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The map label for this gene is folE2

Identifier: 78224266

GI number: 78224266

Start: 3472706

End: 3473491

Strand: Reverse

Name: folE2

Synonym: Gmet_3074

Alternate gene names: 78224266

Gene position: 3473491-3472706 (Counterclockwise)

Preceding gene: 78224267

Following gene: 78224265

Centisome position: 86.89

GC content: 59.41

Gene sequence:

>786_bases
ATGACCACCATGCCCGACATGCAGAAAACCTCCGACACCCGGAAGATTCCCATCAACAAGGTGGGGGTGAAGGACATCTC
CTACCCCATCGTGGTGATGGACAAGAACAAGAAGTTCCAGCAGACCGTGGCCCGGATCAATATGTACGTGGACCTCCCCC
ACCACTTCAAGGGGACTCACATGAGCCGGTTCGTGGAGATCCTCAATGCCTACCGTGAGGATATCGCCCTGGACAAGATG
GAGCCGATCCTCCAGAAGATGAAGGAGAAACTGGGGGCCTCGTCGGCCCACCTGGAGATCGAGTTTCCCTATTTCATCGA
GAAGCGGGCACCGGTCTCCGGCGCCCGCAGCCTCATGGAGTACACCTGCACCTTCTGCGGTTCCCTGGGGGAAGAGTTCG
ACTTCGTGCTGGGGGTGCAGATTCCGGTCACGTCCCTCTGCCCGTGCAGCAAGGAGCTGTCCCGCTACGGGGCCCATAAC
CAGCGGAGCCACATCACCGTGCGCCTGCGGTACACCGACTTCATCTGGATCGAGGACTTGGTGGCGATGATCGAGGAGTG
CGGGTCGAGCCCGGTCTGGTCCCTACTCAAGCGGGTGGACGAACAGTACGTCACCGAGCGGGCCTACGAGAACCCCAAGT
TCGTGGAGGATATCGTGCGCGAGGTGACCCAGAAGCTCCTGGCCCACGATGCTATTACGTGGTTTTCCGTAGAGGCGGAG
AACTTCGAGTCGATCCACAAGCACTCGGCCTACGCGGCCATCGAGCGTGACAAGAAAATGACATGA

Upstream 100 bases:

>100_bases
ACCATCAAGAATCCAGAAGTTAGGAGTCAGGAGTCAGAATAGAAGATGCCTGGTTTTTTCTGGCTCCTGAATTCTGACTC
CTGAATACCCAGAGGTTGTT

Downstream 100 bases:

>100_bases
TTCATGAGGGATTGTTGTCGCCGAATTAATTTTTTTTGACGTGGAGTTCTGTGCCGCCTTGTCCCGTGGGTGTTGATAAC
TATGTTGAAAAGCGCCAAAG

Product: putative GTP cyclohydrolase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MTTMPDMQKTSDTRKIPINKVGVKDISYPIVVMDKNKKFQQTVARINMYVDLPHHFKGTHMSRFVEILNAYREDIALDKM
EPILQKMKEKLGASSAHLEIEFPYFIEKRAPVSGARSLMEYTCTFCGSLGEEFDFVLGVQIPVTSLCPCSKELSRYGAHN
QRSHITVRLRYTDFIWIEDLVAMIEECGSSPVWSLLKRVDEQYVTERAYENPKFVEDIVREVTQKLLAHDAITWFSVEAE
NFESIHKHSAYAAIERDKKMT

Sequences:

>Translated_261_residues
MTTMPDMQKTSDTRKIPINKVGVKDISYPIVVMDKNKKFQQTVARINMYVDLPHHFKGTHMSRFVEILNAYREDIALDKM
EPILQKMKEKLGASSAHLEIEFPYFIEKRAPVSGARSLMEYTCTFCGSLGEEFDFVLGVQIPVTSLCPCSKELSRYGAHN
QRSHITVRLRYTDFIWIEDLVAMIEECGSSPVWSLLKRVDEQYVTERAYENPKFVEDIVREVTQKLLAHDAITWFSVEAE
NFESIHKHSAYAAIERDKKMT
>Mature_260_residues
TTMPDMQKTSDTRKIPINKVGVKDISYPIVVMDKNKKFQQTVARINMYVDLPHHFKGTHMSRFVEILNAYREDIALDKME
PILQKMKEKLGASSAHLEIEFPYFIEKRAPVSGARSLMEYTCTFCGSLGEEFDFVLGVQIPVTSLCPCSKELSRYGAHNQ
RSHITVRLRYTDFIWIEDLVAMIEECGSSPVWSLLKRVDEQYVTERAYENPKFVEDIVREVTQKLLAHDAITWFSVEAEN
FESIHKHSAYAAIERDKKMT

Specific function: Converts GTP to 7,8-dihydroneopterin triphosphate

COG id: COG1469

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP cyclohydrolase IV family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCH4_GEOMG (Q39R36)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_386013.1
- ProteinModelPortal:   Q39R36
- SMR:   Q39R36
- STRING:   Q39R36
- GeneID:   3740772
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_3074
- NMPDR:   fig|269799.3.peg.3189
- eggNOG:   COG1469
- HOGENOM:   HBG626871
- OMA:   SLMDYEV
- ProtClustDB:   PRK13674
- BioCyc:   GMET269799:GMET_3074-MONOMER
- HAMAP:   MF_01527_B
- InterPro:   IPR022838
- InterPro:   IPR003801
- InterPro:   IPR002042
- Gene3D:   G3DSA:3.10.270.10

Pfam domain/function: PF02649 DUF198

EC number: =3.5.4.16

Molecular weight: Translated: 30182; Mature: 30051

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTMPDMQKTSDTRKIPINKVGVKDISYPIVVMDKNKKFQQTVARINMYVDLPHHFKGTH
CCCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHEEECCCCCCCHH
MSRFVEILNAYREDIALDKMEPILQKMKEKLGASSAHLEIEFPYFIEKRAPVSGARSLME
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCHHHHHHHHH
YTCTFCGSLGEEFDFVLGVQIPVTSLCPCSKELSRYGAHNQRSHITVRLRYTDFIWIEDL
HHHHHHHHCCCCCCEEEECCCCHHHCCCCHHHHHHCCCCCCCCEEEEEEEECHHHHHHHH
VAMIEECGSSPVWSLLKRVDEQYVTERAYENPKFVEDIVREVTQKLLAHDAITWFSVEAE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECHH
NFESIHKHSAYAAIERDKKMT
HHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTMPDMQKTSDTRKIPINKVGVKDISYPIVVMDKNKKFQQTVARINMYVDLPHHFKGTH
CCCCCCHHCCCCCCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHEEECCCCCCCHH
MSRFVEILNAYREDIALDKMEPILQKMKEKLGASSAHLEIEFPYFIEKRAPVSGARSLME
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCHHHCCCCCHHHHHHHHH
YTCTFCGSLGEEFDFVLGVQIPVTSLCPCSKELSRYGAHNQRSHITVRLRYTDFIWIEDL
HHHHHHHHCCCCCCEEEECCCCHHHCCCCHHHHHHCCCCCCCCEEEEEEEECHHHHHHHH
VAMIEECGSSPVWSLLKRVDEQYVTERAYENPKFVEDIVREVTQKLLAHDAITWFSVEAE
HHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHEEEECHH
NFESIHKHSAYAAIERDKKMT
HHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA