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The map label for this gene is ahcY [H]

Identifier: 78222508

GI number: 78222508

Start: 1454255

End: 1455685

Strand: Direct

Name: ahcY [H]

Synonym: Gmet_1294

Alternate gene names: 78222508

Gene position: 1454255-1455685 (Clockwise)

Preceding gene: 78222507

Following gene: 78222510

Centisome position: 36.38

GC content: 62.82

Gene sequence:

>1431_bases
ATGTCGACAACCAGCACACCGACCGCGACGACTGCCGCGTTCACTGACTGCCACGTGAGGGATCTCTCCCTTGCCGCCTG
GGGGCGCAAGGAGATGGTCATTGCCGAAACCGAGATGCCGGGCCTCATGGCCATCCGCGAGGAGTACGCCGCCAGCCAGC
CCCTGAAGGGTGCCCGCATTGCCGGTTCGCTCCACATGACCATCCAGACCGCCATGCTCATCGAGACCCTGACGGCGCTG
GGCGCCGAGGTGCGCTGGGCATCGTGCAACATCTTTTCCACCCAGGACCACGCCGCTGCCGCCATTGCCGCAGCCGGCAT
CCCGGTCTTCGCCTACAAGGGGGAATCCCTGGAGGAGTACTGGGAGTTCACTCACCGGATCTTCGAGTGGCACGACGGCG
GCACTCCCAACATGATCCTGGACGACGGCGGCGACGCCACGCTGCTCCTGCACCTGGGGAGCGACGCCGAGAAGGATCCG
TCGGTTGTGGCCAATCCCACCTGTGAAGAAGAGCAGTTCCTCTTCGCCGCCATCAAGAAGCGCCTTGCCGAAAAACCGGA
GTGGTACTCGAAGACCGCCGCAGCCATCAAGGGGGTGACGGAAGAGACCACCACTGGCGTGCACCGGCTCTACCAGATGC
ACGAGAAAGGACGCCTCAAGTTCCCGGCAATCAACGTCAATGACTCGGTCACCAAGTCCAAGTTCGACAACATCTACGGT
TGCCGCGAATCCCTGGTGGACGGCATCAAGCGGGCCACCGACGTGATGGTGGCCGGCAAGGTGGCCGTCATCTGCGGCTA
CGGCGAGGTTGGCAAGGGGTGCGCCCAGGCCATGCGCGGGCTCCAGGCCCAGGTATGGGTCACCGAGATCGACCCCATCT
GCGCCCTCCAGGCCGCCATGGAAGGGTACAAGGTGGTCACCATGGAGTGGGCCGCCGACAAGGCCGACATCTTCGTTACC
ACCACCGGCAACATCAATGTCATCACCCATGACCACATGAAGGCCATGAAGCACAACGCCATTGTCTGCAACATCGGCCA
CTTCGACAACGAGATCGAGGTTGCGGCCCTCAAGCAATACCAGTGGGAGAACATCAAGCCCCAGGTGGACCACATCATCT
TCCCCGACGGCAAGCGGATCATCCTCCTGGCAGAGGGGCGGCTCGTGAACCTGGGGTGCGCCACGGGGCACCCCTCCTAC
GTCATGTCCTCCTCCTTCGCCAACCAGACCTTGGCCCAGATGGAGCTCTTCTGCAATCCCGGCAAATACCCGGTCGGTGT
TTACATGCTTCCCAAAGAGCTGGACGAGAAGGTGGCCCGGCTCCAGCTGAAGACCCTGGGCGCCATGCTCACGGAGCTCA
CCGAAGAGCAGGCCGCCTACATCGGCGTGCCGAAGGCGGGACCCTACAAGACCGATCATTACCGGTACTGA

Upstream 100 bases:

>100_bases
GGAGCGGGAATTCGACTTTGACCCTGCAGTGCCATAGATGTTATAAAATTTCTTTGCCTGTTGCTGTGATACCAAATAAC
CATAACCAACGGAGGATACG

Downstream 100 bases:

>100_bases
TTGGTGCCGAAGTAAGAAGAAAGGCCGTCGGGAATGAATCCCGGCGGCCTTTCTGTTTTTGCATGCATCGTGCGAACTTA
CTGTTTCGCCACCAATCCCT

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MSTTSTPTATTAAFTDCHVRDLSLAAWGRKEMVIAETEMPGLMAIREEYAASQPLKGARIAGSLHMTIQTAMLIETLTAL
GAEVRWASCNIFSTQDHAAAAIAAAGIPVFAYKGESLEEYWEFTHRIFEWHDGGTPNMILDDGGDATLLLHLGSDAEKDP
SVVANPTCEEEQFLFAAIKKRLAEKPEWYSKTAAAIKGVTEETTTGVHRLYQMHEKGRLKFPAINVNDSVTKSKFDNIYG
CRESLVDGIKRATDVMVAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYKVVTMEWAADKADIFVT
TTGNINVITHDHMKAMKHNAIVCNIGHFDNEIEVAALKQYQWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSY
VMSSSFANQTLAQMELFCNPGKYPVGVYMLPKELDEKVARLQLKTLGAMLTELTEEQAAYIGVPKAGPYKTDHYRY

Sequences:

>Translated_476_residues
MSTTSTPTATTAAFTDCHVRDLSLAAWGRKEMVIAETEMPGLMAIREEYAASQPLKGARIAGSLHMTIQTAMLIETLTAL
GAEVRWASCNIFSTQDHAAAAIAAAGIPVFAYKGESLEEYWEFTHRIFEWHDGGTPNMILDDGGDATLLLHLGSDAEKDP
SVVANPTCEEEQFLFAAIKKRLAEKPEWYSKTAAAIKGVTEETTTGVHRLYQMHEKGRLKFPAINVNDSVTKSKFDNIYG
CRESLVDGIKRATDVMVAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYKVVTMEWAADKADIFVT
TTGNINVITHDHMKAMKHNAIVCNIGHFDNEIEVAALKQYQWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSY
VMSSSFANQTLAQMELFCNPGKYPVGVYMLPKELDEKVARLQLKTLGAMLTELTEEQAAYIGVPKAGPYKTDHYRY
>Mature_475_residues
STTSTPTATTAAFTDCHVRDLSLAAWGRKEMVIAETEMPGLMAIREEYAASQPLKGARIAGSLHMTIQTAMLIETLTALG
AEVRWASCNIFSTQDHAAAAIAAAGIPVFAYKGESLEEYWEFTHRIFEWHDGGTPNMILDDGGDATLLLHLGSDAEKDPS
VVANPTCEEEQFLFAAIKKRLAEKPEWYSKTAAAIKGVTEETTTGVHRLYQMHEKGRLKFPAINVNDSVTKSKFDNIYGC
RESLVDGIKRATDVMVAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAMEGYKVVTMEWAADKADIFVTT
TGNINVITHDHMKAMKHNAIVCNIGHFDNEIEVAALKQYQWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSYV
MSSSFANQTLAQMELFCNPGKYPVGVYMLPKELDEKVARLQLKTLGAMLTELTEEQAAYIGVPKAGPYKTDHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=460, Percent_Identity=61.0869565217391, Blast_Score=538, Evalue=1e-153,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=60.9090909090909, Blast_Score=513, Evalue=1e-145,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=49.6774193548387, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=49.6774193548387, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=49.6774193548387, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=49.6774193548387, Blast_Score=466, Evalue=1e-131,
Organism=Homo sapiens, GI21361647, Length=461, Percent_Identity=49.2407809110629, Blast_Score=442, Evalue=1e-124,
Organism=Caenorhabditis elegans, GI17506425, Length=463, Percent_Identity=59.6112311015119, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6320882, Length=475, Percent_Identity=59.1578947368421, Blast_Score=526, Evalue=1e-150,
Organism=Drosophila melanogaster, GI24642172, Length=460, Percent_Identity=60.6521739130435, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24656245, Length=466, Percent_Identity=50.4291845493562, Blast_Score=466, Evalue=1e-131,
Organism=Drosophila melanogaster, GI45553387, Length=469, Percent_Identity=50.7462686567164, Blast_Score=462, Evalue=1e-130,
Organism=Drosophila melanogaster, GI45553385, Length=468, Percent_Identity=50.6410256410256, Blast_Score=459, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52290; Mature: 52159

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTSTPTATTAAFTDCHVRDLSLAAWGRKEMVIAETEMPGLMAIREEYAASQPLKGARI
CCCCCCCCCCEEEECCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEE
AGSLHMTIQTAMLIETLTALGAEVRWASCNIFSTQDHAAAAIAAAGIPVFAYKGESLEEY
ECEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHHHH
WEFTHRIFEWHDGGTPNMILDDGGDATLLLHLGSDAEKDPSVVANPTCEEEQFLFAAIKK
HHHHHHHHEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHH
RLAEKPEWYSKTAAAIKGVTEETTTGVHRLYQMHEKGRLKFPAINVNDSVTKSKFDNIYG
HHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHH
CRESLVDGIKRATDVMVAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAM
HHHHHHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHHH
EGYKVVTMEWAADKADIFVTTTGNINVITHDHMKAMKHNAIVCNIGHFDNEIEVAALKQY
CCCEEEEEEECCCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCEEEEEEHHH
QWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSYVMSSSFANQTLAQMELFCNP
CCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHEEECC
GKYPVGVYMLPKELDEKVARLQLKTLGAMLTELTEEQAAYIGVPKAGPYKTDHYRY
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
STTSTPTATTAAFTDCHVRDLSLAAWGRKEMVIAETEMPGLMAIREEYAASQPLKGARI
CCCCCCCCCEEEECCCCEEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCEE
AGSLHMTIQTAMLIETLTALGAEVRWASCNIFSTQDHAAAAIAAAGIPVFAYKGESLEEY
ECEEEHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHHHCCCEEEEECCCCHHHH
WEFTHRIFEWHDGGTPNMILDDGGDATLLLHLGSDAEKDPSVVANPTCEEEQFLFAAIKK
HHHHHHHHEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCEEECCCCCHHHHHHHHHHH
RLAEKPEWYSKTAAAIKGVTEETTTGVHRLYQMHEKGRLKFPAINVNDSVTKSKFDNIYG
HHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEECCEECCCCCHHHHHHHHHHH
CRESLVDGIKRATDVMVAGKVAVICGYGEVGKGCAQAMRGLQAQVWVTEIDPICALQAAM
HHHHHHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHCCEEEEEEEECCHHHHHHHHH
EGYKVVTMEWAADKADIFVTTTGNINVITHDHMKAMKHNAIVCNIGHFDNEIEVAALKQY
CCCEEEEEEECCCCCCEEEEECCCEEEEECHHHHHHHCCEEEEEECCCCCCEEEEEEHHH
QWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSYVMSSSFANQTLAQMELFCNP
CCCCCCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHEEECC
GKYPVGVYMLPKELDEKVARLQLKTLGAMLTELTEEQAAYIGVPKAGPYKTDHYRY
CCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA