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The map label for this gene is hutH [H]

Identifier: 78047234

GI number: 78047234

Start: 1892504

End: 1894045

Strand: Reverse

Name: hutH [H]

Synonym: XCV1678

Alternate gene names: 78047234

Gene position: 1894045-1892504 (Counterclockwise)

Preceding gene: 162138539

Following gene: 78047233

Centisome position: 36.58

GC content: 68.16

Gene sequence:

>1542_bases
ATGAGTGTTTCTGTTGTCTTGCAACCCGGCCGGGTCACGCTGGCGCAATGGCGTGCGCTGTATCGCGGTGCCGACGTCGC
GTTGGACGATGCATGCGCTGCCGCGGTGCTGCGCAGCGCGCAAACGGTGGAGGCCATCGTGGCGCGTGGCGAGCCGGTGT
ATGGCGTCAACACCGGCTTCGGCAAGCTGGCCAGCGTGCGTATCGAGCCCGAGGATCTGCAGACCCTGCAACGCAATATC
GTGCTCTCGCACGCGGCAGGTGTGGGCGAGCCCACGCCGGTACCGGTGGTGCGGCTGATGATGGCGCTCAAGCTCACCAG
CCTGGCCCAGGGCGCGTCCGGCGTGCAGCCGGGCACGCTGGCGTTGCTGGAAGCGATGCTGCGCGCCGGCATCACCCCGG
TGGTGCCGTGCCAGGGCTCGGTGGGCGCTTCCGGCGACCTGGCACCGCTGTCGCATCTGGCCGCGGTGATGATCGGCGTT
GGCGAAGCCTTCGTCGGCGCGCAGCGACTGCCTGCTGCCGACGCGCTTGCACATGCGCAGCTGCAGCCGCGCGTGCTGGG
CGCAAAGGAAGGGTTGGCCCTGCTCAACGGCACCCAGTTTTCCACCGCCTGCGCCCTGGCCGGTCTGTTCGAGATCGAAA
CCGTCCTGCAGGCCGCGCTGGTCACCGGCGCGTTGTCGGTGGAAGCGGCCAAGGGCTCGGATACGCCCTTCGATGCGCGC
ATTCATGCCTTGCGCGGGCAGCCCGGGCAGATCGCCACCGCGGCGGCATTGCGCGCCCTGATGGCCGATTCGGCCATTCG
CGAATCGCATCGGCTGGGCGATGTGCGCGTGCAGGACCCGTACTGCCTGCGCTGCCAGCCGCAGGTGATGGGTGCGGCGC
TGGATGTGATGCGTCAGGCCGCGCGCACCCTGCAGATCGAAGCCAATGGCGTGTCCGATAACCCACTGGTCCTCAGCGAT
ACCGGTGAAGCGCTGTCTGGCGGCAACTTCCACGCCGAGCCGGTTGCCTTTGCCGCGGACATGCTGGCGATGGCGGTCTG
CGAAATCGGCTCGATCAGCGAACGCCGCACCGCGATGCTGGTCGACCCGGCACTGTCCGGCCTGCCCGCCTTTCTCACCC
CGCGCCCGGGCTTGAACTCCGGCTTCATGATTCCGCAGGTGACAGCCGCCGCGCTGGTATCGGAAAACAAGCAGCGCGCG
TATCCGGCCAGTGTCGATTCGATTCCGACTTCGGCCAATCAGGAAGATCACGTGTCGATGGCTGCGCACGGTGCGCGCCG
CTTGCTGGCGATGGCTGAGAACGCCGCCAACGTCATCGGCATCGAGCTGCTGGCCGCCGTGCAGGGCTGCGATTTCCATG
CGCCACTGCGCTCCAGCACTGCGCTGGAAGCGGCGCGTGCCCTGTTGCGCGCGCAGGTGCCGACACTGCAGGACGACCGC
TACTTTCATCCGGACATGCTGGCTGCCAGCGCATTGGTGCGCTCGGGCGCGCTGGCGCTGGCAGTGGCGATCCCGTTGCC
GGGCGTGGAGCAGGACGTATGA

Upstream 100 bases:

>100_bases
TGGAACATCGATGCGCCGGCCGATCTGGTCTACCGCATGGGCTTCAATCCTCTTCATGCCCGCGTCTGGCGCGGGCATCT
GTGCTGAATCCGGAGTCGTC

Downstream 100 bases:

>100_bases
GTGGGCAGCGCTTATGCAGCGAATCGATACCTGCCTCGTCGCGGCCGCAACTGCAGTCTTTCGCGATCTCTCCAAGCACA
CGCACTTGCGATGACGCCGC

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSVSVVLQPGRVTLAQWRALYRGADVALDDACAAAVLRSAQTVEAIVARGEPVYGVNTGFGKLASVRIEPEDLQTLQRNI
VLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPGTLALLEAMLRAGITPVVPCQGSVGASGDLAPLSHLAAVMIGV
GEAFVGAQRLPAADALAHAQLQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDAR
IHALRGQPGQIATAAALRALMADSAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQAARTLQIEANGVSDNPLVLSD
TGEALSGGNFHAEPVAFAADMLAMAVCEIGSISERRTAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRA
YPASVDSIPTSANQEDHVSMAAHGARRLLAMAENAANVIGIELLAAVQGCDFHAPLRSSTALEAARALLRAQVPTLQDDR
YFHPDMLAASALVRSGALALAVAIPLPGVEQDV

Sequences:

>Translated_513_residues
MSVSVVLQPGRVTLAQWRALYRGADVALDDACAAAVLRSAQTVEAIVARGEPVYGVNTGFGKLASVRIEPEDLQTLQRNI
VLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPGTLALLEAMLRAGITPVVPCQGSVGASGDLAPLSHLAAVMIGV
GEAFVGAQRLPAADALAHAQLQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDAR
IHALRGQPGQIATAAALRALMADSAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQAARTLQIEANGVSDNPLVLSD
TGEALSGGNFHAEPVAFAADMLAMAVCEIGSISERRTAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRA
YPASVDSIPTSANQEDHVSMAAHGARRLLAMAENAANVIGIELLAAVQGCDFHAPLRSSTALEAARALLRAQVPTLQDDR
YFHPDMLAASALVRSGALALAVAIPLPGVEQDV
>Mature_512_residues
SVSVVLQPGRVTLAQWRALYRGADVALDDACAAAVLRSAQTVEAIVARGEPVYGVNTGFGKLASVRIEPEDLQTLQRNIV
LSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPGTLALLEAMLRAGITPVVPCQGSVGASGDLAPLSHLAAVMIGVG
EAFVGAQRLPAADALAHAQLQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDARI
HALRGQPGQIATAAALRALMADSAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQAARTLQIEANGVSDNPLVLSDT
GEALSGGNFHAEPVAFAADMLAMAVCEIGSISERRTAMLVDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAY
PASVDSIPTSANQEDHVSMAAHGARRLLAMAENAANVIGIELLAAVQGCDFHAPLRSSTALEAARALLRAQVPTLQDDRY
FHPDMLAASALVRSGALALAVAIPLPGVEQDV

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family [H]

Homologues:

Organism=Homo sapiens, GI4504333, Length=463, Percent_Identity=44.9244060475162, Blast_Score=369, Evalue=1e-102,
Organism=Caenorhabditis elegans, GI17567831, Length=482, Percent_Identity=45.0207468879668, Blast_Score=347, Evalue=7e-96,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313 [H]

Pfam domain/function: PF00221 PAL [H]

EC number: =4.3.1.3 [H]

Molecular weight: Translated: 53014; Mature: 52882

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00488 PAL_HISTIDASE ; PS00217 SUGAR_TRANSPORT_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSVVLQPGRVTLAQWRALYRGADVALDDACAAAVLRSAQTVEAIVARGEPVYGVNTGF
CCEEEEEECCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
GKLASVRIEPEDLQTLQRNIVLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPGTL
CCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
ALLEAMLRAGITPVVPCQGSVGASGDLAPLSHLAAVMIGVGEAFVGAQRLPAADALAHAQ
HHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHH
LQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDAR
CCCCEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHH
IHALRGQPGQIATAAALRALMADSAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQA
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHHHHHHHHH
ARTLQIEANGVSDNPLVLSDTGEALSGGNFHAEPVAFAADMLAMAVCEIGSISERRTAML
HHEEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEE
VDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAYPASVDSIPTSANQEDHVSM
ECHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
AAHGARRLLAMAENAANVIGIELLAAVQGCDFHAPLRSSTALEAARALLRAQVPTLQDDR
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
YFHPDMLAASALVRSGALALAVAIPLPGVEQDV
CCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCC
>Mature Secondary Structure 
SVSVVLQPGRVTLAQWRALYRGADVALDDACAAAVLRSAQTVEAIVARGEPVYGVNTGF
CEEEEEECCCEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCC
GKLASVRIEPEDLQTLQRNIVLSHAAGVGEPTPVPVVRLMMALKLTSLAQGASGVQPGTL
CCEEEEEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHH
ALLEAMLRAGITPVVPCQGSVGASGDLAPLSHLAAVMIGVGEAFVGAQRLPAADALAHAQ
HHHHHHHHCCCCEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCHHCCCHHHHHHHHH
LQPRVLGAKEGLALLNGTQFSTACALAGLFEIETVLQAALVTGALSVEAAKGSDTPFDAR
CCCCEECCCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCHHHH
IHALRGQPGQIATAAALRALMADSAIRESHRLGDVRVQDPYCLRCQPQVMGAALDVMRQA
HHEECCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEECCCEEECCCHHHHHHHHHHHHHH
ARTLQIEANGVSDNPLVLSDTGEALSGGNFHAEPVAFAADMLAMAVCEIGSISERRTAML
HHEEEEEECCCCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCEEEE
VDPALSGLPAFLTPRPGLNSGFMIPQVTAAALVSENKQRAYPASVDSIPTSANQEDHVSM
ECHHHCCCCCEECCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHH
AAHGARRLLAMAENAANVIGIELLAAVQGCDFHAPLRSSTALEAARALLRAQVPTLQDDR
HHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCC
YFHPDMLAASALVRSGALALAVAIPLPGVEQDV
CCCHHHHHHHHHHHCCCEEEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]