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The map label for this gene is expE1 [H]

Identifier: 77465510

GI number: 77465510

Start: 588614

End: 589222

Strand: Reverse

Name: expE1 [H]

Synonym: RSP_3509

Alternate gene names: 77465510

Gene position: 589222-588614 (Counterclockwise)

Preceding gene: 77465515

Following gene: 77465505

Centisome position: 62.48

GC content: 68.31

Gene sequence:

>609_bases
ATGGCGCGCATCAAGGGAACCGCCCGGAACGACATTCTGCAGGGCACGGATGCCTGGGACATCATCTATGGCGGCAGCGG
AAATGACCGGATCTACGGCGGGGCCGGCAATGACGAGCTGAAGGGCGGCTTCGGCAACGACCGTCTGTGGGGCGGGACCG
GACGGGACGATCTCGAAGGCGGCAGCGGGGACGACATCCTGTCGGGCGGCGCCGGCGACGATGAGCTGGAGGGCGATGCC
GGCAACGACCGGCTCTGGGGCGGCGCGGGCAACGACGAGCTTGAGGGCGGCTCCGGCGCGGACCGGCTCCATGGCGGCTC
GGGTAACGACCGGCTCGACGGAGGGACGGGCAACGACGTGCTGACGGGCGGGGCGGGCCGCGATGTGTTCGAATTCGAGC
GCGGCGATGGCCGGGACCGCATCACCGACTTCACCAATGGCCAGGACCGGCTGGAGCTCGACGATTTCACCCGGATGCAG
GTTCAGGCCGTGATCGACGACGCGCGTCAGGTCGGCGGCAACGTGGTCCTCACCCTGTCGGCGGACACGCAGGTCGTGCT
CGAGAACATGAAGCTCGCGCAGCTGGACATGTCCGACTTCCTGTTCTGA

Upstream 100 bases:

>100_bases
CGCTGACGGCAGGGATCAGAGTGCCGTCAGCCACGTTGTGCGACGACGGGGTCGAGGTCCTCGACCGGACCCTTCAGGCA
ACAGCAAGAGGAGACGCCGC

Downstream 100 bases:

>100_bases
CGGTGGCAGGGAGGCGCGCGGAAGGCACACGCCTGTGTGCCGCCCGTGCGCTTTCTCTGGCCGCAGCCCGGGGCGGTTGC
CGGTGCAGCCGTCATCGGAT

Product: hemolysin-type calcium-binding region, RTX

Products: NA

Alternate protein names: Lkt [H]

Number of amino acids: Translated: 202; Mature: 201

Protein sequence:

>202_residues
MARIKGTARNDILQGTDAWDIIYGGSGNDRIYGGAGNDELKGGFGNDRLWGGTGRDDLEGGSGDDILSGGAGDDELEGDA
GNDRLWGGAGNDELEGGSGADRLHGGSGNDRLDGGTGNDVLTGGAGRDVFEFERGDGRDRITDFTNGQDRLELDDFTRMQ
VQAVIDDARQVGGNVVLTLSADTQVVLENMKLAQLDMSDFLF

Sequences:

>Translated_202_residues
MARIKGTARNDILQGTDAWDIIYGGSGNDRIYGGAGNDELKGGFGNDRLWGGTGRDDLEGGSGDDILSGGAGDDELEGDA
GNDRLWGGAGNDELEGGSGADRLHGGSGNDRLDGGTGNDVLTGGAGRDVFEFERGDGRDRITDFTNGQDRLELDDFTRMQ
VQAVIDDARQVGGNVVLTLSADTQVVLENMKLAQLDMSDFLF
>Mature_201_residues
ARIKGTARNDILQGTDAWDIIYGGSGNDRIYGGAGNDELKGGFGNDRLWGGTGRDDLEGGSGDDILSGGAGDDELEGDAG
NDRLWGGAGNDELEGGSGADRLHGGSGNDRLDGGTGNDVLTGGAGRDVFEFERGDGRDRITDFTNGQDRLELDDFTRMQV
QAVIDDARQVGGNVVLTLSADTQVVLENMKLAQLDMSDFLF

Specific function: One of the virulence factors of A.actinomycetemcomitans might be a cytotoxin, possibly the membrane-bound hemolysin [H]

COG id: COG2931

COG function: function code Q; RTX toxins and related Ca2+-binding proteins

Gene ontology:

Cell location: Cell outer membrane; Multi-pass membrane protein. Secreted (By similarity) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 7 hemolysin-type calcium-binding repeats [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018511
- InterPro:   IPR001343
- InterPro:   IPR018504
- InterPro:   IPR003995
- InterPro:   IPR011049 [H]

Pfam domain/function: PF00353 HemolysinCabind; PF02382 RTX [H]

EC number: NA

Molecular weight: Translated: 21222; Mature: 21091

Theoretical pI: Translated: 3.90; Mature: 3.90

Prosite motif: PS00330 HEMOLYSIN_CALCIUM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARIKGTARNDILQGTDAWDIIYGGSGNDRIYGGAGNDELKGGFGNDRLWGGTGRDDLEG
CCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCC
GSGDDILSGGAGDDELEGDAGNDRLWGGAGNDELEGGSGADRLHGGSGNDRLDGGTGNDV
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
LTGGAGRDVFEFERGDGRDRITDFTNGQDRLELDDFTRMQVQAVIDDARQVGGNVVLTLS
EECCCCCCEEEECCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCCEEEEEC
ADTQVVLENMKLAQLDMSDFLF
CCCHHHHHCCHHEEECHHHHCC
>Mature Secondary Structure 
ARIKGTARNDILQGTDAWDIIYGGSGNDRIYGGAGNDELKGGFGNDRLWGGTGRDDLEG
CCCCCCCCCCCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCCCCCCEECCCCCCCCCC
GSGDDILSGGAGDDELEGDAGNDRLWGGAGNDELEGGSGADRLHGGSGNDRLDGGTGNDV
CCCCCCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCE
LTGGAGRDVFEFERGDGRDRITDFTNGQDRLELDDFTRMQVQAVIDDARQVGGNVVLTLS
EECCCCCCEEEECCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHCCCCEEEEEC
ADTQVVLENMKLAQLDMSDFLF
CCCHHHHHCCHHEEECHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2670940 [H]