Click here to switch to the map view.

The map label for this gene is mmcD [H]

Identifier: 78065512

GI number: 78065512

Start: 965785

End: 966594

Strand: Direct

Name: mmcD [H]

Synonym: Bcep18194_A4040

Alternate gene names: 78065512

Gene position: 965785-966594 (Clockwise)

Preceding gene: 78065511

Following gene: 78065516

Centisome position: 26.14

GC content: 70.86

Gene sequence:

>810_bases
ATGAGCGACACGACGAAACACGACAGCGCGTCGCACGTGACGGTCGACATGGTCGGCGAGCGGATCGCGCGTGTGCGGTT
CGCGAATCCGGCGCGACGCCATGCGCTCGACGCGCCATTGCTCGATGCGCTCGTCGCGTGCCTCGACGCGCTGGCCGAAC
ACCGTCCGCCGCCCGTCGTGATCCTGTCGAACGACGGCAGCGGCGACGTGTGGAGTGCGGGGCACGACCTGCGAGAACTG
GCCGACGATCGCGATCCGCTTGCGTACGGCAAGCCGCTCGAACGGGCGCTGCGACGCGTGCGGACCTACCCGGGCGCGGT
GATCGCGGCGGTGGCGGGCTCGGCGTGGGGCGGGGCGGTCGATCTGGTGATGAGCTGCGACCTGGTGGTCGCGGCGCGCG
ACGCGCGTTTCGCGATGACGCCCGCGAACATCGGCCTGCCGTATTCGACGAGCGGCCTGCTGCGCTTCTACGACAACCTG
CCGATCCACGTGCTGAAGGAGATGTTCTTCTGCGCGCAGCCGCTCGATGCGGAGCGCGCCGCGCATCACGGGCTCGTGAA
CCGGCTGGCCGACGCGGGCGGTGTCGACGATGCGGCGCTCGACGTTGCGCGCACGATTGCTGCGAAGGCGCCGCTCGCGG
TGCACGCGGTGAAGGAGCAGTTGCGCGTGCTGCAGGACGCGCGGCCGTTGCCGGCCGACGCTTTCGAACGGATTGCCGAG
CTGCGCCGGCAAGCGTGCGAAGGCGCGGACTTCAGCGAAGGGTTGCGCGCGTTTGCGGCGCGCCGCGCGCCGGTGTTTCG
CGGCGTCTAG

Upstream 100 bases:

>100_bases
TCGACGTGCTGCGCGAAGCGGGCTATGGCGACGACGCGATCGACACACTGCTGGCCGAGCGCGCGATCTTCCAGGCGGAA
GCCGTGGCGGAGGCCGTGCA

Downstream 100 bases:

>100_bases
GCGACGGGTTGCGCGAGCCGGGCGCACAAGCGGCTGACAGCGTGCGGAGGCGCTCGCGCCGCTGGGCGGATATCGGCTGC
GTCGTTCGCGGCCGCCCGCG

Product: methylmalonyl-CoA decarboxylase

Products: NA

Alternate protein names: MMCD; Transcarboxylase [H]

Number of amino acids: Translated: 269; Mature: 268

Protein sequence:

>269_residues
MSDTTKHDSASHVTVDMVGERIARVRFANPARRHALDAPLLDALVACLDALAEHRPPPVVILSNDGSGDVWSAGHDLREL
ADDRDPLAYGKPLERALRRVRTYPGAVIAAVAGSAWGGAVDLVMSCDLVVAARDARFAMTPANIGLPYSTSGLLRFYDNL
PIHVLKEMFFCAQPLDAERAAHHGLVNRLADAGGVDDAALDVARTIAAKAPLAVHAVKEQLRVLQDARPLPADAFERIAE
LRRQACEGADFSEGLRAFAARRAPVFRGV

Sequences:

>Translated_269_residues
MSDTTKHDSASHVTVDMVGERIARVRFANPARRHALDAPLLDALVACLDALAEHRPPPVVILSNDGSGDVWSAGHDLREL
ADDRDPLAYGKPLERALRRVRTYPGAVIAAVAGSAWGGAVDLVMSCDLVVAARDARFAMTPANIGLPYSTSGLLRFYDNL
PIHVLKEMFFCAQPLDAERAAHHGLVNRLADAGGVDDAALDVARTIAAKAPLAVHAVKEQLRVLQDARPLPADAFERIAE
LRRQACEGADFSEGLRAFAARRAPVFRGV
>Mature_268_residues
SDTTKHDSASHVTVDMVGERIARVRFANPARRHALDAPLLDALVACLDALAEHRPPPVVILSNDGSGDVWSAGHDLRELA
DDRDPLAYGKPLERALRRVRTYPGAVIAAVAGSAWGGAVDLVMSCDLVVAARDARFAMTPANIGLPYSTSGLLRFYDNLP
IHVLKEMFFCAQPLDAERAAHHGLVNRLADAGGVDDAALDVARTIAAKAPLAVHAVKEQLRVLQDARPLPADAFERIAEL
RRQACEGADFSEGLRAFAARRAPVFRGV

Specific function: Unknown

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI31542718, Length=251, Percent_Identity=28.6852589641434, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI70995211, Length=261, Percent_Identity=26.8199233716475, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI194097323, Length=246, Percent_Identity=23.9837398373984, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI87082183, Length=262, Percent_Identity=37.4045801526718, Blast_Score=192, Evalue=2e-50,
Organism=Escherichia coli, GI1787659, Length=249, Percent_Identity=28.9156626506024, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI221142681, Length=213, Percent_Identity=32.3943661971831, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17554946, Length=254, Percent_Identity=27.1653543307087, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI17540714, Length=223, Percent_Identity=26.9058295964126, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17540306, Length=242, Percent_Identity=29.3388429752066, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17534483, Length=237, Percent_Identity=27.0042194092827, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25145438, Length=255, Percent_Identity=27.4509803921569, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17536985, Length=233, Percent_Identity=25.7510729613734, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24653139, Length=253, Percent_Identity=26.0869565217391, Blast_Score=78, Evalue=7e-15,
Organism=Drosophila melanogaster, GI19922422, Length=242, Percent_Identity=26.8595041322314, Blast_Score=75, Evalue=4e-14,
Organism=Drosophila melanogaster, GI20129971, Length=269, Percent_Identity=23.4200743494424, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24653477, Length=269, Percent_Identity=23.4200743494424, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI19920382, Length=216, Percent_Identity=28.7037037037037, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: =4.1.1.41 [H]

Molecular weight: Translated: 28919; Mature: 28788

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTTKHDSASHVTVDMVGERIARVRFANPARRHALDAPLLDALVACLDALAEHRPPPVV
CCCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEE
ILSNDGSGDVWSAGHDLRELADDRDPLAYGKPLERALRRVRTYPGAVIAAVAGSAWGGAV
EEECCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHH
DLVMSCDLVVAARDARFAMTPANIGLPYSTSGLLRFYDNLPIHVLKEMFFCAQPLDAERA
HHHHHCCEEEEECCCCEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCHHHH
AHHGLVNRLADAGGVDDAALDVARTIAAKAPLAVHAVKEQLRVLQDARPLPADAFERIAE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LRRQACEGADFSEGLRAFAARRAPVFRGV
HHHHHHCCCCHHHHHHHHHHHCCCHHCCC
>Mature Secondary Structure 
SDTTKHDSASHVTVDMVGERIARVRFANPARRHALDAPLLDALVACLDALAEHRPPPVV
CCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEE
ILSNDGSGDVWSAGHDLRELADDRDPLAYGKPLERALRRVRTYPGAVIAAVAGSAWGGAV
EEECCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHCCCCCHHH
DLVMSCDLVVAARDARFAMTPANIGLPYSTSGLLRFYDNLPIHVLKEMFFCAQPLDAERA
HHHHHCCEEEEECCCCEEECCCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHCCCCCHHHH
AHHGLVNRLADAGGVDDAALDVARTIAAKAPLAVHAVKEQLRVLQDARPLPADAFERIAE
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
LRRQACEGADFSEGLRAFAARRAPVFRGV
HHHHHHCCCCHHHHHHHHHHHCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9278503 [H]