGCAGGCTCCATCATCACGCTGCTCGGTGCCGCCCGCGGTGCCGTGGCCG
TAGGCTTTTTCAAGGAGATAGTGGGTACCGAGGTCTCGTTCTTCGAGCTTACCTACTACATGGCCCCCATCGGCTGGCTC
ATGGTGTTTCTGCTGTGGGGCTTCTTCATGATTTTCTGCAAGCCCGAACGCGACACCATACCCGGACTGCGTGAAAAGGC
CAGAGAACTGAACAAGCAGATGGGGCCCCTGACCCGCAAGGAAATCATGGCCGCCCTTATCGTGGGCATTGTCATTCTGG
TCATGAGCCTGCGGTCGTTCTTCCCCATGCTTAAAATGCTGGACAAAACGGCCATCATCCTCATTTCCAGCATCGCGTTT
TTCGTATTCAAGATTCTGGATATCAAGGATCTTGAAGATGTGCCGTGGAACATCATCCTGCTGTTTGCGGGCGCCATGAG
CATAGGCTACTGCCTGTGGGAAACCGGCGCGGCAAAGTGGCTGGCCGTCAACTGGCTGGTCATGTTCGAAAAAGCCCACT
GGTTTGTCTTTGTCATGAGCATCTGCTTCTTTGTGCTGATGATGACCAACTTCATCATGAACGTGGCCGCCATAGCCATA
TCGCTGCCGGTGGCGCTGGTTATAGCGCCGTATCTCGGCGTATCGCCCGAGGTTATTCTCTTCGGTGCGCTGGTTGTGGC
GGGTATGCCCTTCCTGTTGCTGGTGGGGGCGGCCCCCAACGCCATCGCGTACGATTCCGGTCAGTTCACTTCCGGCGAGT
TCTTCAAGTACGGGCTGGTCGCCAGTGCGCTGCTGCTGGTAGTGGTCGGGGTTTTCGTTCTGGTGGTCTGGCCGCTTATG
GGCATGCCCATCACCGTGCCCAGAGTAGGCATGTAA

Upstream 100 bases:

>100_bases
GGTGTGCTGCGTCTGGGCGATGTTTTCGACTATCTGAGAACAAAAATTACGGAGTGTGCCGCCGGTTAGCCGGGGTGCTT
TTTTGAAAAAGGAACAACGT

Downstream 100 bases:

>100_bases
CTGCCTGATACAAGCCGGAGCGCGGCTTCGTGCCGTGCTCCGGCATACGGATATGATCCTTATCGAAGGAGAACGGATAT
GTCTGAAAAAGTGCTTATCG

Product: transmembrane transport proteins-like

Products: NA

Alternate protein names: Na(+)/dicarboxylate symporter [H]

Number of amino acids: Translated: 491; Mature: 490

Protein sequence:

>491_residues
MSTKAQSTSFDWKRLCFMLLGVTAFLVIYYSPAWPDAVDPLGERFPLSKEAKGALAVFMFAGLWWVFEVVPIGITSLGIG
VLQVLFFVRPPEKAFKDFMDPSVLFIFASIMIGLVFTKTGLTKRLAYKMLMVVGEKTSRIYLGVFVVTALLTHIMAHTAV
AATVYPLLLAIYALYDDTGSKTRFGKGLFIGMAYVAGAGSIITLLGAARGAVAVGFFKEIVGTEVSFFELTYYMAPIGWL
MVFLLWGFFMIFCKPERDTIPGLREKARELNKQMGPLTRKEIMAALIVGIVILVMSLRSFFPMLKMLDKTAIILISSIAF
FVFKILDIKDLEDVPWNIILLFAGAMSIGYCLWETGAAKWLAVNWLVMFEKAHWFVFVMSICFFVLMMTNFIMNVAAIAI
SLPVALVIAPYLGVSPEVILFGALVVAGMPFLLLVGAAPNAIAYDSGQFTSGEFFKYGLVASALLLVVVGVFVLVVWPLM
GMPITVPRVGM

Sequences:

>Translated_491_residues
MSTKAQSTSFDWKRLCFMLLGVTAFLVIYYSPAWPDAVDPLGERFPLSKEAKGALAVFMFAGLWWVFEVVPIGITSLGIG
VLQVLFFVRPPEKAFKDFMDPSVLFIFASIMIGLVFTKTGLTKRLAYKMLMVVGEKTSRIYLGVFVVTALLTHIMAHTAV
AATVYPLLLAIYALYDDTGSKTRFGKGLFIGMAYVAGAGSIITLLGAARGAVAVGFFKEIVGTEVSFFELTYYMAPIGWL
MVFLLWGFFMIFCKPERDTIPGLREKARELNKQMGPLTRKEIMAALIVGIVILVMSLRSFFPMLKMLDKTAIILISSIAF
FVFKILDIKDLEDVPWNIILLFAGAMSIGYCLWETGAAKWLAVNWLVMFEKAHWFVFVMSICFFVLMMTNFIMNVAAIAI
SLPVALVIAPYLGVSPEVILFGALVVAGMPFLLLVGAAPNAIAYDSGQFTSGEFFKYGLVASALLLVVVGVFVLVVWPLM
GMPITVPRVGM
>Mature_490_residues
STKAQSTSFDWKRLCFMLLGVTAFLVIYYSPAWPDAVDPLGERFPLSKEAKGALAVFMFAGLWWVFEVVPIGITSLGIGV
LQVLFFVRPPEKAFKDFMDPSVLFIFASIMIGLVFTKTGLTKRLAYKMLMVVGEKTSRIYLGVFVVTALLTHIMAHTAVA
ATVYPLLLAIYALYDDTGSKTRFGKGLFIGMAYVAGAGSIITLLGAARGAVAVGFFKEIVGTEVSFFELTYYMAPIGWLM
VFLLWGFFMIFCKPERDTIPGLREKARELNKQMGPLTRKEIMAALIVGIVILVMSLRSFFPMLKMLDKTAIILISSIAFF
VFKILDIKDLEDVPWNIILLFAGAMSIGYCLWETGAAKWLAVNWLVMFEKAHWFVFVMSICFFVLMMTNFIMNVAAIAIS
LPVALVIAPYLGVSPEVILFGALVVAGMPFLLLVGAAPNAIAYDSGQFTSGEFFKYGLVASALLLVVVGVFVLVVWPLMG
MPITVPRVGM

Specific function: Mediates the transport of dicarboxylates across the cytoplasmic membrane via a Na(+)-electrochemical gradient [H]

COG id: COG0471

COG function: function code P; Di- and tricarboxylate transporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SLC13A transporter (TC 2.A.47) family. NADC subfamily [H]

Homologues:

Organism=Homo sapiens, GI301069346, Length=485, Percent_Identity=24.1237113402062, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI301069349, Length=348, Percent_Identity=25.8620689655172, Blast_Score=69, Evalue=7e-12,
Organism=Escherichia coli, GI1786829, Length=396, Percent_Identity=21.969696969697, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI71988385, Length=470, Percent_Identity=23.1914893617021, Blast_Score=85, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI32565804, Length=452, Percent_Identity=22.787610619469, Blast_Score=79, Evalue=4e-15,
Organism=Drosophila melanogaster, GI281362116, Length=449, Percent_Identity=21.826280623608, Blast_Score=72, Evalue=9e-13,
Organism=Drosophila melanogaster, GI281362114, Length=450, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281362112, Length=450, Percent_Identity=22.2222222222222, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001898 [H]

Pfam domain/function: PF00939 Na_sulph_symp [H]

EC number: NA

Molecular weight: Translated: 54126; Mature: 53995

Theoretical pI: Translated: 9.31; Mature: 9.31

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCC
>Mature Secondary Structure 
STKAQSTSFDWKRLCFMLLGVTAFLVIYYSPAWPDAVDPLGERFPLSKEAKGALAVFMF
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCCCCCCCCCCCHHHHHHHH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CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA