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The map label for this gene is hisD

Identifier: 78044940

GI number: 78044940

Start: 961498

End: 962775

Strand: Direct

Name: hisD

Synonym: CHY_1085

Alternate gene names: 78044940

Gene position: 961498-962775 (Clockwise)

Preceding gene: 78044817

Following gene: 78044277

Centisome position: 40.04

GC content: 47.89

Gene sequence:

>1278_bases
ATGAAGTTAATCTTAAATAAAGAAGAACTTTTAGATAAATATTCCCGGCGCAAAGCAGTGGAGGAAGATATAGAGCAACA
GGTACGAAAAATTCTTAATGAAGTGGCAAGTTCGGGGGATGAAGCGTTAATCGAGTACGCCCGGGAGTTTGATGGTTTTA
AGGGGGATTTAAGCAATCTTAAAGTAAGCGAAGAGGAAATAGATAAAGCTTACAGGGAAGTGGACGATGGGTTTTTAAAT
AGTCTTCGCAAAGCAATTCAAAGGGTTTTTGATTTTCACCAAAAGCAACTTCCCCGGAGCTGGTTTACCACGGAAGAAAA
CGGAAATATCCTGGGACAAATTTATACTCCCGTGGAGGTTGCCGGGATTTACGTACCGGGCGGTACTGCAGCCTATCCTT
CGTCGGTGGTGATGAATGCCGTACCGGCAAAAGTTGCCGGGGTAAAAAGAATTGTGATGGTTTCGCCCCAAAAAGGCGAG
CGGATGAATCCTTATGTTTTGGTTGCCGCCCGGGAAGCCGGGGTGACGGAAATTTACCGGGTTGGCGGAGCGCACGCCAT
AGCTGCCCTGGCTTTTGGCACCAAAACCATCCCCAGGGTAGATGTAATTACCGGACCGGGCAATATTTATGTGACCATCG
CCAAAAAGCTCGTTTACGGCACGGTCAATATCGATATGCTGGCAGGCCCCAGTGAGGTGGTGGTTATCGCCGATAGCTCG
GCAAAGCCCGAGTATCTTGCCGCGGATATGTTATCCCAGGCGGAACATGATTCCCTGGCTTCGGGGGTGGTTATTACCTG
GGATGGGGAGCTGGCCCGAAAGACAGCGCAAAAAGTGGAGGAGTATTTAAAGCTCCTACCCCGCCGGGAGATAATTTTAA
AAGCTTTGGAAAATTGCGGAGGAATTGTGGTGGTGGACGATGAAGAGGAAGCTTTACAGCTTGCCAACCAGCTGGCTCCG
GAGCATTTGGAGTTAATGCTCCCCAATCCTTTCGGCTATTTAGCTAAAGTAAAAAATGCCGGAGCGGTTTTTTTGGGACA
GTTTAGTCCTGAACCCATGGGGGATTATTTGGCCGGACCCAATCACGTTTTGCCCACTTCCGGAACTAGCCGCTTTTATT
CGCCCCTGTCGGTGGATAATTTCTTAAAGAAAAGTAGCGTAATTTATTATTCCCAAGAAGGTTTTTTGGCCGATGCCAGG
GATGTTATTAAACTTGCCGAAACGGAAGGGCTATTTGCCCACGCCCTTTCGGTGAAAGTGAGGATTTCCAATGAATAA

Upstream 100 bases:

>100_bases
ACCGCAAGGTTGGTTGCCAACCGGGTAGCCGCCAGGGTTTATGACCGGGAAATAAAAGCAATTGTAAAAAAGTTCAAGAA
TTTAGTTGGGGGCGAAAAAA

Downstream 100 bases:

>100_bases
GCCGAGATATTTTAAAGAAGCCTTTGCCCAGCTAAAGCCCTACGAACCTCATCTGGTTTCCTATGAAATTAAACTTGATG
CCAATGAAAACCCGTATCTT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MKLILNKEELLDKYSRRKAVEEDIEQQVRKILNEVASSGDEALIEYAREFDGFKGDLSNLKVSEEEIDKAYREVDDGFLN
SLRKAIQRVFDFHQKQLPRSWFTTEENGNILGQIYTPVEVAGIYVPGGTAAYPSSVVMNAVPAKVAGVKRIVMVSPQKGE
RMNPYVLVAAREAGVTEIYRVGGAHAIAALAFGTKTIPRVDVITGPGNIYVTIAKKLVYGTVNIDMLAGPSEVVVIADSS
AKPEYLAADMLSQAEHDSLASGVVITWDGELARKTAQKVEEYLKLLPRREIILKALENCGGIVVVDDEEEALQLANQLAP
EHLELMLPNPFGYLAKVKNAGAVFLGQFSPEPMGDYLAGPNHVLPTSGTSRFYSPLSVDNFLKKSSVIYYSQEGFLADAR
DVIKLAETEGLFAHALSVKVRISNE

Sequences:

>Translated_425_residues
MKLILNKEELLDKYSRRKAVEEDIEQQVRKILNEVASSGDEALIEYAREFDGFKGDLSNLKVSEEEIDKAYREVDDGFLN
SLRKAIQRVFDFHQKQLPRSWFTTEENGNILGQIYTPVEVAGIYVPGGTAAYPSSVVMNAVPAKVAGVKRIVMVSPQKGE
RMNPYVLVAAREAGVTEIYRVGGAHAIAALAFGTKTIPRVDVITGPGNIYVTIAKKLVYGTVNIDMLAGPSEVVVIADSS
AKPEYLAADMLSQAEHDSLASGVVITWDGELARKTAQKVEEYLKLLPRREIILKALENCGGIVVVDDEEEALQLANQLAP
EHLELMLPNPFGYLAKVKNAGAVFLGQFSPEPMGDYLAGPNHVLPTSGTSRFYSPLSVDNFLKKSSVIYYSQEGFLADAR
DVIKLAETEGLFAHALSVKVRISNE
>Mature_425_residues
MKLILNKEELLDKYSRRKAVEEDIEQQVRKILNEVASSGDEALIEYAREFDGFKGDLSNLKVSEEEIDKAYREVDDGFLN
SLRKAIQRVFDFHQKQLPRSWFTTEENGNILGQIYTPVEVAGIYVPGGTAAYPSSVVMNAVPAKVAGVKRIVMVSPQKGE
RMNPYVLVAAREAGVTEIYRVGGAHAIAALAFGTKTIPRVDVITGPGNIYVTIAKKLVYGTVNIDMLAGPSEVVVIADSS
AKPEYLAADMLSQAEHDSLASGVVITWDGELARKTAQKVEEYLKLLPRREIILKALENCGGIVVVDDEEEALQLANQLAP
EHLELMLPNPFGYLAKVKNAGAVFLGQFSPEPMGDYLAGPNHVLPTSGTSRFYSPLSVDNFLKKSSVIYYSQEGFLADAR
DVIKLAETEGLFAHALSVKVRISNE

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=409, Percent_Identity=41.8092909535452, Blast_Score=292, Evalue=3e-80,
Organism=Saccharomyces cerevisiae, GI6319819, Length=429, Percent_Identity=38.9277389277389, Blast_Score=267, Evalue=2e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_CARHZ (Q3AD53)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_359931.1
- ProteinModelPortal:   Q3AD53
- SMR:   Q3AD53
- STRING:   Q3AD53
- GeneID:   3728065
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_1085
- NMPDR:   fig|246194.3.peg.1132
- TIGR:   CHY_1085
- eggNOG:   COG0141
- HOGENOM:   HBG329596
- OMA:   IEAFHRQ
- BioCyc:   CHYD246194:CHY_1085-MONOMER
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 46609; Mature: 46609

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS00611 HISOL_DEHYDROGENASE; PS00435 PEROXIDASE_1

Important sites: ACT_SITE 321-321 ACT_SITE 322-322 BINDING 231-231 BINDING 253-253 BINDING 256-256 BINDING 322-322 BINDING 355-355 BINDING 409-409 BINDING 414-414

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLILNKEELLDKYSRRKAVEEDIEQQVRKILNEVASSGDEALIEYAREFDGFKGDLSNL
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHCC
KVSEEEIDKAYREVDDGFLNSLRKAIQRVFDFHQKQLPRSWFTTEENGNILGQIYTPVEV
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCEEE
AGIYVPGGTAAYPSSVVMNAVPAKVAGVKRIVMVSPQKGERMNPYVLVAAREAGVTEIYR
EEEEECCCCCCCCHHHHHHHCCHHHHCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHH
VGGAHAIAALAFGTKTIPRVDVITGPGNIYVTIAKKLVYGTVNIDMLAGPSEVVVIADSS
CCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEHEEEEEEEEEEECCCCEEEEECCC
AKPEYLAADMLSQAEHDSLASGVVITWDGELARKTAQKVEEYLKLLPRREIILKALENCG
CCCHHHHHHHHHHHCCCHHHCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
GIVVVDDEEEALQLANQLAPEHLELMLPNPFGYLAKVKNAGAVFLGQFSPEPMGDYLAGP
CEEEECCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCEEEEECCCCCCCCHHCCCC
NHVLPTSGTSRFYSPLSVDNFLKKSSVIYYSQEGFLADARDVIKLAETEGLFAHALSVKV
CCCCCCCCCCHHCCCCCHHHHHHHCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEE
RISNE
EECCC
>Mature Secondary Structure
MKLILNKEELLDKYSRRKAVEEDIEQQVRKILNEVASSGDEALIEYAREFDGFKGDLSNL
CCEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHCC
KVSEEEIDKAYREVDDGFLNSLRKAIQRVFDFHQKQLPRSWFTTEENGNILGQIYTPVEV
EECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCEEEEEECCEEE
AGIYVPGGTAAYPSSVVMNAVPAKVAGVKRIVMVSPQKGERMNPYVLVAAREAGVTEIYR
EEEEECCCCCCCCHHHHHHHCCHHHHCCEEEEEECCCCCCCCCCEEEEEECCCCHHHHHH
VGGAHAIAALAFGTKTIPRVDVITGPGNIYVTIAKKLVYGTVNIDMLAGPSEVVVIADSS
CCCHHHHHHHHHCCCCCCEEEEEECCCCEEEEEEEEHEEEEEEEEEEECCCCEEEEECCC
AKPEYLAADMLSQAEHDSLASGVVITWDGELARKTAQKVEEYLKLLPRREIILKALENCG
CCCHHHHHHHHHHHCCCHHHCCEEEEECCHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
GIVVVDDEEEALQLANQLAPEHLELMLPNPFGYLAKVKNAGAVFLGQFSPEPMGDYLAGP
CEEEECCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHCCCCEEEEECCCCCCCCHHCCCC
NHVLPTSGTSRFYSPLSVDNFLKKSSVIYYSQEGFLADARDVIKLAETEGLFAHALSVKV
CCCCCCCCCCHHCCCCCHHHHHHHCCEEEEECCCCCCCHHHHHHHHHCCCCEEEEEEEEE
RISNE
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA