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The map label for this gene is hemA

Identifier: 78044730

GI number: 78044730

Start: 1073150

End: 1074499

Strand: Direct

Name: hemA

Synonym: CHY_1207

Alternate gene names: 78044730

Gene position: 1073150-1074499 (Clockwise)

Preceding gene: 78042835

Following gene: 78044433

Centisome position: 44.69

GC content: 38.3

Gene sequence:

>1350_bases
ATGTATTTAGTGGTTGTGGGGGTAAATCACAGGACTGCTCCGGTTGAGGTGCGGGAAAAGTTATCTTTTTCCGACCACCA
ATTAAAAGATGCTTTTTCCGCTTTGCTGTCTTATCCTTCCATTGATGGTTCGGTTATTCTTTCTACTTGCAACCGTACTG
AGGTTTATGTGGCGTCCTTGGATGTTGATACTGGATTAAAAGTAGTAAGGGAATTCTTGGCTAATTGGGCCGGTTTATCT
TTGTCGGATATTAAGAATTATACTTACAATTATACATTGTACGATGCTGTTCATCATCTTTTTCGTGTAGCATCAGGCCT
TGATTCCATGATTTTAGGGGAAACCCAGATCTTGGGTCAGGTACGCGATGCTTTTTTAAAAGCCTCATCTTTAAAAGCGT
CCAATAAAATATTGAATACCCTATTTCAACACGCTATAACTGTGGGCAAAAAAGTTCGAACCGAAACTGGCATTGACAAA
AATCCAGTTTCGATTAGTTATGCCGCAGTTCAATTGGCGTGTTCATTTTTTGGCAGTTTAAAGGATAAGAAGGCGCTTCT
AATTGGTGCTGGTAAAATGAGTAGTTTAACAGCGAAGCATTTAAGTTACTATGGAATTAAAGAAATCATTGTTGCTAACC
GTTCCTTTGAAAAAGCCGAACAGTTTGCCCGGGAGTTTAATGGAATAGCTGTTCCCTTTGCCAAAATCTATGATATCCTC
GCCGAGGTGGATTTGGTAATAAGCTGTACGGGAGCACCTCACCTGATTATCCATAAAGAGCAATTAGAGTTAGTTATCGG
AAACAGGCAGCATCCATTATACCTAATAGATATAGCGGTTCCCCGGGATATTGATCCCGAAATAGCTAAACTTCCAAATG
TTTTTCTCTATGATATTGATAAATTGCAAAATGTGGTCACCAAAAATTTAGAAGAAAGAAAAAAACTGGCTGAAATGGCT
GAAAACATCATTGAAACTGAACTAAAAGCTTTTATTGAATGGCATAGCACCCAGTTTGTAGTTCCAACCATTGTAGCCCT
TAAGAAAAAAGCCGAGGAGATCAAGCAAAAAGAGCTTACTAAAGCTTTAAATAAACTGGGAAATATCAGTGAACGGGAAA
AAAATATCGTTTGTGCCCTTGCTCATACTATTCTTAATCAATTATTGCATACACCAATAGTGAAATTAAAACAGTATGCT
TTAACTCCTCAGGGCCATTTGTACACCGAAATTTTGCAAAACTTATTTGATTTACAAGTTGAAGGGGAACGCCCGAAAAA
TTTCACCCATCCGAGAGAAGAAATGGAGGAAAGTGATGAAAAAAGAAGTTATTGTGGGGAGTCGAGATAG

Upstream 100 bases:

>100_bases
GTGCAAAGAAATTATTAAATGGTAGCAGGAAATTTGATTAATTTGTAGAAATAATTTGTGAAAACTGTATTTAATCCTTA
GATAAAGGAGCGCGTTTAGT

Downstream 100 bases:

>100_bases
TGCTTTAGCTTTGTGGCAAACAAATTGGGTGGTGGAAAGACTAAGCAAAATTCACCCAGAAATAAATTTTAAAATTGTGA
CCATGAAAACAAAAGGGGAT

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 449; Mature: 449

Protein sequence:

>449_residues
MYLVVVGVNHRTAPVEVREKLSFSDHQLKDAFSALLSYPSIDGSVILSTCNRTEVYVASLDVDTGLKVVREFLANWAGLS
LSDIKNYTYNYTLYDAVHHLFRVASGLDSMILGETQILGQVRDAFLKASSLKASNKILNTLFQHAITVGKKVRTETGIDK
NPVSISYAAVQLACSFFGSLKDKKALLIGAGKMSSLTAKHLSYYGIKEIIVANRSFEKAEQFAREFNGIAVPFAKIYDIL
AEVDLVISCTGAPHLIIHKEQLELVIGNRQHPLYLIDIAVPRDIDPEIAKLPNVFLYDIDKLQNVVTKNLEERKKLAEMA
ENIIETELKAFIEWHSTQFVVPTIVALKKKAEEIKQKELTKALNKLGNISEREKNIVCALAHTILNQLLHTPIVKLKQYA
LTPQGHLYTEILQNLFDLQVEGERPKNFTHPREEMEESDEKRSYCGESR

Sequences:

>Translated_449_residues
MYLVVVGVNHRTAPVEVREKLSFSDHQLKDAFSALLSYPSIDGSVILSTCNRTEVYVASLDVDTGLKVVREFLANWAGLS
LSDIKNYTYNYTLYDAVHHLFRVASGLDSMILGETQILGQVRDAFLKASSLKASNKILNTLFQHAITVGKKVRTETGIDK
NPVSISYAAVQLACSFFGSLKDKKALLIGAGKMSSLTAKHLSYYGIKEIIVANRSFEKAEQFAREFNGIAVPFAKIYDIL
AEVDLVISCTGAPHLIIHKEQLELVIGNRQHPLYLIDIAVPRDIDPEIAKLPNVFLYDIDKLQNVVTKNLEERKKLAEMA
ENIIETELKAFIEWHSTQFVVPTIVALKKKAEEIKQKELTKALNKLGNISEREKNIVCALAHTILNQLLHTPIVKLKQYA
LTPQGHLYTEILQNLFDLQVEGERPKNFTHPREEMEESDEKRSYCGESR
>Mature_449_residues
MYLVVVGVNHRTAPVEVREKLSFSDHQLKDAFSALLSYPSIDGSVILSTCNRTEVYVASLDVDTGLKVVREFLANWAGLS
LSDIKNYTYNYTLYDAVHHLFRVASGLDSMILGETQILGQVRDAFLKASSLKASNKILNTLFQHAITVGKKVRTETGIDK
NPVSISYAAVQLACSFFGSLKDKKALLIGAGKMSSLTAKHLSYYGIKEIIVANRSFEKAEQFAREFNGIAVPFAKIYDIL
AEVDLVISCTGAPHLIIHKEQLELVIGNRQHPLYLIDIAVPRDIDPEIAKLPNVFLYDIDKLQNVVTKNLEERKKLAEMA
ENIIETELKAFIEWHSTQFVVPTIVALKKKAEEIKQKELTKALNKLGNISEREKNIVCALAHTILNQLLHTPIVKLKQYA
LTPQGHLYTEILQNLFDLQVEGERPKNFTHPREEMEESDEKRSYCGESR

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=403, Percent_Identity=39.9503722084367, Blast_Score=289, Evalue=3e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_CARHZ (Q3ACT4)

Other databases:

- EMBL:   CP000141
- RefSeq:   YP_360050.1
- ProteinModelPortal:   Q3ACT4
- SMR:   Q3ACT4
- STRING:   Q3ACT4
- GeneID:   3727853
- GenomeReviews:   CP000141_GR
- KEGG:   chy:CHY_1207
- NMPDR:   fig|246194.3.peg.1256
- TIGR:   CHY_1207
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   LLIDIAN
- ProtClustDB:   PRK00045
- BioCyc:   CHYD246194:CHY_1207-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 50499; Mature: 50499

Theoretical pI: Translated: 7.43; Mature: 7.43

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 109-109 BINDING 120-120

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYLVVVGVNHRTAPVEVREKLSFSDHQLKDAFSALLSYPSIDGSVILSTCNRTEVYVASL
CEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEE
DVDTGLKVVREFLANWAGLSLSDIKNYTYNYTLYDAVHHLFRVASGLDSMILGETQILGQ
CCHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VRDAFLKASSLKASNKILNTLFQHAITVGKKVRTETGIDKNPVSISYAAVQLACSFFGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
KDKKALLIGAGKMSSLTAKHLSYYGIKEIIVANRSFEKAEQFAREFNGIAVPFAKIYDIL
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHH
AEVDLVISCTGAPHLIIHKEQLELVIGNRQHPLYLIDIAVPRDIDPEIAKLPNVFLYDID
HHHHHEEEECCCCEEEEEHHHHHEEECCCCCCEEEEEEECCCCCCHHHHHCCCHHEEEHH
KLQNVVTKNLEERKKLAEMAENIIETELKAFIEWHSTQFVVPTIVALKKKAEEIKQKELT
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KALNKLGNISEREKNIVCALAHTILNQLLHTPIVKLKQYALTPQGHLYTEILQNLFDLQV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEE
EGERPKNFTHPREEMEESDEKRSYCGESR
CCCCCCCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MYLVVVGVNHRTAPVEVREKLSFSDHQLKDAFSALLSYPSIDGSVILSTCNRTEVYVASL
CEEEEEECCCCCCCHHHHHHCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEE
DVDTGLKVVREFLANWAGLSLSDIKNYTYNYTLYDAVHHLFRVASGLDSMILGETQILGQ
CCHHHHHHHHHHHHHHCCCCHHHHCCCEEEEEHHHHHHHHHHHHHCCHHHHHHHHHHHHH
VRDAFLKASSLKASNKILNTLFQHAITVGKKVRTETGIDKNPVSISYAAVQLACSFFGSL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCC
KDKKALLIGAGKMSSLTAKHLSYYGIKEIIVANRSFEKAEQFAREFNGIAVPFAKIYDIL
CCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHH
AEVDLVISCTGAPHLIIHKEQLELVIGNRQHPLYLIDIAVPRDIDPEIAKLPNVFLYDID
HHHHHEEEECCCCEEEEEHHHHHEEECCCCCCEEEEEEECCCCCCHHHHHCCCHHEEEHH
KLQNVVTKNLEERKKLAEMAENIIETELKAFIEWHSTQFVVPTIVALKKKAEEIKQKELT
HHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
KALNKLGNISEREKNIVCALAHTILNQLLHTPIVKLKQYALTPQGHLYTEILQNLFDLQV
HHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCEEE
EGERPKNFTHPREEMEESDEKRSYCGESR
CCCCCCCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA