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The map label for this gene is thrS

Identifier: 78222623

GI number: 78222623

Start: 1579409

End: 1581346

Strand: Direct

Name: thrS

Synonym: Gmet_1411

Alternate gene names: 78222623

Gene position: 1579409-1581346 (Clockwise)

Preceding gene: 78222622

Following gene: 78222624

Centisome position: 39.51

GC content: 54.8

Gene sequence:

>1938_bases
ATGCCTCTTCGTGTTAAGGGGGCAGCGATGGGTGACATCAAGGTTGCACTGCCGGATGGTTCGGAAAGGGTTCTTGCCGA
GGGGGCAACGGTGCGCGATCTGGCCGCCTCTATCGGCGCTGGGCTTGCAAAGGCCGCCATTGCCGGCAAAATCAACGGTG
TTGCCGTCGATCTGACGGCGCCTCTTGTGGATGGCGTCAAGGTCGAGATCATAACCGAGAAGTCCCCTGAGGCCCTGGAG
ATTATCCGCCACTCCACCTCCCACCTCATGGCCCAGGCGGTCAAGGAGCTTTTCCCGCAGGCGAAGGTCACCATCGGACC
CGCTGTCGAGAATGGTTTTTATTACGACTTTGATGTCGATCATGCCTTTACTCCCGAAGACCTTGAAAAAATAGAGACCC
GAATGAGGGAGCTCGCCAAGTCTGACCTTAAGCTGGAGCGTCAGGTTCTCTCTAAGGATGAGGCTATCAAGCTCTTCCGG
GATATGGGGGAGAACTACAAGGTCGAGTTGATTGAGGCCATTGGCGATAATACTGTATCTCTCTATCGTCAGGGGGATTT
CGTCGATCTTTGTCGCGGCCCCCATCTCCCATCAACGGCCAACTGTCGTGCTTTCAAGCTTACTTCTCTTGCAGGCGCCT
ACTGGCGCGGCGACGAGAAGAATAAAATGCTCCAGCGGGTCTACGGAACCGCCTTTGCCGACAAGAAGGAACTCGATGCA
TATCTGGAGAGGATCGAAGAGGCCAAGCGCCGCGACCATCGCAAGCTGGGCAGGGAGCTCGATCTTTTCTCGTTTTCCGA
TGAGGTTGGGGCGGGGTTTGTAATCTGGCATCCTAACGGAGCCATGCTGCGGACCATTCTTGAAGATTTCGAGCGCAAGG
AGCACCTGAAGCGCGGTTACGACATCGTTGTGGGGCCACAGATACTTAAGACTGATCTTTGGCAGCGTTCAGGCCACTAC
GATAACTACCGCGAAAACATGTATTTCACCGAAGTGGAGGAGCAGAGCTTCGGCATCAAGCCGATGAACTGTCTCAGTCA
CATGATGATATACAAGTCGCATCTGCGCAGTTATCGGGATCTGCCGCTCCGCTTCTTTGAACTCGGCACCGTGCACCGCC
ATGAGCGGGCCGGCGTCCTCCACGGGCTTCTGCGTGTTCGTTGCTTTACTCAGGACGATGCCCATATCCTCTGTACCCCG
GAACAGCTCGATGACGAGATCAAGGGTGTCATTTCCTTTGTCAACGATGTCATGGGTATTTTCGGGTTCGAGTTCGAGAT
GGAACTCTCCACCCGGCCAGAAAAGTCCATCGGTTCCGATGAGGATTGGGAGCGGGCTACCAATGCGCTTCTCGGGGCGC
TGAAGGATTCCGGACGTCCCTACGAGATTAATGAGGGGGACGGTGCATTTTATGGGCCGAAGATCGATATCAAACTGCGC
GATTCTCTTGACAGAAGGTGGCAGTGTGCTACAATCCAGTGCGATTTTACGCTTCCTGAGCGGTTTGATTTAACCTATGT
CGACGCAGATGGTGAAAGGAAGCGCCCTGTGATGGTTCACCGGGTGATTCTTGGTTCCATCGAGCGCTTCATAGGTGTTC
TTATTGAACATTTTGCTGGTAATTTCCCCGTGTGGCTCTCGCCGGTTCAGGCAATCGTGATGACCGTCACGGACAATCAG
CAGTCCTATGCCGCCCAGGTTTTCGAGGCGCTTCGCTCGAGCGGGATTCGGGTGCGGAAGGACTTCCGCAACGAAAAACT
CGGGTTCAAGATCCGCGAAGCGCAGCTCCAGAAGATTCCGTACATGCTCGTCATTGGCGACAAGGAAGTGGAGTCCGGGA
CGGTGACTCCGCGGTTCCGTGATGGTTCGAACCTCGCGGCCATGAAGCCCGAGGAGTTTGTTGTGTTCATTAACGAAGAC
GTCAAGCGCTTCAAATAG

Upstream 100 bases:

>100_bases
AGCGCTACCTTGACACGGTAGAGGTCGGCGGTTCGAGACCGCCCGCGCCTACCATTCAAAGAACTCGCAGCTAGGGCTGT
GGAAGGGGCATCGAAGTTCG

Downstream 100 bases:

>100_bases
GAGGTGGCGCCATAGCCAAGCCGACCGTAAATGTAAACCAAGCTATCAGAGCCCGTGAGATACGGGTTGTTGGAGCCAAT
AGCGAGCAGCTTGGTATTAT

Product: threonyl-tRNA synthetase

Products: NA

Alternate protein names: Threonine--tRNA ligase; ThrRS [H]

Number of amino acids: Translated: 645; Mature: 644

Protein sequence:

>645_residues
MPLRVKGAAMGDIKVALPDGSERVLAEGATVRDLAASIGAGLAKAAIAGKINGVAVDLTAPLVDGVKVEIITEKSPEALE
IIRHSTSHLMAQAVKELFPQAKVTIGPAVENGFYYDFDVDHAFTPEDLEKIETRMRELAKSDLKLERQVLSKDEAIKLFR
DMGENYKVELIEAIGDNTVSLYRQGDFVDLCRGPHLPSTANCRAFKLTSLAGAYWRGDEKNKMLQRVYGTAFADKKELDA
YLERIEEAKRRDHRKLGRELDLFSFSDEVGAGFVIWHPNGAMLRTILEDFERKEHLKRGYDIVVGPQILKTDLWQRSGHY
DNYRENMYFTEVEEQSFGIKPMNCLSHMMIYKSHLRSYRDLPLRFFELGTVHRHERAGVLHGLLRVRCFTQDDAHILCTP
EQLDDEIKGVISFVNDVMGIFGFEFEMELSTRPEKSIGSDEDWERATNALLGALKDSGRPYEINEGDGAFYGPKIDIKLR
DSLDRRWQCATIQCDFTLPERFDLTYVDADGERKRPVMVHRVILGSIERFIGVLIEHFAGNFPVWLSPVQAIVMTVTDNQ
QSYAAQVFEALRSSGIRVRKDFRNEKLGFKIREAQLQKIPYMLVIGDKEVESGTVTPRFRDGSNLAAMKPEEFVVFINED
VKRFK

Sequences:

>Translated_645_residues
MPLRVKGAAMGDIKVALPDGSERVLAEGATVRDLAASIGAGLAKAAIAGKINGVAVDLTAPLVDGVKVEIITEKSPEALE
IIRHSTSHLMAQAVKELFPQAKVTIGPAVENGFYYDFDVDHAFTPEDLEKIETRMRELAKSDLKLERQVLSKDEAIKLFR
DMGENYKVELIEAIGDNTVSLYRQGDFVDLCRGPHLPSTANCRAFKLTSLAGAYWRGDEKNKMLQRVYGTAFADKKELDA
YLERIEEAKRRDHRKLGRELDLFSFSDEVGAGFVIWHPNGAMLRTILEDFERKEHLKRGYDIVVGPQILKTDLWQRSGHY
DNYRENMYFTEVEEQSFGIKPMNCLSHMMIYKSHLRSYRDLPLRFFELGTVHRHERAGVLHGLLRVRCFTQDDAHILCTP
EQLDDEIKGVISFVNDVMGIFGFEFEMELSTRPEKSIGSDEDWERATNALLGALKDSGRPYEINEGDGAFYGPKIDIKLR
DSLDRRWQCATIQCDFTLPERFDLTYVDADGERKRPVMVHRVILGSIERFIGVLIEHFAGNFPVWLSPVQAIVMTVTDNQ
QSYAAQVFEALRSSGIRVRKDFRNEKLGFKIREAQLQKIPYMLVIGDKEVESGTVTPRFRDGSNLAAMKPEEFVVFINED
VKRFK
>Mature_644_residues
PLRVKGAAMGDIKVALPDGSERVLAEGATVRDLAASIGAGLAKAAIAGKINGVAVDLTAPLVDGVKVEIITEKSPEALEI
IRHSTSHLMAQAVKELFPQAKVTIGPAVENGFYYDFDVDHAFTPEDLEKIETRMRELAKSDLKLERQVLSKDEAIKLFRD
MGENYKVELIEAIGDNTVSLYRQGDFVDLCRGPHLPSTANCRAFKLTSLAGAYWRGDEKNKMLQRVYGTAFADKKELDAY
LERIEEAKRRDHRKLGRELDLFSFSDEVGAGFVIWHPNGAMLRTILEDFERKEHLKRGYDIVVGPQILKTDLWQRSGHYD
NYRENMYFTEVEEQSFGIKPMNCLSHMMIYKSHLRSYRDLPLRFFELGTVHRHERAGVLHGLLRVRCFTQDDAHILCTPE
QLDDEIKGVISFVNDVMGIFGFEFEMELSTRPEKSIGSDEDWERATNALLGALKDSGRPYEINEGDGAFYGPKIDIKLRD
SLDRRWQCATIQCDFTLPERFDLTYVDADGERKRPVMVHRVILGSIERFIGVLIEHFAGNFPVWLSPVQAIVMTVTDNQQ
SYAAQVFEALRSSGIRVRKDFRNEKLGFKIREAQLQKIPYMLVIGDKEVESGTVTPRFRDGSNLAAMKPEEFVVFINEDV
KRFK

Specific function: Thrs Is Also A Translational Repressor Protein, It Controls The Translation Of Its Own Gene By Binding To Its mRNA. [C]

COG id: COG0441

COG function: function code J; Threonyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI38202255, Length=616, Percent_Identity=41.8831168831169, Blast_Score=493, Evalue=1e-139,
Organism=Homo sapiens, GI38570111, Length=623, Percent_Identity=40.9309791332263, Blast_Score=490, Evalue=1e-138,
Organism=Homo sapiens, GI20070344, Length=636, Percent_Identity=38.2075471698113, Blast_Score=424, Evalue=1e-118,
Organism=Escherichia coli, GI1788013, Length=631, Percent_Identity=50.8716323296355, Blast_Score=669, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71984184, Length=619, Percent_Identity=40.5492730210016, Blast_Score=501, Evalue=1e-142,
Organism=Caenorhabditis elegans, GI71984192, Length=619, Percent_Identity=40.5492730210016, Blast_Score=501, Evalue=1e-142,
Organism=Saccharomyces cerevisiae, GI6322112, Length=630, Percent_Identity=41.9047619047619, Blast_Score=502, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6322654, Length=393, Percent_Identity=39.440203562341, Blast_Score=290, Evalue=5e-79,
Organism=Drosophila melanogaster, GI24583842, Length=614, Percent_Identity=41.5309446254072, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI28574141, Length=614, Percent_Identity=41.5309446254072, Blast_Score=503, Evalue=1e-142,
Organism=Drosophila melanogaster, GI24583839, Length=613, Percent_Identity=41.5986949429038, Blast_Score=502, Evalue=1e-142,

Paralogues:

None

Copy number: 700 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004154
- InterPro:   IPR012675
- InterPro:   IPR004095
- InterPro:   IPR012676
- InterPro:   IPR002320
- InterPro:   IPR018163
- InterPro:   IPR012947 [H]

Pfam domain/function: PF03129 HGTP_anticodon; PF02824 TGS; PF00587 tRNA-synt_2b; PF07973 tRNA_SAD [H]

EC number: =6.1.1.3 [H]

Molecular weight: Translated: 73261; Mature: 73129

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLRVKGAAMGDIKVALPDGSERVLAEGATVRDLAASIGAGLAKAAIAGKINGVAVDLTA
CCEEECCCCCCCEEEECCCCCCHHHHCCCHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEC
PLVDGVKVEIITEKSPEALEIIRHSTSHLMAQAVKELFPQAKVTIGPAVENGFYYDFDVD
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCCEEEEECCC
HAFTPEDLEKIETRMRELAKSDLKLERQVLSKDEAIKLFRDMGENYKVELIEAIGDNTVS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEHHCCCEEE
LYRQGDFVDLCRGPHLPSTANCRAFKLTSLAGAYWRGDEKNKMLQRVYGTAFADKKELDA
EEECCCCHHHHCCCCCCCCCCCCEEEEHHHCCHHHCCCCHHHHHHHHHHHHCCCHHHHHH
YLERIEEAKRRDHRKLGRELDLFSFSDEVGAGFVIWHPNGAMLRTILEDFERKEHLKRGY
HHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC
DIVVGPQILKTDLWQRSGHYDNYRENMYFTEVEEQSFGIKPMNCLSHMMIYKSHLRSYRD
EEEECCHHHHHHHHHHCCCCCCHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHC
LPLRFFELGTVHRHERAGVLHGLLRVRCFTQDDAHILCTPEQLDDEIKGVISFVNDVMGI
CCCEEHHHCCHHHHHHHHHHHHHHHHEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
FGFEFEMELSTRPEKSIGSDEDWERATNALLGALKDSGRPYEINEGDGAFYGPKIDIKLR
HCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEECCEEEEEEC
DSLDRRWQCATIQCDFTLPERFDLTYVDADGERKRPVMVHRVILGSIERFIGVLIEHFAG
CCCCCCEEEEEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NFPVWLSPVQAIVMTVTDNQQSYAAQVFEALRSSGIRVRKDFRNEKLGFKIREAQLQKIP
CCCCHHCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHHCCCCCCCEEHHHHHHHCC
YMLVIGDKEVESGTVTPRFRDGSNLAAMKPEEFVVFINEDVKRFK
EEEEECCCCCCCCCCCCEECCCCCEEEECCCEEEEEEECHHHHCC
>Mature Secondary Structure 
PLRVKGAAMGDIKVALPDGSERVLAEGATVRDLAASIGAGLAKAAIAGKINGVAVDLTA
CEEECCCCCCCEEEECCCCCCHHHHCCCHHHHHHHHHCCHHHHHHHHCCCCCEEEEEEC
PLVDGVKVEIITEKSPEALEIIRHSTSHLMAQAVKELFPQAKVTIGPAVENGFYYDFDVD
CCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCEECCCEEEEECCC
HAFTPEDLEKIETRMRELAKSDLKLERQVLSKDEAIKLFRDMGENYKVELIEAIGDNTVS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCEEEEEEHHCCCEEE
LYRQGDFVDLCRGPHLPSTANCRAFKLTSLAGAYWRGDEKNKMLQRVYGTAFADKKELDA
EEECCCCHHHHCCCCCCCCCCCCEEEEHHHCCHHHCCCCHHHHHHHHHHHHCCCHHHHHH
YLERIEEAKRRDHRKLGRELDLFSFSDEVGAGFVIWHPNGAMLRTILEDFERKEHLKRGY
HHHHHHHHHHHHHHHHCCCCCCEECCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCCC
DIVVGPQILKTDLWQRSGHYDNYRENMYFTEVEEQSFGIKPMNCLSHMMIYKSHLRSYRD
EEEECCHHHHHHHHHHCCCCCCHHCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHC
LPLRFFELGTVHRHERAGVLHGLLRVRCFTQDDAHILCTPEQLDDEIKGVISFVNDVMGI
CCCEEHHHCCHHHHHHHHHHHHHHHHEEECCCCCEEEECHHHHHHHHHHHHHHHHHHHHH
FGFEFEMELSTRPEKSIGSDEDWERATNALLGALKDSGRPYEINEGDGAFYGPKIDIKLR
HCCEEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCEECCEEEEEEC
DSLDRRWQCATIQCDFTLPERFDLTYVDADGERKRPVMVHRVILGSIERFIGVLIEHFAG
CCCCCCEEEEEEEEECCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
NFPVWLSPVQAIVMTVTDNQQSYAAQVFEALRSSGIRVRKDFRNEKLGFKIREAQLQKIP
CCCCHHCCCEEEEEEEECCCHHHHHHHHHHHHHCCCEEEHHHCCCCCCCEEHHHHHHHCC
YMLVIGDKEVESGTVTPRFRDGSNLAAMKPEEFVVFINEDVKRFK
EEEEECCCCCCCCCCCCEECCCCCEEEECCCEEEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA