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The map label for this gene is tpm [H]

Identifier: 78067524

GI number: 78067524

Start: 3195995

End: 3196627

Strand: Reverse

Name: tpm [H]

Synonym: Bcep18194_A6055

Alternate gene names: 78067524

Gene position: 3196627-3195995 (Counterclockwise)

Preceding gene: 78067525

Following gene: 78067523

Centisome position: 86.53

GC content: 67.46

Gene sequence:

>633_bases
ATGTCCGATCCGAAACAACCGAAGCCGAATGCGCCGGCCGCCGCCGATTTCACGACGCGCGATCCCGGCAACGCATCGTT
CTGGAACGAGCGTTTCGAGCGTGGCGTGACGCCGTGGGAATTCGGCGGCGTGCCCGAGGGTTTTAGCGTGTTCGCACACC
GGCTCGAGCTGTGCGCGGTGCTGATTCCCGGCTGCGGCAGTGCGCAGGAAGCCGGATGGCTGGCCGAAGCCGGCTGGCCC
GTGCGTGCGATCGATTTCGCCGCGCAGGCGGTGGCTGCCGCGAAGGCGCAGCTCGGCGCGCATGCGGGCGTCGTCGAGCA
GGCCGATTTCTTTGCGTACCGGCCGCCGTTCGACGTGCAGTGGGTGTACGAGCGCGCGTTCCTGTGCGCGCTGCCGCCGG
CCATGCGTGCCGACTATGCGGCGCGCATGGCCGAGCTGCTGCCTGCTGACGGATTGCTGGCCGGCTATTTCTTCCTGATG
GCGAAACCGAAGGGGCCGCCGTTCGGAATCGAGCGTGCCGAACTCGATGCGCTGCTCACGCCGCACTTCGAGCTGATCGA
GGATTTGCCCGTGACCGATTCACTCGCGGTGTTCGAAGGACACGAGCGCTGGCTCACGTGGCGTCGCCGCTGA

Upstream 100 bases:

>100_bases
AGGCGCTGCTGATCTTCGGTCTCGCCGTTGGCGTCGGGGCGCTCGTTGCGCGTGTGCTGATCCTGCTCGCGTACGGCGCC
TGACTGAAAGGAGTACGGCG

Downstream 100 bases:

>100_bases
TGCGCGGGTGTCGCGGCCATTGCCGGAGCGCGGCAGGGTTTCGGCTATAATTCAAGGTTTTGCAAGCCGTTTCCAGTTTC
CGCGGGAAAAATATCATGCC

Product: thiopurine S-methyltransferase

Products: NA

Alternate protein names: Thiopurine methyltransferase [H]

Number of amino acids: Translated: 210; Mature: 209

Protein sequence:

>210_residues
MSDPKQPKPNAPAAADFTTRDPGNASFWNERFERGVTPWEFGGVPEGFSVFAHRLELCAVLIPGCGSAQEAGWLAEAGWP
VRAIDFAAQAVAAAKAQLGAHAGVVEQADFFAYRPPFDVQWVYERAFLCALPPAMRADYAARMAELLPADGLLAGYFFLM
AKPKGPPFGIERAELDALLTPHFELIEDLPVTDSLAVFEGHERWLTWRRR

Sequences:

>Translated_210_residues
MSDPKQPKPNAPAAADFTTRDPGNASFWNERFERGVTPWEFGGVPEGFSVFAHRLELCAVLIPGCGSAQEAGWLAEAGWP
VRAIDFAAQAVAAAKAQLGAHAGVVEQADFFAYRPPFDVQWVYERAFLCALPPAMRADYAARMAELLPADGLLAGYFFLM
AKPKGPPFGIERAELDALLTPHFELIEDLPVTDSLAVFEGHERWLTWRRR
>Mature_209_residues
SDPKQPKPNAPAAADFTTRDPGNASFWNERFERGVTPWEFGGVPEGFSVFAHRLELCAVLIPGCGSAQEAGWLAEAGWPV
RAIDFAAQAVAAAKAQLGAHAGVVEQADFFAYRPPFDVQWVYERAFLCALPPAMRADYAARMAELLPADGLLAGYFFLMA
KPKGPPFGIERAELDALLTPHFELIEDLPVTDSLAVFEGHERWLTWRRR

Specific function: Unknown

COG id: COG0500

COG function: function code QR; SAM-dependent methyltransferases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. TPMT family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022474
- InterPro:   IPR008854
- InterPro:   IPR016822 [H]

Pfam domain/function: PF05724 TPMT [H]

EC number: =2.1.1.67 [H]

Molecular weight: Translated: 23133; Mature: 23002

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPKQPKPNAPAAADFTTRDPGNASFWNERFERGVTPWEFGGVPEGFSVFAHRLELCAV
CCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LIPGCGSAQEAGWLAEAGWPVRAIDFAAQAVAAAKAQLGAHAGVVEQADFFAYRPPFDVQ
HCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEECCCCCHH
WVYERAFLCALPPAMRADYAARMAELLPADGLLAGYFFLMAKPKGPPFGIERAELDALLT
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCCCCCCCCCHHHHHHHHC
PHFELIEDLPVTDSLAVFEGHERWLTWRRR
CCHHHHHCCCCCCCHHEECCHHHHHHCCCC
>Mature Secondary Structure 
SDPKQPKPNAPAAADFTTRDPGNASFWNERFERGVTPWEFGGVPEGFSVFAHRLELCAV
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
LIPGCGSAQEAGWLAEAGWPVRAIDFAAQAVAAAKAQLGAHAGVVEQADFFAYRPPFDVQ
HCCCCCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCEEECCCCCHH
WVYERAFLCALPPAMRADYAARMAELLPADGLLAGYFFLMAKPKGPPFGIERAELDALLT
HHHHHHHHHHCCHHHHHHHHHHHHHHCCCCHHHHHHHHHEECCCCCCCCCCHHHHHHHHC
PHFELIEDLPVTDSLAVFEGHERWLTWRRR
CCHHHHHCCCCCCCHHEECCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA