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The map label for this gene is hdrA2 [H]

Identifier: 78224616

GI number: 78224616

Start: 3845085

End: 3847082

Strand: Direct

Name: hdrA2 [H]

Synonym: Gmet_3426

Alternate gene names: 78224616

Gene position: 3845085-3847082 (Clockwise)

Preceding gene: 78224615

Following gene: 78224617

Centisome position: 96.19

GC content: 64.06

Gene sequence:

>1998_bases
ATGTCCCGAATCGGCGTATTCGTCTGCCATTGCGGCGAGAACATATCAAGGACCGTTGACGTGGAACGGGTAGCTGCCGA
GGCCGCGCGGCTTCCCGGCGTTGCCTATGCCACCGACTACAAGTACATGTGCTCCGACCCGGGCCAGAATCTCCTGAAAA
ACGCCGTGACCGAGCACCGGCTCGACGGGATCGTCGTGGCGGCCTGCAGTCCCCGGATGCACGAGAAAACCTTCCGCAAT
GCCGCGAAGAGCGCGGGGCTGAACCCCTTCCTCTGCGAGATGGCAAACATCCGGGAGCACTGCTCCTGGGTCCACGAGGA
CAGAGACGAAGCCACCGCCAAGGCCAGCGACATCGTCGCCATGATGGTCGCCCGGGTAAAGAAGGACAAGAGGCTCGTCC
CGATCACCGTGCCGGTCACCAAGCGTTCCCTTGTGATCGGCGGCGGCATCGCCGGCATCCAGGCGGCCCTGGATATCGCC
GACGCCGGCCACCAGGTGGTGCTCGTGGAGCGGGAGCCCTCCATCGGCGGGCACATGGCGCAACTCTCCGAGACCTTCCC
GACCCTGGACTGCTCCCAGTGCATCATGACCCCCAAGATGGTCGATGTCGCCAATCACCCCAACATCACGCTTCACACCT
ACAGCGAGATCGAGGCGGTTGACGGCTACATCGGCAACTTCCAGATCACGGTCCGCAAGAAGGCCAGAAGCGTCATCGAG
GAAAAGTGCACCGGCTGCGGCGTCTGCTCCGCCAAGTGCCCCCAGAAGAAGATCCCCAACACCTTCGACAAGAACCTCGG
CACCCGCCCTGCCATCTACGTCCCGTTCCCCCAGGCGGTCCCCAACACCCCGGTCATCGACCGGGCAAACTGCACCTGGT
TCAAGACGGGGAAATGCGGGGTCTGCCAGAAGGTCTGCGGCCCCGGCGCCATCAACTACGAACAAGAGGACCAACTGATC
GTCGAGCCCGTTGGTGCCATCGTGGTCGCCACCGGCTTCGAGCTCTACTCCATTACCGAGAAGCCCAAGGGCTCCCCCAT
CAAGGGATACGGCGAATTCGGCCACGGCACCATCCCCGATGTCATCGACGGCCTCACCTTCGAGCGGCTGGCCTCGGCCT
CCGGCCCCACCGGGGGAAAAATCCTGCGCCCCTCCGATGGCAAAGAGCCCAAGCAGGTGGTCTTTGTCCAGTGCGTCGGA
AGCCGGGCCCGGGAGAAGGGAATCTCCTACTGCTCCAAGATCTGCTGCATGTACACCGCCAAGCACACCATGCTCTACAA
GCACAAGATCCACGACGGCCAGGCCTACGTCTTCTTCATGGACGCCCGGACCCCGGGGAAGAGCTACGACGAGTTCTGGC
GCCGGGCGGTAGAGGAAGAGGAGGCGGTCTACATCCGGGGAATGGTCTCCCGGCTCTATCAGAAGGGTGACAAGGTGGTG
GTCATGGGGAGCGACATCTCCGTGGGGGTCCAGGTGGAGATCGAGGCGGACCTCGTGGTTCTGGCCACTGCGGTGCAGCC
CCGGGCCGGCGCCGACACCCTGGCCCAGAAGCTCGGCATCTCCTACGACAGCTATCACTTCTACTCCGAGGCCCACGCCA
AGCTGAAGCCCGTTGAGTGCGCCACCGCCGGCATCTACCTGGCCGGCGCCTGCCAGGGGCCGAAAGACATCCCCGACACC
GTGAGCCAGGCGAGCGCCGCTGCGGCCAAGGTGATGACCCTCTTTGCCAAGGATGAGCTGGAGCGGGAGCCGATCGTCGC
CAAGGTGAACGAGAAGAACTGCGTGGCCTGCCTCTACTGCAAGAAGGTCTGCCCCTACGGCGCCGTGGAGGAGAAGGAGA
TCCGGGACCGCCAGGGGAACCTGATTCGCGTCGTGGCCTACGTGAACCCCGGGGTCTGCGGCGGCTGCGGCACCTGCCAG
GCGAGCTGCCCGTCCAAATCGGTGGAATTGGATGGCTACACCGACGAACAGATCATGGCCATGATCGAGGCGCTGTAG

Upstream 100 bases:

>100_bases
CATCCCGATCCTTATGAGTATCCCCATTAAACAATAAATATTTTTGCTTTTCTCCGTGCTCTCCGTATCTCCGTGTTATT
GAATTTGTAAGAGGTATTCA

Downstream 100 bases:

>100_bases
GATCAAAAACTTTTTGCCACAGAGGTCACAGAGGACTCAGAGAAAACCAGCATCAAAAAAAATACGCCCGAAGTTACCCT
CTTGCCGAGAGTACAGGGTA

Product: heterodisulfide reductase subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 665; Mature: 664

Protein sequence:

>665_residues
MSRIGVFVCHCGENISRTVDVERVAAEAARLPGVAYATDYKYMCSDPGQNLLKNAVTEHRLDGIVVAACSPRMHEKTFRN
AAKSAGLNPFLCEMANIREHCSWVHEDRDEATAKASDIVAMMVARVKKDKRLVPITVPVTKRSLVIGGGIAGIQAALDIA
DAGHQVVLVEREPSIGGHMAQLSETFPTLDCSQCIMTPKMVDVANHPNITLHTYSEIEAVDGYIGNFQITVRKKARSVIE
EKCTGCGVCSAKCPQKKIPNTFDKNLGTRPAIYVPFPQAVPNTPVIDRANCTWFKTGKCGVCQKVCGPGAINYEQEDQLI
VEPVGAIVVATGFELYSITEKPKGSPIKGYGEFGHGTIPDVIDGLTFERLASASGPTGGKILRPSDGKEPKQVVFVQCVG
SRAREKGISYCSKICCMYTAKHTMLYKHKIHDGQAYVFFMDARTPGKSYDEFWRRAVEEEEAVYIRGMVSRLYQKGDKVV
VMGSDISVGVQVEIEADLVVLATAVQPRAGADTLAQKLGISYDSYHFYSEAHAKLKPVECATAGIYLAGACQGPKDIPDT
VSQASAAAAKVMTLFAKDELEREPIVAKVNEKNCVACLYCKKVCPYGAVEEKEIRDRQGNLIRVVAYVNPGVCGGCGTCQ
ASCPSKSVELDGYTDEQIMAMIEAL

Sequences:

>Translated_665_residues
MSRIGVFVCHCGENISRTVDVERVAAEAARLPGVAYATDYKYMCSDPGQNLLKNAVTEHRLDGIVVAACSPRMHEKTFRN
AAKSAGLNPFLCEMANIREHCSWVHEDRDEATAKASDIVAMMVARVKKDKRLVPITVPVTKRSLVIGGGIAGIQAALDIA
DAGHQVVLVEREPSIGGHMAQLSETFPTLDCSQCIMTPKMVDVANHPNITLHTYSEIEAVDGYIGNFQITVRKKARSVIE
EKCTGCGVCSAKCPQKKIPNTFDKNLGTRPAIYVPFPQAVPNTPVIDRANCTWFKTGKCGVCQKVCGPGAINYEQEDQLI
VEPVGAIVVATGFELYSITEKPKGSPIKGYGEFGHGTIPDVIDGLTFERLASASGPTGGKILRPSDGKEPKQVVFVQCVG
SRAREKGISYCSKICCMYTAKHTMLYKHKIHDGQAYVFFMDARTPGKSYDEFWRRAVEEEEAVYIRGMVSRLYQKGDKVV
VMGSDISVGVQVEIEADLVVLATAVQPRAGADTLAQKLGISYDSYHFYSEAHAKLKPVECATAGIYLAGACQGPKDIPDT
VSQASAAAAKVMTLFAKDELEREPIVAKVNEKNCVACLYCKKVCPYGAVEEKEIRDRQGNLIRVVAYVNPGVCGGCGTCQ
ASCPSKSVELDGYTDEQIMAMIEAL
>Mature_664_residues
SRIGVFVCHCGENISRTVDVERVAAEAARLPGVAYATDYKYMCSDPGQNLLKNAVTEHRLDGIVVAACSPRMHEKTFRNA
AKSAGLNPFLCEMANIREHCSWVHEDRDEATAKASDIVAMMVARVKKDKRLVPITVPVTKRSLVIGGGIAGIQAALDIAD
AGHQVVLVEREPSIGGHMAQLSETFPTLDCSQCIMTPKMVDVANHPNITLHTYSEIEAVDGYIGNFQITVRKKARSVIEE
KCTGCGVCSAKCPQKKIPNTFDKNLGTRPAIYVPFPQAVPNTPVIDRANCTWFKTGKCGVCQKVCGPGAINYEQEDQLIV
EPVGAIVVATGFELYSITEKPKGSPIKGYGEFGHGTIPDVIDGLTFERLASASGPTGGKILRPSDGKEPKQVVFVQCVGS
RAREKGISYCSKICCMYTAKHTMLYKHKIHDGQAYVFFMDARTPGKSYDEFWRRAVEEEEAVYIRGMVSRLYQKGDKVVV
MGSDISVGVQVEIEADLVVLATAVQPRAGADTLAQKLGISYDSYHFYSEAHAKLKPVECATAGIYLAGACQGPKDIPDTV
SQASAAAAKVMTLFAKDELEREPIVAKVNEKNCVACLYCKKVCPYGAVEEKEIRDRQGNLIRVVAYVNPGVCGGCGTCQA
SCPSKSVELDGYTDEQIMAMIEAL

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR012285 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 72168; Mature: 72037

Theoretical pI: Translated: 7.33; Mature: 7.33

Prosite motif: PS00198 4FE4S_FERREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRIGVFVCHCGENISRTVDVERVAAEAARLPGVAYATDYKYMCSDPGQNLLKNAVTEHR
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCHHHHHHHHHHHC
LDGIVVAACSPRMHEKTFRNAAKSAGLNPFLCEMANIREHCSWVHEDRDEATAKASDIVA
CCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
MMVARVKKDKRLVPITVPVTKRSLVIGGGIAGIQAALDIADAGHQVVLVEREPSIGGHMA
HHHHHHHCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHH
QLSETFPTLDCSQCIMTPKMVDVANHPNITLHTYSEIEAVDGYIGNFQITVRKKARSVIE
HHHHHCCCCCHHHHHCCCCCEEECCCCCEEEEEHHHHHHHCCCCCCEEEEEEHHHHHHHH
EKCTGCGVCSAKCPQKKIPNTFDKNLGTRPAIYVPFPQAVPNTPVIDRANCTWFKTGKCG
HHCCCCCCCCCCCCHHHCCCHHHHCCCCCCEEEEECCCCCCCCCCEECCCCCEEECCCCC
VCQKVCGPGAINYEQEDQLIVEPVGAIVVATGFELYSITEKPKGSPIKGYGEFGHGTIPD
HHHHHCCCCCCCCCCCCCEEEECCCEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCHH
VIDGLTFERLASASGPTGGKILRPSDGKEPKQVVFVQCVGSRAREKGISYCSKICCMYTA
HHCCCCHHHHHCCCCCCCCEEECCCCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHHHHH
KHTMLYKHKIHDGQAYVFFMDARTPGKSYDEFWRRAVEEEEAVYIRGMVSRLYQKGDKVV
HHHEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEE
VMGSDISVGVQVEIEADLVVLATAVQPRAGADTLAQKLGISYDSYHFYSEAHAKLKPVEC
EEECCCEEEEEEEEECCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEHHHHCCCCCCCEE
ATAGIYLAGACQGPKDIPDTVSQASAAAAKVMTLFAKDELEREPIVAKVNEKNCVACLYC
ECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEH
KKVCPYGAVEEKEIRDRQGNLIRVVAYVNPGVCGGCGTCQASCPSKSVELDGYTDEQIMA
HHHCCCCCCCHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCHHHHHH
MIEAL
HHHCC
>Mature Secondary Structure 
SRIGVFVCHCGENISRTVDVERVAAEAARLPGVAYATDYKYMCSDPGQNLLKNAVTEHR
CCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEECCCEEECCCCHHHHHHHHHHHC
LDGIVVAACSPRMHEKTFRNAAKSAGLNPFLCEMANIREHCSWVHEDRDEATAKASDIVA
CCCEEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHH
MMVARVKKDKRLVPITVPVTKRSLVIGGGIAGIQAALDIADAGHQVVLVEREPSIGGHMA
HHHHHHHCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHCCCCEEEEEECCCCCCCHHH
QLSETFPTLDCSQCIMTPKMVDVANHPNITLHTYSEIEAVDGYIGNFQITVRKKARSVIE
HHHHHCCCCCHHHHHCCCCCEEECCCCCEEEEEHHHHHHHCCCCCCEEEEEEHHHHHHHH
EKCTGCGVCSAKCPQKKIPNTFDKNLGTRPAIYVPFPQAVPNTPVIDRANCTWFKTGKCG
HHCCCCCCCCCCCCHHHCCCHHHHCCCCCCEEEEECCCCCCCCCCEECCCCCEEECCCCC
VCQKVCGPGAINYEQEDQLIVEPVGAIVVATGFELYSITEKPKGSPIKGYGEFGHGTIPD
HHHHHCCCCCCCCCCCCCEEEECCCEEEEEECCEEEEECCCCCCCCCCCCCCCCCCCCHH
VIDGLTFERLASASGPTGGKILRPSDGKEPKQVVFVQCVGSRAREKGISYCSKICCMYTA
HHCCCCHHHHHCCCCCCCCEEECCCCCCCCHHEEEEEECCCHHHHHHHHHHHHHHHHHHH
KHTMLYKHKIHDGQAYVFFMDARTPGKSYDEFWRRAVEEEEAVYIRGMVSRLYQKGDKVV
HHHEEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCEEE
VMGSDISVGVQVEIEADLVVLATAVQPRAGADTLAQKLGISYDSYHFYSEAHAKLKPVEC
EEECCCEEEEEEEEECCEEEEEECCCCCCCHHHHHHHHCCCCCCEEEHHHHCCCCCCCEE
ATAGIYLAGACQGPKDIPDTVSQASAAAAKVMTLFAKDELEREPIVAKVNEKNCVACLYC
ECCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEH
KKVCPYGAVEEKEIRDRQGNLIRVVAYVNPGVCGGCGTCQASCPSKSVELDGYTDEQIMA
HHHCCCCCCCHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCCCCEEECCCCHHHHHH
MIEAL
HHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9063468; 11930014 [H]