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The map label for this gene is cynR [H]

Identifier: 161702967

GI number: 161702967

Start: 620612

End: 621502

Strand: Direct

Name: cynR [H]

Synonym: Bcep18194_A3730

Alternate gene names: 161702967

Gene position: 620612-621502 (Clockwise)

Preceding gene: 78065204

Following gene: 78065208

Centisome position: 16.8

GC content: 71.16

Gene sequence:

>891_bases
ATGCTACTGCGCCACATCCGCTATTTCCTGGCCGTCGCCGAGCAGCGCAGTTTCACGCGCGCGGCCGACGCGCTGCACGT
CTCGCAGCCGACGCTGTCGCAGCAGGTGCGCCAGCTCGAGGAATCGCTCGGCGTGCAGTTGTTCGACCGCTCGGGCCGCA
CGGTGCAGCTCACCGAGTTCGGCGAAGTCTATGCGCGCCATGCGCGCGCCGCGCTGCACGAGCTCGATACGGGGCAGCGC
GCGCTGCATGACGTCGCCGATCTCGGCAGCGGGTCGTTGCGGCTCGCGATGATGCCGACCTTCGCGGCCTACCTGAGCGG
CTCGCTGATCGACGCGTTCCATGCCGACTATCCGAATGTTGCGCTGTCGATCGACGCGATGCCGCAGGAACGCATCGAGG
CGTTGCTGGCCGACGACCGGCTCGACGCGGGCTTCGCGTTCATGCCGCCGCGCGCGCCGGACATCGACGCGCTGCCGCTG
TGGGACGAGCCGCTTGCGCTCGTGACGGGCCGCACGCACCGTCTCGCGCGGCGCCGCCGCGCACTGACGCCGGCCGAGCT
CGGCGGCGAGCCGCTGGTGCTGCTGAGCCGCGCGTTCGCGACGCGCGAGAGCATCGACCGGTATTTCATCGAGCACGGGG
CGCAGCCGAAGATCGCGATCGAGACGAATACGATCAGCGCGGTGCTGGAACTCGTGCGGTGCGGCCGGCTGGCGACGGTG
CTACCCGACGCGGTCGCGCGCGAGAGCGCCGACCTGTGCGCGCTGGAGATCGATCCGCCGCTGCCGGCGCGCACGGCAGC
CCTGCTGACGCGCAAGGGCGCGTACCGCAGCGTCGCGGCGCGCGCGTTCATCGAGCGTGCGCTCGCGTATCGCGATCCGT
CGGGAGGTTGA

Upstream 100 bases:

>100_bases
ATGCACGGGAACGGATGTGCGTATGATGCGGGAATCGAACCATAGCGTCCAAGACTGGATCGTTATGCACTTCATTGGTA
AAACCAATACATTGGCCGCC

Downstream 100 bases:

>100_bases
CCGGTACGACCGGGCGGTGCGCGCGGCGGGGGCCGCTCGACCGCCCGCCCGCGTTATGCGCGCGGCGTCGGGAAGAAGAT
GCCCGCGCGCTGCGCGGCGT

Product: DNA-binding transcriptional regulator CynR

Products: NA

Alternate protein names: Cyn operon transcriptional activator [H]

Number of amino acids: Translated: 296; Mature: 296

Protein sequence:

>296_residues
MLLRHIRYFLAVAEQRSFTRAADALHVSQPTLSQQVRQLEESLGVQLFDRSGRTVQLTEFGEVYARHARAALHELDTGQR
ALHDVADLGSGSLRLAMMPTFAAYLSGSLIDAFHADYPNVALSIDAMPQERIEALLADDRLDAGFAFMPPRAPDIDALPL
WDEPLALVTGRTHRLARRRRALTPAELGGEPLVLLSRAFATRESIDRYFIEHGAQPKIAIETNTISAVLELVRCGRLATV
LPDAVARESADLCALEIDPPLPARTAALLTRKGAYRSVAARAFIERALAYRDPSGG

Sequences:

>Translated_296_residues
MLLRHIRYFLAVAEQRSFTRAADALHVSQPTLSQQVRQLEESLGVQLFDRSGRTVQLTEFGEVYARHARAALHELDTGQR
ALHDVADLGSGSLRLAMMPTFAAYLSGSLIDAFHADYPNVALSIDAMPQERIEALLADDRLDAGFAFMPPRAPDIDALPL
WDEPLALVTGRTHRLARRRRALTPAELGGEPLVLLSRAFATRESIDRYFIEHGAQPKIAIETNTISAVLELVRCGRLATV
LPDAVARESADLCALEIDPPLPARTAALLTRKGAYRSVAARAFIERALAYRDPSGG
>Mature_296_residues
MLLRHIRYFLAVAEQRSFTRAADALHVSQPTLSQQVRQLEESLGVQLFDRSGRTVQLTEFGEVYARHARAALHELDTGQR
ALHDVADLGSGSLRLAMMPTFAAYLSGSLIDAFHADYPNVALSIDAMPQERIEALLADDRLDAGFAFMPPRAPDIDALPL
WDEPLALVTGRTHRLARRRRALTPAELGGEPLVLLSRAFATRESIDRYFIEHGAQPKIAIETNTISAVLELVRCGRLATV
LPDAVARESADLCALEIDPPLPARTAALLTRKGAYRSVAARAFIERALAYRDPSGG

Specific function: Positively regulates the cynTSX operon, and negatively regulates its own transcription. Binds specifically to the cynR- cynTSX intergenic region [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI157672245, Length=296, Percent_Identity=54.0540540540541, Blast_Score=298, Evalue=3e-82,
Organism=Escherichia coli, GI1790399, Length=277, Percent_Identity=30.3249097472924, Blast_Score=128, Evalue=5e-31,
Organism=Escherichia coli, GI1788887, Length=245, Percent_Identity=32.6530612244898, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1789204, Length=242, Percent_Identity=34.7107438016529, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693105, Length=284, Percent_Identity=27.8169014084507, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI87081904, Length=293, Percent_Identity=29.6928327645051, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788748, Length=287, Percent_Identity=29.9651567944251, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1787530, Length=293, Percent_Identity=28.3276450511945, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1788297, Length=255, Percent_Identity=28.6274509803922, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1788481, Length=296, Percent_Identity=27.027027027027, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1787879, Length=249, Percent_Identity=30.9236947791165, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI2367136, Length=248, Percent_Identity=29.8387096774194, Blast_Score=81, Evalue=8e-17,
Organism=Escherichia coli, GI1789173, Length=163, Percent_Identity=33.1288343558282, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI1787806, Length=288, Percent_Identity=24.6527777777778, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1787589, Length=248, Percent_Identity=29.4354838709677, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1787601, Length=122, Percent_Identity=34.4262295081967, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1789639, Length=122, Percent_Identity=32.7868852459016, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1790208, Length=124, Percent_Identity=37.9032258064516, Blast_Score=71, Evalue=8e-14,
Organism=Escherichia coli, GI1786401, Length=117, Percent_Identity=35.8974358974359, Blast_Score=68, Evalue=7e-13,
Organism=Escherichia coli, GI87082132, Length=171, Percent_Identity=30.4093567251462, Blast_Score=64, Evalue=9e-12,
Organism=Escherichia coli, GI1788296, Length=222, Percent_Identity=28.3783783783784, Blast_Score=61, Evalue=7e-11,
Organism=Escherichia coli, GI1790783, Length=139, Percent_Identity=28.0575539568345, Blast_Score=61, Evalue=8e-11,
Organism=Escherichia coli, GI145693193, Length=121, Percent_Identity=32.2314049586777, Blast_Score=61, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32499; Mature: 32499

Theoretical pI: Translated: 6.73; Mature: 6.73

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLRHIRYFLAVAEQRSFTRAADALHVSQPTLSQQVRQLEESLGVQLFDRSGRTVQLTEF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCCEEEEHHH
GEVYARHARAALHELDTGQRALHDVADLGSGSLRLAMMPTFAAYLSGSLIDAFHADYPNV
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCHHHHHHHCCCCCE
ALSIDAMPQERIEALLADDRLDAGFAFMPPRAPDIDALPLWDEPLALVTGRTHRLARRRR
EEEEECCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHH
ALTPAELGGEPLVLLSRAFATRESIDRYFIEHGAQPKIAIETNTISAVLELVRCGRLATV
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCHHHHH
LPDAVARESADLCALEIDPPLPARTAALLTRKGAYRSVAARAFIERALAYRDPSGG
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MLLRHIRYFLAVAEQRSFTRAADALHVSQPTLSQQVRQLEESLGVQLFDRSGRTVQLTEF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEEEEECCCCEEEEHHH
GEVYARHARAALHELDTGQRALHDVADLGSGSLRLAMMPTFAAYLSGSLIDAFHADYPNV
HHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEHHHHHHHHCCHHHHHHHCCCCCE
ALSIDAMPQERIEALLADDRLDAGFAFMPPRAPDIDALPLWDEPLALVTGRTHRLARRRR
EEEEECCCHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCCCHHHHCCCHHHHHHHHH
ALTPAELGGEPLVLLSRAFATRESIDRYFIEHGAQPKIAIETNTISAVLELVRCGRLATV
CCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCHHHHH
LPDAVARESADLCALEIDPPLPARTAALLTRKGAYRSVAARAFIERALAYRDPSGG
HHHHHHHCCCCEEEEECCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]