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The map label for this gene is icd [H]

Identifier: 78222571

GI number: 78222571

Start: 1521978

End: 1524200

Strand: Direct

Name: icd [H]

Synonym: Gmet_1359

Alternate gene names: 78222571

Gene position: 1521978-1524200 (Clockwise)

Preceding gene: 78222570

Following gene: 78222572

Centisome position: 38.07

GC content: 52.41

Gene sequence:

>2223_bases
ATGGCGACACACAAGATTATTTGGACAGACATTGACGAAGCACCCGCATTGGCAACATATTCCTTGCTGCCGATCATCCA
GAAGTTTACTGCGGGGACAGGTGTTGAGGTTGAGACACGGGACATTTCTCTTGCTGGCCGGATTCTTGCCACTTTCCCGG
AAAACCTGACTGAAGCTCAAAAGGTTCCTGATTATCTGACTCAGTTGGGGGATCTTACCCATAACCCCGAAGCAAATATC
ATTAAGCTCCCAAACATCAGTGCTTCCGTTCCGCAGCTCAAAGAGGCGATCAAAGAGTTGCAGTCCCAAGGGTACAATGT
ACCGGATTACCCTGAAGACCCGAAGAATGACGCTGAGAAAGAGATAAAGGAGCGCTATGCTAAAGTGCTCGGAAGCGCCG
TTAACCCAGTTCTTCGTGAAGGGAACTCGGACCGTCGCGCACCGGTTTCCGTCAAAAACTTCTCCAAGAAGCATCCCCAT
AAACTGGGTGCATGGACCTCGGATTCCAAGGCTGAAGTTGCCCACATGACCACCGGTGACTTTTATGGCAATGAAAAATC
CATTGTCATGGAGAATGGCGGTGGTTTCAGGATTGAGTTGGTGGGTGCAGATGGCAAAACTACCGTTCTGAAAGACAAGC
TTGTTGCCGAAAAAGGCGAAATTCTCGACGGCACCTTCATGAACGTGAAGGCGTTGAGGAAGTTTTATGCAGAGCAGATT
GAGGATGCGAAGAAGAACGGCCAACTCCTCTCTTTGCACCTCAAGGCAACCATGATGAAGGTCTCTGACCCGATCATGTT
CGGGCATGCCGTTTCCGTTTTCTATTCCGACGTTTTCGAAAAGCATGCTGCTACTTTTAAAGAACTGGGCGTCAATCCCA
ACATGGGACTTGGCGACCTCTACAACAAGATACAGTCCCTGTCCGAAGCCAAGAGGGCAGAGATTGAGGCAGACATCCAG
GCTGAGTATGTCAAGCGTCCTGCTATTGCAATGGTGGACTCCGACAAAGGGATCACCAACCTGCATGTGCCTAACGACAT
CATCGTTGATGCCTCCATGCCGGTTGTCGTGCGCGAGTCGGGCAAGATGTGGAATGCGGAAGGCAAGCTGCAGGACACCA
AGGCGATGATTCCCGATCGCTGCTATGCGACCATCTACAAGGCGATTATCCAGGATTGCCAGAAGAACGGTGCCCTTGAT
CCTGCAACCATGGGCTCTGTCCCCAACGTTGGTCTCATGGCCCAAAAGGCTGAAGAGTATGGGTCGCACCCCACGACGTT
CGAAATTCCTGCAAACGGTACTGTCCGTGTAGTTGCCGAGGACGGCAAGGTGCTGATGGAGCAGGCTGTTGAAGCCGGCG
ATATCTGGAGAATGTCCAGAGCAAAAGATATCCCGATCCAGGATTGGGTGAAGCTTGCTGTAAGAAGAGCACGGGCAACG
GGCGCGCACGCCGTGTTCTGGCTGGATAAGAACAGGGCCCATGATGCGAATGTTATCGCAAAAGTAGAGAAGTACTTGAA
GGACCACGATACTGCGGGACTGGAAATCAAGATTCTTGACCCGGTCGCAGCAATGAACTACTCGTTGGAAAGAATCCGCA
AGGGTCTGGATACTATCTCCGTAACCGGTAACGTGCTTCGTGACTACCTCACCGACCTCTTCCCGATTCTCGAAGTCGGC
ACCAGCGCCAAGATGCTCTCTATTGTTCCGCTTCTCGCCGGTGGCGGACTGTTCGAGACAGGTGCGGGTGGATCTGCTCC
CAAGCATGTCCAGCAATTTGTGAAGGAGGGTTACCTGCGCTGGGATTCACTCGGTGAGTTCTCTGCATTTGCCGCTTCTC
TGGAGCATCTTGGCACTACCTTTAAGAATGATAAGGCGCTTGTTCTGGCCGAGACCCTCGATCAGGCCATCGCCAAGTTC
CTCGACAATAACAAGTCGCCGGCCCGTAAGGTCGGCCAGATCGACAACCGTGGCAGCCATTACTATCTTGCCATGTACTG
GGCAGAAGCACTGGCGGCCCAGTCAAAGGATGCCGAGCTCCAGGCGAAATTTGCTCCCGTTGCAAAGAAGCTTCAGGAAA
ACGAAGCCAAGATCAACGAGGAGCTGATTGGCGCCCAGGGCAAGCCCGTTGATATGGGCGGCTATTACCACGCCGACAAG
AAGATGGTGGAAAAGGCAATGCGTCCTAGCCCGACCCTGAACGCAATTATTGATGCTATCTAA

Upstream 100 bases:

>100_bases
CATGTAAGCTGATTCACACCAATTGCCTATAGTTGATGACGTATCTTCTGGCCATTTTACAAGCCTCTGGCGGATTGCCG
TAAAAAATAAAGGAGGGAAC

Downstream 100 bases:

>100_bases
AGGTAGTTGTATCACGCAGATAACCCCAATTCAAAACGGAGGAAGAAAACATGGCACGTAAGAAAATCTCTCTCATCGGT
GGTGGTCAGATTGGTGGCGT

Product: isocitrate dehydrogenase NADP-dependent, monomeric type

Products: NA

Alternate protein names: IDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 740; Mature: 739

Protein sequence:

>740_residues
MATHKIIWTDIDEAPALATYSLLPIIQKFTAGTGVEVETRDISLAGRILATFPENLTEAQKVPDYLTQLGDLTHNPEANI
IKLPNISASVPQLKEAIKELQSQGYNVPDYPEDPKNDAEKEIKERYAKVLGSAVNPVLREGNSDRRAPVSVKNFSKKHPH
KLGAWTSDSKAEVAHMTTGDFYGNEKSIVMENGGGFRIELVGADGKTTVLKDKLVAEKGEILDGTFMNVKALRKFYAEQI
EDAKKNGQLLSLHLKATMMKVSDPIMFGHAVSVFYSDVFEKHAATFKELGVNPNMGLGDLYNKIQSLSEAKRAEIEADIQ
AEYVKRPAIAMVDSDKGITNLHVPNDIIVDASMPVVVRESGKMWNAEGKLQDTKAMIPDRCYATIYKAIIQDCQKNGALD
PATMGSVPNVGLMAQKAEEYGSHPTTFEIPANGTVRVVAEDGKVLMEQAVEAGDIWRMSRAKDIPIQDWVKLAVRRARAT
GAHAVFWLDKNRAHDANVIAKVEKYLKDHDTAGLEIKILDPVAAMNYSLERIRKGLDTISVTGNVLRDYLTDLFPILEVG
TSAKMLSIVPLLAGGGLFETGAGGSAPKHVQQFVKEGYLRWDSLGEFSAFAASLEHLGTTFKNDKALVLAETLDQAIAKF
LDNNKSPARKVGQIDNRGSHYYLAMYWAEALAAQSKDAELQAKFAPVAKKLQENEAKINEELIGAQGKPVDMGGYYHADK
KMVEKAMRPSPTLNAIIDAI

Sequences:

>Translated_740_residues
MATHKIIWTDIDEAPALATYSLLPIIQKFTAGTGVEVETRDISLAGRILATFPENLTEAQKVPDYLTQLGDLTHNPEANI
IKLPNISASVPQLKEAIKELQSQGYNVPDYPEDPKNDAEKEIKERYAKVLGSAVNPVLREGNSDRRAPVSVKNFSKKHPH
KLGAWTSDSKAEVAHMTTGDFYGNEKSIVMENGGGFRIELVGADGKTTVLKDKLVAEKGEILDGTFMNVKALRKFYAEQI
EDAKKNGQLLSLHLKATMMKVSDPIMFGHAVSVFYSDVFEKHAATFKELGVNPNMGLGDLYNKIQSLSEAKRAEIEADIQ
AEYVKRPAIAMVDSDKGITNLHVPNDIIVDASMPVVVRESGKMWNAEGKLQDTKAMIPDRCYATIYKAIIQDCQKNGALD
PATMGSVPNVGLMAQKAEEYGSHPTTFEIPANGTVRVVAEDGKVLMEQAVEAGDIWRMSRAKDIPIQDWVKLAVRRARAT
GAHAVFWLDKNRAHDANVIAKVEKYLKDHDTAGLEIKILDPVAAMNYSLERIRKGLDTISVTGNVLRDYLTDLFPILEVG
TSAKMLSIVPLLAGGGLFETGAGGSAPKHVQQFVKEGYLRWDSLGEFSAFAASLEHLGTTFKNDKALVLAETLDQAIAKF
LDNNKSPARKVGQIDNRGSHYYLAMYWAEALAAQSKDAELQAKFAPVAKKLQENEAKINEELIGAQGKPVDMGGYYHADK
KMVEKAMRPSPTLNAIIDAI
>Mature_739_residues
ATHKIIWTDIDEAPALATYSLLPIIQKFTAGTGVEVETRDISLAGRILATFPENLTEAQKVPDYLTQLGDLTHNPEANII
KLPNISASVPQLKEAIKELQSQGYNVPDYPEDPKNDAEKEIKERYAKVLGSAVNPVLREGNSDRRAPVSVKNFSKKHPHK
LGAWTSDSKAEVAHMTTGDFYGNEKSIVMENGGGFRIELVGADGKTTVLKDKLVAEKGEILDGTFMNVKALRKFYAEQIE
DAKKNGQLLSLHLKATMMKVSDPIMFGHAVSVFYSDVFEKHAATFKELGVNPNMGLGDLYNKIQSLSEAKRAEIEADIQA
EYVKRPAIAMVDSDKGITNLHVPNDIIVDASMPVVVRESGKMWNAEGKLQDTKAMIPDRCYATIYKAIIQDCQKNGALDP
ATMGSVPNVGLMAQKAEEYGSHPTTFEIPANGTVRVVAEDGKVLMEQAVEAGDIWRMSRAKDIPIQDWVKLAVRRARATG
AHAVFWLDKNRAHDANVIAKVEKYLKDHDTAGLEIKILDPVAAMNYSLERIRKGLDTISVTGNVLRDYLTDLFPILEVGT
SAKMLSIVPLLAGGGLFETGAGGSAPKHVQQFVKEGYLRWDSLGEFSAFAASLEHLGTTFKNDKALVLAETLDQAIAKFL
DNNKSPARKVGQIDNRGSHYYLAMYWAEALAAQSKDAELQAKFAPVAKKLQENEAKINEELIGAQGKPVDMGGYYHADKK
MVEKAMRPSPTLNAIIDAI

Specific function: Unknown

COG id: COG2838

COG function: function code C; Monomeric isocitrate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monomeric-type IDH family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001804
- InterPro:   IPR004436 [H]

Pfam domain/function: PF03971 IDH [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 81191; Mature: 81059

Theoretical pI: Translated: 6.48; Mature: 6.48

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATHKIIWTDIDEAPALATYSLLPIIQKFTAGTGVEVETRDISLAGRILATFPENLTEAQ
CCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCHHHHHHH
KVPDYLTQLGDLTHNPEANIIKLPNISASVPQLKEAIKELQSQGYNVPDYPEDPKNDAEK
HHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
EIKERYAKVLGSAVNPVLREGNSDRRAPVSVKNFSKKHPHKLGAWTSDSKAEVAHMTTGD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCC
FYGNEKSIVMENGGGFRIELVGADGKTTVLKDKLVAEKGEILDGTFMNVKALRKFYAEQI
CCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
EDAKKNGQLLSLHLKATMMKVSDPIMFGHAVSVFYSDVFEKHAATFKELGVNPNMGLGDL
HHHHHCCCEEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YNKIQSLSEAKRAEIEADIQAEYVKRPAIAMVDSDKGITNLHVPNDIIVDASMPVVVRES
HHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEECCCCEEECCC
GKMWNAEGKLQDTKAMIPDRCYATIYKAIIQDCQKNGALDPATMGSVPNVGLMAQKAEEY
CCEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHH
GSHPTTFEIPANGTVRVVAEDGKVLMEQAVEAGDIWRMSRAKDIPIQDWVKLAVRRARAT
CCCCCEEEECCCCEEEEEECCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHCC
GAHAVFWLDKNRAHDANVIAKVEKYLKDHDTAGLEIKILDPVAAMNYSLERIRKGLDTIS
CCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEE
VTGNVLRDYLTDLFPILEVGTSAKMLSIVPLLAGGGLFETGAGGSAPKHVQQFVKEGYLR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHCCEE
WDSLGEFSAFAASLEHLGTTFKNDKALVLAETLDQAIAKFLDNNKSPARKVGQIDNRGSH
CCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCE
YYLAMYWAEALAAQSKDAELQAKFAPVAKKLQENEAKINEELIGAQGKPVDMGGYYHADK
EEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHH
KMVEKAMRPSPTLNAIIDAI
HHHHHHHCCCCCHHHHHHCC
>Mature Secondary Structure 
ATHKIIWTDIDEAPALATYSLLPIIQKFTAGTGVEVETRDISLAGRILATFPENLTEAQ
CCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHCCHHHHHHH
KVPDYLTQLGDLTHNPEANIIKLPNISASVPQLKEAIKELQSQGYNVPDYPEDPKNDAEK
HHHHHHHHHHCCCCCCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHH
EIKERYAKVLGSAVNPVLREGNSDRRAPVSVKNFSKKHPHKLGAWTSDSKAEVAHMTTGD
HHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHCCCCCCCCCCCCCCCCCCEEEEEECCC
FYGNEKSIVMENGGGFRIELVGADGKTTVLKDKLVAEKGEILDGTFMNVKALRKFYAEQI
CCCCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHH
EDAKKNGQLLSLHLKATMMKVSDPIMFGHAVSVFYSDVFEKHAATFKELGVNPNMGLGDL
HHHHHCCCEEEEEEHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
YNKIQSLSEAKRAEIEADIQAEYVKRPAIAMVDSDKGITNLHVPNDIIVDASMPVVVRES
HHHHHHHHHHHHHHHCHHHHHHHHCCCCEEEEECCCCCEEEECCCCEEEECCCCEEECCC
GKMWNAEGKLQDTKAMIPDRCYATIYKAIIQDCQKNGALDPATMGSVPNVGLMAQKAEEY
CCEECCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCHHHHHHHHH
GSHPTTFEIPANGTVRVVAEDGKVLMEQAVEAGDIWRMSRAKDIPIQDWVKLAVRRARAT
CCCCCEEEECCCCEEEEEECCCHHHHHHHHHHCCCEECCCCCCCCHHHHHHHHHHHHHCC
GAHAVFWLDKNRAHDANVIAKVEKYLKDHDTAGLEIKILDPVAAMNYSLERIRKGLDTIS
CCEEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHCCCCEEE
VTGNVLRDYLTDLFPILEVGTSAKMLSIVPLLAGGGLFETGAGGSAPKHVQQFVKEGYLR
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECCCCCCCHHHHHHHHHHCCEE
WDSLGEFSAFAASLEHLGTTFKNDKALVLAETLDQAIAKFLDNNKSPARKVGQIDNRGSH
CCCCCHHHHHHHHHHHHCCCCCCCCEEEEHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCE
YYLAMYWAEALAAQSKDAELQAKFAPVAKKLQENEAKINEELIGAQGKPVDMGGYYHADK
EEEHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEECHHH
KMVEKAMRPSPTLNAIIDAI
HHHHHHHCCCCCHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12005040; 4149369; 12467571 [H]