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The map label for this gene is hisG

Identifier: 78044817

GI number: 78044817

Start: 960852

End: 961517

Strand: Direct

Name: hisG

Synonym: CHY_1084

Alternate gene names: 78044817

Gene position: 960852-961517 (Clockwise)

Preceding gene: 78044079

Following gene: 78044940

Centisome position: 40.01

GC content: 43.99

Gene sequence:

>666_bases
ATGAAAAATGGTTTAACTTTTGCCCTGCCTAAAGGGACATTATTTCCCGATACGGTGCGCCTTCTCTATAAAGCGGGTTT
TTTAAAAAAGGAAGAGGTCCTTTTGGAAAGTCGAAAACTCGTAATTAAAGATGGCCCATATACTTTTATTATCTGCCGGC
CGACCGATATCCCCACTTTTGTGGAGCATGGAGCGGCCGACCTGGGTATTGTGGGTAAGGATGTAATTGAAGAGCAGCGA
CGGGAAATTTTTGAACTTTTGGATTTAAAATACGGAAAATGCCATTTTGCCGTGGCGGCACCCAGGGATAACCCTAAAGT
GCACGATTTGGGAAAGCTTACGGAAGTCAGGGCGGCCAGCAAATTTCCCGAAGTAACCCGACGGTTTTTTAAAGGTCTTG
GGGTGCGGGCGGAGGTTATCAAAATGCACGGGAATGTAGAGCTGGCTCCGCTGGTGGGTCTTGCTGATGTAATTGTGGAC
CTGGTTTCTACCGGAAGAACTTTAAGGGAAAATAACTTAATTGAAATAACGAAGATAATGGATATAACCGCAAGGTTGGT
TGCCAACCGGGTAGCCGCCAGGGTTTATGACCGGGAAATAAAAGCAATTGTAAAAAAGTTCAAGAATTTAGTTGGGGGCG
AAAAAAATGAAGTTAATCTTAAATAA

Upstream 100 bases:

>100_bases
GAAAGTATTGCCAATAGTATTGACAAATAATTTTTTTAACCTTATGATTTTAGTATATTAATAATTTAACACTTTAACAA
AATAAAGTGAGGCTATAAAA

Downstream 100 bases:

>100_bases
AGAAGAACTTTTAGATAAATATTCCCGGCGCAAAGCAGTGGAGGAAGATATAGAGCAACAGGTACGAAAAATTCTTAATG
AAGTGGCAAGTTCGGGGGAT

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 221; Mature: 221

Protein sequence:

>221_residues
MKNGLTFALPKGTLFPDTVRLLYKAGFLKKEEVLLESRKLVIKDGPYTFIICRPTDIPTFVEHGAADLGIVGKDVIEEQR
REIFELLDLKYGKCHFAVAAPRDNPKVHDLGKLTEVRAASKFPEVTRRFFKGLGVRAEVIKMHGNVELAPLVGLADVIVD
LVSTGRTLRENNLIEITKIMDITARLVANRVAARVYDREIKAIVKKFKNLVGGEKNEVNLK

Sequences:

>Translated_221_residues
MKNGLTFALPKGTLFPDTVRLLYKAGFLKKEEVLLESRKLVIKDGPYTFIICRPTDIPTFVEHGAADLGIVGKDVIEEQR
REIFELLDLKYGKCHFAVAAPRDNPKVHDLGKLTEVRAASKFPEVTRRFFKGLGVRAEVIKMHGNVELAPLVGLADVIVD
LVSTGRTLRENNLIEITKIMDITARLVANRVAARVYDREIKAIVKKFKNLVGGEKNEVNLK
>Mature_221_residues
MKNGLTFALPKGTLFPDTVRLLYKAGFLKKEEVLLESRKLVIKDGPYTFIICRPTDIPTFVEHGAADLGIVGKDVIEEQR
REIFELLDLKYGKCHFAVAAPRDNPKVHDLGKLTEVRAASKFPEVTRRFFKGLGVRAEVIKMHGNVELAPLVGLADVIVD
LVSTGRTLRENNLIEITKIMDITARLVANRVAARVYDREIKAIVKKFKNLVGGEKNEVNLK

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=195, Percent_Identity=34.3589743589744, Blast_Score=91, Evalue=4e-20,
Organism=Saccharomyces cerevisiae, GI6320896, Length=200, Percent_Identity=29, Blast_Score=80, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_CARHZ (Q3AD54)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359930.1
- ProteinModelPortal:   Q3AD54
- SMR:   Q3AD54
- STRING:   Q3AD54
- GeneID:   3727942
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_1084
- NMPDR:   fig|246194.3.peg.1131
- TIGR:   CHY_1084
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   QVDIIKL
- BioCyc:   CHYD246194:CHY_1084-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01018
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070

Pfam domain/function: PF01634 HisG

EC number: =2.4.2.17

Molecular weight: Translated: 24765; Mature: 24765

Theoretical pI: Translated: 10.14; Mature: 10.14

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNGLTFALPKGTLFPDTVRLLYKAGFLKKEEVLLESRKLVIKDGPYTFIICRPTDIPTF
CCCCCEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCEEEEEECCCCCCHH
VEHGAADLGIVGKDVIEEQRREIFELLDLKYGKCHFAVAAPRDNPKVHDLGKLTEVRAAS
HHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
KFPEVTRRFFKGLGVRAEVIKMHGNVELAPLVGLADVIVDLVSTGRTLRENNLIEITKIM
CCHHHHHHHHHCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCEECCCCCEEHHHHH
DITARLVANRVAARVYDREIKAIVKKFKNLVGGEKNEVNLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MKNGLTFALPKGTLFPDTVRLLYKAGFLKKEEVLLESRKLVIKDGPYTFIICRPTDIPTF
CCCCCEEECCCCCCCHHHHHHHHHHCCCCHHHHHHHCCCEEEECCCEEEEEECCCCCCHH
VEHGAADLGIVGKDVIEEQRREIFELLDLKYGKCHFAVAAPRDNPKVHDLGKLTEVRAAS
HHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHH
KFPEVTRRFFKGLGVRAEVIKMHGNVELAPLVGLADVIVDLVSTGRTLRENNLIEITKIM
CCHHHHHHHHHCCCCCEEEEEECCCEEEHHHHHHHHHHHHHHHCCCEECCCCCEEHHHHH
DITARLVANRVAARVYDREIKAIVKKFKNLVGGEKNEVNLK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA