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The map label for this gene is hemF [H]

Identifier: 78067092

GI number: 78067092

Start: 2722998

End: 2723921

Strand: Direct

Name: hemF [H]

Synonym: Bcep18194_A5623

Alternate gene names: 78067092

Gene position: 2722998-2723921 (Clockwise)

Preceding gene: 78067091

Following gene: 78067093

Centisome position: 73.71

GC content: 67.21

Gene sequence:

>924_bases
ATGACCGATTCGACCTACGACGTAGCGCGCGTGCGCACGTACCTCCAGGACCTGCAGACACGCATCGCCGACGCGCTCGG
CGCGCTCGACGGCACGCCGCTCGCGACCGACGCATGGCAGCGCGGGCCGGCCGAACGCCTGCGCGGCGGCGGCTGCACGC
GGATTCTCGAAGGCGGCCGCGTGTTCGAACGCGCGGGGATCGGCTTTTCCGACGTCGCGGGCGATGCGCTGCCGCCGTCG
GCGAGCGCGGCGCGCCCGCAGCTTGCCGGCCGCGGCTTCGAGGCGCTCGGCGTGTCGCTGGTGCTGCACCCGCGCAATCC
GTACTGCCCGACCGTGCACATGAACGTGCGGATGCTGATCGCGACGAAACCGGGCGAGGAGCCCGTGTTCTGGTTCGGCG
GCGGCATGGATCTGACACCGGTTTACGGTTTCGAGGACGATGCCCGGCATTTCCACCAGACCTGCAAGGATGCGCTCGAC
CCGTTCGGCGTCGAGCTCTACCCGCGCTTCAAGAAATGGTGCGACGAGTATTTCTTCCTGAAGCACCGCAACGAGATGCG
CGGCATCGGCGGGATCTTCTTCGACGATTTTTCGGAGCCCGGTTTCGAACGCTCGTTTGACATGATGCAAAGTGTCGGCG
ACGCGTTCCTGCAGGCCTACCTGCCGATCGTCGAACGCCGCGCCGAGCTGCCGTACGGCGAGCGCGAGCGCGACTTCCAG
GCGTACCGCCGCGGCCGCTACGTCGAATTCAACCTCGTGTTCGACCGCGGCACGCTGTTCGGCCTGCAAAGCGGTGGCCG
GACCGAGTCGATCCTGATGTCGATGCCGCCGGTCGCGAACTGGCGCTATAACTGGCAACCCGAACCGGGTTCGCCGGAAG
CGCGCCTGTACAGCGACTTCATCGTGCCGCGCGACTGGATCTGA

Upstream 100 bases:

>100_bases
GCCTTCGTGCGGCGGCGGCCCCTCTGCCGGGGTTCGTTAGAATGCCCGGCAGAAGCCTTTTTTACGGCCCCCGCTTCGGG
CGAGGGCACCCAGTCCAGAC

Downstream 100 bases:

>100_bases
CCCCTGCTTCAAGAAAAGGACGCGTTTCTGGACACCACCGCCTGCCCCACCCCGCTGCCGCGTCGTATCGGCTTGCTGGG
CGGCACTTTCGACCCGATCC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MTDSTYDVARVRTYLQDLQTRIADALGALDGTPLATDAWQRGPAERLRGGGCTRILEGGRVFERAGIGFSDVAGDALPPS
ASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEEPVFWFGGGMDLTPVYGFEDDARHFHQTCKDALD
PFGVELYPRFKKWCDEYFFLKHRNEMRGIGGIFFDDFSEPGFERSFDMMQSVGDAFLQAYLPIVERRAELPYGERERDFQ
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDFIVPRDWI

Sequences:

>Translated_307_residues
MTDSTYDVARVRTYLQDLQTRIADALGALDGTPLATDAWQRGPAERLRGGGCTRILEGGRVFERAGIGFSDVAGDALPPS
ASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEEPVFWFGGGMDLTPVYGFEDDARHFHQTCKDALD
PFGVELYPRFKKWCDEYFFLKHRNEMRGIGGIFFDDFSEPGFERSFDMMQSVGDAFLQAYLPIVERRAELPYGERERDFQ
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDFIVPRDWI
>Mature_306_residues
TDSTYDVARVRTYLQDLQTRIADALGALDGTPLATDAWQRGPAERLRGGGCTRILEGGRVFERAGIGFSDVAGDALPPSA
SAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLIATKPGEEPVFWFGGGMDLTPVYGFEDDARHFHQTCKDALDP
FGVELYPRFKKWCDEYFFLKHRNEMRGIGGIFFDDFSEPGFERSFDMMQSVGDAFLQAYLPIVERRAELPYGERERDFQA
YRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDFIVPRDWI

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=312, Percent_Identity=43.2692307692308, Blast_Score=254, Evalue=6e-68,
Organism=Escherichia coli, GI1788777, Length=301, Percent_Identity=62.7906976744186, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6320249, Length=307, Percent_Identity=45.928338762215, Blast_Score=274, Evalue=1e-74,
Organism=Drosophila melanogaster, GI17864388, Length=311, Percent_Identity=46.3022508038585, Blast_Score=266, Evalue=1e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 34778; Mature: 34646

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS01021 COPROGEN_OXIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDSTYDVARVRTYLQDLQTRIADALGALDGTPLATDAWQRGPAERLRGGGCTRILEGGR
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHCCCCCHHHHCCCC
VFERAGIGFSDVAGDALPPSASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLI
EEHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEECCCCCCCEEEEEEEEEE
ATKPGEEPVFWFGGGMDLTPVYGFEDDARHFHQTCKDALDPFGVELYPRFKKWCDEYFFL
EECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KHRNEMRGIGGIFFDDFSEPGFERSFDMMQSVGDAFLQAYLPIVERRAELPYGERERDFQ
HHCCHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDF
HHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCEECCCCCCCCCCHHHHHHH
IVPRDWI
CCCCCCC
>Mature Secondary Structure 
TDSTYDVARVRTYLQDLQTRIADALGALDGTPLATDAWQRGPAERLRGGGCTRILEGGR
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHCCCHHHHCCCCCHHHHCCCC
VFERAGIGFSDVAGDALPPSASAARPQLAGRGFEALGVSLVLHPRNPYCPTVHMNVRMLI
EEHHCCCCHHHHCCCCCCCCCCCCCCHHHCCCHHHCCEEEEEECCCCCCCEEEEEEEEEE
ATKPGEEPVFWFGGGMDLTPVYGFEDDARHFHQTCKDALDPFGVELYPRFKKWCDEYFFL
EECCCCCCEEEECCCCCCCEECCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHH
KHRNEMRGIGGIFFDDFSEPGFERSFDMMQSVGDAFLQAYLPIVERRAELPYGERERDFQ
HHCCHHCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
AYRRGRYVEFNLVFDRGTLFGLQSGGRTESILMSMPPVANWRYNWQPEPGSPEARLYSDF
HHHCCCEEEEEEEEECCEEEEECCCCCCCEEEEECCCCCCCEECCCCCCCCCCHHHHHHH
IVPRDWI
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA