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The map label for this gene is ywrD [H]

Identifier: 78067470

GI number: 78067470

Start: 3134848

End: 3136488

Strand: Reverse

Name: ywrD [H]

Synonym: Bcep18194_A6001

Alternate gene names: 78067470

Gene position: 3136488-3134848 (Counterclockwise)

Preceding gene: 78067473

Following gene: 78067469

Centisome position: 84.9

GC content: 68.86

Gene sequence:

>1641_bases
ATGACTGGCTTCAACTGGCACAACCCGTATCCGACGACCCGCATTCCGGTGTTTGCACGCAACGTCGTGTCGACGTCGCA
CCCGCTCGCTGCGCAGGCCGGGCTGCGGATGCTGTGGAAGGGCGGCAACGCGGTCGACGCGGCGCTGGCCGCTGCCGCCG
CGCTCACGGTCGTCGAGCCCGTATCGTGCGGGCTCGGCGGCGACGCGTTCGCGCTCGTGTGGGACGGTGAGCGATTGTCC
GGGCTGAACGCGTCGGGCGTCGGGCCGGCCGCGTGGAACGTCGACTATTTCCGCAAGCGCCACGGCGAGGCGGGCAACGG
CATCGCGAACAAGCCGACGCGCGGCTGGGATACCGTCACCGTGCCGGGCGTGATCGCGGGCTGGGAAGCGCTGCATGCGA
AGTTCGGTTCGCTGCCGTTCGCGGACCTGCTCGAGCCGGCGATCGAGATCGCGGAGCGCGGCTATGCGGTGCCGCCGATC
GTCGCGCACAAGTGGGCGGCCGCGGTGCCGGAACTCAAGGGGCTGCCGGGTTTCGCGGATACCTTCATGCCGCACGGCCG
CGCACCGCAGGTGGGCGAGCGCGTGTGCCTGCCGGGCCATGCGCAGACGCTGCGCACGCTGCAGAAGGAAGGCGCCCGCG
CGTTCTACGAGGGCGTGCTCGCCGAGCGCATCGCCGCGTTCTCCCGCGAAGGCGGCGGCGCGCTGACCGCGGCCGACCTG
CATGCTTACCGGCCGGAATGGGTCGAGCCGATCGGCAAGCGCTTCGGCCGTCACACGATCCACGAGATTCCGCCGAACGG
GCAGGGCATCGCGGCGCTGATCGCGCTCGGCATCGCCGAGCACGCGGGCCTGACCGAATGGCCAGTCGATTCGGTCGACT
CGCAGCATCTGCAGATCGAGGCGATGAAGCTCGCGTTCGCCGATGTCTATCGCTACGTCGCCGATCCGCGCGCGATGGAG
GTCACCCCTGAACAGATGCTCGACGATGCGTATCTCGCCGAACGCGCGAAGCTGATCGATCCCGCGCGCGCGACGCATTT
CGGCGCCGGCCGGCCGCATTCGGGCGGCACGGTCTACCTGTCGGCGGCCGACGAGCGCGGGATGATGGTGAGCTTCATCC
AGTCGAACTACATGGGCTTCGGCTCGGGGCTCGTGGTGCCCGGCACCGGCATCGCGCTGCAGAATCGCGGGCACGGCTTC
TCGATGGATCCGGCTTCGCCGAACGTCGTCGCGGGCGGCAAGCGGCCGTTCCACACGATCATCCCGGCGTTCGTCACCGA
GGAGGTCGACGGTCGCACCGAGGCCGTGATGAGCTTCGGCGTGATGGGTGGCGACATGCAGCCGCAAGGCCACCTGCAGA
CTGTCGTGCGGATGCTTGGCTACGGGCAACAACCGCAGGCTGCCTGCGATGCGCCGCGCTGGAAGGTCAACCGCGACTTC
ACGCTCGACGTCGAGGCAACGATGAATCGCGCGACTGTCGATGCGCTGACCGCACGTGGCCATACGATCAAGTCGATCGA
CGATCCTTACATGGATTTCGGTTCGGGGCAGTTCATCTGGCGTCTCGACCGCGACGATCGCGAGCGTGGCTACGTGGCCG
CGAGCGACAGCCGGCGCGACGGTCTGGCGGCCGGTTTCTGA

Upstream 100 bases:

>100_bases
GAATTTGTGCGATTGTGCCGATCGCGCTGCAATGGCGGATTGCCCGCGCACGCGGGCGCGCGTCCGGCGCGTTCATTCAG
CTTTCGACGAGGTGGAATCG

Downstream 100 bases:

>100_bases
TGGATTGCTGCCGGCTTTCGCCGGCATGTCGTGCGCTTCGCGGGCGGCCGGATGGCCGCCCGTTTCGTTTGCGGCAGCCC
GTATCGCCGAGCGGGCGCAA

Product: gamma-glutamyltransferase 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 546; Mature: 545

Protein sequence:

>546_residues
MTGFNWHNPYPTTRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAALTVVEPVSCGLGGDAFALVWDGERLS
GLNASGVGPAAWNVDYFRKRHGEAGNGIANKPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIEIAERGYAVPPI
VAHKWAAAVPELKGLPGFADTFMPHGRAPQVGERVCLPGHAQTLRTLQKEGARAFYEGVLAERIAAFSREGGGALTAADL
HAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGLTEWPVDSVDSQHLQIEAMKLAFADVYRYVADPRAME
VTPEQMLDDAYLAERAKLIDPARATHFGAGRPHSGGTVYLSAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGHGF
SMDPASPNVVAGGKRPFHTIIPAFVTEEVDGRTEAVMSFGVMGGDMQPQGHLQTVVRMLGYGQQPQAACDAPRWKVNRDF
TLDVEATMNRATVDALTARGHTIKSIDDPYMDFGSGQFIWRLDRDDRERGYVAASDSRRDGLAAGF

Sequences:

>Translated_546_residues
MTGFNWHNPYPTTRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAALTVVEPVSCGLGGDAFALVWDGERLS
GLNASGVGPAAWNVDYFRKRHGEAGNGIANKPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIEIAERGYAVPPI
VAHKWAAAVPELKGLPGFADTFMPHGRAPQVGERVCLPGHAQTLRTLQKEGARAFYEGVLAERIAAFSREGGGALTAADL
HAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGLTEWPVDSVDSQHLQIEAMKLAFADVYRYVADPRAME
VTPEQMLDDAYLAERAKLIDPARATHFGAGRPHSGGTVYLSAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGHGF
SMDPASPNVVAGGKRPFHTIIPAFVTEEVDGRTEAVMSFGVMGGDMQPQGHLQTVVRMLGYGQQPQAACDAPRWKVNRDF
TLDVEATMNRATVDALTARGHTIKSIDDPYMDFGSGQFIWRLDRDDRERGYVAASDSRRDGLAAGF
>Mature_545_residues
TGFNWHNPYPTTRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAALTVVEPVSCGLGGDAFALVWDGERLSG
LNASGVGPAAWNVDYFRKRHGEAGNGIANKPTRGWDTVTVPGVIAGWEALHAKFGSLPFADLLEPAIEIAERGYAVPPIV
AHKWAAAVPELKGLPGFADTFMPHGRAPQVGERVCLPGHAQTLRTLQKEGARAFYEGVLAERIAAFSREGGGALTAADLH
AYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGLTEWPVDSVDSQHLQIEAMKLAFADVYRYVADPRAMEV
TPEQMLDDAYLAERAKLIDPARATHFGAGRPHSGGTVYLSAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGHGFS
MDPASPNVVAGGKRPFHTIIPAFVTEEVDGRTEAVMSFGVMGGDMQPQGHLQTVVRMLGYGQQPQAACDAPRWKVNRDFT
LDVEATMNRATVDALTARGHTIKSIDDPYMDFGSGQFIWRLDRDDRERGYVAASDSRRDGLAAGF

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=556, Percent_Identity=27.5179856115108, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI73915090, Length=556, Percent_Identity=27.5179856115108, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI73915096, Length=556, Percent_Identity=27.5179856115108, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI73915094, Length=556, Percent_Identity=27.5179856115108, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI113429324, Length=556, Percent_Identity=26.4388489208633, Blast_Score=144, Evalue=2e-34,
Organism=Homo sapiens, GI113429326, Length=568, Percent_Identity=26.9366197183099, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI109148539, Length=518, Percent_Identity=27.992277992278, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI153266885, Length=555, Percent_Identity=23.963963963964, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI153266901, Length=556, Percent_Identity=24.1007194244604, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI153266907, Length=553, Percent_Identity=24.0506329113924, Blast_Score=110, Evalue=3e-24,
Organism=Escherichia coli, GI1789856, Length=514, Percent_Identity=29.1828793774319, Blast_Score=178, Evalue=7e-46,
Organism=Caenorhabditis elegans, GI212646519, Length=516, Percent_Identity=25.5813953488372, Blast_Score=125, Evalue=7e-29,
Organism=Caenorhabditis elegans, GI72000294, Length=516, Percent_Identity=25.5813953488372, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17506189, Length=528, Percent_Identity=23.4848484848485, Blast_Score=114, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17542894, Length=567, Percent_Identity=23.9858906525573, Blast_Score=111, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI193208245, Length=511, Percent_Identity=25.0489236790607, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193208247, Length=511, Percent_Identity=25.0489236790607, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI161077878, Length=558, Percent_Identity=26.3440860215054, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24642670, Length=558, Percent_Identity=26.3440860215054, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24642666, Length=558, Percent_Identity=26.3440860215054, Blast_Score=142, Evalue=5e-34,
Organism=Drosophila melanogaster, GI45551474, Length=558, Percent_Identity=26.3440860215054, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI161077880, Length=558, Percent_Identity=26.3440860215054, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI18859741, Length=530, Percent_Identity=25.8490566037736, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI161077496, Length=516, Percent_Identity=26.937984496124, Blast_Score=115, Evalue=7e-26,
Organism=Drosophila melanogaster, GI18859893, Length=504, Percent_Identity=25, Blast_Score=113, Evalue=4e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 58605; Mature: 58474

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS00678 WD_REPEATS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGFNWHNPYPTTRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAALTVVEP
CCCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCHHEEECCCCHHHHHHHHHHHHHHHHH
VSCGLGGDAFALVWDGERLSGLNASGVGPAAWNVDYFRKRHGEAGNGIANKPTRGWDTVT
HHCCCCCCEEEEEECCCHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEE
VPGVIAGWEALHAKFGSLPFADLLEPAIEIAERGYAVPPIVAHKWAAAVPELKGLPGFAD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHCCCCCCHH
TFMPHGRAPQVGERVCLPGHAQTLRTLQKEGARAFYEGVLAERIAAFSREGGGALTAADL
HHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHH
HAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGLTEWPVDSVDSQHLQIE
HHCCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHH
AMKLAFADVYRYVADPRAMEVTPEQMLDDAYLAERAKLIDPARATHFGAGRPHSGGTVYL
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEE
SAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGHGFSMDPASPNVVAGGKRPFHTI
EECCCCCCCCEEHHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEECCCCCHHHH
IPAFVTEEVDGRTEAVMSFGVMGGDMQPQGHLQTVVRMLGYGQQPQAACDAPRWKVNRDF
HHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHCCCCCEECCCCE
TLDVEATMNRATVDALTARGHTIKSIDDPYMDFGSGQFIWRLDRDDRERGYVAASDSRRD
EEEHHHHCCHHHHHHHHHCCCEECCCCCCHHHCCCCCEEEEECCCCCCCCEEEECCCCCC
GLAAGF
CCCCCC
>Mature Secondary Structure 
TGFNWHNPYPTTRIPVFARNVVSTSHPLAAQAGLRMLWKGGNAVDAALAAAAALTVVEP
CCCCCCCCCCCCCCCHHHHHHHCCCCCHHHHHCHHEEECCCCHHHHHHHHHHHHHHHHH
VSCGLGGDAFALVWDGERLSGLNASGVGPAAWNVDYFRKRHGEAGNGIANKPTRGWDTVT
HHCCCCCCEEEEEECCCHHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCEE
VPGVIAGWEALHAKFGSLPFADLLEPAIEIAERGYAVPPIVAHKWAAAVPELKGLPGFAD
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHCCCCCCHH
TFMPHGRAPQVGERVCLPGHAQTLRTLQKEGARAFYEGVLAERIAAFSREGGGALTAADL
HHCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEHHH
HAYRPEWVEPIGKRFGRHTIHEIPPNGQGIAALIALGIAEHAGLTEWPVDSVDSQHLQIE
HHCCCHHHHHHHHHHCCCCHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCEEHH
AMKLAFADVYRYVADPRAMEVTPEQMLDDAYLAERAKLIDPARATHFGAGRPHSGGTVYL
HHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCEEEE
SAADERGMMVSFIQSNYMGFGSGLVVPGTGIALQNRGHGFSMDPASPNVVAGGKRPFHTI
EECCCCCCCCEEHHHCCCCCCCCEEECCCCEEEECCCCCCCCCCCCCCEEECCCCCHHHH
IPAFVTEEVDGRTEAVMSFGVMGGDMQPQGHLQTVVRMLGYGQQPQAACDAPRWKVNRDF
HHHHHHHCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCCHHCCCCCEECCCCE
TLDVEATMNRATVDALTARGHTIKSIDDPYMDFGSGQFIWRLDRDDRERGYVAASDSRRD
EEEHHHHCCHHHHHHHHHCCCEECCCCCCHHHCCCCCEEEEECCCCCCCCEEEECCCCCC
GLAAGF
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]