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The map label for this gene is 78222555

Identifier: 78222555

GI number: 78222555

Start: 1500964

End: 1502382

Strand: Reverse

Name: 78222555

Synonym: Gmet_1343

Alternate gene names: NA

Gene position: 1502382-1500964 (Counterclockwise)

Preceding gene: 78222562

Following gene: 78222529

Centisome position: 37.58

GC content: 62.86

Gene sequence:

>1419_bases
ATGGAAATCATTCACCACGGCGGGCAATACGGCGTAACCGGGTCGTGCCACGAACTCGTCATCTCCGAAAATGCAAGTAT
TCTCATTGATTGCGGTCTGTTCCATGGACATGATGCGGACACCGGAAAGGGGAAGAAGCATACCCCTTTCATCGATTTTC
CCCTCGACCGGGTCCAGGGTCTGGTCCTGACCCACGTCCATATCGACCACTGCGGCCGCATACCCCACCTCATGGGGGCC
GGCTTCCAGGGGCCAATCTGGTGCAGCGAGGCCTCGGCCCTTCTCCTTCCCCTGGTCCTCGAAGACGCCGTCAAGGTGGG
GATCACCCGGGACGAGGGTCTCATCGAGCGGTTCATCGGGGCCATGAAAAAGCGCCTAGCGCCCCTCCCCTACGGCACGT
GGCGCAAGCTCGGTACCTGGGACGGCATGGATGTATCGCTCCGCCTTCAGCAGGCGGGGCACATCCTCGGCTCGGCCTAT
GCGGAACTCAGCGTCGCCCGCCCATCGGTACAGGAAACAACTGCATCGCGACACGACAACGAAACGGTCGTGGTTTTCTC
CGGCGACCTCGGAGCCCCCTTCACACCGCTCCTCCCCGACCCGGCACCACCGGAGCGGGCCGATATCCTGGTGCTGGAGT
CAACCTACGGCGACCGCCTCCATGAAGGGCGGGAACAGCGGCGGGAAAAACTGCGGCAGGTCATCATCCGGGCGCTGGAA
AACCGGGGAGCCCTCCTCGTCCCTGCCTTCAGCATCGGCAGAACCCAGGAACTCCTCTACGAGATTGAATCTCTCATCGC
CGAACACAGGAATGACGAGGCGGCCACGAACCTCCCCTGGGACGACCTTGAAATCATTGTCGACTCTCCCCTGGCCCTCC
GCGTCACCGAGGTCTACGACCGGCTCCGCCATCTCTGGGACCAGGAAGCGACAGAGGTCGTCTCCCAGGGGCGCCATCCC
CTCTCCTTCGAGCAGATGACGGTCATCGAAAACCACAACGACCACCGGGCCACCGTGGACTACCTCCGCGGGACCGCCCG
CCCCTGCGTAGTCATCGCCGCCGGCGGCATGTGCGCCGGAGGACGCATCGTCAACTACCTCAAAGCCCTCATGGGTGACC
CACGCACCGACATTCTCTTTGTCGGTTACCAGGCCCACGGGACGCCGGGGAGAGGAATCCTTGAGGCAGCGCAAACGCGT
ACCGGCACTGGGGAACATACCAGCATCGATCTGGATGGCGGCAGCTATCCCCTCAGGGCCACGGTCCACAGTATCAGCGG
CTACTCGGCCCACGCCGACCAGAGAGATCTGGTCAATTTCGTGCGCGGAATTCCCGTGGCGCCCCGATCCATCCGTCTGG
TGCATGGGGAGGAAAAGGCGCGAAAGGCGTTGGAGGGAGCATTAGGAATAGCGAGGTAG

Upstream 100 bases:

>100_bases
CGAAGCCCCGATCCCCGGTGCGTCCTGATCTCCCTTGACTTTCCCTGGCGAGTTTATTATTAGCTTCTCATTCGTTACGA
TCAGACTGACAGGGGAGATC

Downstream 100 bases:

>100_bases
CGAGATGACCTCCTTTTCTTGCCGCACCCTCAGCTATATTTGAAGGAACGCTCACTGCCGAACGCCGCATCTGGCTGGAG
ATGCCAAATTGCTCATGTCG

Product: Beta-lactamase-like:RNA-metabolising metallo-beta-lactamase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MEIIHHGGQYGVTGSCHELVISENASILIDCGLFHGHDADTGKGKKHTPFIDFPLDRVQGLVLTHVHIDHCGRIPHLMGA
GFQGPIWCSEASALLLPLVLEDAVKVGITRDEGLIERFIGAMKKRLAPLPYGTWRKLGTWDGMDVSLRLQQAGHILGSAY
AELSVARPSVQETTASRHDNETVVVFSGDLGAPFTPLLPDPAPPERADILVLESTYGDRLHEGREQRREKLRQVIIRALE
NRGALLVPAFSIGRTQELLYEIESLIAEHRNDEAATNLPWDDLEIIVDSPLALRVTEVYDRLRHLWDQEATEVVSQGRHP
LSFEQMTVIENHNDHRATVDYLRGTARPCVVIAAGGMCAGGRIVNYLKALMGDPRTDILFVGYQAHGTPGRGILEAAQTR
TGTGEHTSIDLDGGSYPLRATVHSISGYSAHADQRDLVNFVRGIPVAPRSIRLVHGEEKARKALEGALGIAR

Sequences:

>Translated_472_residues
MEIIHHGGQYGVTGSCHELVISENASILIDCGLFHGHDADTGKGKKHTPFIDFPLDRVQGLVLTHVHIDHCGRIPHLMGA
GFQGPIWCSEASALLLPLVLEDAVKVGITRDEGLIERFIGAMKKRLAPLPYGTWRKLGTWDGMDVSLRLQQAGHILGSAY
AELSVARPSVQETTASRHDNETVVVFSGDLGAPFTPLLPDPAPPERADILVLESTYGDRLHEGREQRREKLRQVIIRALE
NRGALLVPAFSIGRTQELLYEIESLIAEHRNDEAATNLPWDDLEIIVDSPLALRVTEVYDRLRHLWDQEATEVVSQGRHP
LSFEQMTVIENHNDHRATVDYLRGTARPCVVIAAGGMCAGGRIVNYLKALMGDPRTDILFVGYQAHGTPGRGILEAAQTR
TGTGEHTSIDLDGGSYPLRATVHSISGYSAHADQRDLVNFVRGIPVAPRSIRLVHGEEKARKALEGALGIAR
>Mature_472_residues
MEIIHHGGQYGVTGSCHELVISENASILIDCGLFHGHDADTGKGKKHTPFIDFPLDRVQGLVLTHVHIDHCGRIPHLMGA
GFQGPIWCSEASALLLPLVLEDAVKVGITRDEGLIERFIGAMKKRLAPLPYGTWRKLGTWDGMDVSLRLQQAGHILGSAY
AELSVARPSVQETTASRHDNETVVVFSGDLGAPFTPLLPDPAPPERADILVLESTYGDRLHEGREQRREKLRQVIIRALE
NRGALLVPAFSIGRTQELLYEIESLIAEHRNDEAATNLPWDDLEIIVDSPLALRVTEVYDRLRHLWDQEATEVVSQGRHP
LSFEQMTVIENHNDHRATVDYLRGTARPCVVIAAGGMCAGGRIVNYLKALMGDPRTDILFVGYQAHGTPGRGILEAAQTR
TGTGEHTSIDLDGGSYPLRATVHSISGYSAHADQRDLVNFVRGIPVAPRSIRLVHGEEKARKALEGALGIAR

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=449, Percent_Identity=25.8351893095768, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI33300633, Length=464, Percent_Identity=23.9224137931034, Blast_Score=119, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI32566029, Length=453, Percent_Identity=25.60706401766, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI32564696, Length=482, Percent_Identity=25.9336099585062, Blast_Score=127, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323307, Length=477, Percent_Identity=25.7861635220126, Blast_Score=132, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24648013, Length=447, Percent_Identity=25.2796420581655, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI21358523, Length=463, Percent_Identity=22.8941684665227, Blast_Score=115, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 51771; Mature: 51771

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIIHHGGQYGVTGSCHELVISENASILIDCGLFHGHDADTGKGKKHTPFIDFPLDRVQG
CCCEECCCCCCCCCCCEEEEEECCCEEEEEECEECCCCCCCCCCCCCCCEECCCHHHHCC
LVLTHVHIDHCGRIPHLMGAGFQGPIWCSEASALLLPLVLEDAVKVGITRDEGLIERFIG
EEEEEEEHHHCCCCHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AMKKRLAPLPYGTWRKLGTWDGMDVSLRLQQAGHILGSAYAELSVARPSVQETTASRHDN
HHHHHCCCCCCCCHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
ETVVVFSGDLGAPFTPLLPDPAPPERADILVLESTYGDRLHEGREQRREKLRQVIIRALE
CEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NRGALLVPAFSIGRTQELLYEIESLIAEHRNDEAATNLPWDDLEIIVDSPLALRVTEVYD
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHH
RLRHLWDQEATEVVSQGRHPLSFEQMTVIENHNDHRATVDYLRGTARPCVVIAAGGMCAG
HHHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCC
GRIVNYLKALMGDPRTDILFVGYQAHGTPGRGILEAAQTRTGTGEHTSIDLDGGSYPLRA
HHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCEE
TVHSISGYSAHADQRDLVNFVRGIPVAPRSIRLVHGEEKARKALEGALGIAR
EEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEIIHHGGQYGVTGSCHELVISENASILIDCGLFHGHDADTGKGKKHTPFIDFPLDRVQG
CCCEECCCCCCCCCCCEEEEEECCCEEEEEECEECCCCCCCCCCCCCCCEECCCHHHHCC
LVLTHVHIDHCGRIPHLMGAGFQGPIWCSEASALLLPLVLEDAVKVGITRDEGLIERFIG
EEEEEEEHHHCCCCHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AMKKRLAPLPYGTWRKLGTWDGMDVSLRLQQAGHILGSAYAELSVARPSVQETTASRHDN
HHHHHCCCCCCCCHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCC
ETVVVFSGDLGAPFTPLLPDPAPPERADILVLESTYGDRLHEGREQRREKLRQVIIRALE
CEEEEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH
NRGALLVPAFSIGRTQELLYEIESLIAEHRNDEAATNLPWDDLEIIVDSPLALRVTEVYD
CCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCEEHHHHHHH
RLRHLWDQEATEVVSQGRHPLSFEQMTVIENHNDHRATVDYLRGTARPCVVIAAGGMCAG
HHHHHHHHHHHHHHHCCCCCCCHHHEEEEECCCCCHHHHHHHHCCCCCEEEEEECCCCCC
GRIVNYLKALMGDPRTDILFVGYQAHGTPGRGILEAAQTRTGTGEHTSIDLDGGSYPLRA
HHHHHHHHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHCCCCCCCCEEEEECCCCCCCEE
TVHSISGYSAHADQRDLVNFVRGIPVAPRSIRLVHGEEKARKALEGALGIAR
EEECCCCCCCCCCHHHHHHHHHCCCCCCCEEEEEECHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA