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The map label for this gene is mug [H]

Identifier: 78067575

GI number: 78067575

Start: 3248882

End: 3249514

Strand: Reverse

Name: mug [H]

Synonym: Bcep18194_A6106

Alternate gene names: 78067575

Gene position: 3249514-3248882 (Counterclockwise)

Preceding gene: 78067576

Following gene: 78067574

Centisome position: 87.96

GC content: 64.93

Gene sequence:

>633_bases
ATGTCCGAGTCAAGCCAGTTGCTTGGCCCGGGTCTTCGGGCCTTGTTTCGTTTACGTCGATGTTCCTTGCGCACCAGGCA
AAACGTGGCTGACGAACTTCCCGACCTCATCGCGCCGCAACTCGACGTGCTCTTCTGCGGGATCAACCCCGGCCTGACCG
CGGCCGCCACCGGCCATCACTTCGCGGGGAGGAGCAACCGCTTCTGGCGCGTGATCCATCTCGCGGGCTTCACGCCGGCG
GAAATTTCGCCGCAGGACGATCACGCGATTCTTCAATATGGCTGCGGCCTGACGGCGGTGGTGAAGCGGCCGACCGCGAG
CGCCGACCAGCTTTCGCGCGCGGAATTCGTCGCCGCGGCTGCCGAGTTCGAGCACAAGGTGGCGCGTTATGGGCCGCGCT
TCGTCGCTTTTCTCGGCAAGGCAGCGTACTCGGCGCTTTCCGGGCAGCGGGAAATCGAGTGGGGATTGCAGCCGGCCCGG
ATGCAGGGATCGAGCGTCTGGGTGCTGCCCAATCCCAGCGGGCGAAATCTCGCGTTCAGTCTCGACGACCTCGTCGACGC
ATATCGTCAGCTTCGTCTGCAGGTGAAGGCCGGTTCCGGTCTTCAACCGGAGGGGCAGGATGCGGCGCGGTGA

Upstream 100 bases:

>100_bases
AAAGCCGTCCGAGCGCACCGGCAGGCGGCGGCTTCGACGAGATGGACGACGATATCCCGTTCTGATCGGCAAGTCGGCAT
CCGCATCACGATGGGCCCGA

Downstream 100 bases:

>100_bases
CCCCGCGCCTCGGTGGCCGGGCGCCGTGCTGCCGCGCGCATTCTTCGACCGCGTCGCCACCGACGTCGCGCCGCAACTGC
TGAACAAGATCCTTGCGGCC

Product: G/U mismatch-specific uracil-DNA glycosylase

Products: NA

Alternate protein names: Double-strand-specific uracil glycosylase; Mismatch-specific uracil DNA-glycosylase; MUG [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSESSQLLGPGLRALFRLRRCSLRTRQNVADELPDLIAPQLDVLFCGINPGLTAAATGHHFAGRSNRFWRVIHLAGFTPA
EISPQDDHAILQYGCGLTAVVKRPTASADQLSRAEFVAAAAEFEHKVARYGPRFVAFLGKAAYSALSGQREIEWGLQPAR
MQGSSVWVLPNPSGRNLAFSLDDLVDAYRQLRLQVKAGSGLQPEGQDAAR

Sequences:

>Translated_210_residues
MSESSQLLGPGLRALFRLRRCSLRTRQNVADELPDLIAPQLDVLFCGINPGLTAAATGHHFAGRSNRFWRVIHLAGFTPA
EISPQDDHAILQYGCGLTAVVKRPTASADQLSRAEFVAAAAEFEHKVARYGPRFVAFLGKAAYSALSGQREIEWGLQPAR
MQGSSVWVLPNPSGRNLAFSLDDLVDAYRQLRLQVKAGSGLQPEGQDAAR
>Mature_209_residues
SESSQLLGPGLRALFRLRRCSLRTRQNVADELPDLIAPQLDVLFCGINPGLTAAATGHHFAGRSNRFWRVIHLAGFTPAE
ISPQDDHAILQYGCGLTAVVKRPTASADQLSRAEFVAAAAEFEHKVARYGPRFVAFLGKAAYSALSGQREIEWGLQPARM
QGSSVWVLPNPSGRNLAFSLDDLVDAYRQLRLQVKAGSGLQPEGQDAAR

Specific function: Excises ethenocytosine and uracil, which can arise by alkylation or deamination of cytosine, respectively, from the corresponding mispairs with guanine in ds-DNA. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone o

COG id: COG3663

COG function: function code L; G:T/U mismatch-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TDG/mug DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI59853162, Length=177, Percent_Identity=34.4632768361582, Blast_Score=111, Evalue=5e-25,
Organism=Escherichia coli, GI1789449, Length=157, Percent_Identity=46.4968152866242, Blast_Score=151, Evalue=3e-38,
Organism=Drosophila melanogaster, GI21356805, Length=145, Percent_Identity=37.9310344827586, Blast_Score=120, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015637
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.28 [H]

Molecular weight: Translated: 22852; Mature: 22721

Theoretical pI: Translated: 9.26; Mature: 9.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESSQLLGPGLRALFRLRRCSLRTRQNVADELPDLIAPQLDVLFCGINPGLTAAATGHH
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEECCCCC
FAGRSNRFWRVIHLAGFTPAEISPQDDHAILQYGCGLTAVVKRPTASADQLSRAEFVAAA
CCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
AEFEHKVARYGPRFVAFLGKAAYSALSGQREIEWGLQPARMQGSSVWVLPNPSGRNLAFS
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHCCCCHHHCCCCEEEEEECCCCCEEEEE
LDDLVDAYRQLRLQVKAGSGLQPEGQDAAR
HHHHHHHHHHHEEEEECCCCCCCCCCCCCC
>Mature Secondary Structure 
SESSQLLGPGLRALFRLRRCSLRTRQNVADELPDLIAPQLDVLFCGINPGLTAAATGHH
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCCEECCCCC
FAGRSNRFWRVIHLAGFTPAEISPQDDHAILQYGCGLTAVVKRPTASADQLSRAEFVAAA
CCCCCCCEEEEEEECCCCCCCCCCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
AEFEHKVARYGPRFVAFLGKAAYSALSGQREIEWGLQPARMQGSSVWVLPNPSGRNLAFS
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHCCCCHHHCCCCEEEEEECCCCCEEEEE
LDDLVDAYRQLRLQVKAGSGLQPEGQDAAR
HHHHHHHHHHHEEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA