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The map label for this gene is tetR [H]

Identifier: 78065325

GI number: 78065325

Start: 758296

End: 758928

Strand: Direct

Name: tetR [H]

Synonym: Bcep18194_A3851

Alternate gene names: 78065325

Gene position: 758296-758928 (Clockwise)

Preceding gene: 78065323

Following gene: 78065328

Centisome position: 20.53

GC content: 70.46

Gene sequence:

>633_bases
ATGAAGGACACAGGGGCGCGGCTGACGCGCGACACGGTACTGCGCGCGGCGCTCGAACTGCTCGACGAAGTCGGCATCGA
CGGGCTGTCGACACGGAAGCTCGCCGAGCGGCTCGGCGTGCAGTCGCCGACGCTTTACTGGCATTTCCGGAACAAGGGCG
AACTGCTCGACGCGATGGCCGAGGCGATCATGCTCGAGCGTCACGATGCGTCGCTGCCGCGGCCGGGCGAAGCGTGGGAT
GCGTGGCTTTTAGACAACGCGCGCAGTTTCCGTCGCGCGCTGCTGGCCTATCGCGACGGCGCGCGCCTGCATGCCGGCAC
GCGGCCGCGCGCGCTGCATTTCAGCTCGATTGAACGCAAGGTTGCGCTGCTCGGCGACGCGGGTTTCGCGCCGGACGAGG
CGGTCGACGTGATGTATGCGCTGGGCCGCTTCGTGGTCGGATGGGTGCTGGAAGAGCAGGCGGAATCAAGCGACGAAGCC
GCTGCGCCGCTACCGGACGCGGCCGAGTACCCGTTGCTTGCCAAGGGCTGGGCCGCGCTGCGCGGGCGCAGCGGCGACGA
CGCGTTCGAGCGCGGCGTCGCGTGGATCGTAGACGGCGCCCGCGCGCGCCTGGCAGCGCGCGAGCGCGGCTGA

Upstream 100 bases:

>100_bases
GGACCGTGGCCAGGATGGCAATCAGGGACGGATTCAAGAGTGTGACTCTATCGGTGATAGAGTGGCGATTATTCCACAGC
TTTCCCTATCGGTGATAGAG

Downstream 100 bases:

>100_bases
CGCGGTCAGCCCGGCGTGCTGCCGTCGAGCACGCGTTCGAGCGCGTCGAGTGCGCGGGCCGTCGAGTCCGGTGCGATGCA
GTCGACGACGATCCGCTCCG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MKDTGARLTRDTVLRAALELLDEVGIDGLSTRKLAERLGVQSPTLYWHFRNKGELLDAMAEAIMLERHDASLPRPGEAWD
AWLLDNARSFRRALLAYRDGARLHAGTRPRALHFSSIERKVALLGDAGFAPDEAVDVMYALGRFVVGWVLEEQAESSDEA
AAPLPDAAEYPLLAKGWAALRGRSGDDAFERGVAWIVDGARARLAARERG

Sequences:

>Translated_210_residues
MKDTGARLTRDTVLRAALELLDEVGIDGLSTRKLAERLGVQSPTLYWHFRNKGELLDAMAEAIMLERHDASLPRPGEAWD
AWLLDNARSFRRALLAYRDGARLHAGTRPRALHFSSIERKVALLGDAGFAPDEAVDVMYALGRFVVGWVLEEQAESSDEA
AAPLPDAAEYPLLAKGWAALRGRSGDDAFERGVAWIVDGARARLAARERG
>Mature_210_residues
MKDTGARLTRDTVLRAALELLDEVGIDGLSTRKLAERLGVQSPTLYWHFRNKGELLDAMAEAIMLERHDASLPRPGEAWD
AWLLDNARSFRRALLAYRDGARLHAGTRPRALHFSSIERKVALLGDAGFAPDEAVDVMYALGRFVVGWVLEEQAESSDEA
AAPLPDAAEYPLLAKGWAALRGRSGDDAFERGVAWIVDGARARLAARERG

Specific function: TetR is the repressor of the tetracycline resistance element; its N-terminal region forms a helix-turn-helix structure and binds DNA. Binding of tetracycline to tetR reduces the repressor affinity for the tetracycline resistance gene (tetA) promoter opera

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR003012
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR004111
- InterPro:   IPR001647 [H]

Pfam domain/function: PF02909 TetR_C; PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23105; Mature: 23105

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: PS01081 HTH_TETR_1 ; PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDTGARLTRDTVLRAALELLDEVGIDGLSTRKLAERLGVQSPTLYWHFRNKGELLDAMA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHH
EAIMLERHDASLPRPGEAWDAWLLDNARSFRRALLAYRDGARLHAGTRPRALHFSSIERK
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEECHHHHHHH
VALLGDAGFAPDEAVDVMYALGRFVVGWVLEEQAESSDEAAAPLPDAAEYPLLAKGWAAL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
RGRSGDDAFERGVAWIVDGARARLAARERG
CCCCCCHHHHCCHHEEECCHHHHHHHHCCC
>Mature Secondary Structure
MKDTGARLTRDTVLRAALELLDEVGIDGLSTRKLAERLGVQSPTLYWHFRNKGELLDAMA
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCEEEEEECCCHHHHHHHH
EAIMLERHDASLPRPGEAWDAWLLDNARSFRRALLAYRDGARLHAGTRPRALHFSSIERK
HHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCCCEECHHHHHHH
VALLGDAGFAPDEAVDVMYALGRFVVGWVLEEQAESSDEAAAPLPDAAEYPLLAKGWAAL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHH
RGRSGDDAFERGVAWIVDGARARLAARERG
CCCCCCHHHHCCHHEEECCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1312499; 6310527; 3208760 [H]