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The map label for this gene is mutY [H]

Identifier: 78067596

GI number: 78067596

Start: 3270705

End: 3271811

Strand: Reverse

Name: mutY [H]

Synonym: Bcep18194_A6127

Alternate gene names: 78067596

Gene position: 3271811-3270705 (Counterclockwise)

Preceding gene: 78067597

Following gene: 78067584

Centisome position: 88.57

GC content: 72.0

Gene sequence:

>1107_bases
TTGAAGCCGCCCCGCATCGCCCCCGCTCCGTTCCCCGTCACGCCGCTGCATCGCACGTTCGCCACGCGCCTGGTCGCGTG
GCAGCGCGAGCATGGCCGCCACGACCTGCCGTGGCAGAACACCCGTGATCCGTACCGGATCTGGCTGTCGGAAATCATGC
TGCAGCAGACGCAGGTGTCGACCGTCATTCCGTACTACACGCGCTTTCTCGAGCGCTACCCCGACGTCGCCGCGCTCGCG
GCCGCGCCGACCGACGACGTGATGGCGCTGTGGGCGGGGCTCGGCTACTACTCGCGCGCGCGCAACCTGCACCGTTGCGC
GCAGGTCGTCGTTGCCGAGCACGGCGGTGCGTTTCCCGCGACGCCCGACGCGCTGGCCGAACTGCCGGGCATCGGCCGTT
CGACGGCCGCGGCGATCGCGTCGTTTGCGTACGGCGCGCGCGCGACGATTCTCGACGGCAACGTGAAGCGCGTGCTTGCA
CGGGTGTTCGGCGTCGAGGGCTTTCCGGGCGAGAAGCGCGTCGAGAACGACATGTGGGCGCTCGCCGAATCGCTGTTGCC
CGATGCCGCGAACGCGGCCGACGTGAGCGCGTATACGCAGGGGCTGATGGATCTCGGCGCGACGCTGTGCGTGCGCGGCA
AGCCCGATTGTGCGCGCTGCCCGTTCGCGGGCGACTGCGTCGCGCAATCGACGGGCCGCCAGCGCGAACTGCCGGCCGCG
CGGCCGAAGAAGGCCGTGCCGACCCGCAAGACCTGGATGCTCGTGCTGCGCGACGGTGACGCCGTGCTGCTCGAGCGGCG
GCCGCCGACCGGTATCTGGGGCGGGCTGTGGAGCCTGCCGCAGGCGGATGGCGACGCCGCGCTCGCGGAACTCGCGCGCG
GCTTCGGCGGTGGCGGCACGGTGCCGCTGGCGCCGCTCACGCACACGTTCACGCATTTCCGGCTCGAGATCGAGCCGCGG
CTGAGCGACATGGCCGACGGCGGTGGCCTGCCTGAGGGCGCGCGGGACGCGGACACCGCCTGGGTGCCGCTGAGCCGGCT
CGACGCGTATGGCGTGCCGGCACCCGTGCGCAAGCTGCTCGATGCACTGAGCGGGCCGTTGCTGTAA

Upstream 100 bases:

>100_bases
CGTATGCAACACGCCGATCCGCCAGATCGTACAGGGCCAGCGGTCGACCTATTTCTGCCCGACCTGCCAGCGTTGAAACC
TTTTTCCACGATTAGATAAC

Downstream 100 bases:

>100_bases
CGAAGGGGGAGGGGCGCGGCGCATGCCGCGCTTTCAAGGAAACGTCGGACGCCCGTGGTTTTTCGCGCCGACGGAAGTGG
CCCTTGGGGGCCTGGCGCGA

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 368; Mature: 368

Protein sequence:

>368_residues
MKPPRIAPAPFPVTPLHRTFATRLVAWQREHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVIPYYTRFLERYPDVAALA
AAPTDDVMALWAGLGYYSRARNLHRCAQVVVAEHGGAFPATPDALAELPGIGRSTAAAIASFAYGARATILDGNVKRVLA
RVFGVEGFPGEKRVENDMWALAESLLPDAANAADVSAYTQGLMDLGATLCVRGKPDCARCPFAGDCVAQSTGRQRELPAA
RPKKAVPTRKTWMLVLRDGDAVLLERRPPTGIWGGLWSLPQADGDAALAELARGFGGGGTVPLAPLTHTFTHFRLEIEPR
LSDMADGGGLPEGARDADTAWVPLSRLDAYGVPAPVRKLLDALSGPLL

Sequences:

>Translated_368_residues
MKPPRIAPAPFPVTPLHRTFATRLVAWQREHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVIPYYTRFLERYPDVAALA
AAPTDDVMALWAGLGYYSRARNLHRCAQVVVAEHGGAFPATPDALAELPGIGRSTAAAIASFAYGARATILDGNVKRVLA
RVFGVEGFPGEKRVENDMWALAESLLPDAANAADVSAYTQGLMDLGATLCVRGKPDCARCPFAGDCVAQSTGRQRELPAA
RPKKAVPTRKTWMLVLRDGDAVLLERRPPTGIWGGLWSLPQADGDAALAELARGFGGGGTVPLAPLTHTFTHFRLEIEPR
LSDMADGGGLPEGARDADTAWVPLSRLDAYGVPAPVRKLLDALSGPLL
>Mature_368_residues
MKPPRIAPAPFPVTPLHRTFATRLVAWQREHGRHDLPWQNTRDPYRIWLSEIMLQQTQVSTVIPYYTRFLERYPDVAALA
AAPTDDVMALWAGLGYYSRARNLHRCAQVVVAEHGGAFPATPDALAELPGIGRSTAAAIASFAYGARATILDGNVKRVLA
RVFGVEGFPGEKRVENDMWALAESLLPDAANAADVSAYTQGLMDLGATLCVRGKPDCARCPFAGDCVAQSTGRQRELPAA
RPKKAVPTRKTWMLVLRDGDAVLLERRPPTGIWGGLWSLPQADGDAALAELARGFGGGGTVPLAPLTHTFTHFRLEIEPR
LSDMADGGGLPEGARDADTAWVPLSRLDAYGVPAPVRKLLDALSGPLL

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298648, Length=411, Percent_Identity=33.0900243309002, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI115298654, Length=411, Percent_Identity=33.0900243309002, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI115298652, Length=411, Percent_Identity=33.0900243309002, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI115298650, Length=411, Percent_Identity=33.0900243309002, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI190358497, Length=411, Percent_Identity=33.0900243309002, Blast_Score=186, Evalue=3e-47,
Organism=Homo sapiens, GI6912520, Length=411, Percent_Identity=33.0900243309002, Blast_Score=186, Evalue=3e-47,
Organism=Escherichia coli, GI1789331, Length=346, Percent_Identity=45.6647398843931, Blast_Score=320, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.-

Molecular weight: Translated: 39770; Mature: 39770

Theoretical pI: Translated: 8.22; Mature: 8.22

Prosite motif: PS01155 ENDONUCLEASE_III_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPPRIAPAPFPVTPLHRTFATRLVAWQREHGRHDLPWQNTRDPYRIWLSEIMLQQTQVS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TVIPYYTRFLERYPDVAALAAAPTDDVMALWAGLGYYSRARNLHRCAQVVVAEHGGAFPA
HHHHHHHHHHHHCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TPDALAELPGIGRSTAAAIASFAYGARATILDGNVKRVLARVFGVEGFPGEKRVENDMWA
CHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHH
LAESLLPDAANAADVSAYTQGLMDLGATLCVRGKPDCARCPFAGDCVAQSTGRQRELPAA
HHHHHCCCCCCHHHHHHHHHHHHHHCHHEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCC
RPKKAVPTRKTWMLVLRDGDAVLLERRPPTGIWGGLWSLPQADGDAALAELARGFGGGGT
CCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHHCCCCCC
VPLAPLTHTFTHFRLEIEPRLSDMADGGGLPEGARDADTAWVPLSRLDAYGVPAPVRKLL
CCCCHHHHCEEEEEEEECCCHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHH
DALSGPLL
HHHCCCCC
>Mature Secondary Structure
MKPPRIAPAPFPVTPLHRTFATRLVAWQREHGRHDLPWQNTRDPYRIWLSEIMLQQTQVS
CCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
TVIPYYTRFLERYPDVAALAAAPTDDVMALWAGLGYYSRARNLHRCAQVVVAEHGGAFPA
HHHHHHHHHHHHCCCCEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
TPDALAELPGIGRSTAAAIASFAYGARATILDGNVKRVLARVFGVEGFPGEKRVENDMWA
CHHHHHHCCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHH
LAESLLPDAANAADVSAYTQGLMDLGATLCVRGKPDCARCPFAGDCVAQSTGRQRELPAA
HHHHHCCCCCCHHHHHHHHHHHHHHCHHEEECCCCCCCCCCCCCCHHHHCCCCCCCCCCC
RPKKAVPTRKTWMLVLRDGDAVLLERRPPTGIWGGLWSLPQADGDAALAELARGFGGGGT
CCCCCCCCCCEEEEEEECCCEEEEECCCCCCCCCHHCCCCCCCCHHHHHHHHHHCCCCCC
VPLAPLTHTFTHFRLEIEPRLSDMADGGGLPEGARDADTAWVPLSRLDAYGVPAPVRKLL
CCCCHHHHCEEEEEEEECCCHHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHHHHHH
DALSGPLL
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: 4Fe-4S Cluster [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Glycosylases; Hydrolysing N-glycosyl compounds [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]