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The map label for this gene is srrB [H]

Identifier: 78222506

GI number: 78222506

Start: 1451923

End: 1452948

Strand: Reverse

Name: srrB [H]

Synonym: Gmet_1292

Alternate gene names: 78222506

Gene position: 1452948-1451923 (Counterclockwise)

Preceding gene: 78222509

Following gene: 78222505

Centisome position: 36.35

GC content: 59.16

Gene sequence:

>1026_bases
ATGTGTAATACTTTTGTAAAACGAAATCCTCCCTTGCAAACGAGACAGGGGGGTGCTACACAAAACACCATGAAGTGGCT
GAAGAGACTCGTAAATCCCCTCATGGCCCTGATCGGCATCCAGGTTGTCTGGGGGCTCCTGGTTTTTTTCTGGATCACCT
GGTTCGTGGGTCGCCACAAGGAGTTCCGGGAACTGGCCGAACGCTACCGCCCCGAACTCCTGGGCCGCGGCTTCGACTGG
GCGGTGCTCGTGGAGGGGATCGTACTCCTCGTCATCATCCTGGTGGGGGTCTACGTCATCTTCATCTACTGGCGCCGCCA
GTCGAACCTGAACCTGGAACAGAAGGACTTCATCTCCCAGGCGACCCACGAGCTCAAGTCGCCCTTGGCCTCCATCAAGC
TCCACCTTGAGACGATCCGTCTCCGCAAGCCTCCTCCCGAGAAGCTGGAACGGTTCCTCGATACCATGCTCGTGGATATC
GACCGGCTCGACAACCTCACCAGCAATATCCTGATGGTCGCCAAGCTTGAACAGCGGCGCCGTGCCTCCCAGTACCCGGT
GGTGGATTTTTCCGCCCTGGTGACCCGGTACATGGACCAGCAACGCCACGTTCTCCCCGAGGGAGGGAACGTGATCCTCG
ACATTGAAAAAGGGATTTCGGCGGCCATCGATGTGGAGGGGATGGAAACGGTTCTGCGGAACCTGTTCGAGAACGCGATC
CTGTACAGCATCGGTGCCCCGGAGATCCGCGTAACGCTGAAACGGGATGGGAACCGCTGCACCCTCTCCTTCCAGGACAA
CGGCAAAGGGATAGACCGGAAAGACCTCAAGAATGTCTTCCGAAAGTTCTACCGCATCCGCAGCAGTGGCGAGGCCATCC
GGGGGACCGGCCTCGGTCTCTGGATCGTCAAGTCAGTGGTAAAGGAGCACGGCGGAACCGTAACCGCCACGAGCGCGGGT
ATCGGAGAGGGGACTAGCTTCATCATCAGCCTCCCCCTCCCCCGCCGTAAGAGGGGCTCCCCATGA

Upstream 100 bases:

>100_bases
ATACCTTGCCTCATGCTTGCCGATCTTCAGCGGTCCCATCAAATTCCTCCCTTACCGGTGTGTTTTACCTCGGCAACCAT
AGCAGAATCGTAACCACTCC

Downstream 100 bases:

>100_bases
CCGAAGAAAAACCCCACATCCTCCTGGTTGAAGACGAGATGCACCTGGCCCGGGGGATATGTTTCAACCTCGAAATGGAA
GGATACCGGGTAAGTCACGT

Product: histidine kinase

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MCNTFVKRNPPLQTRQGGATQNTMKWLKRLVNPLMALIGIQVVWGLLVFFWITWFVGRHKEFRELAERYRPELLGRGFDW
AVLVEGIVLLVIILVGVYVIFIYWRRQSNLNLEQKDFISQATHELKSPLASIKLHLETIRLRKPPPEKLERFLDTMLVDI
DRLDNLTSNILMVAKLEQRRRASQYPVVDFSALVTRYMDQQRHVLPEGGNVILDIEKGISAAIDVEGMETVLRNLFENAI
LYSIGAPEIRVTLKRDGNRCTLSFQDNGKGIDRKDLKNVFRKFYRIRSSGEAIRGTGLGLWIVKSVVKEHGGTVTATSAG
IGEGTSFIISLPLPRRKRGSP

Sequences:

>Translated_341_residues
MCNTFVKRNPPLQTRQGGATQNTMKWLKRLVNPLMALIGIQVVWGLLVFFWITWFVGRHKEFRELAERYRPELLGRGFDW
AVLVEGIVLLVIILVGVYVIFIYWRRQSNLNLEQKDFISQATHELKSPLASIKLHLETIRLRKPPPEKLERFLDTMLVDI
DRLDNLTSNILMVAKLEQRRRASQYPVVDFSALVTRYMDQQRHVLPEGGNVILDIEKGISAAIDVEGMETVLRNLFENAI
LYSIGAPEIRVTLKRDGNRCTLSFQDNGKGIDRKDLKNVFRKFYRIRSSGEAIRGTGLGLWIVKSVVKEHGGTVTATSAG
IGEGTSFIISLPLPRRKRGSP
>Mature_341_residues
MCNTFVKRNPPLQTRQGGATQNTMKWLKRLVNPLMALIGIQVVWGLLVFFWITWFVGRHKEFRELAERYRPELLGRGFDW
AVLVEGIVLLVIILVGVYVIFIYWRRQSNLNLEQKDFISQATHELKSPLASIKLHLETIRLRKPPPEKLERFLDTMLVDI
DRLDNLTSNILMVAKLEQRRRASQYPVVDFSALVTRYMDQQRHVLPEGGNVILDIEKGISAAIDVEGMETVLRNLFENAI
LYSIGAPEIRVTLKRDGNRCTLSFQDNGKGIDRKDLKNVFRKFYRIRSSGEAIRGTGLGLWIVKSVVKEHGGTVTATSAG
IGEGTSFIISLPLPRRKRGSP

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: COG5002

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1790861, Length=211, Percent_Identity=33.175355450237, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=31.0810810810811, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1790346, Length=238, Percent_Identity=28.5714285714286, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788393, Length=226, Percent_Identity=26.1061946902655, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI1786600, Length=221, Percent_Identity=24.8868778280543, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI48994928, Length=249, Percent_Identity=27.710843373494, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1790436, Length=266, Percent_Identity=26.3157894736842, Blast_Score=75, Evalue=4e-15,
Organism=Escherichia coli, GI1786783, Length=223, Percent_Identity=26.0089686098655, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788549, Length=257, Percent_Identity=26.0700389105058, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1786912, Length=137, Percent_Identity=34.3065693430657, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789403, Length=225, Percent_Identity=28, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI1790551, Length=208, Percent_Identity=28.3653846153846, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=25.8771929824561, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38896; Mature: 38896

Theoretical pI: Translated: 10.60; Mature: 10.60

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCNTFVKRNPPLQTRQGGATQNTMKWLKRLVNPLMALIGIQVVWGLLVFFWITWFVGRHK
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EFRELAERYRPELLGRGFDWAVLVEGIVLLVIILVGVYVIFIYWRRQSNLNLEQKDFISQ
HHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ATHELKSPLASIKLHLETIRLRKPPPEKLERFLDTMLVDIDRLDNLTSNILMVAKLEQRR
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RASQYPVVDFSALVTRYMDQQRHVLPEGGNVILDIEKGISAAIDVEGMETVLRNLFENAI
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHH
LYSIGAPEIRVTLKRDGNRCTLSFQDNGKGIDRKDLKNVFRKFYRIRSSGEAIRGTGLGL
EEECCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCHHH
WIVKSVVKEHGGTVTATSAGIGEGTSFIISLPLPRRKRGSP
HHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCCCCC
>Mature Secondary Structure
MCNTFVKRNPPLQTRQGGATQNTMKWLKRLVNPLMALIGIQVVWGLLVFFWITWFVGRHK
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
EFRELAERYRPELLGRGFDWAVLVEGIVLLVIILVGVYVIFIYWRRQSNLNLEQKDFISQ
HHHHHHHHHCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHH
ATHELKSPLASIKLHLETIRLRKPPPEKLERFLDTMLVDIDRLDNLTSNILMVAKLEQRR
HHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RASQYPVVDFSALVTRYMDQQRHVLPEGGNVILDIEKGISAAIDVEGMETVLRNLFENAI
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCEECHHHHHHHHHHHHHHHH
LYSIGAPEIRVTLKRDGNRCTLSFQDNGKGIDRKDLKNVFRKFYRIRSSGEAIRGTGLGL
EEECCCCEEEEEEEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHCCCCEECCCCHHH
WIVKSVVKEHGGTVTATSAGIGEGTSFIISLPLPRRKRGSP
HHHHHHHHHCCCEEEEECCCCCCCCEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA