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The map label for this gene is mprA [H]

Identifier: 78355368

GI number: 78355368

Start: 311087

End: 311455

Strand: Direct

Name: mprA [H]

Synonym: Dde_0321

Alternate gene names: 78355368

Gene position: 311087-311455 (Clockwise)

Preceding gene: 78355367

Following gene: 78355369

Centisome position: 8.34

GC content: 56.1

Gene sequence:

>369_bases
ATGTCTGAGCTGAAGGTGCTGCTGGTTGACGATGAAATTGAATTTGCCGGAACGCTGGCTGAGCGGTTGCGGCTGCGCGG
ATTGCAGGCCGATGTGACCACCGACGGGGAAGAGGCGCTGCGTCTTGTTACCGCGCACAGGCCGGACGTTATGGTGGTTG
ACGTGATGATGCCCGGCATGAACGGGCTGGATGTGTTGCGGCAGGTGCGCACAAATATGCCCGATTTGCCCGTTATCCTG
TTGACAGGAAAGGGCTCTACAAGGGATGGAATTGAAGGCATGAGGCTGGGGGCGTTCGATTATCTGGTCAAGCCCATCAG
CATTGACGACCTTATAGGTAAAATTCACGAAGCCGTTAACGGCGCCTGA

Upstream 100 bases:

>100_bases
GCTGGGCGGGCGCATTGCGGTTGCCAGCGAGGAAGGCAAGGGATCGACGTTCACCATTGAACTGCCCAAGCGTGCAAAGC
CGCAGGAGGAGTCTTAGGCG

Downstream 100 bases:

>100_bases
TGCTGCCCGTCGGCAGGTCGCGCGGACAGGTGCCGGCTCGTGAAAACGCGTGCCGTGTGGCAGGCACGGTACCGTAAACG
GGAGGGCTCATGACGCATGA

Product: response regulator receiver domain-containing protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 122; Mature: 121

Protein sequence:

>122_residues
MSELKVLLVDDEIEFAGTLAERLRLRGLQADVTTDGEEALRLVTAHRPDVMVVDVMMPGMNGLDVLRQVRTNMPDLPVIL
LTGKGSTRDGIEGMRLGAFDYLVKPISIDDLIGKIHEAVNGA

Sequences:

>Translated_122_residues
MSELKVLLVDDEIEFAGTLAERLRLRGLQADVTTDGEEALRLVTAHRPDVMVVDVMMPGMNGLDVLRQVRTNMPDLPVIL
LTGKGSTRDGIEGMRLGAFDYLVKPISIDDLIGKIHEAVNGA
>Mature_121_residues
SELKVLLVDDEIEFAGTLAERLRLRGLQADVTTDGEEALRLVTAHRPDVMVVDVMMPGMNGLDVLRQVRTNMPDLPVILL
TGKGSTRDGIEGMRLGAFDYLVKPISIDDLIGKIHEAVNGA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=35.5140186915888, Blast_Score=85, Evalue=2e-18,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=34.7826086956522, Blast_Score=80, Evalue=3e-17,
Organism=Escherichia coli, GI1789809, Length=112, Percent_Identity=34.8214285714286, Blast_Score=78, Evalue=1e-16,
Organism=Escherichia coli, GI1790437, Length=114, Percent_Identity=31.5789473684211, Blast_Score=74, Evalue=3e-15,
Organism=Escherichia coli, GI87082012, Length=124, Percent_Identity=33.0645161290323, Blast_Score=74, Evalue=4e-15,
Organism=Escherichia coli, GI1786784, Length=113, Percent_Identity=31.858407079646, Blast_Score=74, Evalue=4e-15,
Organism=Escherichia coli, GI1787375, Length=113, Percent_Identity=31.858407079646, Blast_Score=73, Evalue=4e-15,
Organism=Escherichia coli, GI2367329, Length=111, Percent_Identity=43.2432432432432, Blast_Score=71, Evalue=3e-14,
Organism=Escherichia coli, GI1788394, Length=111, Percent_Identity=29.7297297297297, Blast_Score=69, Evalue=9e-14,
Organism=Escherichia coli, GI1790860, Length=115, Percent_Identity=33.9130434782609, Blast_Score=69, Evalue=1e-13,
Organism=Escherichia coli, GI1789402, Length=112, Percent_Identity=29.4642857142857, Blast_Score=68, Evalue=1e-13,
Organism=Escherichia coli, GI1786599, Length=113, Percent_Identity=30.9734513274336, Blast_Score=66, Evalue=6e-13,
Organism=Escherichia coli, GI1787487, Length=103, Percent_Identity=33.0097087378641, Blast_Score=64, Evalue=2e-12,
Organism=Escherichia coli, GI1788905, Length=114, Percent_Identity=31.5789473684211, Blast_Score=61, Evalue=3e-11,
Organism=Escherichia coli, GI1790552, Length=112, Percent_Identity=31.25, Blast_Score=60, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 13312; Mature: 13181

Theoretical pI: Translated: 4.47; Mature: 4.47

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELKVLLVDDEIEFAGTLAERLRLRGLQADVTTDGEEALRLVTAHRPDVMVVDVMMPGM
CCCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCC
NGLDVLRQVRTNMPDLPVILLTGKGSTRDGIEGMRLGAFDYLVKPISIDDLIGKIHEAVN
CHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEECHHHHHHCCCCHHHHHHHHHHHHC
GA
CC
>Mature Secondary Structure 
SELKVLLVDDEIEFAGTLAERLRLRGLQADVTTDGEEALRLVTAHRPDVMVVDVMMPGM
CCEEEEEECCCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCCCCCEEEEEEECCCC
NGLDVLRQVRTNMPDLPVILLTGKGSTRDGIEGMRLGAFDYLVKPISIDDLIGKIHEAVN
CHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEECHHHHHHCCCCHHHHHHHHHHHHC
GA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA