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The map label for this gene is purK [H]

Identifier: 77461842

GI number: 77461842

Start: 6294834

End: 6295916

Strand: Reverse

Name: purK [H]

Synonym: Pfl01_5621

Alternate gene names: 77461842

Gene position: 6295916-6294834 (Counterclockwise)

Preceding gene: 77461843

Following gene: 77461841

Centisome position: 97.79

GC content: 62.97

Gene sequence:

>1083_bases
ATGAAAATCGGTGTAATCGGTGGCGGCCAGTTGGGTCGCATGTTGGCCCTGGCGGGCACCCCGCTGGGCATGAACTTCGC
TTTCCTCGACCCTGCGCCGGACGCTTGCGCCGCTGCGCTGGGCGAACACCTGCGGGCCGATTACGGCGATCAGGATCACC
TGCGTCAATTGGCCGATGAAGTCGATCTGGTGACCTTCGAGTTCGAAAGCGTCCCGGCGGAAACCGTGGCGTTCCTTTCG
CAGTTCGTGCCGGTCTACCCGAGCGCTGAAGCCCTGCGCATCGCCCGCGACCGCTGGTTCGAAAAGAGCATGTTCAAGGA
CCTGGGGATTCCGACCCCAGCGTTCGCCGACATCCAGTCGCAAGCCGACCTGGACGCCGCCGTTGCGTCGATCGGCCTGC
CGGCCGTCCTGAAAACCCGCACCCTGGGTTACGACGGCAAGGGCCAGAAAGTCCTGCGCAAGCCGGAAGATGTGGTCGGT
ACCTTCGCCGAACTGGGCAGCGTGCCTTGCCTGCTGGAAGGCTTCGTGCCATTCACTGGCGAAGTGTCGCTGATCGCCGT
GCGCGCCCGCGATGGCGAGACGAAGTTCTATCCACTGGTGCACAACACCCACGACAGCGGCATCCTCAAGCTGTCGGTCG
CCAGCTCCGATCACCCGCTCCAGGCCCTGGCCGAAGATTATTCCAGCCGCGTGCTCAAACAGCTGGATTATGTCGGTGTG
ATGGCGTTCGAGTTCTTTGAAGTCGACGGCGGCCTCAAGGCCAACGAAATCGCACCGCGCGTGCACAACTCCGGGCACTG
GACCACCGAAGGCGCCGAGTGCAGCCAGTTCGAAAACCACCTGCGGGCCGTTGCCGGTCTGCCGCTGGGTTCGACCGCCA
AGGTCGGCGAGAGCGCGATGCTCAACTTCATCGGCGTTGTTCCGCCGGTTGAAAAAGTCATCGCCATCGACGATTGCCAC
CTGCATCACTACGGCAAGGCCTTCAAGGCCGGGCGCAAGGTCGGTCACGCCAACCTGCGCTGCAAGGACAAGGCGACCCT
CGAGCAACAGATTCTCAAGGTCGAAGCGCTGATCGCCGAGTAA

Upstream 100 bases:

>100_bases
AAGCATCCGCAATTCCACGCGGTACTGAAAACCTTCCGTGCCGAGCAGACAGACAGCGTCCTGGACAATCCAGACCCACG
TATTGCCTGAGGTTGTTGAG

Downstream 100 bases:

>100_bases
CGACAGTTTCATCTGGCAGCGGCGGAACCATTAAGGGGCCGCCGTTCTCTGATGGCAGGATGCGAAAGTCTGGCTAGGCT
TCATCGCATATCTACCATTC

Product: phosphoribosylaminoimidazole carboxylase ATPase subunit

Products: NA

Alternate protein names: N5-CAIR synthase; 5-(carboxyamino)imidazole ribonucleotide synthetase [H]

Number of amino acids: Translated: 360; Mature: 360

Protein sequence:

>360_residues
MKIGVIGGGQLGRMLALAGTPLGMNFAFLDPAPDACAAALGEHLRADYGDQDHLRQLADEVDLVTFEFESVPAETVAFLS
QFVPVYPSAEALRIARDRWFEKSMFKDLGIPTPAFADIQSQADLDAAVASIGLPAVLKTRTLGYDGKGQKVLRKPEDVVG
TFAELGSVPCLLEGFVPFTGEVSLIAVRARDGETKFYPLVHNTHDSGILKLSVASSDHPLQALAEDYSSRVLKQLDYVGV
MAFEFFEVDGGLKANEIAPRVHNSGHWTTEGAECSQFENHLRAVAGLPLGSTAKVGESAMLNFIGVVPPVEKVIAIDDCH
LHHYGKAFKAGRKVGHANLRCKDKATLEQQILKVEALIAE

Sequences:

>Translated_360_residues
MKIGVIGGGQLGRMLALAGTPLGMNFAFLDPAPDACAAALGEHLRADYGDQDHLRQLADEVDLVTFEFESVPAETVAFLS
QFVPVYPSAEALRIARDRWFEKSMFKDLGIPTPAFADIQSQADLDAAVASIGLPAVLKTRTLGYDGKGQKVLRKPEDVVG
TFAELGSVPCLLEGFVPFTGEVSLIAVRARDGETKFYPLVHNTHDSGILKLSVASSDHPLQALAEDYSSRVLKQLDYVGV
MAFEFFEVDGGLKANEIAPRVHNSGHWTTEGAECSQFENHLRAVAGLPLGSTAKVGESAMLNFIGVVPPVEKVIAIDDCH
LHHYGKAFKAGRKVGHANLRCKDKATLEQQILKVEALIAE
>Mature_360_residues
MKIGVIGGGQLGRMLALAGTPLGMNFAFLDPAPDACAAALGEHLRADYGDQDHLRQLADEVDLVTFEFESVPAETVAFLS
QFVPVYPSAEALRIARDRWFEKSMFKDLGIPTPAFADIQSQADLDAAVASIGLPAVLKTRTLGYDGKGQKVLRKPEDVVG
TFAELGSVPCLLEGFVPFTGEVSLIAVRARDGETKFYPLVHNTHDSGILKLSVASSDHPLQALAEDYSSRVLKQLDYVGV
MAFEFFEVDGGLKANEIAPRVHNSGHWTTEGAECSQFENHLRAVAGLPLGSTAKVGESAMLNFIGVVPPVEKVIAIDDCH
LHHYGKAFKAGRKVGHANLRCKDKATLEQQILKVEALIAE

Specific function: Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR) [H]

COG id: COG0026

COG function: function code F; Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786733, Length=359, Percent_Identity=38.4401114206128, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1788155, Length=310, Percent_Identity=25.4838709677419, Blast_Score=91, Evalue=2e-19,
Organism=Saccharomyces cerevisiae, GI6324702, Length=371, Percent_Identity=31.5363881401617, Blast_Score=181, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005875
- InterPro:   IPR011761
- InterPro:   IPR003135
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02222 ATP-grasp [H]

EC number: =6.3.4.18 [H]

Molecular weight: Translated: 38822; Mature: 38822

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50975 ATP_GRASP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIGVIGGGQLGRMLALAGTPLGMNFAFLDPAPDACAAALGEHLRADYGDQDHLRQLADE
CEEEEECCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
VDLVTFEFESVPAETVAFLSQFVPVYPSAEALRIARDRWFEKSMFKDLGIPTPAFADIQS
HCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
QADLDAAVASIGLPAVLKTRTLGYDGKGQKVLRKPEDVVGTFAELGSVPCLLEGFVPFTG
HHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHCCCCEEECCCCCCCC
EVSLIAVRARDGETKFYPLVHNTHDSGILKLSVASSDHPLQALAEDYSSRVLKQLDYVGV
CEEEEEEEECCCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
MAFEFFEVDGGLKANEIAPRVHNSGHWTTEGAECSQFENHLRAVAGLPLGSTAKVGESAM
HHHEEEECCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCHHHH
LNFIGVVPPVEKVIAIDDCHLHHYGKAFKAGRKVGHANLRCKDKATLEQQILKVEALIAE
HHHHCCCCCHHHEEEECCCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKIGVIGGGQLGRMLALAGTPLGMNFAFLDPAPDACAAALGEHLRADYGDQDHLRQLADE
CEEEEECCCHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCHHHHHHHHHH
VDLVTFEFESVPAETVAFLSQFVPVYPSAEALRIARDRWFEKSMFKDLGIPTPAFADIQS
HCEEEEECCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHH
QADLDAAVASIGLPAVLKTRTLGYDGKGQKVLRKPEDVVGTFAELGSVPCLLEGFVPFTG
HHHHHHHHHHCCCCHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHCCCCEEECCCCCCCC
EVSLIAVRARDGETKFYPLVHNTHDSGILKLSVASSDHPLQALAEDYSSRVLKQLDYVGV
CEEEEEEEECCCCCEEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHH
MAFEFFEVDGGLKANEIAPRVHNSGHWTTEGAECSQFENHLRAVAGLPLGSTAKVGESAM
HHHEEEECCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCHHHH
LNFIGVVPPVEKVIAIDDCHLHHYGKAFKAGRKVGHANLRCKDKATLEQQILKVEALIAE
HHHHCCCCCHHHEEEECCCHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8816818; 10984043 [H]