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The map label for this gene is hisIE [H]

Identifier: 78044810

GI number: 78044810

Start: 966492

End: 967103

Strand: Direct

Name: hisIE [H]

Synonym: CHY_1091

Alternate gene names: 78044810

Gene position: 966492-967103 (Clockwise)

Preceding gene: 78044843

Following gene: 78043737

Centisome position: 40.25

GC content: 42.65

Gene sequence:

>612_bases
ATGGAACTTAAGTTTGACGAAAAAGGCTTGATTCCGGCGGTGGTACAGGATATTGATACCAGAGAAGTTTTAATGGTAGC
TTACATGAATGAAGAAAGCGTAAAAAAATCCCTGGAGACCGGTCAAACCTGGTTTTACAGCCGCTCCCGTAACGCTTTAT
GGCATAAAGGGGAGACGTCCGGCAATACCCAGGAAATTGTGGAGATCCGGTATGATTGTGATGCCGACTGCTTATTAATA
AAAGTAAGGCAAAAGGGGGTAGCGTGTCATACCGGAAATTACAGCTGTTTTTACCGAACCCTCTGGGAAGGAAAAGGCGA
GAGAGAAGATTTAAACGAGGTTTTGGCCAAACTCTGGCAGATTATCCTTGACCGGAAACAAAAGCTGCCGGAAGGTTCTT
ATACGGCAAAATTATTTCAAAAAGGAATAGATAAAATTGCCCAGAAGGTGGGCGAAGAAGCGGTAGAAACGGTTATAGCC
TCTAAAAATGATGATAAAGGAGAATTAATTTACGAAGCCGCTGATTTGGTTTATCATCTACTGGTATTACTGGCGGCAAA
GGACGTTGCTCTCGGCGATATTGCGGAGGAACTAAAAAAACGTTTTAAATAA

Upstream 100 bases:

>100_bases
TTGGCAGCTTCGGTGTTTCACTTTGGTAAATTTACCATTAAAGAAGTAAAGAGGTACTTAAAAGAGCGGGGGATACCGGT
CCGATTGGGGGATACCGAAA

Downstream 100 bases:

>100_bases
GTATTTAAATTTGATGGCGCACTCCGGTGCGCTTTTAAATTTTTACCGACCACCTAACACCTACGACCTACCACTTTTTT
ATTGACAGGAAAATTTGTCC

Product: bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein

Products: NA

Alternate protein names: Phosphoribosyl-AMP cyclohydrolase; PRA-CH; Phosphoribosyl-ATP pyrophosphatase; PRA-PH [H]

Number of amino acids: Translated: 203; Mature: 203

Protein sequence:

>203_residues
MELKFDEKGLIPAVVQDIDTREVLMVAYMNEESVKKSLETGQTWFYSRSRNALWHKGETSGNTQEIVEIRYDCDADCLLI
KVRQKGVACHTGNYSCFYRTLWEGKGEREDLNEVLAKLWQIILDRKQKLPEGSYTAKLFQKGIDKIAQKVGEEAVETVIA
SKNDDKGELIYEAADLVYHLLVLLAAKDVALGDIAEELKKRFK

Sequences:

>Translated_203_residues
MELKFDEKGLIPAVVQDIDTREVLMVAYMNEESVKKSLETGQTWFYSRSRNALWHKGETSGNTQEIVEIRYDCDADCLLI
KVRQKGVACHTGNYSCFYRTLWEGKGEREDLNEVLAKLWQIILDRKQKLPEGSYTAKLFQKGIDKIAQKVGEEAVETVIA
SKNDDKGELIYEAADLVYHLLVLLAAKDVALGDIAEELKKRFK
>Mature_203_residues
MELKFDEKGLIPAVVQDIDTREVLMVAYMNEESVKKSLETGQTWFYSRSRNALWHKGETSGNTQEIVEIRYDCDADCLLI
KVRQKGVACHTGNYSCFYRTLWEGKGEREDLNEVLAKLWQIILDRKQKLPEGSYTAKLFQKGIDKIAQKVGEEAVETVIA
SKNDDKGELIYEAADLVYHLLVLLAAKDVALGDIAEELKKRFK

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PRA-PH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=195, Percent_Identity=46.1538461538462, Blast_Score=172, Evalue=2e-44,
Organism=Saccharomyces cerevisiae, GI6319819, Length=179, Percent_Identity=39.1061452513966, Blast_Score=104, Evalue=7e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023019
- InterPro:   IPR008179
- InterPro:   IPR021130
- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH; PF01503 PRA-PH [H]

EC number: =3.5.4.19; =3.6.1.31 [H]

Molecular weight: Translated: 23166; Mature: 23166

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELKFDEKGLIPAVVQDIDTREVLMVAYMNEESVKKSLETGQTWFYSRSRNALWHKGETS
CCCCCCCCCCCHHHHHCCCCHHEEEEEECCHHHHHHHHHCCCCEEEECCCCCCEECCCCC
GNTQEIVEIRYDCDADCLLIKVRQKGVACHTGNYSCFYRTLWEGKGEREDLNEVLAKLWQ
CCHHHHEEEECCCCCCEEEEEEECCCCEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
IILDRKQKLPEGSYTAKLFQKGIDKIAQKVGEEAVETVIASKNDDKGELIYEAADLVYHL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LVLLAAKDVALGDIAEELKKRFK
HHHHHHCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MELKFDEKGLIPAVVQDIDTREVLMVAYMNEESVKKSLETGQTWFYSRSRNALWHKGETS
CCCCCCCCCCCHHHHHCCCCHHEEEEEECCHHHHHHHHHCCCCEEEECCCCCCEECCCCC
GNTQEIVEIRYDCDADCLLIKVRQKGVACHTGNYSCFYRTLWEGKGEREDLNEVLAKLWQ
CCHHHHEEEECCCCCCEEEEEEECCCCEEECCCCHHHHHHHHCCCCCHHHHHHHHHHHHH
IILDRKQKLPEGSYTAKLFQKGIDKIAQKVGEEAVETVIASKNDDKGELIYEAADLVYHL
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
LVLLAAKDVALGDIAEELKKRFK
HHHHHHCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]