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The map label for this gene is 78222410

Identifier: 78222410

GI number: 78222410

Start: 1334409

End: 1335968

Strand: Direct

Name: 78222410

Synonym: Gmet_1195

Alternate gene names: NA

Gene position: 1334409-1335968 (Clockwise)

Preceding gene: 78222404

Following gene: 78222425

Centisome position: 33.38

GC content: 60.83

Gene sequence:

>1560_bases
ATGATGAAGAAAAGGTTGGAACGCTTCGTTTGCTCGCTGTTTATGGTCGTGCTCATGGCGGGATATGGCAATGCCGGGAT
GATGACAGCTTCGGCCGCTGGGACTGCTCCCTATAAGGAGGGGGAGTTGATCGTGAAGTACCGGGAGGGAGTTTCCGAGG
AAGGGAAGGCGGAGGGGCACCGCAGGCACGGCTCGGAGAGGAAGAAGGAATTCCGTGACCTCAACATGGAGCAGGTGAAG
ATCAGACCGGGCCTCGGCGTGGAGAATGCCGTAAAAGAGTTCGAGGCGGACGACGATGTGGAGTATGCGGAGCCGAACTA
TCTGCTGAAGGCCTCGAAAATTCCCACCGACCCGAAGTTCTACAGCACCTGGGGAATGGCGAAGATCAATGCCCCGGCGG
CCTGGGACAATACCACGGGGAGTGCCGGGGTCGTGGTGGCCGTGATCGACAGCGGCGTCGACTACAACCACCCGGACCTA
AAGGCCAACATGTGGATCAACCAGGCGGAACTGAATGGCAAACCGGGAATCGATGACGACGGGGATGGCGTGGTGGACGA
TATCTACGGGTACAACGGCGTAAACAACAACGGCAACCCCATGGACAACAACGGTCACGGCACCCACGTGGCCGGCACTA
TCGGGGCGGTCGGCAATAACGGCATCGGCGTGGCCGGGGTCAACTGGACAGTCAAGATCATGGCCTGCAAATTCCTGGAT
GCAAACGGCTCCGGCTACACCTCCGATGCCATTGAGTGTCTACAGTACGTCAAGAAGATGAAATCCCGCGGGGTGAACAT
CGTCGCCACCAATAACAGCTGGGGGGGCGGAGGCTATTCGCGGGCGCTCTACGACACCATCAACAGCCAGCGGGATATCC
TCTTCATTACCGCCGCCGGCAACGCCGCTGCCAACAACGACACGACCCCGAGTTATCCCGCGGACTACAACCTGCCGAAC
ATCATCGCTGTTGCCGCCACCACGTCGACGGACGGCTTAGCCTCGTTCTCCAATTACGGCCGCCGGACCGTCATGGTGGG
AGCGCCCGGGTACTCCATTCTGAGCACCTATCCCAACAACCAGTACGCCTACCTCTCCGGCACCTCTATGGCGACCCCCC
ACGTCACCGGCCTGGCCGCGCTCATCAAGGCCAAGTATCCGACCATGGACTGGCGGGGGATCAAAAACCTCATCCTTTCC
GGCGGCGACCGCCCGTCGTCGCTGGCCGCCAAGACTGTCACCGGCCGGCGTATCGACGCCTTCGGCTCTCTCACCTGCGT
CGACAGCCGCGTCTTCTCCGCTCTGACATATCCAGCCACCCTCCAGCCTGGTGTGGCAACGACGCTTTCCGCCCTGAGCA
TCAACTGCTCAAAGCCTGCCGGACCTGTCACGGTCTCCCTCAGCACCGGTGGGGTCTTGACCATGCGCGATGACGGTGTC
TACCCCGATCTGGCAGCAGGGGATGGGATATTCACCGGCTCGTGGACCCCCACCGGTACCGCCGAAACCCTCAACTTTTC
ATCGCCCGTCGGTGCCGAGACAGTAACCGTCGGCAAGTAA

Upstream 100 bases:

>100_bases
CGCCGAAATATCGCATCGATATTCCGACCCGGCTTTTTTTGTGCCGGACCGGACGAAAAAGCGGCTCCAGTAGCCGGGAC
ACGTCGAAAGGGGAGGATGG

Downstream 100 bases:

>100_bases
CCGGCATGAAGGTGGCGCCGCCCAACGGCGCCACCTTCCCAATGCAATCCTTTGCTCCGACGCTACCCTAGCGTACCCCC
TCCCAGGTGATGTAGCTGAT

Product: peptidase S8/S53 subtilisin kexin sedolisin

Products: NA

Alternate protein names: Ak.1 protease [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MMKKRLERFVCSLFMVVLMAGYGNAGMMTASAAGTAPYKEGELIVKYREGVSEEGKAEGHRRHGSERKKEFRDLNMEQVK
IRPGLGVENAVKEFEADDDVEYAEPNYLLKASKIPTDPKFYSTWGMAKINAPAAWDNTTGSAGVVVAVIDSGVDYNHPDL
KANMWINQAELNGKPGIDDDGDGVVDDIYGYNGVNNNGNPMDNNGHGTHVAGTIGAVGNNGIGVAGVNWTVKIMACKFLD
ANGSGYTSDAIECLQYVKKMKSRGVNIVATNNSWGGGGYSRALYDTINSQRDILFITAAGNAAANNDTTPSYPADYNLPN
IIAVAATTSTDGLASFSNYGRRTVMVGAPGYSILSTYPNNQYAYLSGTSMATPHVTGLAALIKAKYPTMDWRGIKNLILS
GGDRPSSLAAKTVTGRRIDAFGSLTCVDSRVFSALTYPATLQPGVATTLSALSINCSKPAGPVTVSLSTGGVLTMRDDGV
YPDLAAGDGIFTGSWTPTGTAETLNFSSPVGAETVTVGK

Sequences:

>Translated_519_residues
MMKKRLERFVCSLFMVVLMAGYGNAGMMTASAAGTAPYKEGELIVKYREGVSEEGKAEGHRRHGSERKKEFRDLNMEQVK
IRPGLGVENAVKEFEADDDVEYAEPNYLLKASKIPTDPKFYSTWGMAKINAPAAWDNTTGSAGVVVAVIDSGVDYNHPDL
KANMWINQAELNGKPGIDDDGDGVVDDIYGYNGVNNNGNPMDNNGHGTHVAGTIGAVGNNGIGVAGVNWTVKIMACKFLD
ANGSGYTSDAIECLQYVKKMKSRGVNIVATNNSWGGGGYSRALYDTINSQRDILFITAAGNAAANNDTTPSYPADYNLPN
IIAVAATTSTDGLASFSNYGRRTVMVGAPGYSILSTYPNNQYAYLSGTSMATPHVTGLAALIKAKYPTMDWRGIKNLILS
GGDRPSSLAAKTVTGRRIDAFGSLTCVDSRVFSALTYPATLQPGVATTLSALSINCSKPAGPVTVSLSTGGVLTMRDDGV
YPDLAAGDGIFTGSWTPTGTAETLNFSSPVGAETVTVGK
>Mature_519_residues
MMKKRLERFVCSLFMVVLMAGYGNAGMMTASAAGTAPYKEGELIVKYREGVSEEGKAEGHRRHGSERKKEFRDLNMEQVK
IRPGLGVENAVKEFEADDDVEYAEPNYLLKASKIPTDPKFYSTWGMAKINAPAAWDNTTGSAGVVVAVIDSGVDYNHPDL
KANMWINQAELNGKPGIDDDGDGVVDDIYGYNGVNNNGNPMDNNGHGTHVAGTIGAVGNNGIGVAGVNWTVKIMACKFLD
ANGSGYTSDAIECLQYVKKMKSRGVNIVATNNSWGGGGYSRALYDTINSQRDILFITAAGNAAANNDTTPSYPADYNLPN
IIAVAATTSTDGLASFSNYGRRTVMVGAPGYSILSTYPNNQYAYLSGTSMATPHVTGLAALIKAKYPTMDWRGIKNLILS
GGDRPSSLAAKTVTGRRIDAFGSLTCVDSRVFSALTYPATLQPGVATTLSALSINCSKPAGPVTVSLSTGGVLTMRDDGV
YPDLAAGDGIFTGSWTPTGTAETLNFSSPVGAETVTVGK

Specific function: Unknown

COG id: COG1404

COG function: function code O; Subtilisin-like serine proteases

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S8 family [H]

Homologues:

Organism=Homo sapiens, GI4505579, Length=364, Percent_Identity=24.4505494505494, Blast_Score=77, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320775, Length=313, Percent_Identity=34.185303514377, Blast_Score=110, Evalue=4e-25,
Organism=Saccharomyces cerevisiae, GI6324576, Length=327, Percent_Identity=30.8868501529052, Blast_Score=91, Evalue=4e-19,
Organism=Saccharomyces cerevisiae, GI6319893, Length=194, Percent_Identity=35.5670103092784, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI281360987, Length=330, Percent_Identity=26.0606060606061, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642494, Length=330, Percent_Identity=26.0606060606061, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642490, Length=330, Percent_Identity=26.0606060606061, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI45555723, Length=330, Percent_Identity=26.0606060606061, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642492, Length=330, Percent_Identity=26.0606060606061, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24642488, Length=333, Percent_Identity=25.8258258258258, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24642484, Length=333, Percent_Identity=25.8258258258258, Blast_Score=66, Evalue=5e-11,
Organism=Drosophila melanogaster, GI24642486, Length=333, Percent_Identity=25.8258258258258, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000209
- InterPro:   IPR022398
- InterPro:   IPR015500
- InterPro:   IPR009020 [H]

Pfam domain/function: PF00082 Peptidase_S8 [H]

EC number: NA

Molecular weight: Translated: 54835; Mature: 54835

Theoretical pI: Translated: 6.01; Mature: 6.01

Prosite motif: PS00136 SUBTILASE_ASP ; PS00137 SUBTILASE_HIS ; PS00138 SUBTILASE_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKRLERFVCSLFMVVLMAGYGNAGMMTASAAGTAPYKEGELIVKYREGVSEEGKAEGH
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHH
RRHGSERKKEFRDLNMEQVKIRPGLGVENAVKEFEADDDVEYAEPNYLLKASKIPTDPKF
HHCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCE
YSTWGMAKINAPAAWDNTTGSAGVVVAVIDSGVDYNHPDLKANMWINQAELNGKPGIDDD
EECCCEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEHCCCCCCCCCCC
GDGVVDDIYGYNGVNNNGNPMDNNGHGTHVAGTIGAVGNNGIGVAGVNWTVKIMACKFLD
CCCCHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCEEEEEEEEEEEE
ANGSGYTSDAIECLQYVKKMKSRGVNIVATNNSWGGGGYSRALYDTINSQRDILFITAAG
CCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECC
NAAANNDTTPSYPADYNLPNIIAVAATTSTDGLASFSNYGRRTVMVGAPGYSILSTYPNN
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHCCCEEEEEECCCCCEEEECCCC
QYAYLSGTSMATPHVTGLAALIKAKYPTMDWRGIKNLILSGGDRPSSLAAKTVTGRRIDA
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCEEEC
FGSLTCVDSRVFSALTYPATLQPGVATTLSALSINCSKPAGPVTVSLSTGGVLTMRDDGV
CCCEEEEHHHHHHHHCCCCCCCCCHHHEEHEEEEECCCCCCCEEEEEECCCEEEEECCCC
YPDLAAGDGIFTGSWTPTGTAETLNFSSPVGAETVTVGK
CCCCCCCCCEEECCCCCCCCCCEEECCCCCCCCEEECCC
>Mature Secondary Structure
MMKKRLERFVCSLFMVVLMAGYGNAGMMTASAAGTAPYKEGELIVKYREGVSEEGKAEGH
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCEEEEECCCCCCCCHHHHH
RRHGSERKKEFRDLNMEQVKIRPGLGVENAVKEFEADDDVEYAEPNYLLKASKIPTDPKF
HHCCHHHHHHHHCCCCEEEEECCCCCHHHHHHHCCCCCCCCCCCCCEEEEECCCCCCCCE
YSTWGMAKINAPAAWDNTTGSAGVVVAVIDSGVDYNHPDLKANMWINQAELNGKPGIDDD
EECCCEEEECCCCCCCCCCCCCCEEEEEEECCCCCCCCCCEEEEEEEEHCCCCCCCCCCC
GDGVVDDIYGYNGVNNNGNPMDNNGHGTHVAGTIGAVGNNGIGVAGVNWTVKIMACKFLD
CCCCHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCEEEEEEEEEEEE
ANGSGYTSDAIECLQYVKKMKSRGVNIVATNNSWGGGGYSRALYDTINSQRDILFITAAG
CCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHCCCCCEEEEEECC
NAAANNDTTPSYPADYNLPNIIAVAATTSTDGLASFSNYGRRTVMVGAPGYSILSTYPNN
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHCCCEEEEEECCCCCEEEECCCC
QYAYLSGTSMATPHVTGLAALIKAKYPTMDWRGIKNLILSGGDRPSSLAAKTVTGRRIDA
EEEEEECCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCHHHHHHCCCCCEEEC
FGSLTCVDSRVFSALTYPATLQPGVATTLSALSINCSKPAGPVTVSLSTGGVLTMRDDGV
CCCEEEEHHHHHHHHCCCCCCCCCHHHEEHEEEEECCCCCCCEEEEEECCCEEEEECCCC
YPDLAAGDGIFTGSWTPTGTAETLNFSSPVGAETVTVGK
CCCCCCCCCEEECCCCCCCCCCEEECCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7993087; 10588904 [H]