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The map label for this gene is kmo [H]

Identifier: 78047197

GI number: 78047197

Start: 1853156

End: 1854523

Strand: Reverse

Name: kmo [H]

Synonym: XCV1641

Alternate gene names: 78047197

Gene position: 1854523-1853156 (Counterclockwise)

Preceding gene: 78047198

Following gene: 78047196

Centisome position: 35.81

GC content: 66.67

Gene sequence:

>1368_bases
TTGAGCCCAGTTTCTCCGCGTTCCCTGACCCTGATCGGCGCCGGTCTGGCCGGTTGCCTGCTGGCCATCCTGCTGTCGCG
TCGCGGCTGGCAGGTCACCGTATACGAACGGCGTGGCGACCCGCGCATCAAGGGCTACGAGTCCGGCCGCTCGATCAACC
TGGCGCTGGCCGAGCGCGGCCGGCATGCGCTGCGCCAGGCCGGCGCCGAAGATGCGGTGATGGCCAAGGCGGTGATGATG
CGTGGCCGCATGGTGCACCCAATCATCGGCCAACCGCAGCTGCAACGCTACGGGCGCGACGACAGCGAGGTGATCTGGTC
GATCCACCGCGCCGCGCTGAATGTCGCGCTGCTCGACCTGGCCGAACAGGCCGGCGCGCGCGTGCATTTCTACCGCCGCC
TGCATACCGTGGGCTTCGACGCCGGCTATGCGCGCTTCATCGACGACCGCGACGACCAACCGCACGAGATCCACTTTCAG
AGCTTGATCGGCAGCGATGGCGCCGGCTCGGCCTTGCGCGCGGCGATGCAGCGCAAATCGCCACTGGGCGAACGCACCGA
ATTCCTCGATCACTCGTACAAGGAGCTGGAAATTCCGCCGCAGCCGGGCGGCGGATTCCGGATCGAAGGCAACGCGCTGC
ATCTCTGGCCGCGCGGGCGCTACATGTGCATTGCGCTGCCAAACGATGGCGGTACGTTCACCGTCACCCTGTTCTTGCCC
AACGCCGGCGAGCCGAGCTTTGCCACCACGCGCACCGGCGATGAAGCATTGGCCTTGTTCGCACGCGATTTCCCGGACGC
ATTGCCGCTGATTCCGCAGCTCAGGGAGCATTGGGAAGAGCATCCGCCCGGACTGCTCGGCACGCTGACCCTGGATCGCT
GGCATCTGGATGGCCGCGCATTGCTGATCGGCGACGCCGCCCATGCGATGGTGCCATTCCACGGGCAGGGCATGAATTGC
GCATTCGAAGATTGCGTGGCGTTGGCAGATCAGCTGGACGCGCACGACGACCTCGCCAGCGCGTTCGCGGCCTTCGAGGC
TGCGCGTCGCGACGATGCGGCCGCCATCCAACAGATGGCGCTGGAGAACTACCTGGAAATGCGCGACCGCGTCGACGACC
CCGACTTCCTGCTGCAGCGCGAGCTCGAACAGAAATTGCAGGCGCGCTGGCCCACCCGCTTCGTGCCGCACTACACCATG
GTGACGTTCCTGCGCACGCGCTATTCGATTGCGCTGGCGCGCAGCGAGATCCAGCGCCAGATCCTGGTGGAGGCCACGCG
GGGACACCGCGATCTGTCGCGCATCGACTGGGCTGCCTTGGAAGCGGTTGTGCACGCACGCCTGGAGCCGCTGGACGGCG
CGCATTGA

Upstream 100 bases:

>100_bases
CTCCCAGCCCGCCCGGCGTTGCTGCCGGGGCCACCGTCGTTGCCAGTCGCTGTCTTCCCCTTTTCGCCGGCGCTGCGTCC
GGCTGCTGCCGGACATTGCA

Downstream 100 bases:

>100_bases
CCTCTGCGGAAGACACGGAGGACAGCCTTAGAGCGGCTAACAAAACGTAGTGAGCAGTCGTCAGGTGGGCGCAGACGGCG
CGCTCAGAACCGCAGTACAC

Product: putative kynurenine 3-monooxygenase

Products: NA

Alternate protein names: Kynurenine 3-hydroxylase [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MSPVSPRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERGRHALRQAGAEDAVMAKAVMM
RGRMVHPIIGQPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVGFDAGYARFIDDRDDQPHEIHFQ
SLIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHLWPRGRYMCIALPNDGGTFTVTLFLP
NAGEPSFATTRTGDEALALFARDFPDALPLIPQLREHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNC
AFEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMALENYLEMRDRVDDPDFLLQRELEQKLQARWPTRFVPHYTM
VTFLRTRYSIALARSEIQRQILVEATRGHRDLSRIDWAALEAVVHARLEPLDGAH

Sequences:

>Translated_455_residues
MSPVSPRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERGRHALRQAGAEDAVMAKAVMM
RGRMVHPIIGQPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVGFDAGYARFIDDRDDQPHEIHFQ
SLIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHLWPRGRYMCIALPNDGGTFTVTLFLP
NAGEPSFATTRTGDEALALFARDFPDALPLIPQLREHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNC
AFEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMALENYLEMRDRVDDPDFLLQRELEQKLQARWPTRFVPHYTM
VTFLRTRYSIALARSEIQRQILVEATRGHRDLSRIDWAALEAVVHARLEPLDGAH
>Mature_454_residues
SPVSPRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERGRHALRQAGAEDAVMAKAVMMR
GRMVHPIIGQPQLQRYGRDDSEVIWSIHRAALNVALLDLAEQAGARVHFYRRLHTVGFDAGYARFIDDRDDQPHEIHFQS
LIGSDGAGSALRAAMQRKSPLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHLWPRGRYMCIALPNDGGTFTVTLFLPN
AGEPSFATTRTGDEALALFARDFPDALPLIPQLREHWEEHPPGLLGTLTLDRWHLDGRALLIGDAAHAMVPFHGQGMNCA
FEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMALENYLEMRDRVDDPDFLLQRELEQKLQARWPTRFVPHYTMV
TFLRTRYSIALARSEIQRQILVEATRGHRDLSRIDWAALEAVVHARLEPLDGAH

Specific function: Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid [H]

COG id: COG0654

COG function: function code HC; 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aromatic-ring hydroxylase family. KMO subfamily [H]

Homologues:

Organism=Homo sapiens, GI187960045, Length=425, Percent_Identity=37.1764705882353, Blast_Score=294, Evalue=1e-79,
Organism=Caenorhabditis elegans, GI17562934, Length=452, Percent_Identity=32.7433628318584, Blast_Score=248, Evalue=7e-66,
Organism=Caenorhabditis elegans, GI212646493, Length=408, Percent_Identity=25.9803921568627, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI193208447, Length=369, Percent_Identity=24.390243902439, Blast_Score=124, Evalue=8e-29,
Organism=Saccharomyces cerevisiae, GI6319372, Length=433, Percent_Identity=35.5658198614319, Blast_Score=244, Evalue=3e-65,
Organism=Drosophila melanogaster, GI28573964, Length=419, Percent_Identity=36.9928400954654, Blast_Score=244, Evalue=8e-65,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002938
- InterPro:   IPR003042 [H]

Pfam domain/function: PF01494 FAD_binding_3 [H]

EC number: =1.14.13.9 [H]

Molecular weight: Translated: 50830; Mature: 50699

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPVSPRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERG
CCCCCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEHHHHHH
RHALRQAGAEDAVMAKAVMMRGRMVHPIIGQPQLQRYGRDDSEVIWSIHRAALNVALLDL
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AEQAGARVHFYRRLHTVGFDAGYARFIDDRDDQPHEIHFQSLIGSDGAGSALRAAMQRKS
HHHCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
PLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHLWPRGRYMCIALPNDGGTFTVTLFLP
CCCHHHHHHCCCHHHCCCCCCCCCCEEEECCEEEEECCCCEEEEEEECCCCEEEEEEEEC
NAGEPSFATTRTGDEALALFARDFPDALPLIPQLREHWEEHPPGLLGTLTLDRWHLDGRA
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCE
LLIGDAAHAMVPFHGQGMNCAFEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMA
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
LENYLEMRDRVDDPDFLLQRELEQKLQARWPTRFVPHYTMVTFLRTRYSIALARSEIQRQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILVEATRGHRDLSRIDWAALEAVVHARLEPLDGAH
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SPVSPRSLTLIGAGLAGCLLAILLSRRGWQVTVYERRGDPRIKGYESGRSINLALAERG
CCCCCCCEEEECCCHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEHHHHHH
RHALRQAGAEDAVMAKAVMMRGRMVHPIIGQPQLQRYGRDDSEVIWSIHRAALNVALLDL
HHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHH
AEQAGARVHFYRRLHTVGFDAGYARFIDDRDDQPHEIHFQSLIGSDGAGSALRAAMQRKS
HHHCCCHHHHHHHHHHHCCCCCHHHHCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHCC
PLGERTEFLDHSYKELEIPPQPGGGFRIEGNALHLWPRGRYMCIALPNDGGTFTVTLFLP
CCCHHHHHHCCCHHHCCCCCCCCCCEEEECCEEEEECCCCEEEEEEECCCCEEEEEEEEC
NAGEPSFATTRTGDEALALFARDFPDALPLIPQLREHWEEHPPGLLGTLTLDRWHLDGRA
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEEEEEEECCCE
LLIGDAAHAMVPFHGQGMNCAFEDCVALADQLDAHDDLASAFAAFEAARRDDAAAIQQMA
EEEECCCCEEEEECCCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHH
LENYLEMRDRVDDPDFLLQRELEQKLQARWPTRFVPHYTMVTFLRTRYSIALARSEIQRQ
HHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ILVEATRGHRDLSRIDWAALEAVVHARLEPLDGAH
HHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]