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The map label for this gene is uxaA [H]

Identifier: 78044495

GI number: 78044495

Start: 1118854

End: 1120011

Strand: Direct

Name: uxaA [H]

Synonym: CHY_1256

Alternate gene names: 78044495

Gene position: 1118854-1120011 (Clockwise)

Preceding gene: 78042792

Following gene: 78043980

Centisome position: 46.59

GC content: 40.93

Gene sequence:

>1158_bases
ATGAAAATCAAAGGTTTTGTAAGGCCAGACGGTAAAGTTGGTATCCGTAATCACGTGTTAATAATTCCATCATCGGTTTG
TGCTAGCGAAGTAGCTATGCGGATAGCTTCTCATGTAAATGGAGCAGTAGCTCTCGCCAACCAGCACGGCTGCTGCCAGA
TTGGGGCTGATCTGGAACTTGTTACAAAGACGCTTATAGGACTCGGTAAGAATCCAAATGTAGCAGCTGTTCTTGTTGTA
GGTTTAGGCTGTGAAGGGGTTCCCACTGAGAAGGTTGCTGACGAAATATCAAAAACTGGAAAAAAAGTTGAATATATAAT
TATACAAGATTGTGGGGGAACTTTAAAAGCTGAGGAGATTGGTACAAGACTGGCAAGGCAAATGGCTCAGGAAGTTTCTT
TGCTTAAAAGAGAAGAAGTAGATATCACAAATTTAATATTGGCGGTTGAATGTGGAGGATCTGATACTACCTCTGGGCTT
GCATCAAATCCGGTAGCAGGTTATGTTTCAGATAAACTAATCGAGCTTGGTGGCACTTCAATGTTTTCGGAAACTACAGA
AATAATTGGTGCCGAACACCTACTTGCTAAACGCGCAGTTTCCAAGGAAGTAGCTCAAAAGCTTCTAGAAATAGTTAGAA
GGTGTGAGGAAAAAGCCAAAACAATGGGAGTTGACATGCGTGGAGGACAGCCAACCCCTGGAAATATCGAAGGTGGTATA
AGTACCATAGAAGAAAAATCTCTTGGATGTATATATAAGGGAGGTACTAAACCAGTACAGGGCGTTTTGGAATACGCAGA
GGCACCAACAGGTAAAGGGCTTTATATTATGGATACCCCAGGACAGGATATTGAATCGATAACAGGGATGACAGCAGGTG
GAGCGCAACTAGTAATCTTTACAACAGGTAGAGGAACACCAACTGGTTCACCTATAGCTCCAGTAATAAAAATTACTGCT
AACCCTGATACATTTAAAAAGATGGAAGACAATATCGATTTTAATGCTGGCACGATAATTTTAGGAGATGAAACTATTCG
GGAAGCAGGCGAACGGTTATTTAGTGAAATGATAGAAGTTTGCAATGGCAAGCTTACCAAAGCCGAGGCTCTGAAACATA
GAGAATTTGGAATATATAAACTTATTTCAACCTTTTAA

Upstream 100 bases:

>100_bases
TTATAGGGAGAGCTACAAAGTCCATCAAAGTTGGCGAACATGTTCATGTCCACAACATTGAGAGTTTGCGCGGTAGGGGT
GACTGGGAGGGGGATGTAAA

Downstream 100 bases:

>100_bases
AGATTCAATTTATATGCATAAAAGTCTATAGCAGTCCCCCCTTTTTTTTAGAGGGGGACTGTCACCTTAAAACATTGCAA
CTGCTATACTAAATGCTTTG

Product: UxaA family hydrolase

Products: NA

Alternate protein names: Altronic acid hydratase [H]

Number of amino acids: Translated: 385; Mature: 385

Protein sequence:

>385_residues
MKIKGFVRPDGKVGIRNHVLIIPSSVCASEVAMRIASHVNGAVALANQHGCCQIGADLELVTKTLIGLGKNPNVAAVLVV
GLGCEGVPTEKVADEISKTGKKVEYIIIQDCGGTLKAEEIGTRLARQMAQEVSLLKREEVDITNLILAVECGGSDTTSGL
ASNPVAGYVSDKLIELGGTSMFSETTEIIGAEHLLAKRAVSKEVAQKLLEIVRRCEEKAKTMGVDMRGGQPTPGNIEGGI
STIEEKSLGCIYKGGTKPVQGVLEYAEAPTGKGLYIMDTPGQDIESITGMTAGGAQLVIFTTGRGTPTGSPIAPVIKITA
NPDTFKKMEDNIDFNAGTIILGDETIREAGERLFSEMIEVCNGKLTKAEALKHREFGIYKLISTF

Sequences:

>Translated_385_residues
MKIKGFVRPDGKVGIRNHVLIIPSSVCASEVAMRIASHVNGAVALANQHGCCQIGADLELVTKTLIGLGKNPNVAAVLVV
GLGCEGVPTEKVADEISKTGKKVEYIIIQDCGGTLKAEEIGTRLARQMAQEVSLLKREEVDITNLILAVECGGSDTTSGL
ASNPVAGYVSDKLIELGGTSMFSETTEIIGAEHLLAKRAVSKEVAQKLLEIVRRCEEKAKTMGVDMRGGQPTPGNIEGGI
STIEEKSLGCIYKGGTKPVQGVLEYAEAPTGKGLYIMDTPGQDIESITGMTAGGAQLVIFTTGRGTPTGSPIAPVIKITA
NPDTFKKMEDNIDFNAGTIILGDETIREAGERLFSEMIEVCNGKLTKAEALKHREFGIYKLISTF
>Mature_385_residues
MKIKGFVRPDGKVGIRNHVLIIPSSVCASEVAMRIASHVNGAVALANQHGCCQIGADLELVTKTLIGLGKNPNVAAVLVV
GLGCEGVPTEKVADEISKTGKKVEYIIIQDCGGTLKAEEIGTRLARQMAQEVSLLKREEVDITNLILAVECGGSDTTSGL
ASNPVAGYVSDKLIELGGTSMFSETTEIIGAEHLLAKRAVSKEVAQKLLEIVRRCEEKAKTMGVDMRGGQPTPGNIEGGI
STIEEKSLGCIYKGGTKPVQGVLEYAEAPTGKGLYIMDTPGQDIESITGMTAGGAQLVIFTTGRGTPTGSPIAPVIKITA
NPDTFKKMEDNIDFNAGTIILGDETIREAGERLFSEMIEVCNGKLTKAEALKHREFGIYKLISTF

Specific function: D-galactarate metabolism; first step. [C]

COG id: COG2721

COG function: function code G; Altronate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uxaA family [H]

Homologues:

Organism=Escherichia coli, GI1789516, Length=404, Percent_Identity=34.1584158415842, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI1789475, Length=391, Percent_Identity=32.4808184143223, Blast_Score=205, Evalue=3e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007392
- InterPro:   IPR013974 [H]

Pfam domain/function: PF04295 GD_AH_C; PF08666 SAF [H]

EC number: =4.2.1.7 [H]

Molecular weight: Translated: 40747; Mature: 40747

Theoretical pI: Translated: 5.54; Mature: 5.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIKGFVRPDGKVGIRNHVLIIPSSVCASEVAMRIASHVNGAVALANQHGCCQIGADLEL
CCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCHHH
VTKTLIGLGKNPNVAAVLVVGLGCEGVPTEKVADEISKTGKKVEYIIIQDCGGTLKAEEI
HHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHH
GTRLARQMAQEVSLLKREEVDITNLILAVECGGSDTTSGLASNPVAGYVSDKLIELGGTS
HHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCH
MFSETTEIIGAEHLLAKRAVSKEVAQKLLEIVRRCEEKAKTMGVDMRGGQPTPGNIEGGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
STIEEKSLGCIYKGGTKPVQGVLEYAEAPTGKGLYIMDTPGQDIESITGMTAGGAQLVIF
HHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHCCCCCCCCEEEEE
TTGRGTPTGSPIAPVIKITANPDTFKKMEDNIDFNAGTIILGDETIREAGERLFSEMIEV
ECCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
CNGKLTKAEALKHREFGIYKLISTF
HCCCCCHHHHHHHHHCHHHHHHHCC
>Mature Secondary Structure
MKIKGFVRPDGKVGIRNHVLIIPSSVCASEVAMRIASHVNGAVALANQHGCCQIGADLEL
CCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHCCCEEEEECCCCCEEECCCHHH
VTKTLIGLGKNPNVAAVLVVGLGCEGVPTEKVADEISKTGKKVEYIIIQDCGGTLKAEEI
HHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCHHHH
GTRLARQMAQEVSLLKREEVDITNLILAVECGGSDTTSGLASNPVAGYVSDKLIELGGTS
HHHHHHHHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCH
MFSETTEIIGAEHLLAKRAVSKEVAQKLLEIVRRCEEKAKTMGVDMRGGQPTPGNIEGGI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCH
STIEEKSLGCIYKGGTKPVQGVLEYAEAPTGKGLYIMDTPGQDIESITGMTAGGAQLVIF
HHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHCCCCCCCCEEEEE
TTGRGTPTGSPIAPVIKITANPDTFKKMEDNIDFNAGTIILGDETIREAGERLFSEMIEV
ECCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHH
CNGKLTKAEALKHREFGIYKLISTF
HCCCCCHHHHHHHHHCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579062; 9384377 [H]