Click here to switch to the map view.

The map label for this gene is clcA [H]

Identifier: 78065563

GI number: 78065563

Start: 1020221

End: 1021762

Strand: Reverse

Name: clcA [H]

Synonym: Bcep18194_A4091

Alternate gene names: 78065563

Gene position: 1021762-1020221 (Counterclockwise)

Preceding gene: 78065565

Following gene: 78065557

Centisome position: 27.66

GC content: 69.91

Gene sequence:

>1542_bases
ATGCAACGCCCCGCCCTTCCCGCCCTGTTTCCCGCCCTCACCCGTCGTTCGCTGAGGATCTGGCGCCAGTACGGCGTTTT
CTGGCTCGGTGCGATCGTCGTCGGCCTCACTGCCGTACTTTACGCGCGACTGATCGACTGGGGCTACGAAACCTTCCGCA
CGATGCGCGATCACGCCGCGTGGCTGCCGCTGCTGCTCACGCCGGCCATCGCCGCGGTGTCGGTATGGATCACGCGCCGC
TTCTTCCGTGGCGCCGAGGGCAGCGGTATCCCGCAGGTGATCGCGACGCTGCATGCGCGCCCGAGCGCGTTCGGCTCCCG
GCTGCTGACGCTGCGCATCCTGTTCGGCAAGGTGCTGGTGTCGTTCCTCGGCATCCTGGGCGGCTTCACGATCGGCCGCG
AAGGGCCGACCGTGCAGGTCGGCGCGGCACTGATGTTCAACCTGCGACGCTTCTACCCGCGCTCGAACGCGCAGATCGAA
CGCCAGCTGGTGCTCGCCGGCGCGGCGGCCGGGCTGTCGGCCGCGTTCAATACCCCACTCGCCGGGATCGTGTTCGCGAT
CGAGGAGCTGACGCGCAGCTTCTCCGCGCGCGCCAGCGGCGTGCTGATCACCGCGATCATCCTCGCCGGCGTCGTCGCGC
TCGGCCTGAACGGCAACTACACGTATTTCGGCACGATCGATGCCGGCCCCCATTTCCCGAAACTGCTGGCGCTCGCCGTG
CTGGTCACCGCGATCGTCACGGGGATCGCCGGTGGCCTGTTCTGCTGGCTGCTGCTCAACACGGGGCGCTGGCTGCCCGC
GCGGCTGCTGGGCCTGTATCGCGAGCGGCCGATCACGTTCGCCGCGCTGTGCGGCTTCACGATCGCCGTCGTCGGCCTTA
TATCGGGCGGCACGACCTTCGGCAGCGGCTACGCCGAGGCGCGCGGCCTGCTCGACGGCAGCCAGCATCTGTCGGTGTTC
TATCCGTTCCTGAAGATGATTTCGATGGTCGCGTCGTACCTGCCGGGCATCCCGGGCGGGATCTTCGCGCCGTCGCTGTC
GATCGGCGCCGGGTTCGGCAACCTGCTGCACATCGTGTTCAGCAACATGAGCCTGCCGATGCTGATCGCGCTCGCGATGG
TCGGCTACATGGCGGCCGTCACGCAGTCGCCGATCACGTCGTTCGTGATCGTGATGGAGATGATCAACGGTCACGCGCTC
GTGATTTCACTGATGGCTACCGCGTTGGTGTCGAGCCGCGTGTCGCGCTTTTTCGCGCCGCCGCTCTACGAAACGCTCGC
CCAGCGCTATCTCGCGCCGCCCGTCGCGGCCGCGGAACCGGCTGCGGCCGCCGCGGCGAGCGCGACGGTGGCAACCGGCG
TCACCGAGCCGCAGGATGCGGCCGCGGCACCCGCCGATCCGCTCGACACGCTGCGCGGCGAAGCGCCGGCTGCCGCCGCG
CCGGCCGAAGGCGCAGCGCATGCCCCGGCGCCGCACGACGACGAGCCGGCCGCGGCCGGGACGAAGCGCCCGGCGCAGCC
CGGCCCGCGCGACGCTCAGTAG

Upstream 100 bases:

>100_bases
TACTTTTGCAACAAAATGCATCTCCTTTCGGGAACATTCTCGCGCCCCGCCCGCATCCGGTTCTTTTTATAATTCGATCT
TTGCCTACCGGCCCGCGTCG

Downstream 100 bases:

>100_bases
ATCACGACGGGTGCCGGCCGGTAGTACACGGGCCGGGCCGGCACGACGATGCATCCGGCCAGCGTGATCGCGACGAGCGC
GATTGCGATTGCGGTTCTTT

Product: Cl- channel, voltage gated

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 513; Mature: 513

Protein sequence:

>513_residues
MQRPALPALFPALTRRSLRIWRQYGVFWLGAIVVGLTAVLYARLIDWGYETFRTMRDHAAWLPLLLTPAIAAVSVWITRR
FFRGAEGSGIPQVIATLHARPSAFGSRLLTLRILFGKVLVSFLGILGGFTIGREGPTVQVGAALMFNLRRFYPRSNAQIE
RQLVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTIDAGPHFPKLLALAV
LVTAIVTGIAGGLFCWLLLNTGRWLPARLLGLYRERPITFAALCGFTIAVVGLISGGTTFGSGYAEARGLLDGSQHLSVF
YPFLKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHIVFSNMSLPMLIALAMVGYMAAVTQSPITSFVIVMEMINGHAL
VISLMATALVSSRVSRFFAPPLYETLAQRYLAPPVAAAEPAAAAAASATVATGVTEPQDAAAAPADPLDTLRGEAPAAAA
PAEGAAHAPAPHDDEPAAAGTKRPAQPGPRDAQ

Sequences:

>Translated_513_residues
MQRPALPALFPALTRRSLRIWRQYGVFWLGAIVVGLTAVLYARLIDWGYETFRTMRDHAAWLPLLLTPAIAAVSVWITRR
FFRGAEGSGIPQVIATLHARPSAFGSRLLTLRILFGKVLVSFLGILGGFTIGREGPTVQVGAALMFNLRRFYPRSNAQIE
RQLVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTIDAGPHFPKLLALAV
LVTAIVTGIAGGLFCWLLLNTGRWLPARLLGLYRERPITFAALCGFTIAVVGLISGGTTFGSGYAEARGLLDGSQHLSVF
YPFLKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHIVFSNMSLPMLIALAMVGYMAAVTQSPITSFVIVMEMINGHAL
VISLMATALVSSRVSRFFAPPLYETLAQRYLAPPVAAAEPAAAAAASATVATGVTEPQDAAAAPADPLDTLRGEAPAAAA
PAEGAAHAPAPHDDEPAAAGTKRPAQPGPRDAQ
>Mature_513_residues
MQRPALPALFPALTRRSLRIWRQYGVFWLGAIVVGLTAVLYARLIDWGYETFRTMRDHAAWLPLLLTPAIAAVSVWITRR
FFRGAEGSGIPQVIATLHARPSAFGSRLLTLRILFGKVLVSFLGILGGFTIGREGPTVQVGAALMFNLRRFYPRSNAQIE
RQLVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTIDAGPHFPKLLALAV
LVTAIVTGIAGGLFCWLLLNTGRWLPARLLGLYRERPITFAALCGFTIAVVGLISGGTTFGSGYAEARGLLDGSQHLSVF
YPFLKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHIVFSNMSLPMLIALAMVGYMAAVTQSPITSFVIVMEMINGHAL
VISLMATALVSSRVSRFFAPPLYETLAQRYLAPPVAAAEPAAAAAASATVATGVTEPQDAAAAPADPLDTLRGEAPAAAA
PAEGAAHAPAPHDDEPAAAGTKRPAQPGPRDAQ

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=443, Percent_Identity=28.8939051918736, Blast_Score=82, Evalue=6e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 53873; Mature: 53873

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRPALPALFPALTRRSLRIWRQYGVFWLGAIVVGLTAVLYARLIDWGYETFRTMRDHAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPLLLTPAIAAVSVWITRRFFRGAEGSGIPQVIATLHARPSAFGSRLLTLRILFGKVLV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SFLGILGGFTIGREGPTVQVGAALMFNLRRFYPRSNAQIERQLVLAGAAAGLSAAFNTPL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCH
AGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTIDAGPHFPKLLALAV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
LVTAIVTGIAGGLFCWLLLNTGRWLPARLLGLYRERPITFAALCGFTIAVVGLISGGTTF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
GSGYAEARGLLDGSQHLSVFYPFLKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHIVF
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHCCCHHHHHHHHH
SNMSLPMLIALAMVGYMAAVTQSPITSFVIVMEMINGHALVISLMATALVSSRVSRFFAP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
PLYETLAQRYLAPPVAAAEPAAAAAASATVATGVTEPQDAAAAPADPLDTLRGEAPAAAA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCC
PAEGAAHAPAPHDDEPAAAGTKRPAQPGPRDAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MQRPALPALFPALTRRSLRIWRQYGVFWLGAIVVGLTAVLYARLIDWGYETFRTMRDHAA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPLLLTPAIAAVSVWITRRFFRGAEGSGIPQVIATLHARPSAFGSRLLTLRILFGKVLV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
SFLGILGGFTIGREGPTVQVGAALMFNLRRFYPRSNAQIERQLVLAGAAAGLSAAFNTPL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCH
AGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTIDAGPHFPKLLALAV
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHH
LVTAIVTGIAGGLFCWLLLNTGRWLPARLLGLYRERPITFAALCGFTIAVVGLISGGTTF
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCC
GSGYAEARGLLDGSQHLSVFYPFLKMISMVASYLPGIPGGIFAPSLSIGAGFGNLLHIVF
CCCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHCCCHHHHHHHHH
SNMSLPMLIALAMVGYMAAVTQSPITSFVIVMEMINGHALVISLMATALVSSRVSRFFAP
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCC
PLYETLAQRYLAPPVAAAEPAAAAAASATVATGVTEPQDAAAAPADPLDTLRGEAPAAAA
HHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCCCC
PAEGAAHAPAPHDDEPAAAGTKRPAQPGPRDAQ
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA