Click here to switch to the map view.

The map label for this gene is clpP

Identifier: 78066693

GI number: 78066693

Start: 2279654

End: 2280307

Strand: Reverse

Name: clpP

Synonym: Bcep18194_A5224

Alternate gene names: 78066693

Gene position: 2280307-2279654 (Counterclockwise)

Preceding gene: 78066694

Following gene: 78066692

Centisome position: 61.73

GC content: 63.61

Gene sequence:

>654_bases
ATGATCACTCGCGCTGAATTGCTGGACATGCTTGCTTCGAACGCGCCGCAGGGTTTCGAGGCGCAAGCGCTGGGGCTGGT
GCCGATCGTCGTCGAAACGAGCGGCCGCGGCGAGCGTTCGTACGATATCTACTCGCGCCTCCTGAAGGAGCGCCTGGTGT
TCATGGTCGGCGAAGTGAACGACCAGACCGCCAACCTCGTGGTTGCGCAGCTGCTGTTCCTCGAGAGCGAGAATCCCGAC
AAGGACATCAGCCTGTACATCAACAGCCCGGGCGGGTCGGTGTCGGCCGGCATGGCGATCTACGACACGATGCAGTTCAT
CAAGCCGGACGTGTCGACGCTGTGCATGGGCCTCGCGGCCAGCATGGGTGCGTTCCTGCTCGCGTCGGGTGCGAAGGGCA
AGCGTTTCGCGCTGCCGAACTCGCGCGTGATGATTCACCAGCCACTCGGCGGCGCGCGCGGCCAGGCATCCGACATCGAG
ATCCAGGCACGCGAAATCCTCTACCTGAAGGAGCGGCTGAACCAGTTGCTCGCGCAGCACACGGGCCAGGACGTCGAGCG
CATCGCGCGCGACACCGACCGTGATAACTTCATGTCGAGCGAGGATGCGAAGGCGTACGGGCTGATCGATCAGGTGCTGT
TGAAGCGTCCGTGA

Upstream 100 bases:

>100_bases
CGCACGCCGTTTTTACGTCAAGCGCACGGTTGCCATTAATATGGCGATTGAGCGGGCGTCTTCCTTCCGTTCAATTTTCC
ATTCGAACAAGGTTCATTGA

Downstream 100 bases:

>100_bases
GCTTAAGTGGGGTGCCGCCCCGATTCGTGCGGCGCCCCTGCGACGTCCCGAACGCCTTGAGCATCTGCGGCAAGCGCATC
CAGCCGGCTCCGGTCGCGCC

Product: ATP-dependent Clp protease proteolytic subunit

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MITRAELLDMLASNAPQGFEAQALGLVPIVVETSGRGERSYDIYSRLLKERLVFMVGEVNDQTANLVVAQLLFLESENPD
KDISLYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLASGAKGKRFALPNSRVMIHQPLGGARGQASDIE
IQAREILYLKERLNQLLAQHTGQDVERIARDTDRDNFMSSEDAKAYGLIDQVLLKRP

Sequences:

>Translated_217_residues
MITRAELLDMLASNAPQGFEAQALGLVPIVVETSGRGERSYDIYSRLLKERLVFMVGEVNDQTANLVVAQLLFLESENPD
KDISLYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLASGAKGKRFALPNSRVMIHQPLGGARGQASDIE
IQAREILYLKERLNQLLAQHTGQDVERIARDTDRDNFMSSEDAKAYGLIDQVLLKRP
>Mature_217_residues
MITRAELLDMLASNAPQGFEAQALGLVPIVVETSGRGERSYDIYSRLLKERLVFMVGEVNDQTANLVVAQLLFLESENPD
KDISLYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAASMGAFLLASGAKGKRFALPNSRVMIHQPLGGARGQASDIE
IQAREILYLKERLNQLLAQHTGQDVERIARDTDRDNFMSSEDAKAYGLIDQVLLKRP

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=196, Percent_Identity=57.6530612244898, Blast_Score=243, Evalue=9e-65,
Organism=Escherichia coli, GI1786641, Length=196, Percent_Identity=69.3877551020408, Blast_Score=299, Evalue=8e-83,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=54.8387096774194, Blast_Score=220, Evalue=4e-58,
Organism=Drosophila melanogaster, GI20129427, Length=194, Percent_Identity=55.1546391752577, Blast_Score=240, Evalue=6e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23765; Mature: 23765

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITRAELLDMLASNAPQGFEAQALGLVPIVVETSGRGERSYDIYSRLLKERLVFMVGEVN
CCCHHHHHHHHHCCCCCCCCCHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
DQTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAA
CHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
SMGAFLLASGAKGKRFALPNSRVMIHQPLGGARGQASDIEIQAREILYLKERLNQLLAQH
HHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TGQDVERIARDTDRDNFMSSEDAKAYGLIDQVLLKRP
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MITRAELLDMLASNAPQGFEAQALGLVPIVVETSGRGERSYDIYSRLLKERLVFMVGEVN
CCCHHHHHHHHHCCCCCCCCCHHCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
DQTANLVVAQLLFLESENPDKDISLYINSPGGSVSAGMAIYDTMQFIKPDVSTLCMGLAA
CHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHH
SMGAFLLASGAKGKRFALPNSRVMIHQPLGGARGQASDIEIQAREILYLKERLNQLLAQH
HHHHHHHCCCCCCCEEECCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHH
TGQDVERIARDTDRDNFMSSEDAKAYGLIDQVLLKRP
CCHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA