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The map label for this gene is deoR [H]

Identifier: 77465737

GI number: 77465737

Start: 856811

End: 857575

Strand: Reverse

Name: deoR [H]

Synonym: RSP_3731

Alternate gene names: 77465737

Gene position: 857575-856811 (Counterclockwise)

Preceding gene: 77465746

Following gene: 77465734

Centisome position: 90.94

GC content: 70.07

Gene sequence:

>765_bases
ATGTCTAGTTTGATGTGCCATGGCGGCGGCCTACCGGAGGTGCGAGTGGCAAGACCATCAGGCAGGGCAGAGCGGATCGC
GGCGCTGGGCGAACTGTGCCGGGCGGGCTCGATCGTCCATATCGGCGAGGCGGCGCGCCAGATCGGCGCCTCCGAGATCA
CCATCCGGCGCGATCTGAGCGTGGGCGCAGGGGGGCTCGTCTGCCTCGGCGGCTATGTTATGCGCGCCTCCGAAGGGGCC
GAGGGCTATTCGCTCACCGCGGCCGAAGCCTCCGAGGCGGGCGCCAAGGAGGCGCTCGCGGTGCGGGCGGCGGCGCTGAT
CGAGCCGGGCGACACGGTCTTTCTCGATTGCGGCACGACCACGCCCTATCTCGCCGCGCGGGTGCCGCAGAATGCGCGGG
TGACGGTGGTGACGCAGGCGCTCAACATCGCCGAAACGGTGGCGCGGTTGACAGGTGTCAACCTGATCCTGCTGGCGGGG
ATCTACCACCCCGAGACGGCGAGCTTCTCCTCCGAGGAGGCGGTGGCGATGCTCGGGCGGATCAACATCACCAAGGGCTT
CTTCTCGGCCGCGGGCGTGCATGAGACCGAGGGCGTGACCTGCTTCCACTTCCACGAGGTGCCGGTCAAGCGCGCGGCGC
TGGCGCGGTCCCGCCAGCCCTATCTGGTCTGCGACGGCTCGAAATGGGGCCGGCTGCGCCCCGCGACCTATGCGCGGCTC
GAGGAATTCGAGGGCTGGATCGGCGCGCCGGACCGGGCGGCCTGA

Upstream 100 bases:

>100_bases
ACAGACGGCGCCGATCCTCCTCGCGCCCCCTGCAGTTGCCTATATTGATCGAATCTCGTCAATATGATCTTATTCATTCA
AAACCTGGGCTGGCCTGTCA

Downstream 100 bases:

>100_bases
TCGCCCCTCCGCGGTCGGTCGACCCGCGGAGGGGCGGCGCAGTCAGCCTGCGCTGCCTTCCAGCTTGTCCTGCGTCCGGG
TCTCGAAGTCGCCCGCTTCG

Product: DeoR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 254; Mature: 253

Protein sequence:

>254_residues
MSSLMCHGGGLPEVRVARPSGRAERIAALGELCRAGSIVHIGEAARQIGASEITIRRDLSVGAGGLVCLGGYVMRASEGA
EGYSLTAAEASEAGAKEALAVRAAALIEPGDTVFLDCGTTTPYLAARVPQNARVTVVTQALNIAETVARLTGVNLILLAG
IYHPETASFSSEEAVAMLGRINITKGFFSAAGVHETEGVTCFHFHEVPVKRAALARSRQPYLVCDGSKWGRLRPATYARL
EEFEGWIGAPDRAA

Sequences:

>Translated_254_residues
MSSLMCHGGGLPEVRVARPSGRAERIAALGELCRAGSIVHIGEAARQIGASEITIRRDLSVGAGGLVCLGGYVMRASEGA
EGYSLTAAEASEAGAKEALAVRAAALIEPGDTVFLDCGTTTPYLAARVPQNARVTVVTQALNIAETVARLTGVNLILLAG
IYHPETASFSSEEAVAMLGRINITKGFFSAAGVHETEGVTCFHFHEVPVKRAALARSRQPYLVCDGSKWGRLRPATYARL
EEFEGWIGAPDRAA
>Mature_253_residues
SSLMCHGGGLPEVRVARPSGRAERIAALGELCRAGSIVHIGEAARQIGASEITIRRDLSVGAGGLVCLGGYVMRASEGAE
GYSLTAAEASEAGAKEALAVRAAALIEPGDTVFLDCGTTTPYLAARVPQNARVTVVTQALNIAETVARLTGVNLILLAGI
YHPETASFSSEEAVAMLGRINITKGFFSAAGVHETEGVTCFHFHEVPVKRAALARSRQPYLVCDGSKWGRLRPATYARLE
EFEGWIGAPDRAA

Specific function: This protein is one of the repressors that regulate the expression of deoCABD genes, which encode nucleotide and deoxy ribonucleotide catabolizing enzymes. It also negatively regulates the expression of nupG (a transport protein) and tsx (a pore- forming

COG id: COG1349

COG function: function code KG; Transcriptional regulators of sugar metabolism

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH deoR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787063, Length=223, Percent_Identity=34.9775784753363, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI226510968, Length=236, Percent_Identity=31.7796610169492, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI1789829, Length=213, Percent_Identity=27.6995305164319, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1789059, Length=229, Percent_Identity=27.5109170305677, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1790753, Length=226, Percent_Identity=26.1061946902655, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789519, Length=218, Percent_Identity=24.3119266055046, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787540, Length=213, Percent_Identity=27.2300469483568, Blast_Score=64, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014036
- InterPro:   IPR001034
- InterPro:   IPR018356
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00455 DeoR; PF08220 HTH_DeoR [H]

EC number: NA

Molecular weight: Translated: 26664; Mature: 26533

Theoretical pI: Translated: 7.09; Mature: 7.09

Prosite motif: PS51000 HTH_DEOR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSLMCHGGGLPEVRVARPSGRAERIAALGELCRAGSIVHIGEAARQIGASEITIRRDLS
CCCCEECCCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEECHHHHHCCCCEEEEEECCC
VGAGGLVCLGGYVMRASEGAEGYSLTAAEASEAGAKEALAVRAAALIEPGDTVFLDCGTT
CCCCCCEECCCEEEEECCCCCCEEEEECCHHHCCHHHHHHHHHHHEECCCCEEEEECCCC
TPYLAARVPQNARVTVVTQALNIAETVARLTGVNLILLAGIYHPETASFSSEEAVAMLGR
CCHHEEECCCCCEEEEEEHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHE
INITKGFFSAAGVHETEGVTCFHFHEVPVKRAALARSRQPYLVCDGSKWGRLRPATYARL
EEECHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHH
EEFEGWIGAPDRAA
HHHCCCCCCCCCCC
>Mature Secondary Structure 
SSLMCHGGGLPEVRVARPSGRAERIAALGELCRAGSIVHIGEAARQIGASEITIRRDLS
CCCEECCCCCCCEEEECCCCHHHHHHHHHHHHHCCCEEEECHHHHHCCCCEEEEEECCC
VGAGGLVCLGGYVMRASEGAEGYSLTAAEASEAGAKEALAVRAAALIEPGDTVFLDCGTT
CCCCCCEECCCEEEEECCCCCCEEEEECCHHHCCHHHHHHHHHHHEECCCCEEEEECCCC
TPYLAARVPQNARVTVVTQALNIAETVARLTGVNLILLAGIYHPETASFSSEEAVAMLGR
CCHHEEECCCCCEEEEEEHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHE
INITKGFFSAAGVHETEGVTCFHFHEVPVKRAALARSRQPYLVCDGSKWGRLRPATYARL
EEECHHHHHHCCCCCCCCEEEEEEECCCHHHHHHHHCCCCEEEECCCCCCCCCCHHHHHH
EEFEGWIGAPDRAA
HHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]