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The map label for this gene is sbcB [H]

Identifier: 78047196

GI number: 78047196

Start: 1851452

End: 1852897

Strand: Reverse

Name: sbcB [H]

Synonym: XCV1640

Alternate gene names: 78047196

Gene position: 1852897-1851452 (Counterclockwise)

Preceding gene: 78047197

Following gene: 78047195

Centisome position: 35.78

GC content: 65.01

Gene sequence:

>1446_bases
ATGCCTGACAGCTTTCTCTTCTACGACCTGGAAACCTTCGGCCAGGATCCACGCCGCACCCGCATCGCACAGTTCGCTGC
GGTGCGCACCGATGCGCAGTTGCGCGTGATCGAAGAGCCCATCAGCTTTTTCGTGCAGCCGGCCGATGATCTGCTGCCCT
CGCCCTATGCCACCATGGTGACCGGCATCACCCCGCAACATGCGCTGCGCGAAGGCGTCACCGAAGCAGAGGCGTTCGCG
CGCATCGCCGAACAAATGGGCCGGCCCCAGACCTGCACGCTGGGCTACAACTCGATCCGCTTCGACGACGAATTCATCCG
CTGCGGCCTGTTCCGCAATTTCTACGACCCGTACGAGCGCGAGTGGCGTGGCGGTAACTCGCGCTGGGACCTGCTGGATG
TGCTGCGACTGGTCCATGCGCTGCGCCCGGACGGCATCGTCTGGCCGCAGCGCGAAGATGGCGCTACCTCGTTCAAGCTG
GAGCACCTGGCCGATGCCAACGATGTGCGCGAAGGCGATGCGCACGAAGCCTTGTCGGACGTGTACGCCACCATCGGCAT
GGCGCGCAAATTCCAGCAGCACCAGCCAAAGTTGTGGGACTACGCGCTGCGCCTGCGCGACAAGCGCTTTGCCGCCACCT
TGCTGGATGTCATCGCCATGCAGCCGGTGCTGCATATCTCCCAGCGCTACCCCGCCTCGCGCCTGTGCGCCGCGGCGGTG
TTGCCGCTGACGCGCCACCCGCGCATCGACAGCCGCGTGATCGTGTTCGATCTGGAGGGCGACCCGGAGGTGTTGTTGCG
GCTGAGCCCCGACGATATTGCCGACCGCCTGTACATCCGCGCCGCGGATCTGCCGGAAGGCGAACAGCGCATTCCGTTGA
AGGAAGTGCATCTGAACAAGTCGCCCGCGCTGGTGGCCTGGCAGCATCTGCGCGCTGCAGATTTTCAGCGCTTGGGTGTG
GATCACGACGCGGTAGTGGCCAAGGCGGCACGCTTGCGCGCCTTGGGCCCTGAACTTGCCGAGAAGGTGCGCCAGGTCTA
CGGCAGCGAACGCGCCGCGGTAGCGGCGGTCAACGATGCCGATGCCTCGCTCTACGATGGATTTCTGGCCGAAGGCGACA
AACGCCTGCTTGCACAGGTCCGCGCCAGCGCGCCGGACGAACTGGGCGCGCTGGAAGCGCGCTTTCGCGACCCGCGCCTG
ATCGAGCTGCTGTTTCGCTACCGCGCGCGCAACTGGCCGCAGACACTCTCGTTCGAGGAACAGGAGCGCTGGAACGTGTA
TCGCCGCCAGCGCCTGCTCGAAGACCGCGGCCTGGGTGAAGTCACCCTGGAGCAATACCACGCGCAGATTGCGGATTTAC
GGCGTACTCACTCCGACGATGCTACCAAGCAAGCCCTACTCGATCAGCTCGCCGCCTGGGGTTCGGACCTCCAACGCACG
CTATGA

Upstream 100 bases:

>100_bases
TTTGTTGGCTGCTCTTAGCGTGACGTTGCCGCGATGAGGGATACTGGGCGGCACCGGCAGCGCATACGCCGTGCGCCGCG
CATCTGGATGTCGTACCCGC

Downstream 100 bases:

>100_bases
CCACCTACTTTTCCGACGCCAGCTTCAAGTTCCTGCGCGCCCTGGCCCGCCACAACGACAAGACCTGGTTCAACGACCAT
CGGCATCAGTATGAGGCGCA

Product: exonuclease I

Products: NA

Alternate protein names: Exonuclease I; DNA deoxyribophosphodiesterase; dRPase [H]

Number of amino acids: Translated: 481; Mature: 480

Protein sequence:

>481_residues
MPDSFLFYDLETFGQDPRRTRIAQFAAVRTDAQLRVIEEPISFFVQPADDLLPSPYATMVTGITPQHALREGVTEAEAFA
RIAEQMGRPQTCTLGYNSIRFDDEFIRCGLFRNFYDPYEREWRGGNSRWDLLDVLRLVHALRPDGIVWPQREDGATSFKL
EHLADANDVREGDAHEALSDVYATIGMARKFQQHQPKLWDYALRLRDKRFAATLLDVIAMQPVLHISQRYPASRLCAAAV
LPLTRHPRIDSRVIVFDLEGDPEVLLRLSPDDIADRLYIRAADLPEGEQRIPLKEVHLNKSPALVAWQHLRAADFQRLGV
DHDAVVAKAARLRALGPELAEKVRQVYGSERAAVAAVNDADASLYDGFLAEGDKRLLAQVRASAPDELGALEARFRDPRL
IELLFRYRARNWPQTLSFEEQERWNVYRRQRLLEDRGLGEVTLEQYHAQIADLRRTHSDDATKQALLDQLAAWGSDLQRT
L

Sequences:

>Translated_481_residues
MPDSFLFYDLETFGQDPRRTRIAQFAAVRTDAQLRVIEEPISFFVQPADDLLPSPYATMVTGITPQHALREGVTEAEAFA
RIAEQMGRPQTCTLGYNSIRFDDEFIRCGLFRNFYDPYEREWRGGNSRWDLLDVLRLVHALRPDGIVWPQREDGATSFKL
EHLADANDVREGDAHEALSDVYATIGMARKFQQHQPKLWDYALRLRDKRFAATLLDVIAMQPVLHISQRYPASRLCAAAV
LPLTRHPRIDSRVIVFDLEGDPEVLLRLSPDDIADRLYIRAADLPEGEQRIPLKEVHLNKSPALVAWQHLRAADFQRLGV
DHDAVVAKAARLRALGPELAEKVRQVYGSERAAVAAVNDADASLYDGFLAEGDKRLLAQVRASAPDELGALEARFRDPRL
IELLFRYRARNWPQTLSFEEQERWNVYRRQRLLEDRGLGEVTLEQYHAQIADLRRTHSDDATKQALLDQLAAWGSDLQRT
L
>Mature_480_residues
PDSFLFYDLETFGQDPRRTRIAQFAAVRTDAQLRVIEEPISFFVQPADDLLPSPYATMVTGITPQHALREGVTEAEAFAR
IAEQMGRPQTCTLGYNSIRFDDEFIRCGLFRNFYDPYEREWRGGNSRWDLLDVLRLVHALRPDGIVWPQREDGATSFKLE
HLADANDVREGDAHEALSDVYATIGMARKFQQHQPKLWDYALRLRDKRFAATLLDVIAMQPVLHISQRYPASRLCAAAVL
PLTRHPRIDSRVIVFDLEGDPEVLLRLSPDDIADRLYIRAADLPEGEQRIPLKEVHLNKSPALVAWQHLRAADFQRLGVD
HDAVVAKAARLRALGPELAEKVRQVYGSERAAVAAVNDADASLYDGFLAEGDKRLLAQVRASAPDELGALEARFRDPRLI
ELLFRYRARNWPQTLSFEEQERWNVYRRQRLLEDRGLGEVTLEQYHAQIADLRRTHSDDATKQALLDQLAAWGSDLQRTL

Specific function: Also functions as a DNA deoxyribophosphodiesterase that releases deoxyribose-phosphate moieties following the cleavage DNA at an apurinic/apyrimidinic (AP) site by either an AP endonuclease AP lyase [H]

COG id: COG2925

COG function: function code L; Exonuclease I

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Escherichia coli, GI1788321, Length=474, Percent_Identity=43.0379746835443, Blast_Score=379, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013620
- InterPro:   IPR013520
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00929 Exonuc_X-T; PF08411 Exonuc_X-T_C [H]

EC number: =3.1.11.1 [H]

Molecular weight: Translated: 54927; Mature: 54796

Theoretical pI: Translated: 5.82; Mature: 5.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDSFLFYDLETFGQDPRRTRIAQFAAVRTDAQLRVIEEPISFFVQPADDLLPSPYATMV
CCCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHH
TGITPQHALREGVTEAEAFARIAEQMGRPQTCTLGYNSIRFDDEFIRCGLFRNFYDPYER
CCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCCEECCHHHHHHHHHHHHCCHHHH
EWRGGNSRWDLLDVLRLVHALRPDGIVWPQREDGATSFKLEHLADANDVREGDAHEALSD
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHCCCHHCCCCHHHHHHHH
VYATIGMARKFQQHQPKLWDYALRLRDKRFAATLLDVIAMQPVLHISQRYPASRLCAAAV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LPLTRHPRIDSRVIVFDLEGDPEVLLRLSPDDIADRLYIRAADLPEGEQRIPLKEVHLNK
CCCCCCCCCCCEEEEEEECCCCEEEEEECCHHHHHHEEEEECCCCCCCCCCCHHHHCCCC
SPALVAWQHLRAADFQRLGVDHDAVVAKAARLRALGPELAEKVRQVYGSERAAVAAVNDA
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCC
DASLYDGFLAEGDKRLLAQVRASAPDELGALEARFRDPRLIELLFRYRARNWPQTLSFEE
CHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCH
QERWNVYRRQRLLEDRGLGEVTLEQYHAQIADLRRTHSDDATKQALLDQLAAWGSDLQRT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
L
C
>Mature Secondary Structure 
PDSFLFYDLETFGQDPRRTRIAQFAAVRTDAQLRVIEEPISFFVQPADDLLPSPYATMV
CCCEEEEEHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHCCCCHHHHH
TGITPQHALREGVTEAEAFARIAEQMGRPQTCTLGYNSIRFDDEFIRCGLFRNFYDPYER
CCCCHHHHHHHCCHHHHHHHHHHHHHCCCCEEEECCCCEECCHHHHHHHHHHHHCCHHHH
EWRGGNSRWDLLDVLRLVHALRPDGIVWPQREDGATSFKLEHLADANDVREGDAHEALSD
HHCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEHHHHCCCHHCCCCHHHHHHHH
VYATIGMARKFQQHQPKLWDYALRLRDKRFAATLLDVIAMQPVLHISQRYPASRLCAAAV
HHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
LPLTRHPRIDSRVIVFDLEGDPEVLLRLSPDDIADRLYIRAADLPEGEQRIPLKEVHLNK
CCCCCCCCCCCEEEEEEECCCCEEEEEECCHHHHHHEEEEECCCCCCCCCCCHHHHCCCC
SPALVAWQHLRAADFQRLGVDHDAVVAKAARLRALGPELAEKVRQVYGSERAAVAAVNDA
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCCEEEEECCC
DASLYDGFLAEGDKRLLAQVRASAPDELGALEARFRDPRLIELLFRYRARNWPQTLSFEE
CHHHHHHHHHCCHHHHHHHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCCCCH
QERWNVYRRQRLLEDRGLGEVTLEQYHAQIADLRRTHSDDATKQALLDQLAAWGSDLQRT
HHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHC
L
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3539937; 9097040; 9278503; 1329027 [H]