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The map label for this gene is mprA [H]

Identifier: 78188418

GI number: 78188418

Start: 515910

End: 516587

Strand: Reverse

Name: mprA [H]

Synonym: Cag_0440

Alternate gene names: 78188418

Gene position: 516587-515910 (Counterclockwise)

Preceding gene: 78188419

Following gene: 78188417

Centisome position: 20.08

GC content: 46.02

Gene sequence:

>678_bases
ATGAGGCTTCTCATTATTGAAGATGAGCCCGGTATAGCGGCATTTCTTAAAGATGGGCTTGAGGAGGAATATTTTGCGGT
TGACTTAGCGTTTGATGGTAAAAGTGGGCTTGCTATGGCGTTAAGCAACGACTATGATGTGCTTATTGTGGATTGGATGA
TTCCCGCCTTAAGTGGCATTGAAGTATGCCGACAAGTGCGTAAAGCGGGCTGTTTGGTGCCAATCATTTTTTTAACGGCA
CGCGATACGCTTGAAGATGTGCTCTTTGGACTTGAAGCAGGCGCTAACGATTACATTAAAAAACCTTTTGCTTTTGAAGA
GCTACTTGCCCGCATTCGGGTGCAGTTGCGTAGCCGAACGCAAGGTGAGGAGAGTTTAAGTGCTGGTGGCGTAACGCTTA
ATCCTGCAACTCATCAAGTAACCTATAATGGCAGCGAACTCATTTTAACGCCAAAAGAGTTTGCACTGCTTGAATATCTG
CTGCGCAATAAAGATCGCGTCTGTACTCGGAGCCGCATTATTGAGCATGTGTGGGATATCCACTTTGATGCCGACACTTC
GGTAATTGATGTCTATATCACCTTTTTGCGCCGCAAGCTCGAAGCCGTTGGATGCAACAACTTCATTCAAACCATTCGAG
GCATTGGCTACATTATTCGCGAAGCAACCGCCTCATGA

Upstream 100 bases:

>100_bases
GCTCGCACCACTTTTTGCATAATGAAAAGAGTGGTGCAACTGCGCTTCTCCTACTTCCATCAAAAATCCATCATTAACCA
TTCACCATTAATCATTTCCT

Downstream 100 bases:

>100_bases
ATGCACCGCACGCCAAGCGCTTTCGCGCATTTTTTGCCCCCTTGACTGCAATGAGCTTGCGCAACCGCATTGCATTGTAC
TACACCAGCGCAACCGCCCT

Product: two component transcriptional regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 225; Mature: 225

Protein sequence:

>225_residues
MRLLIIEDEPGIAAFLKDGLEEEYFAVDLAFDGKSGLAMALSNDYDVLIVDWMIPALSGIEVCRQVRKAGCLVPIIFLTA
RDTLEDVLFGLEAGANDYIKKPFAFEELLARIRVQLRSRTQGEESLSAGGVTLNPATHQVTYNGSELILTPKEFALLEYL
LRNKDRVCTRSRIIEHVWDIHFDADTSVIDVYITFLRRKLEAVGCNNFIQTIRGIGYIIREATAS

Sequences:

>Translated_225_residues
MRLLIIEDEPGIAAFLKDGLEEEYFAVDLAFDGKSGLAMALSNDYDVLIVDWMIPALSGIEVCRQVRKAGCLVPIIFLTA
RDTLEDVLFGLEAGANDYIKKPFAFEELLARIRVQLRSRTQGEESLSAGGVTLNPATHQVTYNGSELILTPKEFALLEYL
LRNKDRVCTRSRIIEHVWDIHFDADTSVIDVYITFLRRKLEAVGCNNFIQTIRGIGYIIREATAS
>Mature_225_residues
MRLLIIEDEPGIAAFLKDGLEEEYFAVDLAFDGKSGLAMALSNDYDVLIVDWMIPALSGIEVCRQVRKAGCLVPIIFLTA
RDTLEDVLFGLEAGANDYIKKPFAFEELLARIRVQLRSRTQGEESLSAGGVTLNPATHQVTYNGSELILTPKEFALLEYL
LRNKDRVCTRSRIIEHVWDIHFDADTSVIDVYITFLRRKLEAVGCNNFIQTIRGIGYIIREATAS

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=42.9864253393665, Blast_Score=182, Evalue=1e-47,
Organism=Escherichia coli, GI87082012, Length=217, Percent_Identity=39.1705069124424, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1789402, Length=223, Percent_Identity=39.9103139013453, Blast_Score=153, Evalue=7e-39,
Organism=Escherichia coli, GI1786599, Length=220, Percent_Identity=35.4545454545455, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1790860, Length=220, Percent_Identity=37.7272727272727, Blast_Score=134, Evalue=3e-33,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=35.4545454545455, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=32.7272727272727, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=36.3636363636364, Blast_Score=114, Evalue=4e-27,
Organism=Escherichia coli, GI1789809, Length=226, Percent_Identity=30.9734513274336, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI2367329, Length=232, Percent_Identity=32.3275862068966, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1787375, Length=223, Percent_Identity=30.4932735426009, Blast_Score=107, Evalue=6e-25,
Organism=Escherichia coli, GI1787229, Length=226, Percent_Identity=27.4336283185841, Blast_Score=84, Evalue=5e-18,
Organism=Escherichia coli, GI1790863, Length=227, Percent_Identity=29.5154185022026, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI145693140, Length=230, Percent_Identity=26.5217391304348, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=29.9065420560748, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25246; Mature: 25246

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLIIEDEPGIAAFLKDGLEEEYFAVDLAFDGKSGLAMALSNDYDVLIVDWMIPALSGI
CEEEEEECCCCHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCEEEHHHHHHHHHHH
EVCRQVRKAGCLVPIIFLTARDTLEDVLFGLEAGANDYIKKPFAFEELLARIRVQLRSRT
HHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHCC
QGEESLSAGGVTLNPATHQVTYNGSELILTPKEFALLEYLLRNKDRVCTRSRIIEHVWDI
CCCHHHCCCCEEECCCCEEEEECCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
HFDADTSVIDVYITFLRRKLEAVGCNNFIQTIRGIGYIIREATAS
EECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLLIIEDEPGIAAFLKDGLEEEYFAVDLAFDGKSGLAMALSNDYDVLIVDWMIPALSGI
CEEEEEECCCCHHHHHHCCCCCCEEEEEEEECCCCCEEEEECCCCCEEEHHHHHHHHHHH
EVCRQVRKAGCLVPIIFLTARDTLEDVLFGLEAGANDYIKKPFAFEELLARIRVQLRSRT
HHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHCCCCCHHHCCCCCHHHHHHHHHHHHHHCC
QGEESLSAGGVTLNPATHQVTYNGSELILTPKEFALLEYLLRNKDRVCTRSRIIEHVWDI
CCCHHHCCCCEEECCCCEEEEECCCEEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
HFDADTSVIDVYITFLRRKLEAVGCNNFIQTIRGIGYIIREATAS
EECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA