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The map label for this gene is copR [H]

Identifier: 77465251

GI number: 77465251

Start: 298522

End: 299196

Strand: Reverse

Name: copR [H]

Synonym: RSP_3241

Alternate gene names: 77465251

Gene position: 299196-298522 (Counterclockwise)

Preceding gene: 77465255

Following gene: 77465250

Centisome position: 31.73

GC content: 69.04

Gene sequence:

>675_bases
ATGAAGATCCTGCTTGCCGAGGACGACCGCCAGACCGCCGACTACCTCCGCCAGGGTCTTCTGGCCGAGGGCTACAGCGT
GGATCATGTGCCCGACGGGCGCGACGCGCTGGTGCAGGCGACGCTGCAACCCTACGACCTCCTCGTGGTCGACCGGATGA
TGCCGGGGCTCGACGGGCTCTCGCTCGTCAAGGCGCTGCGCTCGGCGCAGATCAAGGCGCCGATCCTGATCCTCACCGCC
ATGGGCGGGGTGACGGACCGGGTCGAGGGGTTGCAGGCCGGGGCCGACGATTATCTGGTCAAGCCCTTCGCCTTCTCGGA
ACTGTCAGCGCGGCTGGCGGCGCTGGCGCGTCGTCCTGCCCTGGCCGAGGGGGCGCGCGATCTTCTGCGGGTGGGCGATC
TCACGCTCGACACCGTGCGCCGCACCGTCAGCCGCGGCGGCACCGAGATCGACCTCCAGCCGCGCGAATTCCGGCTTCTC
GAACATCTGATGCGGGCCGCGGGGCGCGTGCAGACGCGCACCATGCTGCTCGAAGCGGTCTGGGATTTCCATTTCGATCC
CGGCACCAGCGTCGTCGAGACCCACATGAGCCGCCTGCGCGCCAAGATCGACCGGCCGTTCGACAAGCCGCTGCTCCACA
CGGTCCGGGGCGCGGGCTACATGCTGAAGGCATGA

Upstream 100 bases:

>100_bases
CGTGATCGGGATCGGGCCGCCTCGAACCTTACCGAACCGTGAGAATGCGGAAAGGTTGCGGCAAGACGGGGGGCGCAGAC
TCCCGTCGATGGAGAATGAC

Downstream 100 bases:

>100_bases
GCCTGCGCCCCTCCCCCGATCCGCAGGCGGGGATCTCGCGCCTGTCCGGCTCCTCCTCGCTGCGGCTGGCGGCGCGGCTT
GCGCTGATCTTCGTGGGGGC

Product: two-component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 224; Mature: 224

Protein sequence:

>224_residues
MKILLAEDDRQTADYLRQGLLAEGYSVDHVPDGRDALVQATLQPYDLLVVDRMMPGLDGLSLVKALRSAQIKAPILILTA
MGGVTDRVEGLQAGADDYLVKPFAFSELSARLAALARRPALAEGARDLLRVGDLTLDTVRRTVSRGGTEIDLQPREFRLL
EHLMRAAGRVQTRTMLLEAVWDFHFDPGTSVVETHMSRLRAKIDRPFDKPLLHTVRGAGYMLKA

Sequences:

>Translated_224_residues
MKILLAEDDRQTADYLRQGLLAEGYSVDHVPDGRDALVQATLQPYDLLVVDRMMPGLDGLSLVKALRSAQIKAPILILTA
MGGVTDRVEGLQAGADDYLVKPFAFSELSARLAALARRPALAEGARDLLRVGDLTLDTVRRTVSRGGTEIDLQPREFRLL
EHLMRAAGRVQTRTMLLEAVWDFHFDPGTSVVETHMSRLRAKIDRPFDKPLLHTVRGAGYMLKA
>Mature_224_residues
MKILLAEDDRQTADYLRQGLLAEGYSVDHVPDGRDALVQATLQPYDLLVVDRMMPGLDGLSLVKALRSAQIKAPILILTA
MGGVTDRVEGLQAGADDYLVKPFAFSELSARLAALARRPALAEGARDLLRVGDLTLDTVRRTVSRGGTEIDLQPREFRLL
EHLMRAAGRVQTRTMLLEAVWDFHFDPGTSVVETHMSRLRAKIDRPFDKPLLHTVRGAGYMLKA

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=224, Percent_Identity=45.5357142857143, Blast_Score=197, Evalue=6e-52,
Organism=Escherichia coli, GI87082012, Length=224, Percent_Identity=43.3035714285714, Blast_Score=183, Evalue=7e-48,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=40.990990990991, Blast_Score=156, Evalue=8e-40,
Organism=Escherichia coli, GI1790552, Length=228, Percent_Identity=42.5438596491228, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=33.3333333333333, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1786911, Length=220, Percent_Identity=33.1818181818182, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=34.375, Blast_Score=118, Evalue=3e-28,
Organism=Escherichia coli, GI1786599, Length=222, Percent_Identity=32.8828828828829, Blast_Score=114, Evalue=6e-27,
Organism=Escherichia coli, GI2367329, Length=228, Percent_Identity=38.1578947368421, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1788394, Length=224, Percent_Identity=31.6964285714286, Blast_Score=104, Evalue=4e-24,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=30.8370044052863, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=31.140350877193, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=28.5714285714286, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=31.140350877193, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790437, Length=112, Percent_Identity=37.5, Blast_Score=74, Evalue=6e-15,
Organism=Escherichia coli, GI1788713, Length=128, Percent_Identity=35.15625, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1788550, Length=109, Percent_Identity=33.0275229357798, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 24800; Mature: 24800

Theoretical pI: Translated: 7.88; Mature: 7.88

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILLAEDDRQTADYLRQGLLAEGYSVDHVPDGRDALVQATLQPYDLLVVDRMMPGLDGL
CEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCHH
SLVKALRSAQIKAPILILTAMGGVTDRVEGLQAGADDYLVKPFAFSELSARLAALARRPA
HHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCCC
LAEGARDLLRVGDLTLDTVRRTVSRGGTEIDLQPREFRLLEHLMRAAGRVQTRTMLLEAV
HHHHHHHHHHHCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
WDFHFDPGTSVVETHMSRLRAKIDRPFDKPLLHTVRGAGYMLKA
HHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECC
>Mature Secondary Structure
MKILLAEDDRQTADYLRQGLLAEGYSVDHVPDGRDALVQATLQPYDLLVVDRMMPGLDGL
CEEEEECCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCCCCCHH
SLVKALRSAQIKAPILILTAMGGVTDRVEGLQAGADDYLVKPFAFSELSARLAALARRPA
HHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCCC
LAEGARDLLRVGDLTLDTVRRTVSRGGTEIDLQPREFRLLEHLMRAAGRVQTRTMLLEAV
HHHHHHHHHHHCCCHHHHHHHHHHCCCCEECCCHHHHHHHHHHHHHHCHHHHHHHHHHHH
WDFHFDPGTSVVETHMSRLRAKIDRPFDKPLLHTVRGAGYMLKA
HHHCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]