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The map label for this gene is strD [H]

Identifier: 78044259

GI number: 78044259

Start: 863545

End: 864609

Strand: Direct

Name: strD [H]

Synonym: CHY_0976

Alternate gene names: 78044259

Gene position: 863545-864609 (Clockwise)

Preceding gene: 78043288

Following gene: 78043500

Centisome position: 35.96

GC content: 38.4

Gene sequence:

>1065_bases
ATGAAAGCCCTAATTCTCTCCGGTGGTCAAGGCACGCGCCTTCGCCCGTTAACCTACAGTATAGCAAAGCAATTAGTACC
TGTGGCCAATAAACCCATATTACATTTTGTAATTGAAGACATAATTAATGCCGGTATAACTGATATTGGAGTAATTATTG
CTCCCGAAACGGGAGAAGAGATCAAGAAAAGCATTACCAATGCTGGTTTTCCTGCAAAATTTACTTTTATTCTTCAGGAA
AAACCTTTAGGTCTTGCCCATGCGGTAAAAGTAGCCAAAGACTATCTTGAAGATGATGATTTTATCATGTACTTAGGAGA
CAACTTAATAAACTCCGGAATTAAGGAATTTGTGGAAGAATACAAAGAAAACCGCTATGATGCGACGATCTTGTTAAAAG
AAGTTCAGGATCCAACCCGCTTTGGGGTGGCAGTGGTTGATGAAAATTTTAAAGTTCAAAGACTAATTGAAAAGCCCAAA
GAGCCACCATCAAATTTAGCTTTGGTTGGTATTTATATTTTTTCACCAAAAATCTTTTCTGCGATTGACAGAATTAAGCC
TTCTTGGCGTGGAGAGTTGGAAATAACTGATGCTATTCAGGAATTAATAAACCAGGGAGGCATGGTTAAAGCGCATAAGA
TTACCGGCTGGTGGCTTGATACCGGGAAAAAAGACGATTTATTGGAAGCAAACCGGGTAGTATTAGATGACTTAATACAA
AGGGATATAAGAGGAAAAATTGATGAGCAAACAAAAATAAACGGAAGAGTAGTAATTGAAGGAGGAGCAGAAATAGAAAA
CTCCATTATCCGCGGCCCAGCAGTAATTGGGAAAAACACCAAAGTTAAAAACTCCTTTATCGGTTCCTATACCAGTATAG
GTAACAACTGTTTAGTTGAAAATTCAGCCATAGAATTTTCGGTAATCCTTGACCACTCGGAAATCATTGGTGTAGAAAGA
CTTGATGAAAGCTTAATCGGAAGAAAAACAAGGGTAATAAAAGACGGTTCAGTAAACAAAGCCGTAAAGCTAATGATTGG
TGACGATGCGGAGGTACGGTTATAG

Upstream 100 bases:

>100_bases
TTACCGGGAAGAAATCTGGCGGGAGATTGAGAAGGAGAATAAAGAAGCGGTGGGGGAAAGTATTGAAAAAATTAATTTTG
ACATGTAGAGGGGAATTTTT

Downstream 100 bases:

>100_bases
TGGAATTCCAAAAAGGAGAAATTGAAGGGGTAATAATAAGACCTTTAAAAAAACACATAGACGAACGCGGTTGGCTCTGT
GAACTCTTTCGGCAGGATGA

Product: glucose-1-phosphate thymidylyltransferase

Products: NA

Alternate protein names: Sugar-nucleotidylation enzyme; dTDP-glucose pyrophosphorylase; dTDP-glucose synthase [H]

Number of amino acids: Translated: 354; Mature: 354

Protein sequence:

>354_residues
MKALILSGGQGTRLRPLTYSIAKQLVPVANKPILHFVIEDIINAGITDIGVIIAPETGEEIKKSITNAGFPAKFTFILQE
KPLGLAHAVKVAKDYLEDDDFIMYLGDNLINSGIKEFVEEYKENRYDATILLKEVQDPTRFGVAVVDENFKVQRLIEKPK
EPPSNLALVGIYIFSPKIFSAIDRIKPSWRGELEITDAIQELINQGGMVKAHKITGWWLDTGKKDDLLEANRVVLDDLIQ
RDIRGKIDEQTKINGRVVIEGGAEIENSIIRGPAVIGKNTKVKNSFIGSYTSIGNNCLVENSAIEFSVILDHSEIIGVER
LDESLIGRKTRVIKDGSVNKAVKLMIGDDAEVRL

Sequences:

>Translated_354_residues
MKALILSGGQGTRLRPLTYSIAKQLVPVANKPILHFVIEDIINAGITDIGVIIAPETGEEIKKSITNAGFPAKFTFILQE
KPLGLAHAVKVAKDYLEDDDFIMYLGDNLINSGIKEFVEEYKENRYDATILLKEVQDPTRFGVAVVDENFKVQRLIEKPK
EPPSNLALVGIYIFSPKIFSAIDRIKPSWRGELEITDAIQELINQGGMVKAHKITGWWLDTGKKDDLLEANRVVLDDLIQ
RDIRGKIDEQTKINGRVVIEGGAEIENSIIRGPAVIGKNTKVKNSFIGSYTSIGNNCLVENSAIEFSVILDHSEIIGVER
LDESLIGRKTRVIKDGSVNKAVKLMIGDDAEVRL
>Mature_354_residues
MKALILSGGQGTRLRPLTYSIAKQLVPVANKPILHFVIEDIINAGITDIGVIIAPETGEEIKKSITNAGFPAKFTFILQE
KPLGLAHAVKVAKDYLEDDDFIMYLGDNLINSGIKEFVEEYKENRYDATILLKEVQDPTRFGVAVVDENFKVQRLIEKPK
EPPSNLALVGIYIFSPKIFSAIDRIKPSWRGELEITDAIQELINQGGMVKAHKITGWWLDTGKKDDLLEANRVVLDDLIQ
RDIRGKIDEQTKINGRVVIEGGAEIENSIIRGPAVIGKNTKVKNSFIGSYTSIGNNCLVENSAIEFSVILDHSEIIGVER
LDESLIGRKTRVIKDGSVNKAVKLMIGDDAEVRL

Specific function: Involved in the biosynthesis of the streptose moiety of streptomycin. Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis [H]

COG id: COG1209

COG function: function code M; dTDP-glucose pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-1-phosphate thymidylyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=339, Percent_Identity=27.7286135693215, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI11761621, Length=339, Percent_Identity=28.3185840707965, Blast_Score=127, Evalue=1e-29,
Organism=Escherichia coli, GI1790224, Length=237, Percent_Identity=35.8649789029536, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1788351, Length=236, Percent_Identity=34.3220338983051, Blast_Score=146, Evalue=2e-36,
Organism=Escherichia coli, GI1788355, Length=270, Percent_Identity=25.1851851851852, Blast_Score=88, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI133931050, Length=320, Percent_Identity=32.1875, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI17509979, Length=375, Percent_Identity=24, Blast_Score=71, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6320148, Length=321, Percent_Identity=30.5295950155763, Blast_Score=131, Evalue=1e-31,
Organism=Drosophila melanogaster, GI21355443, Length=321, Percent_Identity=30.2180685358255, Blast_Score=131, Evalue=7e-31,
Organism=Drosophila melanogaster, GI24644084, Length=321, Percent_Identity=30.2180685358255, Blast_Score=131, Evalue=7e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005908
- InterPro:   IPR005835 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.24 [H]

Molecular weight: Translated: 39232; Mature: 39232

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALILSGGQGTRLRPLTYSIAKQLVPVANKPILHFVIEDIINAGITDIGVIIAPETGEE
CCEEEEECCCCCEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHH
IKKSITNAGFPAKFTFILQEKPLGLAHAVKVAKDYLEDDDFIMYLGDNLINSGIKEFVEE
HHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
YKENRYDATILLKEVQDPTRFGVAVVDENFKVQRLIEKPKEPPSNLALVGIYIFSPKIFS
HHHCCCCEEEEEECCCCCHHCCEEEECCCCHHHHHHHCCCCCCCCEEEEEEEEECCHHHH
AIDRIKPSWRGELEITDAIQELINQGGMVKAHKITGWWLDTGKKDDLLEANRVVLDDLIQ
HHHHCCCCCCCCEEHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHH
RDIRGKIDEQTKINGRVVIEGGAEIENSIIRGPAVIGKNTKVKNSFIGSYTSIGNNCLVE
HHHCCCCCCCEECCCEEEEECCCHHHHHHHCCCEEECCCCCCCHHHCCCHHHCCCCEEEE
NSAIEFSVILDHSEIIGVERLDESLIGRKTRVIKDGSVNKAVKLMIGDDAEVRL
CCCEEEEEEECCHHHHHHHHHHHHHHCCHHEEEECCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MKALILSGGQGTRLRPLTYSIAKQLVPVANKPILHFVIEDIINAGITDIGVIIAPETGEE
CCEEEEECCCCCEECHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHH
IKKSITNAGFPAKFTFILQEKPLGLAHAVKVAKDYLEDDDFIMYLGDNLINSGIKEFVEE
HHHHHHCCCCCEEEEEEEECCCCCHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
YKENRYDATILLKEVQDPTRFGVAVVDENFKVQRLIEKPKEPPSNLALVGIYIFSPKIFS
HHHCCCCEEEEEECCCCCHHCCEEEECCCCHHHHHHHCCCCCCCCEEEEEEEEECCHHHH
AIDRIKPSWRGELEITDAIQELINQGGMVKAHKITGWWLDTGKKDDLLEANRVVLDDLIQ
HHHHCCCCCCCCEEHHHHHHHHHHCCCCEEEEEEEEEEECCCCCCCHHHHHHHHHHHHHH
RDIRGKIDEQTKINGRVVIEGGAEIENSIIRGPAVIGKNTKVKNSFIGSYTSIGNNCLVE
HHHCCCCCCCEECCCEEEEECCCHHHHHHHCCCEEECCCCCCCHHHCCCHHHCCCCEEEE
NSAIEFSVILDHSEIIGVERLDESLIGRKTRVIKDGSVNKAVKLMIGDDAEVRL
CCCEEEEEEECCHHHHHHHHHHHHHHCCHHEEEECCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3118332 [H]