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The map label for this gene is serS [H]

Identifier: 78065554

GI number: 78065554

Start: 1010672

End: 1011973

Strand: Direct

Name: serS [H]

Synonym: Bcep18194_A4082

Alternate gene names: 78065554

Gene position: 1010672-1011973 (Clockwise)

Preceding gene: 78065552

Following gene: 78065555

Centisome position: 27.36

GC content: 66.36

Gene sequence:

>1302_bases
ATGCTCGACATCCAGTTGCTGCGCAAAGACCTCGACGGCGTCGCCCAGCGCCTCGCCGATCGCGGCTACACCCTCGACGT
CGCCGCGTTTTCCGCCCTCGAAGCGGAACGCCGCGCGATCCAGACCCGCACCGAAGAGCTCCAGGCGCGCCGCAACAGCC
TGTCGAAGCAGATCGGCGCGATGAAGGGGAAGGGCGAGGACACGTCGGCCGTGATGGCCGAGGTCGGCGGGATCGGCGAC
GAAATGAAGGCGGGAGAGGCCAAGCTCGGCGAAATCCAGGCGCGCCTGTCCGACCTGATGCTGGGCATGCCGAACGTCGC
GCATGAAAGCGTGCCGGTCGGCAAGGACGAAGCCGACAACGTCGAGGCGCGCCGCTGGGGCACGCCGCGCCAGTTCGATT
TCGAAGTGAAGGATCACGTCGACGTCGGCACGCCGCTCGGCCTCGATTTCGAAACCGGCGCGAAGCTCGCCGGCGCGCGC
TTCACGATGCTGCGCGGCTCGATCGCACGCCTGCACCGCGCGCTCGCGCAGTTCATGATCGACACGCACACGCTGCAGCA
CGGCTATACCGAGACGTATACGCCGTACATCGTGAACCCCGAGATCCTGTACGGCACGGGCCAGTTGCCGAAGTTCGCGG
ACGACATGTTCCGCGTCGAGAAGGGCGGCGAGGAGAACAAGGTCACGCAATACCTGATCTCCACGTCGGAAATCTCGCTG
ACGAACACCGTGCGCGAGTCGATCGTCGACGCGTCCGCGCTGCCGATCAAGCTGACCGCGCATTCCCCGTGCTTCCGCTC
GGAAGCCGGTTCGTACGGCCGCGACACGCGCGGCATGATCCGCCAGCACCAGTTCGACAAGGTCGAGATGGTGCAGGTTG
TCGCACCGGAAGCGTCGTACGCGGCGCTCGACGAGATGGTCGGCCATGCGGAAGCGATCCTGCAGAAGCTCGGCCTGCCG
TACCGCGTGATCACGCTGTGCACGGGCGACATGGGCTTCTCGGCGGCGAAGACGTTCGACCTCGAAGTGTGGCTGCCTGC
GCAGAACACCTATCGCGAGATCTCGAGCTGCTCGAACACCGAAGCGTTCCAGGCGCGCCGGATGCAGGCGCGTTTCCGCA
ACGCGCAGGGCAAGCCCGAGCTCGTGCATACGCTGAACGGTTCGGGTCTCGCGGTCGGCCGCACGCTCGTCGCGGTTCTG
GAGAACTACCAGAACGCGGACGGTTCGGTCACGGTGCCGGAAGCGCTGCGTCCGTACATGGGCGGCATCGAGCGCATCGA
CGCGCCGGCACAGGCGTCGTAA

Upstream 100 bases:

>100_bases
GTCATCGCCCGTTTGCAGCATAGTCCGTCCGGCCAGTGCCGTGGCGGCCCCGCGGTGCGTTAGAATTCCCGTCTTACACA
ACGATTCTCCAAGTCCTCCC

Downstream 100 bases:

>100_bases
GCGCGCGTTCCGGCAAACTCTCGAATGCCCCGCAAAAAATTTGCAAAAAGGGCTTGTGAGAGGCGAAGAGATCGTTCTAT
AATCTTTTCTTTCGCGGAAA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 433; Mature: 433

Protein sequence:

>433_residues
MLDIQLLRKDLDGVAQRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGKGEDTSAVMAEVGGIGD
EMKAGEAKLGEIQARLSDLMLGMPNVAHESVPVGKDEADNVEARRWGTPRQFDFEVKDHVDVGTPLGLDFETGAKLAGAR
FTMLRGSIARLHRALAQFMIDTHTLQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGEENKVTQYLISTSEISL
TNTVRESIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPEASYAALDEMVGHAEAILQKLGLP
YRVITLCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEALRPYMGGIERIDAPAQAS

Sequences:

>Translated_433_residues
MLDIQLLRKDLDGVAQRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGKGEDTSAVMAEVGGIGD
EMKAGEAKLGEIQARLSDLMLGMPNVAHESVPVGKDEADNVEARRWGTPRQFDFEVKDHVDVGTPLGLDFETGAKLAGAR
FTMLRGSIARLHRALAQFMIDTHTLQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGEENKVTQYLISTSEISL
TNTVRESIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPEASYAALDEMVGHAEAILQKLGLP
YRVITLCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEALRPYMGGIERIDAPAQAS
>Mature_433_residues
MLDIQLLRKDLDGVAQRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGAMKGKGEDTSAVMAEVGGIGD
EMKAGEAKLGEIQARLSDLMLGMPNVAHESVPVGKDEADNVEARRWGTPRQFDFEVKDHVDVGTPLGLDFETGAKLAGAR
FTMLRGSIARLHRALAQFMIDTHTLQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGEENKVTQYLISTSEISL
TNTVRESIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPEASYAALDEMVGHAEAILQKLGLP
YRVITLCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNTEAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVL
ENYQNADGSVTVPEALRPYMGGIERIDAPAQAS

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=469, Percent_Identity=32.8358208955224, Blast_Score=230, Evalue=2e-60,
Organism=Homo sapiens, GI8923421, Length=419, Percent_Identity=29.3556085918854, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI225579074, Length=335, Percent_Identity=32.5373134328358, Blast_Score=177, Evalue=2e-44,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=63.1701631701632, Blast_Score=563, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17539260, Length=335, Percent_Identity=36.4179104477612, Blast_Score=228, Evalue=6e-60,
Organism=Caenorhabditis elegans, GI17542084, Length=366, Percent_Identity=31.4207650273224, Blast_Score=159, Evalue=2e-39,
Organism=Saccharomyces cerevisiae, GI6320226, Length=449, Percent_Identity=31.1804008908686, Blast_Score=211, Evalue=1e-55,
Organism=Saccharomyces cerevisiae, GI6321799, Length=386, Percent_Identity=30.3108808290155, Blast_Score=189, Evalue=1e-48,
Organism=Drosophila melanogaster, GI24581334, Length=468, Percent_Identity=33.3333333333333, Blast_Score=221, Evalue=9e-58,
Organism=Drosophila melanogaster, GI17737985, Length=362, Percent_Identity=30.939226519337, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47488; Mature: 47488

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIQLLRKDLDGVAQRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGKGEDTSAVMAEVGGIGDEMKAGEAKLGEIQARLSDLMLGMPNVAHESVPVGKDEADN
CCCCCCCHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEARRWGTPRQFDFEVKDHVDVGTPLGLDFETGAKLAGARFTMLRGSIARLHRALAQFMI
CHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DTHTLQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGEENKVTQYLISTSEISL
HHHHHHCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCHH
TNTVRESIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPEASY
HHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHEECCCHHH
AALDEMVGHAEAILQKLGLPYRVITLCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCCCH
EAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPEALRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHHH
GGIERIDAPAQAS
CCHHHCCCCCCCC
>Mature Secondary Structure
MLDIQLLRKDLDGVAQRLADRGYTLDVAAFSALEAERRAIQTRTEELQARRNSLSKQIGA
CCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MKGKGEDTSAVMAEVGGIGDEMKAGEAKLGEIQARLSDLMLGMPNVAHESVPVGKDEADN
CCCCCCCHHHHHHHHCCCCCHHCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
VEARRWGTPRQFDFEVKDHVDVGTPLGLDFETGAKLAGARFTMLRGSIARLHRALAQFMI
CHHHHCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
DTHTLQHGYTETYTPYIVNPEILYGTGQLPKFADDMFRVEKGGEENKVTQYLISTSEISL
HHHHHHCCCCCCCCCEEECCEEEECCCCCCHHHHHHHHHHCCCCHHHHHHHHHCCCCCHH
TNTVRESIVDASALPIKLTAHSPCFRSEAGSYGRDTRGMIRQHQFDKVEMVQVVAPEASY
HHHHHHHHHCCCCCEEEEECCCCCHHHCCCCCCCCHHHHHHHHCCCHHHHHHEECCCHHH
AALDEMVGHAEAILQKLGLPYRVITLCTGDMGFSAAKTFDLEVWLPAQNTYREISSCSNT
HHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCEEEEEEEEECCHHHHHHHHCCCCH
EAFQARRMQARFRNAQGKPELVHTLNGSGLAVGRTLVAVLENYQNADGSVTVPEALRPYM
HHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHCCCCCCEECHHHHHHHH
GGIERIDAPAQAS
CCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA