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The map label for this gene is idnD [H]

Identifier: 78065204

GI number: 78065204

Start: 617932

End: 618990

Strand: Direct

Name: idnD [H]

Synonym: Bcep18194_A3728

Alternate gene names: 78065204

Gene position: 617932-618990 (Clockwise)

Preceding gene: 78065203

Following gene: 161702967

Centisome position: 16.73

GC content: 69.88

Gene sequence:

>1059_bases
ATGCGTATGCGTTGCATGTGTGTCGTGATCCACGGGCCGAACGACCTGCGGGTGGAAGAGCAGGACGCGGGCGAGATCGG
CCCGGGCCAGGTGCGTGTCGATGTCGCGATGGGCGGCATCTGCGGCTCCGATCTCCATTACTTCCGGCACGGCGGTTTCG
GTGCGATCCGGCTGCAGCAGCCGATGGTGCTCGGCCACGAGGTGGCCGGCACGGTCGCGGAAGTGGCGCCGGACGTGACG
TCGGTGAAGGTCGGCGATCGCGTCGCGGTCAATCCGAGCCGGCCGTGCGGCGCATGCCGCTACTGCCTCGAAGGGCTGCC
GAACCAGTGTCTCGACATGCGCTTCTACGGCAGCGCGATGCGGATGCCGCACGTGCAGGGCGCGTTCCGCAATGCACTCG
TGTGCGACGCGGTGCAGTGCGTGAAGGTCGCCGATCACGTGCCGCTGTCGCTCGCGGCGCTCGCCGAACCGTTCGCGGTC
GGGCTGCACGCGGTGTCGCGCGCGGGCCCGCTGATCGGCAAGCGCGTGCTCGTGTCGGGCTGCGGGCCGATCGGCGTGCT
GGCGGTTGCGGCGGCGCGCGTGCACGGCGCGGCGGAGATCGTCGCGACCGACGTGGTCGAGGCGCCGCTCGAAGTGGCGA
GCGCGCTCGGCGCCGACCGCACGATCAATGCGGCGACCGATGCCGGCTGGGTCGAGCGTTACGCTGCCGACAAGGGCACG
TTCGACGTGATGATCGAGTGTTCGGGCAATGCGCGCGCGTTGCGCGACGGGCTGGACGTGATGCGTCCGCGCGGCGTCGT
CGTGCAGCTCGGGCTTGGCGGCGATGTCAGCCTGCCGCAGAACGTCGTGGTCGCGAAGGAGCTGTCGATCTGCGGATCGT
TCCGTTTTCATGCGGAATTCGCGCTCGCGGTGCAGCTGATCAACGCGGGGCGCGTCGACCTGCGCCCGGCCGTCACGCGC
GTGTTCCCGATGCGCGATGCGAACCTCGCGTTCGAACTGGCCGGCGACCGGCAGCGCGCGATGAAGGTGCTGATCGACTT
CGCGGACGAGGCTGCATGA

Upstream 100 bases:

>100_bases
ATCGAGACGCGCCAGGCGATGGGCTGGCTCGTGCGCGACAACCTTGCCGCGCACTTCGCCGGTGCGCCGCTGGTCACGCC
GGTCGTCTGAGGAGGCTGTC

Downstream 100 bases:

>100_bases
TCGTGAGGCGCTGACGCACGACGGTATCCGCGTCATGAAAAAAGGCACGCCCGCGGTTCGCGCGGCGTGCCTTTTTTGCG
TCGTACTGCGGAAACGGACT

Product: zinc-containing alcohol dehydrogenase superfamily protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MRMRCMCVVIHGPNDLRVEEQDAGEIGPGQVRVDVAMGGICGSDLHYFRHGGFGAIRLQQPMVLGHEVAGTVAEVAPDVT
SVKVGDRVAVNPSRPCGACRYCLEGLPNQCLDMRFYGSAMRMPHVQGAFRNALVCDAVQCVKVADHVPLSLAALAEPFAV
GLHAVSRAGPLIGKRVLVSGCGPIGVLAVAAARVHGAAEIVATDVVEAPLEVASALGADRTINAATDAGWVERYAADKGT
FDVMIECSGNARALRDGLDVMRPRGVVVQLGLGGDVSLPQNVVVAKELSICGSFRFHAEFALAVQLINAGRVDLRPAVTR
VFPMRDANLAFELAGDRQRAMKVLIDFADEAA

Sequences:

>Translated_352_residues
MRMRCMCVVIHGPNDLRVEEQDAGEIGPGQVRVDVAMGGICGSDLHYFRHGGFGAIRLQQPMVLGHEVAGTVAEVAPDVT
SVKVGDRVAVNPSRPCGACRYCLEGLPNQCLDMRFYGSAMRMPHVQGAFRNALVCDAVQCVKVADHVPLSLAALAEPFAV
GLHAVSRAGPLIGKRVLVSGCGPIGVLAVAAARVHGAAEIVATDVVEAPLEVASALGADRTINAATDAGWVERYAADKGT
FDVMIECSGNARALRDGLDVMRPRGVVVQLGLGGDVSLPQNVVVAKELSICGSFRFHAEFALAVQLINAGRVDLRPAVTR
VFPMRDANLAFELAGDRQRAMKVLIDFADEAA
>Mature_352_residues
MRMRCMCVVIHGPNDLRVEEQDAGEIGPGQVRVDVAMGGICGSDLHYFRHGGFGAIRLQQPMVLGHEVAGTVAEVAPDVT
SVKVGDRVAVNPSRPCGACRYCLEGLPNQCLDMRFYGSAMRMPHVQGAFRNALVCDAVQCVKVADHVPLSLAALAEPFAV
GLHAVSRAGPLIGKRVLVSGCGPIGVLAVAAARVHGAAEIVATDVVEAPLEVASALGADRTINAATDAGWVERYAADKGT
FDVMIECSGNARALRDGLDVMRPRGVVVQLGLGGDVSLPQNVVVAKELSICGSFRFHAEFALAVQLINAGRVDLRPAVTR
VFPMRDANLAFELAGDRQRAMKVLIDFADEAA

Specific function: Catalyzes the NADH/NADPH-dependent oxidation of L- idonate to 5-ketogluconate (5KG) [H]

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI156627571, Length=333, Percent_Identity=35.1351351351351, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI71565152, Length=361, Percent_Identity=23.2686980609418, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI4501933, Length=348, Percent_Identity=26.7241379310345, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI4501939, Length=358, Percent_Identity=25.4189944134078, Blast_Score=79, Evalue=7e-15,
Organism=Homo sapiens, GI156523966, Length=358, Percent_Identity=25.4189944134078, Blast_Score=79, Evalue=8e-15,
Organism=Homo sapiens, GI4501929, Length=360, Percent_Identity=26.1111111111111, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI34577061, Length=349, Percent_Identity=26.3610315186246, Blast_Score=74, Evalue=2e-13,
Organism=Homo sapiens, GI262073058, Length=355, Percent_Identity=22.8169014084507, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI71743840, Length=355, Percent_Identity=22.8169014084507, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI71565154, Length=271, Percent_Identity=25.4612546125461, Blast_Score=70, Evalue=3e-12,
Organism=Escherichia coli, GI1790718, Length=348, Percent_Identity=41.9540229885057, Blast_Score=276, Evalue=2e-75,
Organism=Escherichia coli, GI1788073, Length=325, Percent_Identity=34.1538461538462, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1790045, Length=315, Percent_Identity=33.6507936507937, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1787863, Length=349, Percent_Identity=30.3724928366762, Blast_Score=144, Evalue=7e-36,
Organism=Escherichia coli, GI1788407, Length=316, Percent_Identity=29.1139240506329, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI1788075, Length=345, Percent_Identity=27.536231884058, Blast_Score=108, Evalue=5e-25,
Organism=Escherichia coli, GI226510992, Length=334, Percent_Identity=29.6407185628743, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI87082125, Length=334, Percent_Identity=27.5449101796407, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1786552, Length=351, Percent_Identity=28.4900284900285, Blast_Score=79, Evalue=5e-16,
Organism=Escherichia coli, GI87081918, Length=327, Percent_Identity=28.4403669724771, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786518, Length=256, Percent_Identity=28.90625, Blast_Score=71, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=350, Percent_Identity=36.5714285714286, Blast_Score=215, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17562878, Length=337, Percent_Identity=36.7952522255193, Blast_Score=196, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI25146526, Length=274, Percent_Identity=27.7372262773723, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=242, Percent_Identity=28.5123966942149, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=242, Percent_Identity=28.5123966942149, Blast_Score=75, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6323099, Length=313, Percent_Identity=33.8658146964856, Blast_Score=179, Evalue=8e-46,
Organism=Saccharomyces cerevisiae, GI6319955, Length=337, Percent_Identity=34.4213649851632, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6322619, Length=337, Percent_Identity=34.4213649851632, Blast_Score=177, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6319257, Length=356, Percent_Identity=28.9325842696629, Blast_Score=133, Evalue=4e-32,
Organism=Saccharomyces cerevisiae, GI6319258, Length=374, Percent_Identity=28.6096256684492, Blast_Score=119, Evalue=1e-27,
Organism=Saccharomyces cerevisiae, GI6320033, Length=369, Percent_Identity=25.4742547425474, Blast_Score=98, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6319621, Length=297, Percent_Identity=29.6296296296296, Blast_Score=86, Evalue=9e-18,
Organism=Saccharomyces cerevisiae, GI6323729, Length=278, Percent_Identity=28.0575539568345, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6323961, Length=277, Percent_Identity=28.158844765343, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=276, Percent_Identity=28.2608695652174, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319949, Length=264, Percent_Identity=29.1666666666667, Blast_Score=70, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17737897, Length=334, Percent_Identity=38.0239520958084, Blast_Score=205, Evalue=3e-53,
Organism=Drosophila melanogaster, GI17137530, Length=334, Percent_Identity=36.5269461077844, Blast_Score=199, Evalue=2e-51,
Organism=Drosophila melanogaster, GI221457811, Length=319, Percent_Identity=25.0783699059561, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45550770, Length=319, Percent_Identity=25.0783699059561, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI45551930, Length=319, Percent_Identity=25.0783699059561, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17737895, Length=351, Percent_Identity=25.3561253561254, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.264 [H]

Molecular weight: Translated: 37156; Mature: 37156

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
6.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMRCMCVVIHGPNDLRVEEQDAGEIGPGQVRVDVAMGGICGSDLHYFRHGGFGAIRLQQ
CCEEEEEEEEECCCCCEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHCCCEEEEEECC
PMVLGHEVAGTVAEVAPDVTSVKVGDRVAVNPSRPCGACRYCLEGLPNQCLDMRFYGSAM
CCEECHHHHHHHHHHCCCCEEEECCCEEEECCCCCHHHHHHHHHCCCHHHHHHEECCCHH
RMPHVQGAFRNALVCDAVQCVKVADHVPLSLAALAEPFAVGLHAVSRAGPLIGKRVLVSG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCHHEEEC
CGPIGVLAVAAARVHGAAEIVATDVVEAPLEVASALGADRTINAATDAGWVERYAADKGT
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHCCCCC
FDVMIECSGNARALRDGLDVMRPRGVVVQLGLGGDVSLPQNVVVAKELSICGSFRFHAEF
EEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHCCEEHHHHH
ALAVQLINAGRVDLRPAVTRVFPMRDANLAFELAGDRQRAMKVLIDFADEAA
EEEEEHHCCCCCCCCHHHHHEECCCCCCEEEEECCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRMRCMCVVIHGPNDLRVEEQDAGEIGPGQVRVDVAMGGICGSDLHYFRHGGFGAIRLQQ
CCEEEEEEEEECCCCCEEECCCCCCCCCCEEEEEEEECCCCCCCHHHHHCCCEEEEEECC
PMVLGHEVAGTVAEVAPDVTSVKVGDRVAVNPSRPCGACRYCLEGLPNQCLDMRFYGSAM
CCEECHHHHHHHHHHCCCCEEEECCCEEEECCCCCHHHHHHHHHCCCHHHHHHEECCCHH
RMPHVQGAFRNALVCDAVQCVKVADHVPLSLAALAEPFAVGLHAVSRAGPLIGKRVLVSG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCHHCCHHEEEC
CGPIGVLAVAAARVHGAAEIVATDVVEAPLEVASALGADRTINAATDAGWVERYAADKGT
CCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCCCHHHHHHHCCCCC
FDVMIECSGNARALRDGLDVMRPRGVVVQLGLGGDVSLPQNVVVAKELSICGSFRFHAEF
EEEEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCEEEEEHHHHHCCEEHHHHH
ALAVQLINAGRVDLRPAVTRVFPMRDANLAFELAGDRQRAMKVLIDFADEAA
EEEEEHHCCCCCCCCHHHHHEECCCCCCEEEEECCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 9658018 [H]