Click here to switch to the map view.

The map label for this gene is purH

Identifier: 78188239

GI number: 78188239

Start: 288300

End: 289874

Strand: Reverse

Name: purH

Synonym: Cag_0258

Alternate gene names: 78188239

Gene position: 289874-288300 (Counterclockwise)

Preceding gene: 78188253

Following gene: 78188238

Centisome position: 11.27

GC content: 47.17

Gene sequence:

>1575_bases
ATGTCTGATCCTGTTATTAAACGGGCGCTGGTGTCGGTGTCCGATAAAACTGGTATTGTTGATTTTTGCCGTGAGCTTTC
AGAGCTTGGCGTTGAAATTTTTTCAACCGGTGGTACCTTAAAAACCCTTCAGGATGCAGGCATTGCGGCTGCATCAATCT
CCACCATTACAGGTTTTCCTGAAATTATGGATGGACGTGTTAAAACACTGCATCCCAAAATTCACGGTGGATTGCTTGCT
GTACGCGAAAACGCCAACCACGTCAAGCAGGCAGCAGATAATGGCATTAGCTTTATTGATTTGGTTGTGGTGAACCTTTA
TCCTTTTGAGGCAACGGTTGCAAAACCCAACGTTTCATTTGAAGATGCTATTGAAAATATTGACATCGGTGGACCTTCAA
TGTTGCGCAGTGCAGCAAAAAATAATGAATCCGTAACGGTGGTAACCGATAGCGCCGATTATGCGTTAGTGTTGCAAGAA
ATGCGTGCCAACAATGGAGCAACAACTCGTGCTACCCGCTTGCATTTAGCACTAAAAGTGTTTGAACTAACCTCCCGCTA
CGATCGCGCTATTGCAACCTACCTTGCAGGCAAAGTATCAGCAGCCGAAGCCGCCGCCAGCACCATGAGCGTTCAACTTG
CTAAAGAGCTTGATATGCGCTATGGCGAAAATCCTCACCAAAACGCAGGCTTGTATCGGCTAACCGATAGCAACGGTACC
CGCTCTTTTGAAGAGTTTTTCGAAAAACTGCACGGCAAAGAGCTTTCCTACAACAACATGCTCGATATTGCCGCTGCAAC
CTCGCTTATTGAAGAATTCCGTGGCGAAGAGCCAACGGTGGTGATTATTAAGCACACCAATCCTTGCGGTGTTGCACAAG
CCTCAAGCTTAGTTGATGCGTGGCACCGTGCATTCTCAACTGATACGCAAGCACCATTTGGCGGCATTGTAGCTTTTAAC
CGTCCGCTTGATATGGCTGCGGCTCAAGCTGTTAATGAAATTTTCACCGAAATTTTGATTGCTCCCGCCTTTGAGGATGG
AGTTCTTGAGTTGTTGATGAAAAAGAAGGATCGTCGTCTTGTGGTGCAGAAAAAAGCGTTACCACAAAGTGGATGGGAAT
TTAAATCCACGCCATTTGGCATGTTGGTGCAAGAGCGCGACAGCAAAATTGTTGCCAAAGAGGATCTCAAAGTAGTAACC
AAACGCCAGCCAACTGAGGCTGAAATTGCCGACTTGATGTTTGCATGGAAAATTTGCAAACACATTAAATCGAACACCAT
TCTGTACGTTAAAAACCGCCAAACCTATGGCGTTGGTGCAGGGCAGATGTCGCGCGTGGATTCCTCAAAAATTGCACGTT
GGAAGGCTTCCGAAGTAAACCTTGATCTGCACGGCTCCGTTGTAGCATCCGACGCATTCTTCCCCTTTGCTGACGGCTTA
CTTGCAGCGGCTGAAGCGGGCGTAACGGCAGTTATTCAACCCGGTGGCTCCATTCGCGATAACGAGGTAATTGAAGCGGC
TGATGCCAACAACCTCGCTATGGTCTTTACCGGCATGAGGCATTTCAAGCACTAA

Upstream 100 bases:

>100_bases
CAAATAACAACTGGGCATCAGAAAAAGAGGAATATGGGTAAAATTGTTACATTTCGCCCCTTGAACCTCCTCGCTTTCTC
CAAACAATAATTTTCTGCAC

Downstream 100 bases:

>100_bases
GAGTTATTGTAACCGAATAAACATGCGCCTATGAGACTGAAAAGTATGAGGTTAGAAAACTTTAGAGCAGTAGAACATGC
TGTTATAGAGTTTGGAAATC

Product: bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase

Number of amino acids: Translated: 524; Mature: 523

Protein sequence:

>524_residues
MSDPVIKRALVSVSDKTGIVDFCRELSELGVEIFSTGGTLKTLQDAGIAAASISTITGFPEIMDGRVKTLHPKIHGGLLA
VRENANHVKQAADNGISFIDLVVVNLYPFEATVAKPNVSFEDAIENIDIGGPSMLRSAAKNNESVTVVTDSADYALVLQE
MRANNGATTRATRLHLALKVFELTSRYDRAIATYLAGKVSAAEAAASTMSVQLAKELDMRYGENPHQNAGLYRLTDSNGT
RSFEEFFEKLHGKELSYNNMLDIAAATSLIEEFRGEEPTVVIIKHTNPCGVAQASSLVDAWHRAFSTDTQAPFGGIVAFN
RPLDMAAAQAVNEIFTEILIAPAFEDGVLELLMKKKDRRLVVQKKALPQSGWEFKSTPFGMLVQERDSKIVAKEDLKVVT
KRQPTEAEIADLMFAWKICKHIKSNTILYVKNRQTYGVGAGQMSRVDSSKIARWKASEVNLDLHGSVVASDAFFPFADGL
LAAAEAGVTAVIQPGGSIRDNEVIEAADANNLAMVFTGMRHFKH

Sequences:

>Translated_524_residues
MSDPVIKRALVSVSDKTGIVDFCRELSELGVEIFSTGGTLKTLQDAGIAAASISTITGFPEIMDGRVKTLHPKIHGGLLA
VRENANHVKQAADNGISFIDLVVVNLYPFEATVAKPNVSFEDAIENIDIGGPSMLRSAAKNNESVTVVTDSADYALVLQE
MRANNGATTRATRLHLALKVFELTSRYDRAIATYLAGKVSAAEAAASTMSVQLAKELDMRYGENPHQNAGLYRLTDSNGT
RSFEEFFEKLHGKELSYNNMLDIAAATSLIEEFRGEEPTVVIIKHTNPCGVAQASSLVDAWHRAFSTDTQAPFGGIVAFN
RPLDMAAAQAVNEIFTEILIAPAFEDGVLELLMKKKDRRLVVQKKALPQSGWEFKSTPFGMLVQERDSKIVAKEDLKVVT
KRQPTEAEIADLMFAWKICKHIKSNTILYVKNRQTYGVGAGQMSRVDSSKIARWKASEVNLDLHGSVVASDAFFPFADGL
LAAAEAGVTAVIQPGGSIRDNEVIEAADANNLAMVFTGMRHFKH
>Mature_523_residues
SDPVIKRALVSVSDKTGIVDFCRELSELGVEIFSTGGTLKTLQDAGIAAASISTITGFPEIMDGRVKTLHPKIHGGLLAV
RENANHVKQAADNGISFIDLVVVNLYPFEATVAKPNVSFEDAIENIDIGGPSMLRSAAKNNESVTVVTDSADYALVLQEM
RANNGATTRATRLHLALKVFELTSRYDRAIATYLAGKVSAAEAAASTMSVQLAKELDMRYGENPHQNAGLYRLTDSNGTR
SFEEFFEKLHGKELSYNNMLDIAAATSLIEEFRGEEPTVVIIKHTNPCGVAQASSLVDAWHRAFSTDTQAPFGGIVAFNR
PLDMAAAQAVNEIFTEILIAPAFEDGVLELLMKKKDRRLVVQKKALPQSGWEFKSTPFGMLVQERDSKIVAKEDLKVVTK
RQPTEAEIADLMFAWKICKHIKSNTILYVKNRQTYGVGAGQMSRVDSSKIARWKASEVNLDLHGSVVASDAFFPFADGLL
AAAEAGVTAVIQPGGSIRDNEVIEAADANNLAMVFTGMRHFKH

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family

Homologues:

Organism=Homo sapiens, GI20127454, Length=495, Percent_Identity=35.959595959596, Blast_Score=256, Evalue=3e-68,
Organism=Escherichia coli, GI1790439, Length=529, Percent_Identity=51.0396975425331, Blast_Score=513, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI71985564, Length=519, Percent_Identity=32.9479768786127, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI71985574, Length=355, Percent_Identity=25.9154929577465, Blast_Score=91, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6323056, Length=487, Percent_Identity=34.0862422997947, Blast_Score=246, Evalue=5e-66,
Organism=Saccharomyces cerevisiae, GI6323768, Length=488, Percent_Identity=33.6065573770492, Blast_Score=243, Evalue=4e-65,
Organism=Drosophila melanogaster, GI24649832, Length=494, Percent_Identity=36.0323886639676, Blast_Score=267, Evalue=1e-71,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): PUR9_CHLCH (Q3ATZ1)

Other databases:

- EMBL:   CP000108
- RefSeq:   YP_378577.1
- HSSP:   P31335
- ProteinModelPortal:   Q3ATZ1
- SMR:   Q3ATZ1
- STRING:   Q3ATZ1
- GeneID:   3748179
- GenomeReviews:   CP000108_GR
- KEGG:   cch:Cag_0258
- eggNOG:   COG0138
- HOGENOM:   HBG498048
- OMA:   ASDGFFP
- ProtClustDB:   PRK00881
- BioCyc:   CCHL340177:CAG_0258-MONOMER
- HAMAP:   MF_00139
- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607
- Gene3D:   G3DSA:3.40.50.1380
- PANTHER:   PTHR11692
- PIRSF:   PIRSF000414
- SMART:   SM00798
- SMART:   SM00851
- TIGRFAMs:   TIGR00355

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS; SSF53927 Cytidine_deaminase-like; SSF52335 MGS-like_dom

EC number: =2.1.2.3; =3.5.4.10

Molecular weight: Translated: 56981; Mature: 56849

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPVIKRALVSVSDKTGIVDFCRELSELGVEIFSTGGTLKTLQDAGIAAASISTITGFP
CCCHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHCCCHHHHHHHHCCCH
EIMDGRVKTLHPKIHGGLLAVRENANHVKQAADNGISFIDLVVVNLYPFEATVAKPNVSF
HHHCCCCEEECCHHCCCEEEEECCHHHHHHHHHCCCCEEEEEEEEEECCEEEEECCCCCH
EDAIENIDIGGPSMLRSAAKNNESVTVVTDSADYALVLQEMRANNGATTRATRLHLALKV
HHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
FELTSRYDRAIATYLAGKVSAAEAAASTMSVQLAKELDMRYGENPHQNAGLYRLTDSNGT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
RSFEEFFEKLHGKELSYNNMLDIAAATSLIEEFRGEEPTVVIIKHTNPCGVAQASSLVDA
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHH
WHRAFSTDTQAPFGGIVAFNRPLDMAAAQAVNEIFTEILIAPAFEDGVLELLMKKKDRRL
HHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCE
VVQKKALPQSGWEFKSTPFGMLVQERDSKIVAKEDLKVVTKRQPTEAEIADLMFAWKICK
EHHHHCCCCCCCCCCCCCCCCEEECCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHH
HIKSNTILYVKNRQTYGVGAGQMSRVDSSKIARWKASEVNLDLHGSVVASDAFFPFADGL
HHCCCEEEEEECCCEECCCCCHHHHCCHHHHHEEECCEECEEECCCEEECCCCCHHHHHH
LAAAEAGVTAVIQPGGSIRDNEVIEAADANNLAMVFTGMRHFKH
HHHHHCCCEEEECCCCCCCCCCEEEECCCCCEEEEEECHHHHCC
>Mature Secondary Structure 
SDPVIKRALVSVSDKTGIVDFCRELSELGVEIFSTGGTLKTLQDAGIAAASISTITGFP
CCHHHHHHHHHCCCCCCHHHHHHHHHHCCEEEEECCCCHHHHHHCCCHHHHHHHHCCCH
EIMDGRVKTLHPKIHGGLLAVRENANHVKQAADNGISFIDLVVVNLYPFEATVAKPNVSF
HHHCCCCEEECCHHCCCEEEEECCHHHHHHHHHCCCCEEEEEEEEEECCEEEEECCCCCH
EDAIENIDIGGPSMLRSAAKNNESVTVVTDSADYALVLQEMRANNGATTRATRLHLALKV
HHHHHHCCCCCHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHCCCCCCCHHHHHHHHHHH
FELTSRYDRAIATYLAGKVSAAEAAASTMSVQLAKELDMRYGENPHQNAGLYRLTDSNGT
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCC
RSFEEFFEKLHGKELSYNNMLDIAAATSLIEEFRGEEPTVVIIKHTNPCGVAQASSLVDA
CHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHHH
WHRAFSTDTQAPFGGIVAFNRPLDMAAAQAVNEIFTEILIAPAFEDGVLELLMKKKDRRL
HHHHHCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCE
VVQKKALPQSGWEFKSTPFGMLVQERDSKIVAKEDLKVVTKRQPTEAEIADLMFAWKICK
EHHHHCCCCCCCCCCCCCCCCEEECCCCCEEEHHHHHHHHCCCCCHHHHHHHHHHHHHHH
HIKSNTILYVKNRQTYGVGAGQMSRVDSSKIARWKASEVNLDLHGSVVASDAFFPFADGL
HHCCCEEEEEECCCEECCCCCHHHHCCHHHHHEEECCEECEEECCCEEECCCCCHHHHHH
LAAAEAGVTAVIQPGGSIRDNEVIEAADANNLAMVFTGMRHFKH
HHHHHCCCEEEECCCCCCCCCCEEEECCCCCEEEEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA