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The map label for this gene is aroE

Identifier: 78222604

GI number: 78222604

Start: 1558696

End: 1559556

Strand: Direct

Name: aroE

Synonym: Gmet_1392

Alternate gene names: 78222604

Gene position: 1558696-1559556 (Clockwise)

Preceding gene: 78222603

Following gene: 78222605

Centisome position: 38.99

GC content: 62.72

Gene sequence:

>861_bases
ATGGATATCACGGGAAAGACACGGGTGCTTGGCATTATCGGCTGGCCGGTGGCCCATTCCCTGTCGCCGCTCATGCAGAA
CGCCGCCCTGGAGGCCATGGGGCTCGACTGGATCTACGTTCCCTTCGCCGTGCGCCCGGAAGACCTCGCCAGTGCCGTGG
CGGGACTCAGGACCCTTGGCGTTTCCGGATTCAACGTGACCATCCCCCACAAGACCGCCATCATCCCCCTTCTTGACCGT
ATTACCCCCGAGGCGCGCCTCATGGGGGCGGTCAACACGGTGAAACGGGAAGGGGATGATCTTGTGGGTTACAATACCGA
CGGTGAGGGCTTCATCCGGTCCCTGGCGGAAGACCTCGGGTTTGTCCCGGCCGGAAGGCGCATCCTTGTCCTGGGAGCTG
GGGGAGCGGCCCGGGCTGCTGTGGCATCACTGGCCCGGGGAGGGGCCGCTACCGTCATGATTGCCAACCGGAGCGTGGCC
AGGGGGGAGGAGCTGGTGGAAGCATTTCAAGGTGTGTTTGGCGGCACGCAATTTGCTGCAATGCCTCTCGATATCCCCCT
GATCAATGCAGAAGTCCAAAATTTTGACTTGCTCGTTAATACCACGTCCGTGGGGATGGGGGAAACCGCATTCGAAGGGC
TCGATATCTCGCGCATGAACCCCGCTGCTTCCGTGTACGACATGGTCTATGCCCCCTGGGAAACACCGCTTCTTGCCGAG
GCATCCCGGGGGGGGAGGCGGTGCGCGAACGGGATCGGCATGCTTGTGGCGCAGGGTGAGTGCGCCCTTGCCATCTGGAC
CGGCATGGAGCCGCCACCCGGCATCATGAGGAGACGTGTTCTGGCAGCCCTGAAGCGCTAA

Upstream 100 bases:

>100_bases
TTCCCCGGGGGTGGAAGAACTGCGCCTGGCCGCCGCCATCGCGCCAGAACTGAGGGGTCAGGTGGAGCAGATGCTCGGCG
CGTACGGGGTGAGGTGAGCC

Downstream 100 bases:

>100_bases
CCACTTCTTGACATTGGGGTTTTGCCACCCTACCATTACGGCGACTTTTTCCGCGGAGAATCTATGCAGGCCAGCAGACT
GGGAGAACTCCTGGTTCGAA

Product: shikimate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 286; Mature: 286

Protein sequence:

>286_residues
MDITGKTRVLGIIGWPVAHSLSPLMQNAALEAMGLDWIYVPFAVRPEDLASAVAGLRTLGVSGFNVTIPHKTAIIPLLDR
ITPEARLMGAVNTVKREGDDLVGYNTDGEGFIRSLAEDLGFVPAGRRILVLGAGGAARAAVASLARGGAATVMIANRSVA
RGEELVEAFQGVFGGTQFAAMPLDIPLINAEVQNFDLLVNTTSVGMGETAFEGLDISRMNPAASVYDMVYAPWETPLLAE
ASRGGRRCANGIGMLVAQGECALAIWTGMEPPPGIMRRRVLAALKR

Sequences:

>Translated_286_residues
MDITGKTRVLGIIGWPVAHSLSPLMQNAALEAMGLDWIYVPFAVRPEDLASAVAGLRTLGVSGFNVTIPHKTAIIPLLDR
ITPEARLMGAVNTVKREGDDLVGYNTDGEGFIRSLAEDLGFVPAGRRILVLGAGGAARAAVASLARGGAATVMIANRSVA
RGEELVEAFQGVFGGTQFAAMPLDIPLINAEVQNFDLLVNTTSVGMGETAFEGLDISRMNPAASVYDMVYAPWETPLLAE
ASRGGRRCANGIGMLVAQGECALAIWTGMEPPPGIMRRRVLAALKR
>Mature_286_residues
MDITGKTRVLGIIGWPVAHSLSPLMQNAALEAMGLDWIYVPFAVRPEDLASAVAGLRTLGVSGFNVTIPHKTAIIPLLDR
ITPEARLMGAVNTVKREGDDLVGYNTDGEGFIRSLAEDLGFVPAGRRILVLGAGGAARAAVASLARGGAATVMIANRSVA
RGEELVEAFQGVFGGTQFAAMPLDIPLINAEVQNFDLLVNTTSVGMGETAFEGLDISRMNPAASVYDMVYAPWETPLLAE
ASRGGRRCANGIGMLVAQGECALAIWTGMEPPPGIMRRRVLAALKR

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=287, Percent_Identity=36.2369337979094, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1789675, Length=262, Percent_Identity=37.0229007633588, Blast_Score=138, Evalue=5e-34,
Organism=Saccharomyces cerevisiae, GI6320332, Length=289, Percent_Identity=27.3356401384083, Blast_Score=85, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_GEOMG (Q39VU8)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384351.1
- HSSP:   Q9SQT8
- ProteinModelPortal:   Q39VU8
- SMR:   Q39VU8
- STRING:   Q39VU8
- GeneID:   3738613
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1392
- NMPDR:   fig|269799.3.peg.1233
- eggNOG:   COG0169
- HOGENOM:   HBG553408
- OMA:   EDAFETE
- PhylomeDB:   Q39VU8
- ProtClustDB:   CLSK828389
- BioCyc:   GMET269799:GMET_1392-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 30155; Mature: 30155

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: NA

Important sites: ACT_SITE 71-71

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDITGKTRVLGIIGWPVAHSLSPLMQNAALEAMGLDWIYVPFAVRPEDLASAVAGLRTLG
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHC
VSGFNVTIPHKTAIIPLLDRITPEARLMGAVNTVKREGDDLVGYNTDGEGFIRSLAEDLG
CCCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHC
FVPAGRRILVLGAGGAARAAVASLARGGAATVMIANRSVARGEELVEAFQGVFGGTQFAA
CCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEE
MPLDIPLINAEVQNFDLLVNTTSVGMGETAFEGLDISRMNPAASVYDMVYAPWETPLLAE
ECCCCEEECCCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHHH
ASRGGRRCANGIGMLVAQGECALAIWTGMEPPPGIMRRRVLAALKR
HCCCCHHHHCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDITGKTRVLGIIGWPVAHSLSPLMQNAALEAMGLDWIYVPFAVRPEDLASAVAGLRTLG
CCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECHHHHHHHHHHHHHHC
VSGFNVTIPHKTAIIPLLDRITPEARLMGAVNTVKREGDDLVGYNTDGEGFIRSLAEDLG
CCCCEEECCCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHHHC
FVPAGRRILVLGAGGAARAAVASLARGGAATVMIANRSVARGEELVEAFQGVFGGTQFAA
CCCCCCEEEEEECCCHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCEEEE
MPLDIPLINAEVQNFDLLVNTTSVGMGETAFEGLDISRMNPAASVYDMVYAPWETPLLAE
ECCCCEEECCCCCCEEEEEEECCCCCCCHHHCCCCCCCCCCHHHHHHHHCCCCCCCHHHH
ASRGGRRCANGIGMLVAQGECALAIWTGMEPPPGIMRRRVLAALKR
HCCCCHHHHCCCEEEEECCCEEEEEECCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA