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The map label for this gene is ilvD

Identifier: 78222473

GI number: 78222473

Start: 1418400

End: 1420061

Strand: Direct

Name: ilvD

Synonym: Gmet_1259

Alternate gene names: 78222473

Gene position: 1418400-1420061 (Clockwise)

Preceding gene: 78222472

Following gene: 78222474

Centisome position: 35.48

GC content: 60.95

Gene sequence:

>1662_bases
ATGCGCAGTGACACCATAAAGCAGGGGATCGAACGGACTCCGCACCGAGCCCTCATCAAGGGAACCGGGGTTCCCCAAAG
CGAAATGGCAAAACCCTTCATCGGCGTTGCCACCAGCTTCACTGACCTTATCCCTGGTCACGTAGGAATGCGTGACCTGG
AGCGATTTATTGAGAAGGGAATCCACAGCGGCGGCGGTTACGCCTTTTTCTTCGGCATTCCCGGTGTCTGTGACGGAATC
GCCATGGGGCACAAGGGGATGCACTACTCTCTCCCGACCCGCGAACTGATTGCCGATATGGTTGAGTCGGTGGCCGAAGC
CCATCGCCTCGATGGCCTCGTGCTGCTCACCAACTGCGATAAGATCACCCCTGGTATGCTTATGGCGGCTGCTCGGCTTG
ATATCCCCACCATCGTGGTAACCGCCGGCCCCATGATGGCCGGCCGCGGTGTTGAAGGGCGCCGCTTTTCCTTCGTGACC
GATACTTTTGAGGCCATGGCACGCTACAAGGCCGGTGTCATCGATGCGAAGGAGCTTCAGGTCTGCGAGGACAACGCCTG
TCCCGGTATGGGGTCGTGCCAGGGGCTCTTTACCGCCAATACCATGGCTATTCTCACCGAAACCCTCGGCATGAGTCTCC
CTCGTTGTGGGACGGCCCTGGCGGTTTCCGCCCTCAAGCGTCGCATAGCATTCGCCTCGGGTGAGAAGATCGTGGACCTG
GTCCGCAATGGGGTTACCCCGCGCCAGATCCTGACACGTGCTGCATTTGAAAACGCCATCCGGGTGGATCTCGCCCTCGG
CGGTTCCTCTAATACGGTCCTCCACCTCCTGGCCATTGCCCGGGAGGCAGGGGTTGATCTCCCTCTCGAAACCTTCGATA
TCCTTTCCAAGGAGACGCCGCAGATTGCCTCCATGAATCCCGCTGGAGAGTATTTCATGGAGGATCTCGACGCGGCCGGC
GGTGTTGTCGGGGTGTTGAAACAACTCGGTGGCACCATTAAGGACAGCCCGACCGTCTTGGGGCTTACCACCCGCGAGTT
GGCCTCCACGGTGGAATCGGTGGATGAGCGGGTGATCCGTCCCGTTTCCGACCCGGTCAAGAAAGAAGGGGGAATCGCTG
TCCTCTTCGGTAATCTCGCACCCAAAGGTGCCGTGGTGAAGCAGTCGGGGGTGTCTGCTCCCATGATGCAGTTCGAGGGG
ACTGCCCGCTGTTTCGACTCGGAGGAACTCGCCATGGCCGCCCTCATGGGGGGGAAGATCACGTCTGGCGACGTGGTGGT
CATTCGTTACGAAGGGCCCAAGGGTGGTCCGGGGATGCGGGAGATGCTCGCACCGACCGCAACCCTCATGGGACTCGGCC
TCGGCGATTCCGTTGCCCTTGTTACCGACGGCCGTTTTTCCGGCGGCACCCGTGGCCCCTGTATCGGCCACATATCCCCG
GAGGCGGCAGAAGGGGGCCCCATCGCCCTGGTTGAAGAGGGGGACAGGATCCGTCTCGATATTCCCAACCGGAAGCTGGA
GCTCCTTGTGGATGAGTCGATCCTCGCGGAACGCCGCAGCCGCTGGGTAGCCCCTGAGCCCAAGATCAAGACCGGATGGC
TTGCCCGCTATGCCAAGGTGGTTACTTCGGCATACACCGGCGCGGTTACCACAGCCGAATAG

Upstream 100 bases:

>100_bases
GAGATAATTGAATTTTGGATTATGCTCGCGAAACAGTTGGTCGGATCGAAGGCTCTTCTTGGGTACCACCCCATTAGATT
CTACAGCAGAGGTCTTTCAG

Downstream 100 bases:

>100_bases
GAACGATTCTGCAATCGCTCCCGTAGACCAGTCGCTCCACTATCTGATTTCCCTTTTGGGAGGTTTTTCTATGAAAATGA
CAGGTGCACGAATCCTCCTT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 553; Mature: 553

Protein sequence:

>553_residues
MRSDTIKQGIERTPHRALIKGTGVPQSEMAKPFIGVATSFTDLIPGHVGMRDLERFIEKGIHSGGGYAFFFGIPGVCDGI
AMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCDKITPGMLMAAARLDIPTIVVTAGPMMAGRGVEGRRFSFVT
DTFEAMARYKAGVIDAKELQVCEDNACPGMGSCQGLFTANTMAILTETLGMSLPRCGTALAVSALKRRIAFASGEKIVDL
VRNGVTPRQILTRAAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDILSKETPQIASMNPAGEYFMEDLDAAG
GVVGVLKQLGGTIKDSPTVLGLTTRELASTVESVDERVIRPVSDPVKKEGGIAVLFGNLAPKGAVVKQSGVSAPMMQFEG
TARCFDSEELAMAALMGGKITSGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALVTDGRFSGGTRGPCIGHISP
EAAEGGPIALVEEGDRIRLDIPNRKLELLVDESILAERRSRWVAPEPKIKTGWLARYAKVVTSAYTGAVTTAE

Sequences:

>Translated_553_residues
MRSDTIKQGIERTPHRALIKGTGVPQSEMAKPFIGVATSFTDLIPGHVGMRDLERFIEKGIHSGGGYAFFFGIPGVCDGI
AMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCDKITPGMLMAAARLDIPTIVVTAGPMMAGRGVEGRRFSFVT
DTFEAMARYKAGVIDAKELQVCEDNACPGMGSCQGLFTANTMAILTETLGMSLPRCGTALAVSALKRRIAFASGEKIVDL
VRNGVTPRQILTRAAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDILSKETPQIASMNPAGEYFMEDLDAAG
GVVGVLKQLGGTIKDSPTVLGLTTRELASTVESVDERVIRPVSDPVKKEGGIAVLFGNLAPKGAVVKQSGVSAPMMQFEG
TARCFDSEELAMAALMGGKITSGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALVTDGRFSGGTRGPCIGHISP
EAAEGGPIALVEEGDRIRLDIPNRKLELLVDESILAERRSRWVAPEPKIKTGWLARYAKVVTSAYTGAVTTAE
>Mature_553_residues
MRSDTIKQGIERTPHRALIKGTGVPQSEMAKPFIGVATSFTDLIPGHVGMRDLERFIEKGIHSGGGYAFFFGIPGVCDGI
AMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCDKITPGMLMAAARLDIPTIVVTAGPMMAGRGVEGRRFSFVT
DTFEAMARYKAGVIDAKELQVCEDNACPGMGSCQGLFTANTMAILTETLGMSLPRCGTALAVSALKRRIAFASGEKIVDL
VRNGVTPRQILTRAAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDILSKETPQIASMNPAGEYFMEDLDAAG
GVVGVLKQLGGTIKDSPTVLGLTTRELASTVESVDERVIRPVSDPVKKEGGIAVLFGNLAPKGAVVKQSGVSAPMMQFEG
TARCFDSEELAMAALMGGKITSGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALVTDGRFSGGTRGPCIGHISP
EAAEGGPIALVEEGDRIRLDIPNRKLELLVDESILAERRSRWVAPEPKIKTGWLARYAKVVTSAYTGAVTTAE

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=43.8943894389439, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1788157, Length=554, Percent_Identity=31.9494584837545, Blast_Score=215, Evalue=7e-57,
Organism=Escherichia coli, GI2367371, Length=479, Percent_Identity=32.5678496868476, Blast_Score=201, Evalue=1e-52,
Organism=Escherichia coli, GI1786464, Length=477, Percent_Identity=32.7044025157233, Blast_Score=186, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6322476, Length=552, Percent_Identity=42.2101449275362, Blast_Score=404, Evalue=1e-113,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_GEOMG (Q39W79)

Other databases:

- EMBL:   CP000148
- RefSeq:   YP_384220.1
- ProteinModelPortal:   Q39W79
- SMR:   Q39W79
- STRING:   Q39W79
- GeneID:   3739758
- GenomeReviews:   CP000148_GR
- KEGG:   gme:Gmet_1259
- NMPDR:   fig|269799.3.peg.1937
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   KVPCLSK
- PhylomeDB:   Q39W79
- ProtClustDB:   PRK00911
- BioCyc:   GMET269799:GMET_1259-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 58484; Mature: 58484

Theoretical pI: Translated: 6.14; Mature: 6.14

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSDTIKQGIERTPHRALIKGTGVPQSEMAKPFIGVATSFTDLIPGHVGMRDLERFIEKG
CCCHHHHHHHHCCCCCEEEECCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
IHSGGGYAFFFGIPGVCDGIAMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCD
CCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCC
KITPGMLMAAARLDIPTIVVTAGPMMAGRGVEGRRFSFVTDTFEAMARYKAGVIDAKELQ
CCCHHHHHHHHHCCCCEEEEECCCHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHH
VCEDNACPGMGSCQGLFTANTMAILTETLGMSLPRCGTALAVSALKRRIAFASGEKIVDL
HCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
VRNGVTPRQILTRAAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDILSKETP
HHCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
QIASMNPAGEYFMEDLDAAGGVVGVLKQLGGTIKDSPTVLGLTTRELASTVESVDERVIR
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHC
PVSDPVKKEGGIAVLFGNLAPKGAVVKQSGVSAPMMQFEGTARCFDSEELAMAALMGGKI
CCCCHHHCCCCEEEEECCCCCCCCEEECCCCCCCHHHCCCCHHCCCCHHHHHHHHHCCCC
TSGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALVTDGRFSGGTRGPCIGHISP
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCC
EAAEGGPIALVEEGDRIRLDIPNRKLELLVDESILAERRSRWVAPEPKIKTGWLARYAKV
CCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VTSAYTGAVTTAE
HHHHHCCCEECCC
>Mature Secondary Structure
MRSDTIKQGIERTPHRALIKGTGVPQSEMAKPFIGVATSFTDLIPGHVGMRDLERFIEKG
CCCHHHHHHHHCCCCCEEEECCCCCHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
IHSGGGYAFFFGIPGVCDGIAMGHKGMHYSLPTRELIADMVESVAEAHRLDGLVLLTNCD
CCCCCCEEEEECCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEECCC
KITPGMLMAAARLDIPTIVVTAGPMMAGRGVEGRRFSFVTDTFEAMARYKAGVIDAKELQ
CCCHHHHHHHHHCCCCEEEEECCCHHCCCCCCCCEEEHHHHHHHHHHHHHCCCCCHHHHH
VCEDNACPGMGSCQGLFTANTMAILTETLGMSLPRCGTALAVSALKRRIAFASGEKIVDL
HCCCCCCCCCCCCCCEEHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHH
VRNGVTPRQILTRAAFENAIRVDLALGGSSNTVLHLLAIAREAGVDLPLETFDILSKETP
HHCCCCHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCHHHHHHHCCCCC
QIASMNPAGEYFMEDLDAAGGVVGVLKQLGGTIKDSPTVLGLTTRELASTVESVDERVIR
CCCCCCCHHHHHHHHHHHCCHHHHHHHHHCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHC
PVSDPVKKEGGIAVLFGNLAPKGAVVKQSGVSAPMMQFEGTARCFDSEELAMAALMGGKI
CCCCHHHCCCCEEEEECCCCCCCCEEECCCCCCCHHHCCCCHHCCCCHHHHHHHHHCCCC
TSGDVVVIRYEGPKGGPGMREMLAPTATLMGLGLGDSVALVTDGRFSGGTRGPCIGHISP
CCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCEEECCCC
EAAEGGPIALVEEGDRIRLDIPNRKLELLVDESILAERRSRWVAPEPKIKTGWLARYAKV
CCCCCCCEEEEECCCEEEEECCCCEEEEEECHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
VTSAYTGAVTTAE
HHHHHCCCEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA