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The map label for this gene is mprB [H]

Identifier: 77465250

GI number: 77465250

Start: 297131

End: 298525

Strand: Reverse

Name: mprB [H]

Synonym: RSP_3240

Alternate gene names: 77465250

Gene position: 298525-297131 (Counterclockwise)

Preceding gene: 77465251

Following gene: 77465242

Centisome position: 31.66

GC content: 72.26

Gene sequence:

>1395_bases
ATGAGCCTGCGCCCCTCCCCCGATCCGCAGGCGGGGATCTCGCGCCTGTCCGGCTCCTCCTCGCTGCGGCTGGCGGCGCG
GCTTGCGCTGATCTTCGTGGGGGCCACGCTTCTGGCCGGGCTCGTGTCGGTCCCGCTGCTGACGGGCGCGCTGAAGGACC
GGCTGCGCGCGGATGCCCGGCAGATGGCGGAGTCGCTGGCCGCGACCTGGCAGGTGGCGGGGCTGGTCGATCTGCACGCC
CAGATCGCGGCGAATGTGGCCACCACGCGCGACTTCGCCAACCTCTATCTCTTCATCGACAATTCCGGCCGGATCGTCTT
CGGCAACTTCCACCTGCCCGAGCCCTTCGTCGGGTCGCGCGAACTCGTCTCGGGGCGAGACATGCTGCTGCCGGGCGCGG
CGCCCGACGGGATCGGCTTCTCGGCCTACGGGTTGCGCATCCCGGCGGGCTATGTGATCGCGGCCCGCCAGACGAGCGCG
CTCGACGAGGTGCGGGCGATCGTGATCCGGGCGGTGGCCTCGGGGCTGGCGCTCGCGCTTCTGCTGGCACTGGGGGTGGC
GGGGATCCTCGCCTGGGGGGCGGAACGGCGGATCGCGCGCCTTTCGAGCGTGCTCACGCGGGCGTCGGCCGGCGATCTGT
CCGAGCGGGTGCAGGATGCGGGCAGCGACGACATCGGCCGCATCGCGGGCGCCGTGAATGCGACGCTCGACCAGCTGGAG
CTGACGGTCGAGAGCCTCCGGCAGGTCTCCTCCGACGTGGCACACGATCTGAGGACGCCCATCACGCGCCTGCGCACCTC
GCTCGAACCCTTGATGCTGCGCGAGGATCTGCCTGAGGATGCCGCGGCGGACATCGCCTCGGCGGTCGGTCAGGCGGACC
GGATCGTGCGGATCTTCAACGCCGTGCTGCGCATCGCCCAGATCGAGGGCGGCGGCGCCCGCCCGCGCTTCGCGAGGCTC
GATCTGGGGCGGCTTGCCGACGATCTCCACGAACTGCTGGAGCCGGTGGCCGAGGAGATGGGTCACCGCATCGACGCCCG
GATCGAGCCCGTGGCGGTCGAGGGCGACCGCGATCTGCTCGCGCAGGCCATCTCCAACCTCGTCGAGAATGCCTTCCGCC
ATTGCCCACCGCCCGCCCATGTCGCGCTGACGGTGAGGCGCGAGGGGGCGGAGGCGGTGGTGACGGTCGAGGATGACGGG
CCGGGCATTCCCGCGGCCGAGCGCGAGGCGGTCTTCCGCCGCTTCTACCGGCTCGAGCGGAGCCGCAACAGCGAGGGAAG
CGGCTTGGGCCTCAGCCTCGTCGCCGCGGTGGCGCGCCTTCACGGCGGCCGCGTCGAGCTGCACGACGCGGAGCCCGGCC
TGCGCGTTACGCTGCGGCTGCCGGTCGGAGAGTGA

Upstream 100 bases:

>100_bases
TCGTCGAGACCCACATGAGCCGCCTGCGCGCCAAGATCGACCGGCCGTTCGACAAGCCGCTGCTCCACACGGTCCGGGGC
GCGGGCTACATGCTGAAGGC

Downstream 100 bases:

>100_bases
GACGAGCCGTAGCTTATGGGCTGCCCGAAGCAAACTCCCGAGCCGGGCGGAGCGCCTTTGAGAAATCGCCGGCACCCGTG
CCTCATTCAACGGCCGACCG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Mycobacterial persistence regulator B [H]

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSLRPSPDPQAGISRLSGSSSLRLAARLALIFVGATLLAGLVSVPLLTGALKDRLRADARQMAESLAATWQVAGLVDLHA
QIAANVATTRDFANLYLFIDNSGRIVFGNFHLPEPFVGSRELVSGRDMLLPGAAPDGIGFSAYGLRIPAGYVIAARQTSA
LDEVRAIVIRAVASGLALALLLALGVAGILAWGAERRIARLSSVLTRASAGDLSERVQDAGSDDIGRIAGAVNATLDQLE
LTVESLRQVSSDVAHDLRTPITRLRTSLEPLMLREDLPEDAAADIASAVGQADRIVRIFNAVLRIAQIEGGGARPRFARL
DLGRLADDLHELLEPVAEEMGHRIDARIEPVAVEGDRDLLAQAISNLVENAFRHCPPPAHVALTVRREGAEAVVTVEDDG
PGIPAAEREAVFRRFYRLERSRNSEGSGLGLSLVAAVARLHGGRVELHDAEPGLRVTLRLPVGE

Sequences:

>Translated_464_residues
MSLRPSPDPQAGISRLSGSSSLRLAARLALIFVGATLLAGLVSVPLLTGALKDRLRADARQMAESLAATWQVAGLVDLHA
QIAANVATTRDFANLYLFIDNSGRIVFGNFHLPEPFVGSRELVSGRDMLLPGAAPDGIGFSAYGLRIPAGYVIAARQTSA
LDEVRAIVIRAVASGLALALLLALGVAGILAWGAERRIARLSSVLTRASAGDLSERVQDAGSDDIGRIAGAVNATLDQLE
LTVESLRQVSSDVAHDLRTPITRLRTSLEPLMLREDLPEDAAADIASAVGQADRIVRIFNAVLRIAQIEGGGARPRFARL
DLGRLADDLHELLEPVAEEMGHRIDARIEPVAVEGDRDLLAQAISNLVENAFRHCPPPAHVALTVRREGAEAVVTVEDDG
PGIPAAEREAVFRRFYRLERSRNSEGSGLGLSLVAAVARLHGGRVELHDAEPGLRVTLRLPVGE
>Mature_463_residues
SLRPSPDPQAGISRLSGSSSLRLAARLALIFVGATLLAGLVSVPLLTGALKDRLRADARQMAESLAATWQVAGLVDLHAQ
IAANVATTRDFANLYLFIDNSGRIVFGNFHLPEPFVGSRELVSGRDMLLPGAAPDGIGFSAYGLRIPAGYVIAARQTSAL
DEVRAIVIRAVASGLALALLLALGVAGILAWGAERRIARLSSVLTRASAGDLSERVQDAGSDDIGRIAGAVNATLDQLEL
TVESLRQVSSDVAHDLRTPITRLRTSLEPLMLREDLPEDAAADIASAVGQADRIVRIFNAVLRIAQIEGGGARPRFARLD
LGRLADDLHELLEPVAEEMGHRIDARIEPVAVEGDRDLLAQAISNLVENAFRHCPPPAHVALTVRREGAEAVVTVEDDGP
GIPAAEREAVFRRFYRLERSRNSEGSGLGLSLVAAVARLHGGRVELHDAEPGLRVTLRLPVGE

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. In response to en

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788279, Length=286, Percent_Identity=28.3216783216783, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788393, Length=278, Percent_Identity=28.0575539568345, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1786783, Length=359, Percent_Identity=24.7910863509749, Blast_Score=99, Evalue=4e-22,
Organism=Escherichia coli, GI1787894, Length=325, Percent_Identity=27.3846153846154, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790346, Length=269, Percent_Identity=28.6245353159851, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790551, Length=308, Percent_Identity=26.9480519480519, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1790861, Length=300, Percent_Identity=29.6666666666667, Blast_Score=92, Evalue=9e-20,
Organism=Escherichia coli, GI1786600, Length=223, Percent_Identity=30.9417040358744, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1789808, Length=293, Percent_Identity=27.6450511945392, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1786912, Length=218, Percent_Identity=29.3577981651376, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1787374, Length=271, Percent_Identity=25.0922509225092, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI145693157, Length=221, Percent_Identity=29.8642533936652, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1789403, Length=220, Percent_Identity=29.5454545454545, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790436, Length=222, Percent_Identity=25.6756756756757, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI87081816, Length=226, Percent_Identity=28.3185840707965, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 49351; Mature: 49220

Theoretical pI: Translated: 5.89; Mature: 5.89

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLRPSPDPQAGISRLSGSSSLRLAARLALIFVGATLLAGLVSVPLLTGALKDRLRADAR
CCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMAESLAATWQVAGLVDLHAQIAANVATTRDFANLYLFIDNSGRIVFGNFHLPEPFVGSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEECCCCCCCCCCCH
ELVSGRDMLLPGAAPDGIGFSAYGLRIPAGYVIAARQTSALDEVRAIVIRAVASGLALAL
HHHCCCCEECCCCCCCCCCCCEECEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
LLALGVAGILAWGAERRIARLSSVLTRASAGDLSERVQDAGSDDIGRIAGAVNATLDQLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LTVESLRQVSSDVAHDLRTPITRLRTSLEPLMLREDLPEDAAADIASAVGQADRIVRIFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AVLRIAQIEGGGARPRFARLDLGRLADDLHELLEPVAEEMGHRIDARIEPVAVEGDRDLL
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHH
AQAISNLVENAFRHCPPPAHVALTVRREGAEAVVTVEDDGPGIPAAEREAVFRRFYRLER
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
SRNSEGSGLGLSLVAAVARLHGGRVELHDAEPGLRVTLRLPVGE
CCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCC
>Mature Secondary Structure 
SLRPSPDPQAGISRLSGSSSLRLAARLALIFVGATLLAGLVSVPLLTGALKDRLRADAR
CCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QMAESLAATWQVAGLVDLHAQIAANVATTRDFANLYLFIDNSGRIVFGNFHLPEPFVGSR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEEEEEECCCEEEEECCCCCCCCCCCH
ELVSGRDMLLPGAAPDGIGFSAYGLRIPAGYVIAARQTSALDEVRAIVIRAVASGLALAL
HHHCCCCEECCCCCCCCCCCCEECEECCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
LLALGVAGILAWGAERRIARLSSVLTRASAGDLSERVQDAGSDDIGRIAGAVNATLDQLE
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LTVESLRQVSSDVAHDLRTPITRLRTSLEPLMLREDLPEDAAADIASAVGQADRIVRIFN
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
AVLRIAQIEGGGARPRFARLDLGRLADDLHELLEPVAEEMGHRIDARIEPVAVEGDRDLL
HHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHH
AQAISNLVENAFRHCPPPAHVALTVRREGAEAVVTVEDDGPGIPAAEREAVFRRFYRLER
HHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHH
SRNSEGSGLGLSLVAAVARLHGGRVELHDAEPGLRVTLRLPVGE
CCCCCCCCCHHHHHHHHHHHCCCEEEEECCCCCEEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA