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The map label for this gene is ptpA [H]

Identifier: 78048293

GI number: 78048293

Start: 3113796

End: 3115148

Strand: Reverse

Name: ptpA [H]

Synonym: XCV2737

Alternate gene names: 78048293

Gene position: 3115148-3113796 (Counterclockwise)

Preceding gene: 78048294

Following gene: 78048292

Centisome position: 60.16

GC content: 65.19

Gene sequence:

>1353_bases
TTGCGGTGGATGCACGCAGCGGGCGCGCGCGTGGCAGTCGGCGAAGACGCCCGCACCTTCGTGTATGCCGACCGCAGCTT
TCGCCACGACGTAGACGCGCGTGGCGATGAGGTGCTGTGGATCTCCGAGCGCGATGGCTGGCGGCACCTGTATCTGTTCG
ATGGACGCAGCGGCAAGGTGAAGCGCCAGCTCACCCGCGGGCCGTGGGTGGTGCGCGATGTGCTGCGCGTGGACGATGCG
CAACGCCGCATCTGGTTCACTGCCAGCGGGATGGATGCGGGCAAGGACCCGTACGACCGGCAGCTCTACAGCGTTGATTT
CGACGGCCGCCGGTTGACCCGCCTGACCCACGCCGATGCCGACCACGACGTGGCCATTGCCGATGATGGCCTGCATTACG
TCGATGTCTATTCGCGTCCGGACCTGCCGCCGGTGATGGAGCTGCACGCCATCGATGGCCAGCTGCTGCACACCGTGGAG
CGTGGCACGATCGACAAGCTGCAGGCCGCCGGCTGGCGCGCGCCGGAGACCTTCGTGGCCAAGGGGCGCGACGGCACCAC
CGATATCTGGGGCATGGTGGTGCGTCCGCGCGACTACGATCCGCGCAAGACCTATCCGGTGATCGAAAACATCTATGCGG
GGCCGCACGATTCCTTCGTGCCCAAGACGTTCTGGCCGTTCGGTTATCACTCCGGCGGCGACAAGCAGATCGGCATGCAG
GCGCAGGCCGATCTGGGTTTCATCGTGGTAATGATCGACGGCATGGGGACCGCCAACCGCTCCAAGGCGTTTCATGATGT
CGCGTGGAAAAACCTGGGCGATTCAGGGTTTGCCGACCGCATTGCCTGGCATCGTGCGCTGGCGGCCAAGGACCCGTCCT
ACGACATCAGCCGCGTCGGCATCTACGGTGCATCGGCCGGCGGGCAGAGCACGCTGGGAGCGCTCGAGCGTCACCCGGAG
TTCTACAAGGTGGGCGTTGCGTTCGCCGGGTGCTACGACAACCGCATGGACAAGATCAGCTGGAACGAGCAGTGGATGGG
CTGGCCGGTGGATGCCAGCTACGTCGCAGCCTCGGGCGTGGTCAATGCGAGCAAGCTGCAGGGCGACCTGCTGCTGATCG
TGGGCGAGCAGGACAGCAATGTGGATCCGGCGTCCACCGCACAAGTCGTCGATGCCCTGATCAAGGCCGGCAAGGAATTC
GACCTGCTCACCGTGCCGGGTGGCGAGCATTCGGTTGGCCGCTCCAGCGGGCCGATCGATTACGTGCAACGTCGACAGTA
CGACTTCTTCGTGCGCCATCTGCGCAACGAGCCCACGCCGCACTGGAATTCCCTGCCATCGGAGGCGCAATGA

Upstream 100 bases:

>100_bases
TTCGACAACCCGTATTCGTTGTCGCCGCTGCAGTGGCGCAGCGACGGGCGCAGTGTCGCGTTCGACTATGTGCAACGCGG
CTTCCAGCGCATGCGCGTGA

Downstream 100 bases:

>100_bases
TGCGTTTGTCTGCTCGATTCAAGCCGCAGCGGCGCAGCCGGGTGGCGGGTCTGCTGTGGTCGCTGGCATTGCTGGCTGGC
AACGCACCGTTGCTTGCGGC

Product: putative peptidase (fragment)

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 450; Mature: 450

Protein sequence:

>450_residues
MRWMHAAGARVAVGEDARTFVYADRSFRHDVDARGDEVLWISERDGWRHLYLFDGRSGKVKRQLTRGPWVVRDVLRVDDA
QRRIWFTASGMDAGKDPYDRQLYSVDFDGRRLTRLTHADADHDVAIADDGLHYVDVYSRPDLPPVMELHAIDGQLLHTVE
RGTIDKLQAAGWRAPETFVAKGRDGTTDIWGMVVRPRDYDPRKTYPVIENIYAGPHDSFVPKTFWPFGYHSGGDKQIGMQ
AQADLGFIVVMIDGMGTANRSKAFHDVAWKNLGDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQSTLGALERHPE
FYKVGVAFAGCYDNRMDKISWNEQWMGWPVDASYVAASGVVNASKLQGDLLLIVGEQDSNVDPASTAQVVDALIKAGKEF
DLLTVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRNEPTPHWNSLPSEAQ

Sequences:

>Translated_450_residues
MRWMHAAGARVAVGEDARTFVYADRSFRHDVDARGDEVLWISERDGWRHLYLFDGRSGKVKRQLTRGPWVVRDVLRVDDA
QRRIWFTASGMDAGKDPYDRQLYSVDFDGRRLTRLTHADADHDVAIADDGLHYVDVYSRPDLPPVMELHAIDGQLLHTVE
RGTIDKLQAAGWRAPETFVAKGRDGTTDIWGMVVRPRDYDPRKTYPVIENIYAGPHDSFVPKTFWPFGYHSGGDKQIGMQ
AQADLGFIVVMIDGMGTANRSKAFHDVAWKNLGDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQSTLGALERHPE
FYKVGVAFAGCYDNRMDKISWNEQWMGWPVDASYVAASGVVNASKLQGDLLLIVGEQDSNVDPASTAQVVDALIKAGKEF
DLLTVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRNEPTPHWNSLPSEAQ
>Mature_450_residues
MRWMHAAGARVAVGEDARTFVYADRSFRHDVDARGDEVLWISERDGWRHLYLFDGRSGKVKRQLTRGPWVVRDVLRVDDA
QRRIWFTASGMDAGKDPYDRQLYSVDFDGRRLTRLTHADADHDVAIADDGLHYVDVYSRPDLPPVMELHAIDGQLLHTVE
RGTIDKLQAAGWRAPETFVAKGRDGTTDIWGMVVRPRDYDPRKTYPVIENIYAGPHDSFVPKTFWPFGYHSGGDKQIGMQ
AQADLGFIVVMIDGMGTANRSKAFHDVAWKNLGDSGFADRIAWHRALAAKDPSYDISRVGIYGASAGGQSTLGALERHPE
FYKVGVAFAGCYDNRMDKISWNEQWMGWPVDASYVAASGVVNASKLQGDLLLIVGEQDSNVDPASTAQVVDALIKAGKEF
DLLTVPGGEHSVGRSSGPIDYVQRRQYDFFVRHLRNEPTPHWNSLPSEAQ

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI18450280, Length=418, Percent_Identity=28.4688995215311, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI37577089, Length=418, Percent_Identity=28.4688995215311, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI194394146, Length=367, Percent_Identity=27.5204359673025, Blast_Score=122, Evalue=7e-28,
Organism=Homo sapiens, GI37577091, Length=418, Percent_Identity=26.0765550239234, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI16933540, Length=379, Percent_Identity=22.9551451187335, Blast_Score=81, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508017, Length=260, Percent_Identity=28.8461538461538, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17508019, Length=260, Percent_Identity=28.8461538461538, Blast_Score=110, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17564632, Length=229, Percent_Identity=26.6375545851528, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17564634, Length=229, Percent_Identity=26.6375545851528, Blast_Score=69, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6321817, Length=405, Percent_Identity=25.679012345679, Blast_Score=86, Evalue=8e-18,
Organism=Drosophila melanogaster, GI45550825, Length=440, Percent_Identity=25.4545454545455, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45553511, Length=440, Percent_Identity=25.4545454545455, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI45551969, Length=440, Percent_Identity=25.4545454545455, Blast_Score=108, Evalue=6e-24,
Organism=Drosophila melanogaster, GI24582032, Length=389, Percent_Identity=23.3933161953728, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 50351; Mature: 50351

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRWMHAAGARVAVGEDARTFVYADRSFRHDVDARGDEVLWISERDGWRHLYLFDGRSGKV
CCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCH
KRQLTRGPWVVRDVLRVDDAQRRIWFTASGMDAGKDPYDRQLYSVDFDGRRLTRLTHADA
HHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEECCCC
DHDVAIADDGLHYVDVYSRPDLPPVMELHAIDGQLLHTVERGTIDKLQAAGWRAPETFVA
CCCEEEECCCCEEEEECCCCCCCCCCEEECCCCHHHHHHHCCCHHHHHHCCCCCCHHHEE
KGRDGTTDIWGMVVRPRDYDPRKTYPVIENIYAGPHDSFVPKTFWPFGYHSGGDKQIGMQ
CCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECCE
AQADLGFIVVMIDGMGTANRSKAFHDVAWKNLGDSGFADRIAWHRALAAKDPSYDISRVG
ECCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEE
IYGASAGGQSTLGALERHPEFYKVGVAFAGCYDNRMDKISWNEQWMGWPVDASYVAASGV
EEECCCCCCHHHHHHHHCCCEEEEEEEEEEHHCCCCCCCCCCCCCCCCCCCHHHHHHCCC
VNASKLQGDLLLIVGEQDSNVDPASTAQVVDALIKAGKEFDLLTVPGGEHSVGRSSGPID
CCHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHH
YVQRRQYDFFVRHLRNEPTPHWNSLPSEAQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRWMHAAGARVAVGEDARTFVYADRSFRHDVDARGDEVLWISERDGWRHLYLFDGRSGKV
CCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCH
KRQLTRGPWVVRDVLRVDDAQRRIWFTASGMDAGKDPYDRQLYSVDFDGRRLTRLTHADA
HHHHHCCCHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEECCCC
DHDVAIADDGLHYVDVYSRPDLPPVMELHAIDGQLLHTVERGTIDKLQAAGWRAPETFVA
CCCEEEECCCCEEEEECCCCCCCCCCEEECCCCHHHHHHHCCCHHHHHHCCCCCCHHHEE
KGRDGTTDIWGMVVRPRDYDPRKTYPVIENIYAGPHDSFVPKTFWPFGYHSGGDKQIGMQ
CCCCCCCCEEEEEECCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCCCEECCE
AQADLGFIVVMIDGMGTANRSKAFHDVAWKNLGDSGFADRIAWHRALAAKDPSYDISRVG
ECCCCCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCEEEE
IYGASAGGQSTLGALERHPEFYKVGVAFAGCYDNRMDKISWNEQWMGWPVDASYVAASGV
EEECCCCCCHHHHHHHHCCCEEEEEEEEEEHHCCCCCCCCCCCCCCCCCCCHHHHHHCCC
VNASKLQGDLLLIVGEQDSNVDPASTAQVVDALIKAGKEFDLLTVPGGEHSVGRSSGPID
CCHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHH
YVQRRQYDFFVRHLRNEPTPHWNSLPSEAQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA