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The map label for this gene is copS [H]

Identifier: 78188417

GI number: 78188417

Start: 514411

End: 515913

Strand: Reverse

Name: copS [H]

Synonym: Cag_0439

Alternate gene names: 78188417

Gene position: 515913-514411 (Counterclockwise)

Preceding gene: 78188418

Following gene: 78188415

Centisome position: 20.06

GC content: 48.17

Gene sequence:

>1503_bases
ATGAATGCACCGCACGCCAAGCGCTTTCGCGCATTTTTTGCCCCCTTGACTGCAATGAGCTTGCGCAACCGCATTGCATT
GTACTACACCAGCGCAACCGCCCTCCTTATTGCCCTCCTGTTAACAACCGTTTACTTTGCCGTCAATCGTGTGGTTTATG
AGCACTTTGACGAAGAACTCCGCCACGAAGTTGCCGAAACCTTTGGTCATCTTCATCTGCTGCCTTACAATTTTGAAAGC
AACAACAATGCGCAATTCCGCAATATAGACGAAGAGTATCGCTGGCGCTCAAAAGAGAATAATGCAAAAGGGTACCACCC
AAAACCTTACAAAAAACGAAAGCGACAAGTTGATGCAGAATTAATGCAATTAGTTACGGTGGATGGGGAAATTCTTGCCC
AATCTGCAACGCTAAACAACCATCGCCTTACCATTGAACCAAAGCGGCAAGGCATGGCTTTTTTTACCAGTACGGTAGGC
AGCTCGGCAGTTCGGCAAGTGCAAGTTCCACTCTACAATCGTCAACAGCAATTAACCGGTTATTTGCTGATTGCAATGCC
ACTGAGCAACGCCATGTTAGTGTTGCGCGATTTGCAGGAAGTGCTACTGCTCTCATTCCCCATGATGCTGTTGATTCTTT
TTGCGCTTACTCGCCTTATTGCAGGGCGTAGCATTCGCCCCATTGAAAAAGTGATTACTACGGCTGAGCAAATGTCGCAA
AGTACGCTTGACCAACGCATTCCACTACCCCGCCATCGCGATGAACTCTACCGTCTCTCCTCCACAATTAACGCTCTCTT
TGATAGAATGCAAGATGCTTTTTTGCGCGAAAAGCAATTTACCGCCGATGCCTCACATGAGCTAAAAACCCCCTTATCAG
TGGTAAAAGGAACGCTTGAGGTGTTAGTTCGCAAGCCACGCGAACGAGAACATTACGAAACACGCATCCACTTTTGCCTG
CAAGAACTAAACCGCATGGCGCTGATGATTGACCAACTCCTCATGCTGGCACGCTACGAAAGCAGCACCATGCAACCACA
TATTGAAACCGTACCACTGCACCGCCATATTGAAGCACTTATTGAGCGAAACCAAGCAGCCGCCACAACGCGCGGTATAA
CGCTCTGCACCACAGGCACCATCAATGCCACCGTTGCGGCTGATGCGGGAATGGTTGATATGATGTTGGAAAATATTGTA
TCAAACGCCCTGAAATACTCACCATCAGGCACCACCATTACCCTAAGCGTTCAAAAAAATGAAAACGGCACAAGCTGCAC
CATACAAGACCAAGGCATTGGCATTCCACCCGAAAAAGTACGTGCTGTTTTTGAGCGCTTTTACCGCGTTGATGAAGCAC
GAAGCTCCGCTACAGGCGGGCTGGGCTTAGGGCTTTCGATTGTAAAAAAGCTTGCGGATTTGCAGCAAGTAACTATTGCT
GTTGAAAGCGAAGTAGGCAAAGGCACAACAATTTGCCTCACGTTTCGGGATGGAGGGAGATAG

Upstream 100 bases:

>100_bases
ATATCACCTTTTTGCGCCGCAAGCTCGAAGCCGTTGGATGCAACAACTTCATTCAAACCATTCGAGGCATTGGCTACATT
ATTCGCGAAGCAACCGCCTC

Downstream 100 bases:

>100_bases
ATTGGATTCATATTGACGATTGCCGCAAGAGCAGCTTTTGCACTTGCACCGCAATCATTTGGTTCCTCGCTATTTCGAGT
GGGTAAGGGCTGGTAAAGCG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 500; Mature: 500

Protein sequence:

>500_residues
MNAPHAKRFRAFFAPLTAMSLRNRIALYYTSATALLIALLLTTVYFAVNRVVYEHFDEELRHEVAETFGHLHLLPYNFES
NNNAQFRNIDEEYRWRSKENNAKGYHPKPYKKRKRQVDAELMQLVTVDGEILAQSATLNNHRLTIEPKRQGMAFFTSTVG
SSAVRQVQVPLYNRQQQLTGYLLIAMPLSNAMLVLRDLQEVLLLSFPMMLLILFALTRLIAGRSIRPIEKVITTAEQMSQ
STLDQRIPLPRHRDELYRLSSTINALFDRMQDAFLREKQFTADASHELKTPLSVVKGTLEVLVRKPREREHYETRIHFCL
QELNRMALMIDQLLMLARYESSTMQPHIETVPLHRHIEALIERNQAAATTRGITLCTTGTINATVAADAGMVDMMLENIV
SNALKYSPSGTTITLSVQKNENGTSCTIQDQGIGIPPEKVRAVFERFYRVDEARSSATGGLGLGLSIVKKLADLQQVTIA
VESEVGKGTTICLTFRDGGR

Sequences:

>Translated_500_residues
MNAPHAKRFRAFFAPLTAMSLRNRIALYYTSATALLIALLLTTVYFAVNRVVYEHFDEELRHEVAETFGHLHLLPYNFES
NNNAQFRNIDEEYRWRSKENNAKGYHPKPYKKRKRQVDAELMQLVTVDGEILAQSATLNNHRLTIEPKRQGMAFFTSTVG
SSAVRQVQVPLYNRQQQLTGYLLIAMPLSNAMLVLRDLQEVLLLSFPMMLLILFALTRLIAGRSIRPIEKVITTAEQMSQ
STLDQRIPLPRHRDELYRLSSTINALFDRMQDAFLREKQFTADASHELKTPLSVVKGTLEVLVRKPREREHYETRIHFCL
QELNRMALMIDQLLMLARYESSTMQPHIETVPLHRHIEALIERNQAAATTRGITLCTTGTINATVAADAGMVDMMLENIV
SNALKYSPSGTTITLSVQKNENGTSCTIQDQGIGIPPEKVRAVFERFYRVDEARSSATGGLGLGLSIVKKLADLQQVTIA
VESEVGKGTTICLTFRDGGR
>Mature_500_residues
MNAPHAKRFRAFFAPLTAMSLRNRIALYYTSATALLIALLLTTVYFAVNRVVYEHFDEELRHEVAETFGHLHLLPYNFES
NNNAQFRNIDEEYRWRSKENNAKGYHPKPYKKRKRQVDAELMQLVTVDGEILAQSATLNNHRLTIEPKRQGMAFFTSTVG
SSAVRQVQVPLYNRQQQLTGYLLIAMPLSNAMLVLRDLQEVLLLSFPMMLLILFALTRLIAGRSIRPIEKVITTAEQMSQ
STLDQRIPLPRHRDELYRLSSTINALFDRMQDAFLREKQFTADASHELKTPLSVVKGTLEVLVRKPREREHYETRIHFCL
QELNRMALMIDQLLMLARYESSTMQPHIETVPLHRHIEALIERNQAAATTRGITLCTTGTINATVAADAGMVDMMLENIV
SNALKYSPSGTTITLSVQKNENGTSCTIQDQGIGIPPEKVRAVFERFYRVDEARSSATGGLGLGLSIVKKLADLQQVTIA
VESEVGKGTTICLTFRDGGR

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon copABCD. Specifically recognizes or transduces a signal only in response to copper. This would lead to phosphorylation of CopR in the cyto

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786783, Length=314, Percent_Identity=28.9808917197452, Blast_Score=150, Evalue=2e-37,
Organism=Escherichia coli, GI1786600, Length=212, Percent_Identity=34.9056603773585, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1790551, Length=294, Percent_Identity=28.5714285714286, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1788279, Length=273, Percent_Identity=28.5714285714286, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1789403, Length=283, Percent_Identity=28.6219081272085, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1788393, Length=269, Percent_Identity=26.0223048327138, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1790346, Length=249, Percent_Identity=28.9156626506024, Blast_Score=99, Evalue=7e-22,
Organism=Escherichia coli, GI1790861, Length=314, Percent_Identity=27.7070063694268, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1787894, Length=261, Percent_Identity=27.2030651340996, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788713, Length=242, Percent_Identity=28.5123966942149, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1789149, Length=366, Percent_Identity=23.4972677595628, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI48994928, Length=237, Percent_Identity=27.8481012658228, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI145693157, Length=219, Percent_Identity=28.7671232876712, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1786912, Length=201, Percent_Identity=26.865671641791, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1790436, Length=232, Percent_Identity=24.5689655172414, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1787374, Length=278, Percent_Identity=22.6618705035971, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI1788549, Length=223, Percent_Identity=23.7668161434978, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87082128, Length=299, Percent_Identity=25.752508361204, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI87081816, Length=263, Percent_Identity=23.1939163498099, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR006290
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 56595; Mature: 56595

Theoretical pI: Translated: 9.44; Mature: 9.44

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPHAKRFRAFFAPLTAMSLRNRIALYYTSATALLIALLLTTVYFAVNRVVYEHFDEEL
CCCCHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHEVAETFGHLHLLPYNFESNNNAQFRNIDEEYRWRSKENNAKGYHPKPYKKRKRQVDAE
HHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
LMQLVTVDGEILAQSATLNNHRLTIEPKRQGMAFFTSTVGSSAVRQVQVPLYNRQQQLTG
HHHHHHCCHHHHHHHEECCCCEEEECCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHCE
YLLIAMPLSNAMLVLRDLQEVLLLSFPMMLLILFALTRLIAGRSIRPIEKVITTAEQMSQ
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
STLDQRIPLPRHRDELYRLSSTINALFDRMQDAFLREKQFTADASHELKTPLSVVKGTLE
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHH
VLVRKPREREHYETRIHFCLQELNRMALMIDQLLMLARYESSTMQPHIETVPLHRHIEAL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
IERNQAAATTRGITLCTTGTINATVAADAGMVDMMLENIVSNALKYSPSGTTITLSVQKN
HHCCHHHHHHCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHEECCCCCEEEEEEEEC
ENGTSCTIQDQGIGIPPEKVRAVFERFYRVDEARSSATGGLGLGLSIVKKLADLQQVTIA
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHE
VESEVGKGTTICLTFRDGGR
EECCCCCCEEEEEEECCCCC
>Mature Secondary Structure
MNAPHAKRFRAFFAPLTAMSLRNRIALYYTSATALLIALLLTTVYFAVNRVVYEHFDEEL
CCCCHHHHHHHHHHHHHHHHHHCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RHEVAETFGHLHLLPYNFESNNNAQFRNIDEEYRWRSKENNAKGYHPKPYKKRKRQVDAE
HHHHHHHHCCEEEEEEECCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCHHHHHHHHHHH
LMQLVTVDGEILAQSATLNNHRLTIEPKRQGMAFFTSTVGSSAVRQVQVPLYNRQQQLTG
HHHHHHCCHHHHHHHEECCCCEEEECCCCCCHHHHHHHHHHHHHHEEECCCCCCHHHHCE
YLLIAMPLSNAMLVLRDLQEVLLLSFPMMLLILFALTRLIAGRSIRPIEKVITTAEQMSQ
EEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
STLDQRIPLPRHRDELYRLSSTINALFDRMQDAFLREKQFTADASHELKTPLSVVKGTLE
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCHHHHHHHHHH
VLVRKPREREHYETRIHFCLQELNRMALMIDQLLMLARYESSTMQPHIETVPLHRHIEAL
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
IERNQAAATTRGITLCTTGTINATVAADAGMVDMMLENIVSNALKYSPSGTTITLSVQKN
HHCCHHHHHHCCEEEEECCCCCEEEECCCCHHHHHHHHHHHHHHEECCCCCEEEEEEEEC
ENGTSCTIQDQGIGIPPEKVRAVFERFYRVDEARSSATGGLGLGLSIVKKLADLQQVTIA
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHE
VESEVGKGTTICLTFRDGGR
EECCCCCCEEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8449873 [H]