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The map label for this gene is kefB [H]

Identifier: 78067584

GI number: 78067584

Start: 3259124

End: 3261130

Strand: Reverse

Name: kefB [H]

Synonym: Bcep18194_A6115

Alternate gene names: 78067584

Gene position: 3261130-3259124 (Counterclockwise)

Preceding gene: 78067596

Following gene: 78067583

Centisome position: 88.28

GC content: 67.71

Gene sequence:

>2007_bases
GTGATTTCCCCGCTCGAAATGACCCTGCTGCTGCTGCTGGCCTCAGTGGTGGGCGTCGTCGTATTCCGCTCGTTGAACCT
GCCGCCGATGCTCGGCTACCTGACCGTCGGCATCCTGGTCGGCCCGCATGCGTTCGGCATCGCGGCAGATCTGGAGCGGG
CCGAGCACCTTGCGGAATTCGGCGTGGTGTTCCTGATGTTTTCGATCGGCCTCGAGTTCTCGCTGGCGAAGCTGAGGGCG
ATGCAGCGGCTCGTGTTCGGGCTCGGGCTGCTGCAGGTCGTCGCGACCCTCGTGCTCGCGCTCGTGCTCGGCATGCTGTT
CGAGCACTGGGTACATATCACTTGGCAGGGCAGCATTGCACTCGGCGGCGCGCTCGCGATGTCGTCGACGGCGATCGTGT
CGAAGATGCTCGCCGAGCGGCTCGAGATCGAGACCGAGCACGGCCGCAACATCTTCGGCGTACTGCTGTTCCAGGATCTC
GCGGTGGTGCCGCTGCTGATCGTGATCGCCGCGTTCGGCGCCGAATCGTCGAAGGACCTCGCGATCACGCTCGGCTTCGC
GGCCGTCAAGATCGTGATCGCGCTCACGCTGCTGCTGGTCATCGGCCAGCGCTTCATGACGCGCTGGCTCAACGTCGTCG
CGCGGCGCCGCTCGCAGGAACTGTTCGTGCTGAACCTGCTGCTCGTCACGCTCGGCGCCGCGTTCATCACCGACCGCTTC
GGCCTGTCGCTCGCGCTCGGCGCGTTCATCGCGGGGATGCTGATCTCCGAGACGCCGTTCCGCCATCAGGTGGAGGAGGA
CATCAAGCCGTTCCGCGACGTGCTGCTCGGCCTGTTCTTCGTGACGACCGGGATGTTGCTCGATCCGCGCGTGATCTGGG
AGCACCCGTTCCTCGTGCTCGGTTTCTTCGTCGGGCAGATCCTGTTCAAGGGGACGATGATCGCCGGGCTCGCGCGGCTG
TTCGGCGCGACGCCGGGCGTCGCGATGCGTACCGGCATCGGGCTCGCGCAGGCCGGCGAATTCGGCTTCGTGCTGCTGAA
CCTGATCCTCGACCGGCATCTCGTCGATTCGACGCTGTTGCAGGCGATCCTCGCGTCGATGCTGCTGTCGATGCTCGCGG
CGCCGTTCCTGATCCAGAACGCCGACCGGATCGTGATGCGGCTGTCGTCGACCGAATGGATGCAGCAGTCGCTGCAGATG
ACGCGGATCGCGACGCAAAGCCTCAAGCAGCGCGGCCACGTGATCATTTGCGGCTACGGCCGCGCAGGGCAGAACCTGGC
GCGGATGCTCGAACAGGAAGGCATTCCGTACGTCGCGCTCGACCTCGACCCCGATCGCGTGAGCGCGGCCGGGGCGGCCG
GCGAATCGGTCGTGTTCGGTGACGCGGCGCGCCGCGAGTCGCTGCTCGCGGCCGGTATCCACCGCGCGGCGGCGGTGGCG
ATCACCTACGCGAACACGCCGTCCGCGCTGCGCGTGCTGCATCACGTGCACGAACTCGAGCCGACGCTGCCCGCGATCGT
GCGTACCGTCGACGATGCCGATCTCGAGAAGCTGCTCGCGGCCGGCGCGACCGAAGTGATTCCGGAAATCGTCGAAGGCA
GCCTGATGCTCGCGTCGCACACGCTGGTGCTGGTCGGCGTGCCGATGCGCAAGGTCGTGCGGCGCGTCGAGGAAATGCGC
GACGAACGCTACAGCCTGCTGCGCGGCTATTTCCGCGGCGCGGACGACGCGGACGACGACGACCACGAGCAGGTGCGGCT
ACAATCGGTGCCGGTCGATGCGCGCGCGGACGCGGTCGGGCGTTCGCTGGAAGAACTGGGGCTGTATGCACTCGGGCTCG
AAGTCACGGCGATCCGCCGGCACGGCATCCGCGGCGTCGAACCCGATCCGCAAACCAAGCTGCGCGCGAGCGACATCGTC
GTGCTGCGCGGGCTGCCCGAGGCGCTCGCGCTCGCGGAGGAGCGGCTGTCGCGCCATCGGCGCGATCCGCCGGCCGCGGC
TGCCTGA

Upstream 100 bases:

>100_bases
TTCGCCGCGCCGGGCCTTCGGACTCGTCCGAGGTCGCCCGACCACCGCCACCACCCGCGCCCGCATTGCCGTGGCCCCGA
CGAACGAGGACGCTTCGCCC

Downstream 100 bases:

>100_bases
GCCGTGCTTGGTTTGATAACCTGACCCGTATTTATTCGAAACGGTGCCCGATCTTCGCGCACCGTTTTTTTCGGAGAGTT
TCATGCCGCATTCGTCGTCG

Product: Sodium/hydrogen exchanger

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter; NEM-activatable K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHAFGIAADLERAEHLAEFGVVFLMFSIGLEFSLAKLRA
MQRLVFGLGLLQVVATLVLALVLGMLFEHWVHITWQGSIALGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDL
AVVPLLIVIAAFGAESSKDLAITLGFAAVKIVIALTLLLVIGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
GLSLALGAFIAGMLISETPFRHQVEEDIKPFRDVLLGLFFVTTGMLLDPRVIWEHPFLVLGFFVGQILFKGTMIAGLARL
FGATPGVAMRTGIGLAQAGEFGFVLLNLILDRHLVDSTLLQAILASMLLSMLAAPFLIQNADRIVMRLSSTEWMQQSLQM
TRIATQSLKQRGHVIICGYGRAGQNLARMLEQEGIPYVALDLDPDRVSAAGAAGESVVFGDAARRESLLAAGIHRAAAVA
ITYANTPSALRVLHHVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASHTLVLVGVPMRKVVRRVEEMR
DERYSLLRGYFRGADDADDDDHEQVRLQSVPVDARADAVGRSLEELGLYALGLEVTAIRRHGIRGVEPDPQTKLRASDIV
VLRGLPEALALAEERLSRHRRDPPAAAA

Sequences:

>Translated_668_residues
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHAFGIAADLERAEHLAEFGVVFLMFSIGLEFSLAKLRA
MQRLVFGLGLLQVVATLVLALVLGMLFEHWVHITWQGSIALGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDL
AVVPLLIVIAAFGAESSKDLAITLGFAAVKIVIALTLLLVIGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
GLSLALGAFIAGMLISETPFRHQVEEDIKPFRDVLLGLFFVTTGMLLDPRVIWEHPFLVLGFFVGQILFKGTMIAGLARL
FGATPGVAMRTGIGLAQAGEFGFVLLNLILDRHLVDSTLLQAILASMLLSMLAAPFLIQNADRIVMRLSSTEWMQQSLQM
TRIATQSLKQRGHVIICGYGRAGQNLARMLEQEGIPYVALDLDPDRVSAAGAAGESVVFGDAARRESLLAAGIHRAAAVA
ITYANTPSALRVLHHVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASHTLVLVGVPMRKVVRRVEEMR
DERYSLLRGYFRGADDADDDDHEQVRLQSVPVDARADAVGRSLEELGLYALGLEVTAIRRHGIRGVEPDPQTKLRASDIV
VLRGLPEALALAEERLSRHRRDPPAAAA
>Mature_668_residues
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHAFGIAADLERAEHLAEFGVVFLMFSIGLEFSLAKLRA
MQRLVFGLGLLQVVATLVLALVLGMLFEHWVHITWQGSIALGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDL
AVVPLLIVIAAFGAESSKDLAITLGFAAVKIVIALTLLLVIGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
GLSLALGAFIAGMLISETPFRHQVEEDIKPFRDVLLGLFFVTTGMLLDPRVIWEHPFLVLGFFVGQILFKGTMIAGLARL
FGATPGVAMRTGIGLAQAGEFGFVLLNLILDRHLVDSTLLQAILASMLLSMLAAPFLIQNADRIVMRLSSTEWMQQSLQM
TRIATQSLKQRGHVIICGYGRAGQNLARMLEQEGIPYVALDLDPDRVSAAGAAGESVVFGDAARRESLLAAGIHRAAAVA
ITYANTPSALRVLHHVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASHTLVLVGVPMRKVVRRVEEMR
DERYSLLRGYFRGADDADDDDHEQVRLQSVPVDARADAVGRSLEELGLYALGLEVTAIRRHGIRGVEPDPQTKLRASDIV
VLRGLPEALALAEERLSRHRRDPPAAAA

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=346, Percent_Identity=27.1676300578035, Blast_Score=102, Evalue=2e-21,
Organism=Escherichia coli, GI1786232, Length=512, Percent_Identity=33.203125, Blast_Score=241, Evalue=1e-64,
Organism=Escherichia coli, GI1789749, Length=543, Percent_Identity=32.2283609576427, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI1786685, Length=535, Percent_Identity=29.9065420560748, Blast_Score=201, Evalue=2e-52,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR020884
- InterPro:   IPR004771
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 72626; Mature: 72626

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHAFGIAADLERAEHLAEF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GVVFLMFSIGLEFSLAKLRAMQRLVFGLGLLQVVATLVLALVLGMLFEHWVHITWQGSIA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEE
LGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDLAVVPLLIVIAAFGAESSKDL
ECHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
AITLGFAAVKIVIALTLLLVIGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GLSLALGAFIAGMLISETPFRHQVEEDIKPFRDVLLGLFFVTTGMLLDPRVIWEHPFLVL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHH
GFFVGQILFKGTMIAGLARLFGATPGVAMRTGIGLAQAGEFGFVLLNLILDRHLVDSTLL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHH
QAILASMLLSMLAAPFLIQNADRIVMRLSSTEWMQQSLQMTRIATQSLKQRGHVIICGYG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
RAGQNLARMLEQEGIPYVALDLDPDRVSAAGAAGESVVFGDAARRESLLAAGIHRAAAVA
CCCHHHHHHHHHCCCCEEEEECCHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHEEE
ITYANTPSALRVLHHVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASH
EEECCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEC
TLVLVGVPMRKVVRRVEEMRDERYSLLRGYFRGADDADDDDHEQVRLQSVPVDARADAVG
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEHHCCCCCCHHHHHH
RSLEELGLYALGLEVTAIRRHGIRGVEPDPQTKLRASDIVVLRGLPEALALAEERLSRHR
CCHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHC
RDPPAAAA
CCCCCCCC
>Mature Secondary Structure
MISPLEMTLLLLLASVVGVVVFRSLNLPPMLGYLTVGILVGPHAFGIAADLERAEHLAEF
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
GVVFLMFSIGLEFSLAKLRAMQRLVFGLGLLQVVATLVLALVLGMLFEHWVHITWQGSIA
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECCEE
LGGALAMSSTAIVSKMLAERLEIETEHGRNIFGVLLFQDLAVVPLLIVIAAFGAESSKDL
ECHHHHHHHHHHHHHHHHHHHHCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
AITLGFAAVKIVIALTLLLVIGQRFMTRWLNVVARRRSQELFVLNLLLVTLGAAFITDRF
EEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
GLSLALGAFIAGMLISETPFRHQVEEDIKPFRDVLLGLFFVTTGMLLDPRVIWEHPFLVL
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCHHHHH
GFFVGQILFKGTMIAGLARLFGATPGVAMRTGIGLAQAGEFGFVLLNLILDRHLVDSTLL
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCHHCCCCHHHHHHHHHHHHHHHHHHHH
QAILASMLLSMLAAPFLIQNADRIVMRLSSTEWMQQSLQMTRIATQSLKQRGHVIICGYG
HHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
RAGQNLARMLEQEGIPYVALDLDPDRVSAAGAAGESVVFGDAARRESLLAAGIHRAAAVA
CCCHHHHHHHHHCCCCEEEEECCHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHHHHEEE
ITYANTPSALRVLHHVHELEPTLPAIVRTVDDADLEKLLAAGATEVIPEIVEGSLMLASH
EEECCCHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHCCCCEEEEC
TLVLVGVPMRKVVRRVEEMRDERYSLLRGYFRGADDADDDDHEQVRLQSVPVDARADAVG
CEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHEEHHCCCCCCHHHHHH
RSLEELGLYALGLEVTAIRRHGIRGVEPDPQTKLRASDIVVLRGLPEALALAEERLSRHR
CCHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHHC
RDPPAAAA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA