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The map label for this gene is hemN [H]

Identifier: 78065490

GI number: 78065490

Start: 943068

End: 944459

Strand: Reverse

Name: hemN [H]

Synonym: Bcep18194_A4018

Alternate gene names: 78065490

Gene position: 944459-943068 (Counterclockwise)

Preceding gene: 78065494

Following gene: 78065489

Centisome position: 25.57

GC content: 67.96

Gene sequence:

>1392_bases
ATGCGTTCAGGTTCTGCCGACACACTGTTCCGTCCCGATTTGCTCGCGAAGTACGGCGCGAACGGGCCGCGCTATACGTC
GTACCCCACCGCGCTCCAGTTCCGCGACGATTTCGACCCGGCCGACTATTTGCGCGCCGCGAGCGACCCCGGCGCATCGT
CGAGCGAGCTGTCGCTGTACTTCCACATTCCGTTCTGCAACACCGCGTGCTTCTACTGCGGCTGCAACAAGATCGCGACC
AACAACCACCGCCGCGCGCGCCCGTATCTCGACCAGCTCAAGCGCGAGATGGCGCTGCAGGCCGCGCTGTTCGATCCCGC
GCGCCCGGTCACGCAACTGCACTGGGGCGGCGGCACGCCTACCTTCCTGTCCGACGACGAAACGGCCGAGCTGATGGCGG
CCACGCGCGAGCACTTCGCGCTCGCGCCGGATGCCGACGCCGAGTTCTCGATCGAGATCGACCCGCGCACGGTCACGCCC
GCGACGCTCGTCCACCTGCGCACCATCGGCTTCAACCGGCTGAGCCTCGGCGTGCAGGATTTCGATCCGGTCGTGCAGCA
GGCGATCAACCGCATCCAGCCGCTCGCGATGACGGCCGACCTGCTCTCCGCCGCGCGCACGACGGGCTTTCATTCGGTCA
GCGTCGACCTGATCTACGGGCTGCCGCACCAGACCGTGTCCGTATTCGCGCGCACGCTCGAAACGATCATCGAACTCGCG
CCCGACCGGCTGTCGGTGTTCGGCTACGCGCACATGCCGCACCTGTTCAAGATGCAGCGTCAGATCGACGACGCGACGCT
GCCGCCGCCGGAAACGCGCATCGCGCTGCTCGGCCTCGCGATCGACATGCTGACGTCGGCCGGCTACGTGTACATCGGGA
TGGACCACTTCGCGCGGCCGTCCGACGAACTCGTGCGCGCGCAGAAGAACGGCACGCTGCAGCGCAATTTCCAGGGCTAC
AGCACGCGTGCGGATACCGATCTCGTCGGGTTCGGCGTGTCGTCGATCGGCAAGGTCGGCGACGTCTACGCGCAGAACGC
GAAAGACCTGCCCGCCTACGGCGCCGCGCTCGACGCGGGCCGGCTGCCGATCGCGCGCGGCGTGCGGCTCACGCCCGACG
ACCGGCTGCGCCGCGACGTGATCACGCAACTGATGTGCAACCTCGACCTGCCGTTCTCGCATGTCGAGGCCGCGCACGGC
ATCCGCTTCGCCGATCATTTCGCGCGCGAACTCGACGCGCTGCGCCCGTTCGAGCGGGACGGGCTGCTGACGATCGCGGC
CGACCGCCTGACGATCCACCCGGCCGGCCGGATGGTCGTGCGCAACATCGCGATGGCGTTCGACGCGTATCTCGGCCAGA
CGCAGCAGCAGCGCTATTCGCGCACGGTCTAG

Upstream 100 bases:

>100_bases
CCACTCCGCATTGTGCCATCCCCGGCTGCGACGTTATTACACAATGCAGCCGAATCGCGCGTTTATATACTCGAAAGCAT
CTAAAAAGCGCGAGGTTGTC

Downstream 100 bases:

>100_bases
GGCCAGACGGCTCCCAGGCCACCGGCCGCACGCGGGCGGCCGGTTTGATACAGTGTGGGGCTTACGCCCCGCCAGATTCC
GCACGATGCGCACCACCAAA

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 463; Mature: 463

Protein sequence:

>463_residues
MRSGSADTLFRPDLLAKYGANGPRYTSYPTALQFRDDFDPADYLRAASDPGASSSELSLYFHIPFCNTACFYCGCNKIAT
NNHRRARPYLDQLKREMALQAALFDPARPVTQLHWGGGTPTFLSDDETAELMAATREHFALAPDADAEFSIEIDPRTVTP
ATLVHLRTIGFNRLSLGVQDFDPVVQQAINRIQPLAMTADLLSAARTTGFHSVSVDLIYGLPHQTVSVFARTLETIIELA
PDRLSVFGYAHMPHLFKMQRQIDDATLPPPETRIALLGLAIDMLTSAGYVYIGMDHFARPSDELVRAQKNGTLQRNFQGY
STRADTDLVGFGVSSIGKVGDVYAQNAKDLPAYGAALDAGRLPIARGVRLTPDDRLRRDVITQLMCNLDLPFSHVEAAHG
IRFADHFARELDALRPFERDGLLTIAADRLTIHPAGRMVVRNIAMAFDAYLGQTQQQRYSRTV

Sequences:

>Translated_463_residues
MRSGSADTLFRPDLLAKYGANGPRYTSYPTALQFRDDFDPADYLRAASDPGASSSELSLYFHIPFCNTACFYCGCNKIAT
NNHRRARPYLDQLKREMALQAALFDPARPVTQLHWGGGTPTFLSDDETAELMAATREHFALAPDADAEFSIEIDPRTVTP
ATLVHLRTIGFNRLSLGVQDFDPVVQQAINRIQPLAMTADLLSAARTTGFHSVSVDLIYGLPHQTVSVFARTLETIIELA
PDRLSVFGYAHMPHLFKMQRQIDDATLPPPETRIALLGLAIDMLTSAGYVYIGMDHFARPSDELVRAQKNGTLQRNFQGY
STRADTDLVGFGVSSIGKVGDVYAQNAKDLPAYGAALDAGRLPIARGVRLTPDDRLRRDVITQLMCNLDLPFSHVEAAHG
IRFADHFARELDALRPFERDGLLTIAADRLTIHPAGRMVVRNIAMAFDAYLGQTQQQRYSRTV
>Mature_463_residues
MRSGSADTLFRPDLLAKYGANGPRYTSYPTALQFRDDFDPADYLRAASDPGASSSELSLYFHIPFCNTACFYCGCNKIAT
NNHRRARPYLDQLKREMALQAALFDPARPVTQLHWGGGTPTFLSDDETAELMAATREHFALAPDADAEFSIEIDPRTVTP
ATLVHLRTIGFNRLSLGVQDFDPVVQQAINRIQPLAMTADLLSAARTTGFHSVSVDLIYGLPHQTVSVFARTLETIIELA
PDRLSVFGYAHMPHLFKMQRQIDDATLPPPETRIALLGLAIDMLTSAGYVYIGMDHFARPSDELVRAQKNGTLQRNFQGY
STRADTDLVGFGVSSIGKVGDVYAQNAKDLPAYGAALDAGRLPIARGVRLTPDDRLRRDVITQLMCNLDLPFSHVEAAHG
IRFADHFARELDALRPFERDGLLTIAADRLTIHPAGRMVVRNIAMAFDAYLGQTQQQRYSRTV

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=265, Percent_Identity=26.4150943396226, Blast_Score=87, Evalue=5e-17,
Organism=Escherichia coli, GI87082341, Length=451, Percent_Identity=49.6674057649667, Blast_Score=452, Evalue=1e-128,
Organism=Escherichia coli, GI1789325, Length=283, Percent_Identity=29.6819787985866, Blast_Score=105, Evalue=8e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51235; Mature: 51235

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRSGSADTLFRPDLLAKYGANGPRYTSYPTALQFRDDFDPADYLRAASDPGASSSELSLY
CCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCCCCCEEEE
FHIPFCNTACFYCGCNKIATNNHRRARPYLDQLKREMALQAALFDPARPVTQLHWGGGTP
EECCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCC
TFLSDDETAELMAATREHFALAPDADAEFSIEIDPRTVTPATLVHLRTIGFNRLSLGVQD
CCCCCCHHHHHHHHHHHHEEECCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEECCHHH
FDPVVQQAINRIQPLAMTADLLSAARTTGFHSVSVDLIYGLPHQTVSVFARTLETIIELA
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHC
PDRLSVFGYAHMPHLFKMQRQIDDATLPPPETRIALLGLAIDMLTSAGYVYIGMDHFARP
CCHHEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCC
SDELVRAQKNGTLQRNFQGYSTRADTDLVGFGVSSIGKVGDVYAQNAKDLPAYGAALDAG
HHHHHHHHCCCCEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RLPIARGVRLTPDDRLRRDVITQLMCNLDLPFSHVEAAHGIRFADHFARELDALRPFERD
CCCHHCCCEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
GLLTIAADRLTIHPAGRMVVRNIAMAFDAYLGQTQQQRYSRTV
CEEEEEECEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHCCC
>Mature Secondary Structure
MRSGSADTLFRPDLLAKYGANGPRYTSYPTALQFRDDFDPADYLRAASDPGASSSELSLY
CCCCCCCCCCCCHHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHCCCCCCCCCCEEEE
FHIPFCNTACFYCGCNKIATNNHRRARPYLDQLKREMALQAALFDPARPVTQLHWGGGTP
EECCCCCCCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCC
TFLSDDETAELMAATREHFALAPDADAEFSIEIDPRTVTPATLVHLRTIGFNRLSLGVQD
CCCCCCHHHHHHHHHHHHEEECCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEECCHHH
FDPVVQQAINRIQPLAMTADLLSAARTTGFHSVSVDLIYGLPHQTVSVFARTLETIIELA
HHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHC
PDRLSVFGYAHMPHLFKMQRQIDDATLPPPETRIALLGLAIDMLTSAGYVYIGMDHFARP
CCHHEEEEEHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCEEEEEHHHHCCC
SDELVRAQKNGTLQRNFQGYSTRADTDLVGFGVSSIGKVGDVYAQNAKDLPAYGAALDAG
HHHHHHHHCCCCEEECCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
RLPIARGVRLTPDDRLRRDVITQLMCNLDLPFSHVEAAHGIRFADHFARELDALRPFERD
CCCHHCCCEECCHHHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCCCCC
GLLTIAADRLTIHPAGRMVVRNIAMAFDAYLGQTQQQRYSRTV
CEEEEEECEEEECCCHHHHHHHHHHHHHHHHCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9396835 [H]