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The map label for this gene is ubiB

Identifier: 78067525

GI number: 78067525

Start: 3196645

End: 3198222

Strand: Reverse

Name: ubiB

Synonym: Bcep18194_A6056

Alternate gene names: 78067525

Gene position: 3198222-3196645 (Counterclockwise)

Preceding gene: 78067526

Following gene: 78067524

Centisome position: 86.58

GC content: 64.83

Gene sequence:

>1578_bases
ATGCGCATTTTCCGTTTCATCAAGATTGTCTACACCGTCATCCGCTTTGGTCTCGACGAAGTGATGCTGTCCCGGATCGA
CGACCGGCGCGTGAAGCTGCTGCTGCGGATCACGACGATCGGCCGCCGTTATTCCGATCCGCCTGCCGTGCGGCTGCGTC
ACGCGCTCGAAAGTCTCGGCCCGATCTTCGTGAAGTTCGGCCAGGTGCTGTCCACGCGCCGCGACTTGCTGTCGGTCGAT
TTCGCGAACGAACTCGCGAAGCTGCAGGACCAGGTGCCGCCGTTCGATTCGGCGGTCGCGATCGGGATCATCGAGAAGTC
GCTCGGTGCACCGGTCGACGAGCTGTTCGACGAATTCGAGCGTGAGCCGATCGCAAGCGCGTCGATTGCGCAGGTGCATT
TCGCGAAGCTGAAGCAGGGCCAGCACGCGGGCAAGGCCGTCGCCGTCAAGGTGCTGCGCCCGAACATGCTGTCCGTGATC
GATTCCGACCTCGCGCTGATGCGCGACATCGCGATCTGGACCGAGCGCATGTGGGCCGACGGCCGGCGCCTGAAGCCGCG
CGAAGTGGTCGCCGAATTCGACAAGTACCTGCACGACGAGCTCGACCTGATGCGCGAGGCCGCCAACGGCAGCCAGCTGC
GCCGCAACTTCGCGGGCCTCGACCTGCTGCTCGTGCCCGAGATGTTCTGGGATTTCTCGACGTCGCAGGTGCTCGTGATG
GAGCGCATGACCGGCGTGCCGATCAGCCAGGTCGAGACGCTGCGTTCGGCCGGCGTCGACATCAAGAAGCTCGCGCGCGA
AGGCGTCGAGATCTTCTTCACGCAGGTGTTCCGCGACGGCTTCTTCCACGCGGACATGCACCCGGGCAACATCCAGGTGA
GCCTCGATCCGAACACGTTCGGCCGCTACGTCGCGCTCGATTTCGGGATCGTCGGCGCACTGTCCGATTTCGACAAGAAC
TACCTCGCGCAGAACTTCCTCGCGTTCTTCAAGCGCGACTATCACCGCGTCGCGACGCTTCACCTCGAATCGGGCTGGGT
GCCGCCCGAAACGCGCGTCGAGGAGCTCGAAAGCGCGATCCGCGCGGTGTGCGAGCCGTATTTCGACCGCGCGCTGAAGG
ACATCTCGCTCGGCCAGGTGCTGATGCGCCTGTTCTCGACGTCGCGCCGCTTCAACGTCGAGATCCAGCCGCAGCTCGTG
CTGCTGCAGAAGACGATGCTGAACGTCGAGGGCCTCGGCCGCTCGCTCGATCCTGAATTGGATCTCTGGAAGACCGCGAA
GCCGTACCTCGAGCGCTGGATGACCGAGCAGATCGGCCTGCGCGGCTGGTACGAGCGCTTCAAGGTCGAGGCGCCGCAGT
GGAGCAAGACGCTGCCGCAATTGCCGCGCCTGATCCACCATGCGATGGCCGCGCGCCATGATGCACCGCGCGCCGCGAGC
GAAGACCTGATGCGCCAGATCCTCGTCGAGCAGAAGCGGACGAACCGGCTGCTGCAGGCGCTGCTGATCTTCGGTCTCGC
CGTTGGCGTCGGGGCGCTCGTTGCGCGTGTGCTGATCCTGCTCGCGTACGGCGCCTGA

Upstream 100 bases:

>100_bases
GCGCTCGCGCGGGTCGAAAAGCGGGTCGAGCGACTCGAACAAAAAATCGGCGCGCGCACGGGTTCCGGCCCGCGCGGCGC
GCACTGAGGGGCCGCAGGGC

Downstream 100 bases:

>100_bases
CTGAAAGGAGTACGGCGATGTCCGATCCGAAACAACCGAAGCCGAATGCGCCGGCCGCCGCCGATTTCACGACGCGCGAT
CCCGGCAACGCATCGTTCTG

Product: putative ubiquinone biosynthesis protein UbiB

Products: 2-octaprenyl-6-hydroxyphenol [C]

Alternate protein names: NA

Number of amino acids: Translated: 525; Mature: 525

Protein sequence:

>525_residues
MRIFRFIKIVYTVIRFGLDEVMLSRIDDRRVKLLLRITTIGRRYSDPPAVRLRHALESLGPIFVKFGQVLSTRRDLLSVD
FANELAKLQDQVPPFDSAVAIGIIEKSLGAPVDELFDEFEREPIASASIAQVHFAKLKQGQHAGKAVAVKVLRPNMLSVI
DSDLALMRDIAIWTERMWADGRRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMFWDFSTSQVLVM
ERMTGVPISQVETLRSAGVDIKKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPNTFGRYVALDFGIVGALSDFDKN
YLAQNFLAFFKRDYHRVATLHLESGWVPPETRVEELESAIRAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLV
LLQKTMLNVEGLGRSLDPELDLWKTAKPYLERWMTEQIGLRGWYERFKVEAPQWSKTLPQLPRLIHHAMAARHDAPRAAS
EDLMRQILVEQKRTNRLLQALLIFGLAVGVGALVARVLILLAYGA

Sequences:

>Translated_525_residues
MRIFRFIKIVYTVIRFGLDEVMLSRIDDRRVKLLLRITTIGRRYSDPPAVRLRHALESLGPIFVKFGQVLSTRRDLLSVD
FANELAKLQDQVPPFDSAVAIGIIEKSLGAPVDELFDEFEREPIASASIAQVHFAKLKQGQHAGKAVAVKVLRPNMLSVI
DSDLALMRDIAIWTERMWADGRRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMFWDFSTSQVLVM
ERMTGVPISQVETLRSAGVDIKKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPNTFGRYVALDFGIVGALSDFDKN
YLAQNFLAFFKRDYHRVATLHLESGWVPPETRVEELESAIRAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLV
LLQKTMLNVEGLGRSLDPELDLWKTAKPYLERWMTEQIGLRGWYERFKVEAPQWSKTLPQLPRLIHHAMAARHDAPRAAS
EDLMRQILVEQKRTNRLLQALLIFGLAVGVGALVARVLILLAYGA
>Mature_525_residues
MRIFRFIKIVYTVIRFGLDEVMLSRIDDRRVKLLLRITTIGRRYSDPPAVRLRHALESLGPIFVKFGQVLSTRRDLLSVD
FANELAKLQDQVPPFDSAVAIGIIEKSLGAPVDELFDEFEREPIASASIAQVHFAKLKQGQHAGKAVAVKVLRPNMLSVI
DSDLALMRDIAIWTERMWADGRRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMFWDFSTSQVLVM
ERMTGVPISQVETLRSAGVDIKKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPNTFGRYVALDFGIVGALSDFDKN
YLAQNFLAFFKRDYHRVATLHLESGWVPPETRVEELESAIRAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLV
LLQKTMLNVEGLGRSLDPELDLWKTAKPYLERWMTEQIGLRGWYERFKVEAPQWSKTLPQLPRLIHHAMAARHDAPRAAS
EDLMRQILVEQKRTNRLLQALLIFGLAVGVGALVARVLILLAYGA

Specific function: Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis [H]

COG id: COG0661

COG function: function code R; Predicted unusual protein kinase

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC1 family. UbiB subfamily [H]

Homologues:

Organism=Homo sapiens, GI41393593, Length=276, Percent_Identity=31.8840579710145, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI40254938, Length=262, Percent_Identity=30.9160305343511, Blast_Score=125, Evalue=8e-29,
Organism=Homo sapiens, GI32261307, Length=390, Percent_Identity=27.9487179487179, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI217035081, Length=217, Percent_Identity=31.3364055299539, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI34147522, Length=192, Percent_Identity=27.6041666666667, Blast_Score=70, Evalue=7e-12,
Organism=Escherichia coli, GI2367309, Length=472, Percent_Identity=52.1186440677966, Blast_Score=486, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17559152, Length=278, Percent_Identity=30.2158273381295, Blast_Score=135, Evalue=6e-32,
Organism=Caenorhabditis elegans, GI32565180, Length=201, Percent_Identity=30.8457711442786, Blast_Score=68, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6325148, Length=441, Percent_Identity=27.891156462585, Blast_Score=136, Evalue=6e-33,
Organism=Saccharomyces cerevisiae, GI6323282, Length=250, Percent_Identity=28.8, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6321319, Length=238, Percent_Identity=26.0504201680672, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI22024280, Length=272, Percent_Identity=31.6176470588235, Blast_Score=135, Evalue=5e-32,
Organism=Drosophila melanogaster, GI24662575, Length=317, Percent_Identity=28.391167192429, Blast_Score=119, Evalue=5e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004147
- InterPro:   IPR011009
- InterPro:   IPR010232 [H]

Pfam domain/function: PF03109 ABC1 [H]

EC number: NA

Molecular weight: Translated: 59910; Mature: 59910

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS50011 PROTEIN_KINASE_DOM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRIFRFIKIVYTVIRFGLDEVMLSRIDDRRVKLLLRITTIGRRYSDPPAVRLRHALESLG
CHHHHHHHHHHHHHHHCHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
PIFVKFGQVLSTRRDLLSVDFANELAKLQDQVPPFDSAVAIGIIEKSLGAPVDELFDEFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCHHHHHHHHC
REPIASASIAQVHFAKLKQGQHAGKAVAVKVLRPNMLSVIDSDLALMRDIAIWTERMWAD
CCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCC
GRRLKPREVVAEFDKYLHDELDLMREAANGSQLRRNFAGLDLLLVPEMFWDFSTSQVLVM
CCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHCCCCCHHHHH
ERMTGVPISQVETLRSAGVDIKKLAREGVEIFFTQVFRDGFFHADMHPGNIQVSLDPNTF
HHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCC
GRYVALDFGIVGALSDFDKNYLAQNFLAFFKRDYHRVATLHLESGWVPPETRVEELESAI
CCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHHHHHHHHHH
RAVCEPYFDRALKDISLGQVLMRLFSTSRRFNVEIQPQLVLLQKTMLNVEGLGRSLDPEL
HHHHHHHHHHHHHHCHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCC
DLWKTAKPYLERWMTEQIGLRGWYERFKVEAPQWSKTLPQLPRLIHHAMAARHDAPRAAS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHH
EDLMRQILVEQKRTNRLLQALLIFGLAVGVGALVARVLILLAYGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 2-octaprenylphenol; O2 [C]

Specific reaction: 2 2-octaprenylphenol + O2 = 2 2-octaprenyl-6-hydroxyphenol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA