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The map label for this gene is prlC [H]

Identifier: 78066916

GI number: 78066916

Start: 2520762

End: 2522849

Strand: Direct

Name: prlC [H]

Synonym: Bcep18194_A5447

Alternate gene names: 78066916

Gene position: 2520762-2522849 (Clockwise)

Preceding gene: 78066915

Following gene: 78066918

Centisome position: 68.24

GC content: 66.76

Gene sequence:

>2088_bases
ATGTCCGCCAGCGCCAACACCAACCCGCTTCTCGATTTCTCGGGCCTGCCCCGCTTCGGCGAGATCCGTCCGGAACACGT
GACGCCCGCGCTCGACACGCTGCTCGAAGCCGCCAACCATGCGGTCGACACGGCAAGCGCGGCCGCGACGCCGGCAACCT
GGGCAGAAGTCGTCGAGACGGTCGAGCACGCAACGGAGCCGCTCGGTCGCGCCTGGGGCATCGTCGGCCACCTGAACGCG
GTCGCCGATACGCCCGAGCTGCGGGCCGCCTATGGCGAGAACCTGCCGCGCGTAACCGAATTCTGGTCGAGCGTCGGCCA
GAACCTCGCGCTGTACGAGAAGTACAAGGCGATCGCCGCAAGCGCCGAATACGCGACGCTGTCCACCGAACGCAAGAAGA
TCCTCGACAACGCGCTGCGCGATTTCCGCCTGTCGGGCGCCGAGTTGCCCGAGGACCAGAAGCCGCGCTTCGCCGAACTG
CAGGAACAGCAGGCCGCACTGTCGAAGGCCTTTTCCGACCACGTGCTCGACGCGACCAACGCGTACGCGTATTTCGTTCA
GGACGAAGCCGACCTGGCCGGCCTACCCGGCGACGCGATCGAGGCCGCGCGCGAAGCCGCGCAAAAGGATGCCAAGGAAG
GCTGGAAATTCACGCTGCACTTCCCGTCGTACTTCCCGGTGCTGCAATACGCGGACAACCGCGCACTGCGCGAGACGCTC
TACCGCGCCTATGCGACGCGCGCGTCGGAACTCGGGCCGCAGTACGGCGACGGCAAGGCCGAATGGGACAACACGGCGAT
CGTCGCCGATGCACTGAAGCTGCGCCGCGAAGAAGCGCTGATGCTCGGCTTCCGCAACTTCGCCGAAGTATCGCTCGCGC
CGAAGATGGCCGAATCGCCGCAGCAGGTCATCGCGTTCCTCGAGGATCTCGCAACGCGTGCGCGCCCGCACGCGGACAAG
GACTGGGACGAGCTGCGCACGTTCGCCGCGAAGGAACTCGGCCTCGCCGAACTCGCGCCGTGGGACGTCGCATTCGCAGC
CGAAAAGCTGCGCCAGCAGCGCTATGCGTTCTCGGAAAACGAGGTCAAGCAGTACTTCCCGGAGCCGGCCGCGCTGAAGG
GCCTGTTCACCGTCACCGAGACGCTGTTCGGCGTGCAGATCAAGCCGGACGACGCGCCGGTGTGGCACAAGGACGTGCGT
TTCTTCCGCGTCGAGAACCGCGACGGCTCGCTCGTCGCGCAGTTCTATCTCGACCTGTACGCGCGCGAAGGCAAGCGCGG
CGGCGCATGGATGGACGACGCGCGTTCGCGCGCGAAGCGCGGCAGCAGCGTGCAGACGCCGGTCGCCTATCTCACCTGCA
ATTTCTCGGCACCGGTCGGCGGCAAGCCCGCGTGCTTCACGCACGACGAAGTCATCACGCTGTTCCATGAGTTCGGCCAC
GGGCTGCACCACATGCTCACGCGTGTCGACGAGCTCGGCGTGTCGGGCATCAACGGCGTCGAATGGGATGCCGTCGAACT
GCCGTCGCAGTTCATGGAAAACTTCTGCTGGGAATGGGACGTGCTGTCGTCGATGTCGTCGCACGTCGACACGGGCGCCA
CGCTGCCGCGCGAGCTGTTCGACAAGATGATCGCGGCGAAGAACTTCCAGAGCGGGCTCGGCACGCTGCGCCAGATCGTG
TTCTCGATGTTCGACATGCTGCTGCACGTCGACTTCGACCCGGCGGGCGCCACCGGCGTGACCGCGTTCGCGCGCGAGAT
CAACGAACGCTATCACGTGATCCCGCAAGCCGCGTTCTCGCGCTGGCCGAACACGTTCAGCCACATCTTCGCGGGAGGCT
ACGCGGCCGGCTACTACAGCTACAAGTGGGCCGAAGTGCTGTCGGCCGACGCGTACGCGGCGTTCGAGGAAGCGGCTGCC
GCGAGCGGCAGCGTGCTCGATGCGGCGACCGGCACGCGCTATCGCCGTGAAATCCTCGAGGTCGGCGGCAGCCGCCCGGC
GATGGATTCGTTCAAGGCGTTCCGCGGCCGCGAGCCGCAGATCGATGCGCTGCTGCGCCACAACGGGATGGCCACGCCCG
CGCACTGA

Upstream 100 bases:

>100_bases
GCGCGCGATGCGCCCCAATAATGTCGATATCGGGCGCCGCGTTGCCTTGCGCGCCTTACCCTTTTCACTCCGGTTCATCC
GGCAACAGACAGGGAGTCTT

Downstream 100 bases:

>100_bases
GTGCCGCCCGGCCCTTCCGGCTGCATGCAAGCAAAGGCACCGCTTCGGCGGTGCCTTTTTTCATGGCGCGGGCGATGCGT
CGTCGAATAGCGAGAACTGC

Product: oligopeptidase A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 695; Mature: 694

Protein sequence:

>695_residues
MSASANTNPLLDFSGLPRFGEIRPEHVTPALDTLLEAANHAVDTASAAATPATWAEVVETVEHATEPLGRAWGIVGHLNA
VADTPELRAAYGENLPRVTEFWSSVGQNLALYEKYKAIAASAEYATLSTERKKILDNALRDFRLSGAELPEDQKPRFAEL
QEQQAALSKAFSDHVLDATNAYAYFVQDEADLAGLPGDAIEAAREAAQKDAKEGWKFTLHFPSYFPVLQYADNRALRETL
YRAYATRASELGPQYGDGKAEWDNTAIVADALKLRREEALMLGFRNFAEVSLAPKMAESPQQVIAFLEDLATRARPHADK
DWDELRTFAAKELGLAELAPWDVAFAAEKLRQQRYAFSENEVKQYFPEPAALKGLFTVTETLFGVQIKPDDAPVWHKDVR
FFRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGSSVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGATLPRELFDKMIAAKNFQSGLGTLRQIV
FSMFDMLLHVDFDPAGATGVTAFAREINERYHVIPQAAFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAA
ASGSVLDAATGTRYRREILEVGGSRPAMDSFKAFRGREPQIDALLRHNGMATPAH

Sequences:

>Translated_695_residues
MSASANTNPLLDFSGLPRFGEIRPEHVTPALDTLLEAANHAVDTASAAATPATWAEVVETVEHATEPLGRAWGIVGHLNA
VADTPELRAAYGENLPRVTEFWSSVGQNLALYEKYKAIAASAEYATLSTERKKILDNALRDFRLSGAELPEDQKPRFAEL
QEQQAALSKAFSDHVLDATNAYAYFVQDEADLAGLPGDAIEAAREAAQKDAKEGWKFTLHFPSYFPVLQYADNRALRETL
YRAYATRASELGPQYGDGKAEWDNTAIVADALKLRREEALMLGFRNFAEVSLAPKMAESPQQVIAFLEDLATRARPHADK
DWDELRTFAAKELGLAELAPWDVAFAAEKLRQQRYAFSENEVKQYFPEPAALKGLFTVTETLFGVQIKPDDAPVWHKDVR
FFRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGSSVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGATLPRELFDKMIAAKNFQSGLGTLRQIV
FSMFDMLLHVDFDPAGATGVTAFAREINERYHVIPQAAFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAA
ASGSVLDAATGTRYRREILEVGGSRPAMDSFKAFRGREPQIDALLRHNGMATPAH
>Mature_694_residues
SASANTNPLLDFSGLPRFGEIRPEHVTPALDTLLEAANHAVDTASAAATPATWAEVVETVEHATEPLGRAWGIVGHLNAV
ADTPELRAAYGENLPRVTEFWSSVGQNLALYEKYKAIAASAEYATLSTERKKILDNALRDFRLSGAELPEDQKPRFAELQ
EQQAALSKAFSDHVLDATNAYAYFVQDEADLAGLPGDAIEAAREAAQKDAKEGWKFTLHFPSYFPVLQYADNRALRETLY
RAYATRASELGPQYGDGKAEWDNTAIVADALKLRREEALMLGFRNFAEVSLAPKMAESPQQVIAFLEDLATRARPHADKD
WDELRTFAAKELGLAELAPWDVAFAAEKLRQQRYAFSENEVKQYFPEPAALKGLFTVTETLFGVQIKPDDAPVWHKDVRF
FRVENRDGSLVAQFYLDLYAREGKRGGAWMDDARSRAKRGSSVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGHG
LHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGATLPRELFDKMIAAKNFQSGLGTLRQIVF
SMFDMLLHVDFDPAGATGVTAFAREINERYHVIPQAAFSRWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAAA
SGSVLDAATGTRYRREILEVGGSRPAMDSFKAFRGREPQIDALLRHNGMATPAH

Specific function: May play a specific role in the degradation of signal peptides after they are released from precursor forms of secreted proteins. Can cleave N-acetyl-L-Ala(4) [H]

COG id: COG0339

COG function: function code E; Zn-dependent oligopeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M3 family [H]

Homologues:

Organism=Homo sapiens, GI4507491, Length=620, Percent_Identity=30.8064516129032, Blast_Score=291, Evalue=2e-78,
Organism=Homo sapiens, GI14149738, Length=631, Percent_Identity=30.2694136291601, Blast_Score=275, Evalue=1e-73,
Organism=Homo sapiens, GI156105687, Length=706, Percent_Identity=24.6458923512748, Blast_Score=171, Evalue=1e-42,
Organism=Escherichia coli, GI1789913, Length=686, Percent_Identity=50.5830903790087, Blast_Score=693, Evalue=0.0,
Organism=Escherichia coli, GI1787819, Length=691, Percent_Identity=29.9565846599132, Blast_Score=268, Evalue=6e-73,
Organism=Caenorhabditis elegans, GI71999758, Length=526, Percent_Identity=24.7148288973384, Blast_Score=130, Evalue=3e-30,
Organism=Saccharomyces cerevisiae, GI6319793, Length=694, Percent_Identity=28.6743515850144, Blast_Score=277, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6322715, Length=615, Percent_Identity=24.2276422764228, Blast_Score=137, Evalue=6e-33,
Organism=Drosophila melanogaster, GI21356111, Length=702, Percent_Identity=25.7834757834758, Blast_Score=233, Evalue=4e-61,
Organism=Drosophila melanogaster, GI20129717, Length=564, Percent_Identity=25.354609929078, Blast_Score=157, Evalue=2e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001567 [H]

Pfam domain/function: PF01432 Peptidase_M3 [H]

EC number: =3.4.24.70 [H]

Molecular weight: Translated: 76969; Mature: 76838

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: PS00142 ZINC_PROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSASANTNPLLDFSGLPRFGEIRPEHVTPALDTLLEAANHAVDTASAAATPATWAEVVET
CCCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VEHATEPLGRAWGIVGHLNAVADTPELRAAYGENLPRVTEFWSSVGQNLALYEKYKAIAA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
SAEYATLSTERKKILDNALRDFRLSGAELPEDQKPRFAELQEQQAALSKAFSDHVLDATN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
AYAYFVQDEADLAGLPGDAIEAAREAAQKDAKEGWKFTLHFPSYFPVLQYADNRALRETL
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCHHHHHHH
YRAYATRASELGPQYGDGKAEWDNTAIVADALKLRREEALMLGFRNFAEVSLAPKMAESP
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCH
QQVIAFLEDLATRARPHADKDWDELRTFAAKELGLAELAPWDVAFAAEKLRQQRYAFSEN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCHH
EVKQYFPEPAALKGLFTVTETLFGVQIKPDDAPVWHKDVRFFRVENRDGSLVAQFYLDLY
HHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
AREGKRGGAWMDDARSRAKRGSSVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
HHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGATLPRELF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHH
DKMIAAKNFQSGLGTLRQIVFSMFDMLLHVDFDPAGATGVTAFAREINERYHVIPQAAFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
RWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAAASGSVLDAATGTRYRREILE
HCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHH
VGGSRPAMDSFKAFRGREPQIDALLRHNGMATPAH
CCCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SASANTNPLLDFSGLPRFGEIRPEHVTPALDTLLEAANHAVDTASAAATPATWAEVVET
CCCCCCCCCCCCCCCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
VEHATEPLGRAWGIVGHLNAVADTPELRAAYGENLPRVTEFWSSVGQNLALYEKYKAIAA
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHCCCHHHHHHHHHHHH
SAEYATLSTERKKILDNALRDFRLSGAELPEDQKPRFAELQEQQAALSKAFSDHVLDATN
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
AYAYFVQDEADLAGLPGDAIEAAREAAQKDAKEGWKFTLHFPSYFPVLQYADNRALRETL
CEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCHHHHHHH
YRAYATRASELGPQYGDGKAEWDNTAIVADALKLRREEALMLGFRNFAEVSLAPKMAESP
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCH
QQVIAFLEDLATRARPHADKDWDELRTFAAKELGLAELAPWDVAFAAEKLRQQRYAFSEN
HHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHCCCHH
EVKQYFPEPAALKGLFTVTETLFGVQIKPDDAPVWHKDVRFFRVENRDGSLVAQFYLDLY
HHHHHCCCHHHHHHHHHHHHHHHCCEECCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHH
AREGKRGGAWMDDARSRAKRGSSVQTPVAYLTCNFSAPVGGKPACFTHDEVITLFHEFGH
HHCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCEECHHHHHHHHHHHHH
GLHHMLTRVDELGVSGINGVEWDAVELPSQFMENFCWEWDVLSSMSSHVDTGATLPRELF
HHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHH
DKMIAAKNFQSGLGTLRQIVFSMFDMLLHVDFDPAGATGVTAFAREINERYHVIPQAAFS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHH
RWPNTFSHIFAGGYAAGYYSYKWAEVLSADAYAAFEEAAAASGSVLDAATGTRYRREILE
HCCHHHHHHHHCCHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHHHHHH
VGGSRPAMDSFKAFRGREPQIDALLRHNGMATPAH
CCCCCCCHHHHHHHCCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1325967; 8366062; 8041620; 9278503 [H]